Search Results - "MCCARROLL, Matthew N"
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DaXi—high-resolution, large imaging volume and multi-view single-objective light-sheet microscopy
Published in Nature methods (01-04-2022)“…The promise of single-objective light-sheet microscopy is to combine the convenience of standard single-objective microscopes with the speed, coverage,…”
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Deep phenotypic profiling of neuroactive drugs in larval zebrafish
Published in Nature communications (17-11-2024)“…Behavioral larval zebrafish screens leverage a high-throughput small molecule discovery format to find neuroactive molecules relevant to mammalian physiology…”
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Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism
Published in Journal of Virology (15-08-2009)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
Published in Nature communications (09-09-2019)“…Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity—a phenomenon known as paradoxical…”
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Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology
Published in ACS chemical biology (15-04-2016)“…Many psychiatric drugs modulate the nervous system through multitarget mechanisms. However, systematic identification of multitarget compounds has been…”
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Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish
Published in PloS one (17-12-2013)“…Essential cellular components of the paired sensory organs of the vertebrate head are derived from transient thickenings of embryonic ectoderm known as cranial…”
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Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation
Published in Development (Cambridge) (01-08-2012)“…Pax gene haploinsufficiency causes a variety of congenital defects. Renal-coloboma syndrome, resulting from mutations in Pax2, is characterized by kidney…”
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A non-hallucinogenic psychedelic analogue with therapeutic potential
Published in Nature (London) (21-01-2021)“…The psychedelic alkaloid ibogaine has anti-addictive properties in both humans and animals 1 . Unlike most medications for the treatment of substance use…”
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Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge
Published in Journal of the American Chemical Society (09-11-2022)“…Delivering cargo molecules across the plasma membrane is critical for biomedical research, and the need to develop molecularly well-defined tags that enable…”
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A Multimodal, In Vivo Approach for Assessing Structurally and Phenotypically Related Neuroactive Molecules
Published in ACS chemical neuroscience (20-11-2024)“…A recently reported behavioral screen in larval zebrafish for phenocopiers of known anesthetics and associated drugs yielded an isoflavone. Related isoflavones…”
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Fgf3 and Fgf10a Work in Concert to Promote Maturation of the Epibranchial Placodes in Zebrafish: e85087
Published in PloS one (01-12-2013)“…Essential cellular components of the paired sensory organs of the vertebrate head are derived from transient thickenings of embryonic ectoderm known as cranial…”
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115 HIV Vpu complexes with βTrCP to direct the degradation of the virus release inhibitor BST-2 (Tetherin)
Published in Journal of acquired immune deficiency syndromes (1999) (01-06-2009)Get full text
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Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism
Published in Journal of virology (01-08-2009)“…The primary roles attributed to the human immunodeficiency virus type 1 (HIV-1) Vpu protein are the degradation of the viral receptor CD4 and the enhancement…”
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