Search Results - "MCCARTY, Marya"

Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content by McCarty, Marya F, Somcio, Ray J, Stoeltzing, Oliver, Wey, Jane, Fan, Fan, Liu, Wenbiao, Bucana, Corazon, Ellis, Lee M

“…We hypothesized that overexpression of PDGF-BB in colorectal cancer (CRC) and pancreatic cancer cells would result in increased pericyte coverage of ECs in…”
Get full text

Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells by FAN FAN, WEY, Jane S, ELLIS, Lee M, MCCARTY, Marya F, BELCHEVA, Anna, WENBIAO LIU, BAUER, Todd W, SOMCIO, Ray J, YAN WU, HOOPER, Andrea, HICKLIN, Daniel J

“…Vascular endothelial growth factor (VEGF) is associated with tumor angiogenesis and poor prognosis in human colorectal cancer (CRC). VEGF receptor-1 (VEGFR-1…”
Get full text

Vascular endothelial growth factor receptor‐1 promotes migration and invasion in pancreatic carcinoma cell lines by Wey, Jane S., Fan, Fan, Gray, Michael J., Bauer, Todd W., McCarty, Marya F., Somcio, Ray, Liu, Wenbiao, Evans, Douglas B., Wu, Yan, Hicklin, Daniel J., Ellis, Lee M.

“…BACKGROUND Vascular endothelial growth factor receptor‐1 (VEGFR‐1) is one of three receptor tyrosine kinases for VEGF, a key regulator of angiogenesis in…”
Get full text

Fully Humanized Neutralizing Antibodies to Interleukin-8 (ABX-IL8) Inhibit Angiogenesis, Tumor Growth, and Metastasis of Human Melanoma by Huang, Suyun, Mills, Lisa, Mian, Badar, Tellez, Carmen, McCarty, Marya, Yang, X.-D., Gudas, Jean M., Bar-Eli, Menashe

“…Interleukin-8 (IL-8) has recently been shown to contribute to human melanoma progression by functioning as a mitogenic and angiogenic factor. In the present…”
Get full text

Role of Hypoxia-Inducible Factor 1α in Gastric Cancer Cell Growth, Angiogenesis, and Vessel Maturation by Stoeltzing, Oliver, McCarty, Marya F., Wey, Jane S., Fan, Fan, Liu, Wenbiao, Belcheva, Anna, Bucana, Corazon D., Semenza, Gregg L., Ellis, Lee M.

“…Background: Hypoxia-inducible factor 1 (HIF-1), a heterodimer comprising the oxygen-regulated subunit, HIF-1α, and HIF-1β, mediates transcription of the gene…”
Get full text

Inhibition of integrin α5β1 function with a small peptide (ATN‐161) plus continuous 5‐FU infusion reduces colorectal liver metastases and improves survival in mice by Stoeltzing, Oliver, Liu, Wenbiao, Reinmuth, Niels, Fan, Fan, Parry, Graham C., Parikh, Alexander A., McCarty, Marya F., Bucana, Corazon D., Mazar, Andrew P., Ellis, Lee M.

“…Integrin α5β1 is expressed on activated endothelial cells and plays a critical role in tumor angiogenesis. We hypothesized that a novel integrin α5β1…”
Get full text

Blockade of Epidermal Growth Factor Receptor Signaling on Tumor Cells and Tumor-Associated Endothelial Cells for Therapy of Human Carcinomas by Baker, Cheryl H., Kedar, Daniel, McCarty, Marya F., Tsan, Rachel, Weber, Kristen L., Bucana, Corazon D., Fidler, Isaiah J.

“…The purpose of this study was to determine whether the expression of epidermal growth factor receptor (EGF-R) and activated EGF-R by tumor-associated…”
Get full text

ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and angiogenesis of gastric cancer by McCarty, Marya F, Wey, Jane, Stoeltzing, Oliver, Liu, Wenbiao, Fan, Fan, Bucana, Corazon, Mansfield, Paul F, Ryan, Anderson J, Ellis, Lee M

“…Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) have been strongly implicated in the growth and metastasis of gastric cancer. The…”
Get full text

Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors by STOELTZING, Oliver, AHMAD, Syed A, ELLIS, Lee M, WENBIAO LIU, MCCARTY, Marya F, WEY, Jane S, PARIKH, Alexander A, FAN FAN, REINMUTH, Niels, KAWAGUCHI, Michiya, BUCANA, Corazon D

“…Angiopoietin (Ang)-1 and -2 are critical regulators of embryonic and postnatal neovascularization. Ang-1 activates the endothelial cell-specific tyrosine…”
Get full text

Up-regulation of flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1 by HAZARIKA, Parul, MCCARTY, Marya F, PRIETO, Victor G, GEORGE, Saira, BABU, Daniel, KOUL, Dimpy, BAR-ELI, Menashe, DUVIC, Madeleine

“…Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction…”
Get full text

Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors by GRAY, Michael J, WEY, Jane S, BELCHEVA, Anna, MCCARTY, Marya F, TREVINO, Jose G, EVANS, Douglas B, ELLIS, Lee M, GALLICK, Gary E

“…Neuropilin-1 (NRP-1) was first described as a coreceptor implicated in neuronal guidance that bound members of the semaphorin/collapsin family. NRP-1 is also…”
Get full text

Expression of Interleukin-8 Correlates with Angiogenesis, Tumorigenicity, and Metastasis of Human Prostate Cancer Cells Implanted Orthotopically in Nude Mice by Kim, Sun Jin, Uehara, Hisanori, Karashima, Takashi, Mccarty, Marya, Shih, Nancy, Fidler, Isaiah J.

“…We determined whether the expression of interleukin-8 (IL-8) by human prostate cancer cells correlates with induction of angiogenesis, tumorigenicity, and…”
Get full text

Interleukin-1β regulates angiopoietin-1 expression in human endothelial cells by FAN FAN, STOELTZING, Oliver, WENBIAO LIU, MCCARTY, Marya F, JUNG, Young D, REINMUTH, Niels, ELLIS, Lee M

“…Angiopoietin (Ang)-1 is an important regulator of endothelial cell (EC) survival and stabilization. Ang-1 exerts its biological effects by binding to the…”
Get full text

Upregulation of neuropilin-1 by basic fibroblast growth factor enhances vascular smooth muscle cell migration in response to VEGF by Liu, Wenbiao, Parikh, Alexander A., Stoeltzing, Oliver, Fan, Fan, McCarty, Marya F., Wey, Jane, Hicklin, Daniel J., Ellis, Lee M.

“…Neuropilin-1 (NRP-1) is a co-receptor for vascular endothelial growth factor (VEGF). During neovascularization, vascular smooth muscle cells (VSMCs) and…”
Get full text

Evidence for the causal role of endogenous interferon-alpha/beta in the regulation of angiogenesis, tumorigenicity, and metastasis of cutaneous neoplasms by McCarty, Marya F, Bielenberg, Diane, Donawho, Cherrie, Bucana, Corazon D, Fidler, Isaiah J

“…Primary tumor growth and metastasis depend on angiogenesis, which is determined by the balance between proangiogenic and antiangiogenic molecules. Interferon…”
Get full text

Quantitative and qualitative in vivo angiogenesis assay by McCarty, Marya F, Baker, Cheryl H, Bucana, Corazon D, Fidler, Isaiah J

“…We describe the development and optimization of an in vivo angiogenesis assay utilizing gelfoam sponges impregnated with 0.4% agarose and different…”
Get more information

Mechanisms of Anti-Angiogenic Tyrosine Kinase Inhibition on Wound Healing: The Obvious and Not So Obvious by McCarty, Marya F., Ellis, Lee M.

“…No Abstract Available Commentary to: Title: SU5416 Delays Wound Healing Through Inhibition of TGF-β1 Activation Authors: Zishan A. Haroon, Khalid Amin, Wilfred…”
Get full text

MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis by Deng, Yong, Yang, Jianhua, McCarty, Marya, Su, Bing

“…Mitogen-activated protein kinase kinase kinase 3 (MEKK3) plays an essential role in embryonic angiogenesis, but its role in tumor growth and angiogenesis is…”
Get more information

Contributions of Stromal Metalloproteinase-9 to Angiogenesis and Growth of Human Ovarian Carcinoma in Mice by Huang, Suyun, Van Arsdall, Melissa, Tedjarati, Sean, McCarty, Marya, Wu, Wenjuan, Langley, Robert, Fidler, Isaiah J.

“…Background: The expression level of several matrix metalloproteinases (MMPs), including MMP-2 and MMP-9, in ovarian cancer cells is directly associated with…”
Get full text

Loss of Activator Protein-2α Results in Overexpression of Protease-activated Receptor-1 and Correlates with the Malignant Phenotype of Human Melanoma by Tellez, Carmen, McCarty, Marya, Ruiz, Maribelis, Bar-Eli, Menashe

“…Increasing evidence implicates the protease-activated receptor-1 (PAR-1) as a contributor to tumor invasion and metastasis of human melanoma. Here we…”
Get full text