Search Results - "MCCAY, P. B"

Demonstration of free radical generation in stunned myocardium of intact dogs with the use of the spin trap α-phenyl N-tert-butyl nitrone by BOLLI, R, PATEL, B. S, JEROUDI, M. O, LAI, E. K, MCCAY, P. B

“…Recent studies suggest that oxygen free radicals may mediate postischemic myocardial dysfunction ("stunning"), but all the evidence for this hypothesis is…”
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Marked Reduction of Free Radical Generation and Contractile Dysfunction by Antioxidant Therapy Begun at the Time of Reperfusion Evidence That Myocardial "Stunning" Is a Manifestation of Reperfusion Injury by Bolli, Roberto, Jeroudi, Mohamed O, Patel, Bharat S, Aruoma, Okezie I, Halliwell, Barry, Lai, Edward K, McCay, Paul B

“…Recent evidence suggests that postischemic myocardial dysfunction (“stunning”) may be mediated by oxygen free radicals, but the exact time window during which…”
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Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog by Bolli, R, Jeroudi, M.O, Patel, B.S, DuBose, C.M, Lai, E.K, Roberts, R, McCay, P.B

“…Electron paramagnetic resonance (EPR) spectroscopy was used to investigate whether (i) the free radicals produced in the ``stunned'' myocardium (myocardium…”
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Vitamin E: interactions with free radicals and ascorbate by MCCAY, P. B

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Demonstration of free radical generation in the stunned myocardium in the conscious dog and identification of major differences between conscious and open-chest dogs by XIAO-YING LI, MCCAY, P. B, ZUGHAIB, M, JEROUDI, M. O, TRIANA, J. F, BOLLI, R

“…Conscious dogs undergoing a 15-min coronary occlusion were given alpha-phenyl N-tert-butyl nitrone (PBN) and the local coronary venous plasma was analyzed by…”
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Reactive Free Radical Generation in vivo in Heart and Liver of Ethanol-Fed Rats: Correlation with Radical Formation in vitro by Reinke, L. A., Lai, E. K., DuBose, C. M., McCay, P. B.

“…Rats fed a high-fat ethanol-containing diet for 2 weeks were found to generate free radicals in liver and heart in vivo. The radicals are believed to be…”
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Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro by McCay, P B, Lai, E K, Poyer, J L, DuBose, C M, Janzen, E G

“…Free radical reactions involved in the metabolism of carbon tetrachloride by rat liver have been considered to be a cause of at least part of the injury…”
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Iron-mediated radical reactions upon reperfusion contribute to myocardial "stunning" by Bolli, R, Patel, B S, Jeroudi, M O, Li, X Y, Triana, J F, Lai, E K, McCay, P B

“…Recent evidence suggests that postischemic myocardial dysfunction ("stunning") is mediated by iron-catalyzed free radical reactions, but the exact time window…”
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Free Radical Formation in Livers of Rats Treated Acutely and Chronically with Alcohol by Reinke, Lester A., Moore, Danny R., McCay, Paul B.

“…The spin trapping method was used to assess formation of free radical intermediates in vivo before and after acute alcohol administration to rats. Ascorbyi…”
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Direct Evidence That the Hydroxyl Radical Plays a Pathogenetic Role in Myocardial “Stunning” in the Conscious Dog and Demonstration That Stunning Can Be Markedly Attenuated Without Subsequent Adverse Effects by Sekili, Selim, McCay, Paul B, Li, Xiao-Ying, Zughaib, Marcel, Sun, Jian-Zhong, Tang, Liang, Thornby, John I, Bolli, Roberto

“…Recent studies suggest that the hydroxyl radical (·OH) plays a pathogenetic role in postischemic ventricular dysfunction (myocardial “stunning”). This concept,…”
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Metabolism of ethanol to 1-hydroxyethyl radicals in vivo: detection with intravenous administration of alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone by Moore, D R, Reinke, L A, McCay, P B

“…Intravenous administration of the spin-trapping agent alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (POBN) to anesthetized but otherwise untreated rats was used…”
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Prevention of DMBA-induced rat mammary carcinomas comparing leuprolide, oophorectomy, and tamoxifen by HOLLINGSWORTH, A. B, LERNER, M. R, LIGHTFOOT, S. A, WILKERSON, K. B, HANAS, J. S, MCCAY, P. B, BRACKETT, D. J

“…Leuprolide, a gonadotropin releasing hormone agonist, is currently being evaluated in a pilot study of premenopausal women for the prevention of breast cancer…”
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Catechol adrenergic agents enhance hydroxyl radical generation in xanthine oxidase systems containing ferritin: implications for ischemia/reperfusion by Allen, D R, Wallis, G L, McCay, P B

“…Iron chelators have been reported to protect tissues against reperfusion injury. This implies that iron is being released into the plasma or is made accessible…”
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Free radicals and septic shock in primates: the role of tumor necrosis factor by Lloyd, S S, Chang, A K, Taylor, Jr, F B, Janzen, E G, McCay, P B

“…The role of free radicals in septic-shock-associated tissue injury and the mechanisms underlying the generation of free radicals in sepsis was investigated in…”
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Lack of myocardial lipid peroxidation during acute reperfusion injury in perfused guinea pig hearts by Barrington, P L, Lai, E, McCay, P B

“…The aim was to test the hypothesis that free radical induced lipid peroxidation contributes to the arrhythmias and contractile changes associated with…”
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Hepatic nuclear envelope cytochrome P-450 in rats fed 2-acetylaminofluorene. Effect of dietary fats and butylated hydroxytoluene by Carubelli, R, McCay, P B

“…Early losses of nuclear envelope (NE) cytochrome P-450 occur during 2-acetylaminofluorene (AAF)-hepatocarcinogenesis. Butylated hydroxytoluene (BHT), which…”
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Evidence that the large loss of glutathione observed in ischemia/reperfusion of the small intestine is not due to oxidation to glutathione disulfide by Gibson, D D, Brackett, D J, Squires, R A, Balla, A K, Lerner, M R, McCay, P B, Pennington, L R

“…Reperfusion injury following ischemia is thought to be the consequence of reactive oxygen species possibly generated either by xanthine oxidase activity or by…”
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Hydroxyl radicals are generated by hepatic microsomes during NADPH oxidation: relationship to ethanol metabolism by McCay, P B, Reinke, L A, Rau, J M

“…Ethanol is metabolized to acetaldehyde by hepatic microsomes in a reaction that requires cytochrome P-450, and a role for hydroxyl radicals has been implicated…”
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Development of Circulatory and Metabolic Shock Following Transient Portal Triad Occlusion by Gonce, Mike E., Brackett, Daniel J., Squires, Ronald A., Gibson, Donald D., Balla, Andre K., Lerner, Megan R., McCay, Paul B., Pennington, Larry R.

“…Liver ischemia is purposefully induced by portal triad occlusion (PTO) in several clinical situations including liver surgery for trauma, tumor, and…”
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GSH‐dependent inhibition of lipid peroxidation: Properties of a potent cytosolic system which protects cell membranes by Gibson, Donald D., Hawrylko, Josephine, McCay, Paul B.

“…Properties of a heat labile, nondialyzable cytosolic factor which prevents lipid peroxidation in membranous organelles are described. The factor is present in…”
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