Search Results - "MCCLOSKEY, Timothy C"

CoMFA, Synthesis, and Pharmacological Evaluation of (E)-3-(2-Carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic Acids:  3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic Acid, a Potent Selective Glycine-Site NMDA Receptor Antagonist by Baron, Bruce M, Cregge, Robert J, Farr, Robert A, Friedrich, Dirk, Gross, Raymond S, Harrison, Boyd L, Janowick, David A, Matthews, Donald, McCloskey, Timothy C, Meikrantz, Scott, Nyce, Philip L, Vaz, Roy, Metz, William A

“…(E)-3-(2-Carboxy-2-phenylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acid, 1, is a potent and selective antagonist of the glycine site of the…”
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Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist by Baron, Bruce M, Harrison, Boyd L, Kehne, John H, Schmidt, Christopher J, Van Giersbergen, Paul L.M, White, H.Steven, Siegel, Barry W, Senyah, Yaw, McCloskey, Timothy C, Fadayel, Gina M, Taylor, Vicki L, Murawsky, Michael K, Nyce, Phillip, Salituro, Francesco G

“…MDL 105,519, ( E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1 H-indole-2-carboxylic acid, is a potent and selective inhibitor of [ 3H]glycine binding to the…”
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Effects of the CRF1 receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups by Kehne, John H., Coverdale, Shane, McCloskey, Timothy C., Hoffman, Diane C., Cassella, James V.

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5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents by Kane, John M, Staeger, Michael A, Dalton, Christopher R, Miller, Francis P, Dudley, Mark W, Ogden, Ann Marie L, Kehne, John H, Ketteler, Herbert J, McCloskey, Timothy C

“…Selected examples from three series of isomeric (alkylthio)-1,2,4-triazoles were prepared and examined for anticonvulsant activity versus strychnine-,…”
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Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties by Kehne, John H, Kane, J.Michael, Chaney, Stephen F, Hurst, Gail, McCloskey, Timothy C, Petty, Margaret A, Senyah, Yaw, Wolf, Harold H, Zobrist, Ray, White, H.Steve

“…The compound 5-(4-chlorophenyl)-2,4-dihydro-4-ethyl-3H-1,2,4-triazol-3-one (MDL 27,192) was evaluated in a variety of rodent models to assess its…”
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Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile by Kehne, J H, Baron, B M, Carr, A A, Chaney, S F, Elands, J, Feldman, D J, Frank, R A, van Giersbergen, P L, McCloskey, T C, Johnson, M P, McCarty, D R, Poirot, M, Senyah, Y, Siegel, B W, Widmaier, C

“…In preclinical studies, [R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4- piperidinemethanol] [formula: see text] (MDL 100,907), a putative…”
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5-HT modulation of auditory and visual sensorimotor gating: II. Effects of the 5-HT2A antagonist MDL 100,907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats by Padich, R A, McCloskey, T C, Kehne, J H

“…Increasing evidence suggests an important role of 5-HT, and 5-HT2A receptors in particular, in the etiology and treatment of schizophrenia. The prepulse…”
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CoMFA, Synthesis, and Pharmacological Evaluation of ( E )-3-(2-Carboxy-2-arylvinyl)-4,6-dichloro-1 H -indole-2-carboxylic Acids:  3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1 H -indole-2-carboxylic Acid, a Potent Selective Glycine-Site NMDA Receptor Antagonist by Baron, Bruce M., Cregge, Robert J., Farr, Robert A., Friedrich, Dirk, Gross, Raymond S., Harrison, Boyd L., Janowick, David A., Matthews, Donald, McCloskey, Timothy C., Meikrantz, Scott, Nyce, Philip L., Vaz, Roy, Metz, William A.

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CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonis by BARON, Bruce M, CREGGE, Robert J, NYCE, Philip L, VAZ, Roy, METZ, William A, FARR, Robert A, FRIEDRICH, Dirk, GROSS, Raymond S, HARRISON, Boyd L, JANOWICK, David A, MATTHEWS, Donald, MCCLOSKEY, Timothy C, MEIKRANTZ, Scott

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5-HT modulation of auditory and visual sensorimotor gating: I. Effects of 5-HT releasers on sound and light prepulse inhibition in Wistar rats by Kehne, J H, Padich, R A, McCloskey, T C, Taylor, V L, Schmidt, C J

“…Increasing evidence suggests an important role for serotonin (5-HT) neurons in the etiology and treatment of schizophrenia. The prepulse inhibition paradigm is…”
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Effects of the CRF 1 receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups by Kehne, John H., Coverdale, Shane, McCloskey, Timothy C., Hoffman, Diane C., Cassella, James V.

“…CRF 1 receptor antagonists have been proposed as novel pharmacological treatments for depression, anxiety and stress disorders. The primary goal of the present…”
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NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations by Kehne, J H, McCloskey, T C, Baron, B M, Chi, E M, Harrison, B L, Whitten, J P, Palfreyman, M G

“…Pre-weaning rat pups emit ultrasonic vocalizations when removed from the litter. These 'separation-induced vocalizations' (SIV) are suppressed by classical…”
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Dopaminergic, glutamatergic, and serotonergic modulation of sensory gating: Use of prepulse inhibition for evaluating antipsychotic activity and psychotomimetic potential of novel therapeutic compounds by Kehne, John H., McCloskey, Timothy C., Padich, Robert A.

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MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles by Kehne, John H., Baron, Bruce M., Harrison, Boyd L., McCloskey, Timothy C., Palfreyman, Michael G., Poirot, Matthieu, Salituro, Francesco G., Siegel, Barry W., Slone, Amy L., Van Giersbergen, Paul L.M., White, H.Steven

“…Glycine receptor antagonists have been proposed to have multiple therapeutic applications, including the treatment of stroke, epilepsy, and anxiety. The…”
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Buspirone effects in an animal conflict procedure: comparison with diazepam and phenobarbital by McCloskey, T C, Paul, B K, Commissaris, R L

“…Buspirone has been introduced as a novel non-benzodiazepine anti-anxiety agent. The Conditioned Suppression of Drinking (CSD) paradigm is an "animal model" for…”
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Antagonism of the anti-conflict effects of phenobarbital, but not diazepam, by the A-1 adenosine agonistl-PIA by Commissaris, Randall L., McCloskey, Timothy C., Damian, Gracia M., Brown, Brian D., Barraco, Robin A., Altman, Harvey J.

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Antagonism of the anti-conflict effects of phenobarbital, but not diazepam, by the A-1 adenosine agonist l-PIA by Commissaris, R L, McCloskey, T C, Damian, G M, Brown, B D, Barraco, R A, Altman, H J

“…The present study examined the effects of the anxiolytics diazepam and phenobarbital, the A-1 adenosine agonist N6-R-phenylisopropyladenosine (l-PIA), and the…”
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beta-Carboline and pentylenetetrazol effects on conflict behavior in the rat by Hill, T J, Fontana, D J, McCloskey, T C, Commissaris, R L

“…The beta-carbolines and the convulsant agent pentylenetetrazol (PTZ) have been reported as "anxiogenic" in several animal models for anxiety. The present study…”
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The effects of beta-antagonists and anxiolytics on conflict behavior in the rat by Fontana, D J, McCloskey, T C, Jolly, S K, Commissaris, R L

“…The present studies were designed to evaluate the effects of beta-adrenoceptor antagonists and traditional anxiolytics (phenobarbital and diazepam), alone and…”
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MDL 27,531 reduces spontaneous hindlimb contractions in rats with chronic transections of the spinal cord by Kehne, J H, Ketteler, H J, Kane, J M, McCloskey, T C, Senyah, Y, Palfreyman, M G

“…Disrupted glycinergic inhibition in the brainstem and spinal cord may contribute to some of the alterations in reflex control seen in patients with spastic…”
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