Search Results - "MCCARTY, M"

Evaluating the state of the science for adeno-associated virus integration: An integrated perspective by Sabatino, Denise E., Bushman, Frederic D., Chandler, Randy J., Crystal, Ronald G., Davidson, Beverly L., Dolmetsch, Ricardo, Eggan, Kevin C., Gao, Guangping, Gil-Farina, Irene, Kay, Mark A., McCarty, Douglas M., Montini, Eugenio, Ndu, Adora, Yuan, Jing

“…On August 18, 2021, the American Society of Gene and Cell Therapy (ASGCT) hosted a virtual roundtable on adeno-associated virus (AAV) integration, featuring…”
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Correction of Neurological Disease of Mucopolysaccharidosis IIIB in Adult Mice by rAAV9 Trans-Blood–Brain Barrier Gene Delivery by Fu, Haiyan, DiRosario, Julianne, Killedar, Smruti, Zaraspe, Kimberly, McCarty, Douglas M

“…The greatest challenge in developing therapies for mucopolysaccharidosis (MPS) IIIB is to achieve efficient central nervous system (CNS) delivery across the…”
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Autologous transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia achieves outcomes similar to allogeneic transplantation: results of CALGB Study 10001 (Alliance) by Wetzler, Meir, Watson, Dorothy, Stock, Wendy, Koval, Gregory, Mulkey, Flora A, Hoke, Eva E, McCarty, John M, Blum, William G, Powell, Bayard L, Marcucci, Guido, Bloomfield, Clara D, Linker, Charles A, Larson, Richard A

“…Allogeneic stem cell transplantation is the standard approach to Philadelphia chromosome positive acute lymphoblastic leukemia. We hypothesized that imatinib…”
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Differences in patient-reported hormone therapy use for menopause symptoms by provider specialty by McCarty, M. E., Thomas, H. N.

“…Hormone therapy (HT) is an effective treatment for menopause symptoms in select women. This study aimed to determine whether there is different prevalence of…”
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Spectroscopic, Steady-State Kinetic, and Mechanistic Characterization of the Radical SAM Enzyme QueE, Which Catalyzes a Complex Cyclization Reaction in the Biosynthesis of 7‑Deazapurines by McCarty, Reid M, Krebs, Carsten, Bandarian, Vahe

“…7-Carboxy-7-deazaguanine (CDG) synthase (QueE) catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to…”
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GenK-Catalyzed C‑6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-Dependent Radical SAM Enzyme by Kim, Hak Joong, McCarty, Reid M, Ogasawara, Yasushi, Liu, Yung-nan, Mansoorabadi, Steven O, LeVieux, Jake, Liu, Hung-wen

“…The existence of cobalamin (Cbl)-dependent enzymes that are members of the radical S-adenosyl-l-methionine (SAM) superfamily was previously predicted on the…”
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Improving stem cell mobilization strategies: future directions by Bensinger, W, DiPersio, J F, McCarty, J M

“…Autologous hematopoietic SCT (auto-HSCT) provides hematopoietic support after high-dose chemotherapy and is the standard of care for patients with multiple…”
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Integration of adeno-associated virus (AAV) and recombinant AAV vectors by McCarty, Douglas M, Young, Jr, Samuel M, Samulski, R Jude

“…The driving interest in adeno-associated virus (AAV) has been its potential as a gene delivery vector. The early observation that AAV can establish a latent…”
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Mercury Exposure and Children's Health by Bose-O'Reilly, Stephan, MD, MPH, McCarty, Kathleen M., ScD, MPH, Steckling, Nadine, BSc, Lettmeier, Beate, PhD

“…Abstract Acute or chronic mercury exposure can cause adverse effects during any period of development. Mercury is a highly toxic element; there is no known…”
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Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo by MCCARTY, D. M, FU, H, MONAHAN, P. E, TOULSON, C. E, NAIK, P, SAMULSKI, R. J

“…An important limitation of recombinant adeno-associated virus (rAAV) vector efficiency is the requirement of hostcell-mediated synthesis of double-stranded DNA…”
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The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars by Lin, Chia-I, McCarty, Reid M, Liu, Hung-wen

“…Carbohydrates serve many structural and functional roles in biology. While the majority of monosaccharides are characterized by the chemical composition…”
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The role of endogenous and exogenous enzymes in chronic wounds: A focus on the implications of aberrant levels of both host and bacterial proteases in wound healing by McCarty, Sara M., Cochrane, Christine A., Clegg, Peter D., Percival, Steven L.

“…Cutaneous wound healing is orchestrated by a number of physiological pathways that ultimately lead to reformation of skin integrity and the production of…”
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Arsenic geochemistry and human health in South East Asia by McCarty, Kathleen M, Hanh, Hoang Thi, Kim, Kyoung-Woong

“…Arsenic occurs naturally in many environmental components and enters the human body through several exposure pathways. Natural enrichment of arsenic may result…”
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Optimized allele-specific silencing of the dominant-negative COL6A1 G293R substitution causing collagen VI-related dystrophy by Brull, Astrid, Sarathy, Apurva, Bolduc, Véronique, Chen, Grace S., McCarty, Riley M., Bönnemann, Carsten G.

“…Collagen VI-related dystrophies (COL6-RDs) are a group of severe, congenital-onset muscular dystrophies for which there is no effective causative treatment…”
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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis by MCCARTY, D. M, MONAHAN, P. E, SAMULSKI, R. J

“…Adeno-associated virus (AAV) vectors package single-stranded genomes and require host-cell synthesis of the complementary strand for transduction. However,…”
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Maintenance azacitidine after myeloablative allogeneic hematopoietic cell transplantation for myeloid malignancies by Maples, Kathryn T., Sabo, Roy T., McCarty, John M., Toor, Amir A., Hawks, Kelly G.

“…Allogeneic hematopoietic cell transplantation (HCT) is a curative option for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), but…”
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Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores by Donkervoort, Sandra, Kutzner, Carl E., Hu, Ying, Lornage, Xavière, Rendu, John, Stojkovic, Tanya, Baets, Jonathan, Neuhaus, Sarah B., Tanboon, Jantima, Maroofian, Reza, Bolduc, Véronique, Mroczek, Magdalena, Conijn, Stefan, Kuntz, Nancy L., Töpf, Ana, Monges, Soledad, Lubieniecki, Fabiana, McCarty, Riley M., Chao, Katherine R., Governali, Serena, Böhm, Johann, Boonyapisit, Kanokwan, Malfatti, Edoardo, Sangruchi, Tumtip, Horkayne-Szakaly, Iren, Hedberg-Oldfors, Carola, Efthymiou, Stephanie, Noguchi, Satoru, Djeddi, Sarah, Iida, Aritoshi, di Rosa, Gabriella, Fiorillo, Chiara, Salpietro, Vincenzo, Darin, Niklas, Fauré, Julien, Houlden, Henry, Oldfors, Anders, Nishino, Ichizo, de Ridder, Willem, Straub, Volker, Pokrzywa, Wojciech, Laporte, Jocelyn, Foley, A. Reghan, Romero, Norma B., Ottenheijm, Coen, Hoppe, Thorsten, Bönnemann, Carsten G.

“…The myosin-directed chaperone UNC-45B is essential for sarcomeric organization and muscle function from Caenorhabditis elegans to humans. The pathological…”
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Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification by Miles, Zachary D, McCarty, Reid M, Molnar, Gabriella, Bandarian, Vahe

“…Transfer RNA is one of the most richly modified biological molecules. Biosynthetic pathways that introduce these modifications are underexplored, largely…”
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Terrestrial locomotion in elongate fishes: exploring the roles of morphology and substrate in facilitating locomotion by Mehta, R. S., Akesson, K., Redmann, E., McCarty‐Glenn, M., Ortega, R., Syed, S., Yap‐Chiongco, M., Jacquemetton, C., Ward, A. B., Kitchener, Andrew

“…Highly elongate body plans have evolved multiple times in the Actinopterygii, and members of many of these groups are known to use lateral undulation on land…”
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Evaluating the effects of nest management on a recovering raptor using integrated population modeling by Cappello, Caroline D., Jacobson, Kenneth V., Driscoll, James T., McCarty, Kyle M., Bauder, Javan M.

“…Evaluating population responses to management is a crucial component of successful conservation programs. Models predicting population growth under different…”
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