Search Results - "MCCLUSKEY, R. T"

Glycoprotein 330/Megalin: Probable Role in Receptor-Mediated Transport of Apolipoprotein J Alone and in a Complex with Alzheimer Disease Amyloid β at the Blood-Brain and Blood-Cerebrospinal Fluid Barriers by Zlokovic, Berislav V., Martel, Cynthia L., Matsubara, Etsuro, McComb, J. Gordon, Zheng, Gang, McCluskey, Robert T., Frangione, Blas, Ghiso, Jorge

“…A soluble form of Alzheimer disease amyloid β -protein (sAβ ) is transported in the blood and cerebrospinal fluid mainly complexed with apolipoprotein J…”
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Wegener's Granulomatosis Autoantigen Is a Novel Neutrophil Serine Proteinase by Niles, John L., McCluskey, Robert T., Ahmad, Mir F., Arnaout, M. Amin

“…Circulating IgG autoantibodies that produce cytoplasmic immunofluorescence staining of ethanol-fixed normal neutrophils have recently been found in a large…”
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Antibodies to intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 prevent crescent formation in rat autoimmune glomerulonephritis by NISHIKAWA, K, GUO, Y.-J, MIYASAKA, M, TAMATANI, T, COLLINS, A. B, SY, M.-S, MCCLUSKEY, R. T, ANDRES, G

“…In patients with glomerulonephritis widespread crescents are associated with a poor prognosis. Crescent formation appears to depend on the migration of…”
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Comparison of anti-GBM antibodies in sera with or without ANCA by HELLMARK, T, NILES, J. L, COLLINS, A. B, MCCLUSKEY, R. T, BRUNMARK, C

“…An appreciable percentage of patients with serum anti-glomerular basement membrane (anti-GBM) antibodies also have antineutrophil cytoplasmic antibodies…”
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Induction of Heymann nephritis with a gp330/megalin fusion protein by Raychowdhury, R, Zheng, G, Brown, D, McCluskey, RT

“…There is considerable evidence that glomerular deposits in Heymann nephritis, a rat model of membranous nephritis, result from shedding of immune complexes…”
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Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70 by Maheswaran, S, Englert, C, Zheng, G, Lee, S B, Wong, J, Harkin, D P, Bean, J, Ezzell, R, Garvin, A J, McCluskey, R T, DeCaprio, J A, Haber, D A

“…The Wilms tumor suppressor WT1 encodes a zinc finger transcription factor that is expressed in glomerular podocytes during a narrow window in kidney…”
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Targeting of thyroglobulin to transcytosis following megalin-mediated endocytosis: Evidence for a preferential pH-independent pathway by MARINO, M, LIST, S, PINCHERS, A, CHIOVATO, L, MCCLUSKEY, R. T

“…TG internalized from the colloid by megalin, bypasses the lysosomal pathway and is transported across thyrocytes by transcytosis. Although most of the…”
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Identification of thyroglobulin in orbital tissues of patients with thyroid-associated ophthalmopathy by Marinò, M, Lisi, S, Pinchera, A, Mazzi, B, Latrofa, F, Sellari-Franceschini, S, McCluskey, R T, Chiovato, L

“…Thyroid-associated ophthalmopathy (TAO) is thought to have an autoimmune pathogenesis because of its association with autoimmune thyroid disease, in particular…”
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Cytotoxicity and apoptosis in human renal allografts: identification, distribution, and quantitation of cells with a cytotoxic granule protein GMP-17 (TIA-1) and cells with fragmented nuclear DNA by Meehan, S M, McCluskey, R T, Pascual, M, Preffer, F I, Anderson, P, Schlossman, S F, Colvin, R B

“…In the present study, we analyzed human renal allografts using immunohistochemical techniques to determine the site, identity, and frequency of (a) cytotoxic…”
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Megalin in thyroid physiology and pathology by Marinò, M, Pinchera, A, McCluskey, R T, Chiovato, L

“…Megalin, a member of the low density lipoprotein endocytic receptor family, is expressed on the apical surface of thyroid epithelial cells, directly facing the…”
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Tissue factor in crescentic glomerulonephritis by MCCLUSKEY, R. T

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Phosphoinositide 3-kinase inhibits megalin-mediated transcytosis of thyroglobulin across thyroid epithelial cells at a post-sorting level by MARINO, Michele, CHIOVATO, Luca, LISI, Simonetta, PINCHERA, Aldo, MCCLUSKEY, Robert T

“…Phosphoinositide 3-kinase (PI3-K) is implicated in various cellular processes involving signaling, including intracellular trafficking. PI3-K has been shown to…”
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Autoimmune Target in Heymann Nephritis is a Glycoprotein with Homology to the LDL Receptor by Raychowdhury, Raktima, Niles, John L., McCluskey, Robert T., Smith, John A.

“…The pathogenesis of Heymann nephritis, a rat model of human membranous glomerulonephritis, depends on the interaction of autoantibodies with a renal…”
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Bilateral renal enlargement: an unusual presentation of bacterial pyelonephritis by Noseworthy, P A, Chicano, S L, McCluskey, R T, Bazari, H

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Detection of two forms of GP330. Their role in Heymann nephritis by Bachinsky, DR, Zheng, G, Niles, JL, McLaughlin, M, Abbate, M, Andres, G, Brown, D, McCluskey, RT

“…Heymann nephritis is characterized by glomerular immune deposits that contain a glycoprotein called gp330. The deposits are believed to result from shedding of…”
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Binding of rat thyroglobulin to heparan sulfate proteoglycans by Marinò, M, Andrews, D, McCluskey, R T

“…We previously showed that rat thyroglobulin (Tg) is a heparin-binding protein and that heparin inhibits Tg binding to megalin (gp330), an endocytic Tg receptor…”
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Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis by MARINO, M, CHIOVATO, L, FRIEDLANDER, J. A, LATROFA, F, PINCHERA, A, MCCLUSKEY, R. T

“…Megalin (gp330) is a multiligand receptor found on the apical surface of selected epithelial cells, including thyroid cells. We recently showed that megalin is…”
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Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway by Lisi, S, Chiovato, L, Pinchera, A, Marcocci, C, Menconi, F, Morabito, E, Altea, M A, McCluskey, R T, Marinò, M

“…Secretion of thyroglobulin (Tg) by thyrocytes requires several endoplasmic reticulum (ER)-resident molecular chaperones. The receptor-associated protein (RAP),…”
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Colchicine-induced redistribution of an apical membrane glycoprotein (gp330) in proximal tubules by Gutmann, E J, Niles, J L, McCluskey, R T, Brown, D

“…Factors governing the selective, polarized insertion of membrane proteins are poorly understood, but some studies have suggested that microtubules are involved…”
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Correlation of antineutrophil cytoplasmic antibodies with the extrarenal histopathology of Wegener's (pathergic) granulomatosis and related forms of vasculitis by Fienberg, R, Mark, E J, Goodman, M, McCluskey, R T, Niles, J L

“…We studied the histologic findings from extrarenal biopsies (especially of the lung or upper respiratory tract) or autopsies of 68 patients who were tested for…”
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