Search Results - "MCCALL, Charles E"

Epigenetic and metabolic programming of innate immunity in sepsis by Vachharajani, Vidula, McCall, Charles E

“…Sepsis, the 10th leading cause of death, is the most expensive condition in the United States. The immune response in sepsis transitions from hyperinflammatory…”
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MicroRNAs Distinguish Translational from Transcriptional Silencing during Endotoxin Tolerance by El Gazzar, Mohamed, McCall, Charles E.

“…We reported that gene-selective formation of facultative heterochromatin silences transcription of acute inflammatory genes during endotoxin (LPS) tolerance,…”
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Sirtuins Link Inflammation and Metabolism by Yoza, Barbara K., Hoth, Jason J., Wang, Xianfeng, Liu, Tiefu, Vachharajani, Vidula, McCall, Charles E.

“…Sirtuins (SIRT), first discovered in yeast as NAD+ dependent epigenetic and metabolic regulators, have comparable activities in human physiology and disease…”
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Mitochondrial Sirtuin 4 Resolves Immune Tolerance in Monocytes by Rebalancing Glycolysis and Glucose Oxidation Homeostasis by Tao, Jie, Zhang, Jingpu, Ling, Yun, McCall, Charles E, Liu, Tie Fu

“…The goal of this investigation was to define the molecular mechanism underlying physiologic conversion of immune tolerance to resolution of the acute…”
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Myeloid-Derived Suppressor Cells Evolve during Sepsis and Can Enhance or Attenuate the Systemic Inflammatory Response by BRUDECKI, Laura, FERGUSON, Donald A, MCCALL, Charles E, EL GAZZAR, Mohamed

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-α during TLR4-induced gene reprogramming by El Gazzar, Mohamed, Church, Ashley, Liu, Tiefu, McCall, Charles E.

“…MicroRNA‐146a supports the inflammatory response shift from initiation to adaptation by disrupting translation of proinflammatory genes, leading endotoxin…”
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Glutathionylation of pyruvate dehydrogenase complex E2 and inflammatory cytokine production during acute inflammation are magnified by mitochondrial oxidative stress by Long, David L., McCall, Charles E., Poole, Leslie B.

“…Lipopolysaccharide (LPS) is a known inducer of inflammatory signaling which triggers generation of reactive oxygen species (ROS) and cell death in responsive…”
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Resveratrol attenuates microvascular inflammation in sepsis via SIRT‐1‐Induced modulation of adhesion molecules in ob/ob mice by Wang, Xianfeng, Buechler, Nancy L., Yoza, Barbara K., McCall, Charles E., Vachharajani, Vidula T.

“…Objective Obesity, a sirtuin‐1 (SIRT‐1) ‐deficient state, increases morbidity and resource utilization in critically ill patients. SIRT‐1 deficiency increases…”
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Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice by Wang, Xianfeng, Buechler, Nancy L, Martin, Ayana, Wells, Jonathan, Yoza, Barbara, McCall, Charles E, Vachharajani, Vidula

“…Obesity increases morbidity and resource utilization in sepsis patients. Sepsis transitions from early/hyper-inflammatory to late/hypo-inflammatory phase…”
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Sirtuins and Immuno-Metabolism of Sepsis by Wang, Xianfeng, Buechler, Nancy L, Woodruff, Alan G, Long, David L, Zabalawi, Manal, Yoza, Barbara K, McCall, Charles E, Vachharajani, Vidula

“…Sepsis and septic shock are the leading causes of death in non-coronary intensive care units worldwide. During sepsis-associated immune dysfunction, the…”
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Fueling the flame: bioenergy couples metabolism and inflammation by Liu, Tie Fu, Brown, Candice M., El Gazzar, Mohamed, McPhail, Linda, Millet, Patrick, Rao, Anuradha, Vachharajani, Vidula T., Yoza, Barbara K., McCall, Charles E.

“…Review on how the integration of bioenergetics and metabolism controls inflammation progression. We review the emerging concept that changes in cellular…”
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Frontline Science: Myeloid cell‐specific deletion of Cebpb decreases sepsis‐induced immunosuppression in mice by McPeak, Melissa B., Youssef, Dima, Williams, Danielle A., Pritchett, Christopher L., Yao, Zhi Q., McCall, Charles E., El Gazzar, Mohamed

“…Mechanisms by which C/EBPβ promotes sepsis‐induced immunosuppression. Sepsis inflammation accelerates myeloid cell generation to compensate for rapid…”
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Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction by Mainali, Rabina, Zabalawi, Manal, Long, David, Buechler, Nancy, Quillen, Ellen, Key, Chia-Chi, Zhu, Xuewei, Parks, John S, Furdui, Cristina, Stacpoole, Peter W, Martinez, Jennifer, McCall, Charles E, Quinn, Matthew A

“…Metabolic reprogramming between resistance and tolerance occurs within the immune system in response to sepsis. While metabolic tissues such as the liver are…”
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Inhibiting KDM6A Demethylase Represses Long Non-Coding RNA Hotairm1 Transcription in MDSC During Sepsis by Bah, Isatou, Youssef, Dima, Yao, Zhi Q, McCall, Charles E, El Gazzar, Mohamed

“…Myeloid-derived suppressor cells (MDSCs) prolong sepsis by promoting immunosuppression. We reported that sepsis MDSC development requires long non-coding RNA…”
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MicroRNAs regulatory networks in myeloid lineage development and differentiation: regulators of the regulators by El Gazzar, Mohamed, McCall, Charles E

“…MicroRNAs (miRNAs) are abundant small molecules of ∼22 nucleotides that reprogram gene expression by targeting mRNA degradation and translation disruption. An…”
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Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis by Dai, Jun, Kumbhare, Ajinkya, Youssef, Dima, McCall, Charles E, Gazzar, Mohamed El

“…Myeloid precursor cell reprogramming into a myeloid-derived suppressor cell (MDSC) contributes to high mortality rates in mouse and human sepsis. S100A9 mRNA…”
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Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation by Meyers, Allison K., Wang, Zhan, Han, Wenzheng, Zhao, Qingxia, Zabalawi, Manal, Duan, Likun, Liu, Juan, Zhang, Qianyi, Manne, Rajesh K., Lorenzo, Felipe, Quinn, Matthew A., Song, Qianqian, Fan, Daping, Lin, Hui-Kuan, Furdui, Cristina M., Locasale, Jason W., McCall, Charles E., Zhu, Xuewei

“…Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction. Here, we show that…”
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Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation by McCall, Charles E., El Gazzar, Mohamed, Liu, Tiefu, Vachharajani, Vidula, Yoza, Barbara

“…NAD+‐dependent bioenergetics integrate with epigenetic‐dependent regulation of proteins and microRNAs to guide the course of acute systemic inflammation. Acute…”
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Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease by Ding, Jingzhong, Reynolds, Lindsay M, Zeller, Tanja, Müller, Christian, Lohman, Kurt, Nicklas, Barbara J, Kritchevsky, Stephen B, Huang, Zhiqing, de la Fuente, Alberto, Soranzo, Nicola, Settlage, Robert E, Chuang, Chia-Chi, Howard, Timothy, Xu, Ning, Goodarzi, Mark O, Chen, Y-D Ida, Rotter, Jerome I, Siscovick, David S, Parks, John S, Murphy, Susan, Jacobs, Jr, David R, Post, Wendy, Tracy, Russell P, Wild, Philipp S, Blankenberg, Stefan, Hoeschele, Ina, Herrington, David, McCall, Charles E, Liu, Yongmei

“…Obesity is linked to type 2 diabetes (T2D) and cardiovascular diseases; however, the underlying molecular mechanisms remain unclear. We aimed to identify…”
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Editorial: The Roles of Mitochondria in Immunity by Patil, Naeem K, Bohannon, Julia K, Vachharajani, Vidula, McCall, Charles E

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