Search Results - "MCCONNELL, Beth B"

Mammalian Krüppel-like factors in health and diseases by McConnell, Beth B, Yang, Vincent W

“…The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological processes that include proliferation, differentiation, growth,…”
Get full text

The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology by McConnell, Beth B., Ghaleb, Amr M., Nandan, Mandayam O., Yang, Vincent W.

“…The Krüppel‐like factors (KLFs) comprise a family of evolutionarily conserved zinc finger transcription factors that regulate numerous biological processes…”
Get full text

Krüppel-Like Factor 5 Is Important for Maintenance of Crypt Architecture and Barrier Function in Mouse Intestine by McConnell, Beth B, Kim, Samuel S, Yu, Ke, Ghaleb, Amr M, Takeda, Norifumi, Manabe, Ichiro, Nusrat, Asma, Nagai, Ryozo, Yang, Vincent W

“…Background & Aims Krüppel-like factor 5 (KLF5) is transcription factor that is expressed by dividing epithelial cells of the intestinal epithelium. KLF5…”
Get full text

Notch1 Regulates the Effects of Matrix Metalloproteinase-9 on Colitis-Associated Cancer in Mice by Garg, Pallavi, Jeppsson, Sabrina, Dalmasso, Guillaume, Ghaleb, Amr M, McConnell, Beth B, Yang, Vincent W, Gewirtz, Andrew T, Merlin, Didier, Sitaraman, Shanthi V

“…Background & Aims Inflammatory bowel disease increases the risks of colon cancer and colitis-associated cancer (CAC). Epithelial cell–derived matrix…”
Get full text

Krüppel-Like Factor 5 Protects Against Dextran Sulfate Sodium−Induced Colonic Injury in Mice by Promoting Epithelial Repair by McConnell, Beth B, Kim, Samuel S, Bialkowska, Agnieszka B, Yu, Ke, Sitaraman, Shanthi V, Yang, Vincent W

“…Background & Aims Krüppel-like factor 5 (KLF5) is a transcription factor that promotes proliferation, is highly expressed in dividing crypt cells of the…”
Get full text

The role of inflammation in the pathogenesis of colorectal cancer by McConnell, Beth B., Yang, Vincent W.

“…Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and…”
Get full text

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations by Nandan, Mandayam O, Ghaleb, Amr M, McConnell, Beth B, Patel, Nilesh V, Robine, Sylvie, Yang, Vincent W

“…Both mutational inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene and activation of the KRAS oncogene are implicated in the…”
Get full text

Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene by Ghaleb, Amr M., McConnell, Beth B., Kaestner, Klaus H., Yang, Vincent W.

“…The zinc finger transcription factor, Krüppel-like factor 4 (KLF4), is expressed in the post-mitotic, differentiated epithelial cells lining the intestinal…”
Get full text

Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon by Nandan, Mandayam O., Ghaleb, Amr M., Liu, Yang, Bialkowska, Agnieszka B., McConnell, Beth B., Shroyer, Kenneth R., Robine, Sylvie, Yang, Vincent W.

“…Krüppel-like factor 5 (KLF5) is a pro-proliferative transcriptional regulator primarily expressed in the intestinal crypt epithelial cells. Constitutive…”
Get full text

SUMOylation Regulates Nuclear Localization of Krüppel-like Factor 5 by Du, James X., Bialkowska, Agnieszka B., McConnell, Beth B., Yang, Vincent W.

“…SUMOylation is a form of post-translational modification shown to control nuclear transport. Krüppel-like factor 5 (KLF5) is an important mediator of cell…”
Get full text

A Small Ubiquitin-related Modifier-interacting Motif Functions as the Transcriptional Activation Domain of Krüppel-like Factor 4 by Du, James X., McConnell, Beth B., Yang, Vincent W.

“…The zinc finger transcription factor, Krüppel-like factor 4 (KLF4), regulates numerous biological processes, including proliferation, differentiation, and…”
Get full text

Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine by McConnell, Beth B, Bialkowska, Agnieszka B, Nandan, Mandayam O, Ghaleb, Amr M, Gordon, Frank J, Yang, Vincent W

“…Inactivation of the tumor suppressor adenomatous polyposis coli, with the resultant activation of beta-catenin, is the initiating event in the development of a…”
Get full text

Krüppel-Like Factor 5 Mediates Cellular Transformation During Oncogenic KRAS -Induced Intestinal Tumorigenesis by Nandan, Mandayam O, McConnell, Beth B, Ghaleb, Amr M, Bialkowska, Agnieszka B, Sheng, Hongmiao, Shao, Jinyi, Babbin, Brian A, Robine, Sylvie, Yang, Vincent W

“…Background & Aims: Krüppel-like factor 5 (KLF5) is a zinc finger–transcription factor that regulates cell proliferation. Oncogenic KRAS mutations are commonly…”
Get full text

Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli-dependent intestinal tumorigenesis by GHALEB, Amr M, MCCONNELL, Beth B, NANDAN, Mandayam O, KATZ, Jonathan P, KAESTNER, Klaus H, YANG, Vincent W

“…The zinc finger transcription factor Krüppel-like factor 4 (KLF4) is frequently down-regulated in colorectal cancer. Previous studies showed that the…”
Get full text

Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells by Chanchevalap, Sengthong, Nandan, Mandayam O, McConnell, Beth B, Charrier, Laetitia, Merlin, Didier, Katz, Jonathan P, Yang, Vincent W

“…Lipopolysaccharide (LPS) is a bacterially-derived endotoxin that elicits a strong proinflammatory response in intestinal epithelial cells. It is well…”
Get full text

Intestine-Specific Deletion of the KrüPpel-Like Factor 4 (KLF4) Gene Protects Mice From Dextran Sulfate Sodium (DSS)-Induced Colitis by Ghaleb, Amr, McConnell, Beth B, Yang, Vincent W

Get full text

TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers by CONWAY, Kerry E, MCCONNELL, Beth B, BOWRING, Claire E, DONALD, Carlton D, WARREN, Stephen T, VERTINO, Paula M

“…Gene silencing associated with aberrant methylation of promoter region CpG islands is an acquired epigenetic alteration that serves as an alternative to…”
Get full text

Krüppel-Like Factor 5 Mediates Transmissible Murine Colonic Hyperplasia Caused by Citrobacter rodentium Infection by McConnell, Beth B, Klapproth, Jan–Michael A, Sasaki, Maiko, Nandan, Mandayam O, Yang, Vincent W

“…Background & Aims: Krüppel-like factor 5 (KLF5) is a transcription factor that is highly expressed in proliferating crypt cells of the intestinal epithelium…”
Get full text

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts by McConnell, Beth B., Starborg, Maria, Brookes, Sharon, Peters, Gordon

“…After a limited number of population doublings (PDs), cultures of normal mammalian diploid cells undergo an irreversible growth arrest known as replicative…”
Get full text

KrüPpel-Like Factor 5 is a Key Factor for Maintenance of Crypt Architecture and Barrier Function in the Mouse Intestine by McConnell, Beth B, Kim, Samuel S, Ghaleb, Amr, Takeda, Norifumi, Manabe, Ichiro, Nusrat, Asma, Nagai, Ryozo, Yang, Vincent W

Get full text