Search Results - "MCCABE, Nuala"

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition by MCCABE, Nuala, TURNER, Nicholas C, SMITH, Graeme C. M, ASHWORTH, Alan, LORD, Christopher J, KLUZEK, Katarzyna, BIALKOWSKA, Aneta, SWIFT, Sally, GIAVARA, Sabrina, O'CONNOR, Mark J, TUFT, Andrew N, ZDZIENICKA, Malgorzata Z

“…Deficiency in either of the breast cancer susceptibility proteins BRCA1 or BRCA2 induces profound cellular sensitivity to the inhibition of poly(ADP-ribose)…”
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DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1 by Martin, Sarah A., McCabe, Nuala, Mullarkey, Michelle, Cummins, Robert, Burgess, Darren J., Nakabeppu, Yusaku, Oka, Sugako, Kay, Elaine, Lord, Christopher J., Ashworth, Alan

“…Synthetic sickness/lethality (SSL) can be exploited to develop therapeutic strategies for cancer. Deficiencies in the tumor suppressor proteins MLH1 and MSH2…”
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FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion by Stanicka, Joanna, Rieger, Leonie, O’Shea, Sandra, Cox, Orla, Coleman, Michael, O’Flanagan, Ciara, Addario, Barbara, McCabe, Nuala, Kennedy, Richard, O’Connor, Rosemary

“…IGF-1 receptor (IGF-1R) and integrin cooperative signaling promotes cancer cell survival, proliferation, and motility, but whether this influences cancer…”
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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy by Smith, Graeme C. M, Ashworth, Alan, Farmer, Hannah, McCabe, Nuala, Lord, Christopher J, Tutt, Andrew N. J, Johnson, Damian A, Richardson, Tobias B, Santarosa, Manuela, Dillon, Krystyna J, Hickson, Ian, Knights, Charlotte, Martin, Niall M. B, Jackson, Stephen P

“…BRCA1 and BRCA2 are important for DNA double-strand break repair by homologous recombination, and mutations in these genes predispose to breast and other…”
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Defining the molecular evolution of extrauterine high grade serous carcinoma by Beirne, James P, McArt, Darragh G, Roddy, Aideen, McDermott, Clara, Ferris, Jennifer, Buckley, Niamh E, Coulter, Paula, McCabe, Nuala, Eddie, Sharon L, Dunne, Philip D, O'Reilly, Paul, Gilmore, Alan, Feeney, Laura, Ewing, David Lyons, Drapkin, Ronny I, Salto-Tellez, Manuel, Kennedy, Richard D, Harley, Ian J.G, McCluggage, W. Glenn, Mullan, Paul B

“…AbstractObjectiveHigh grade serous carcinoma (HGSC) is the most common and most aggressive, subtype of epithelial ovarian cancer. It presents as advanced stage…”
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BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents by MULLAN, Paul B, QUINN, Jennifer E, MAHESWARAN, Shyamala, LIU, Edison, HABER, Daniel A, JOHNSTON, Patrick G, HARKIN, D. Paul, GILMORE, Paula M, MCWILLIAMS, Stewart, ANDREWS, Heather, GERVIN, Celine, MCCABE, Nuala, MCKENNA, Sarah, WHITE, Pat, SONG, Young-Han

“…BRCA1 is a tumour suppressor gene implicated in the predisposition to early onset breast and ovarian cancer. We have generated cell lines with inducible…”
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BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency by McCabe, Nuala, Lord, Christopher J., Tutt, Andrew NJ, Martin, Niall, Smith, Graeme C.M., Ashworth, Alan

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Abstract 2135: Characterization of robust and prognostic molecular subtypes in prostate cancer by McKinney, Cathal, McCabe, Nuala, Harkin, Paul, Kennedy, Richard, Blayney, Jaine

“…Abstract Introduction: Multiple biomarkers and molecular subtypes have been proposed in prostate cancer (PCa) with limited overlap, in part due to the…”
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Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer by Parkes, Eileen E, Walker, Steven M, Taggart, Laura E, McCabe, Nuala, Knight, Laura A, Wilkinson, Richard, McCloskey, Karen D, Buckley, Niamh E, Savage, Kienan I, Salto-Tellez, Manuel, McQuaid, Stephen, Harte, Mary T, Mullan, Paul B, Harkin, D Paul, Kennedy, Richard D

“…Previously we identified a DNA damage response-deficient (DDRD) molecular subtype within breast cancer. A 44-gene assay identifying this subtype was validated…”
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Abstract P2-08-09: Investigation of autoantibodies (AAbs) in HER2+ breast cancer (BC) patients treated in the neo-adjuvant setting by Collins, Denis Martin, Qiu, Ji, Blayney, Jaine, McCabe, Nuala, Kennedy, Richard, LaBaer, Joshua, Crown, John

“…Abstract Background: HER2+ breast cancer is treated with anti-HER2 IgG monoclonal antibody therapies such as trastuzumab and pertuzumab. These antibodies…”
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Abstract 370: The role of DLX1 as a biomarker and novel target in poor prognostic prostate cancer by Forsythe, Nicholas, McKinney, Cathal, McCabe, Nuala, Kennedy, Richard D.

“…Abstract Introduction: Previous work from our lab has identified a molecularly distinct subgroup of primary prostate cancers with biology similar to metastatic…”
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miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA by Ray, Jessica, Haughey, Charles, Hoey, Christianne, Jeon, Jouhyun, Murphy, Ross, Dura-Perez, Lara, McCabe, Nuala, Downes, Michelle, Jain, Suneil, Boutros, Paul C., Mills, Ian G., Liu, Stanley K.

“…Radiation therapy is a common treatment for prostate cancer, however recurrence remains a problem. MicroRNA expression is altered in prostate cancer and may…”
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BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency by McCabe, Nuala, Lord, Christopher J, Tutt, Andrew N J, Martin, Niall M B, Smith, Graeme C M, Ashworth, Alan

“…We have previously demonstrated that deficiency of either the BRCA1 or BRCA2 breast cancer susceptibility proteins confers substantial cellular sensitivity to…”
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Abstract 3163: The role of early response genes (ERG’s) as a biomarker of response to Wee1 targeted therapies by Dunne, Victoria L., McGivern, Niamh, Savage, Kienan I., McCabe, Nuala, Kennedy, Richard

“…Abstract Introduction: WEE1 kinase is a key component in maintaining the G2/M cell cycle checkpoint for pre-mitotic DNA repair, and is overexpressed in several…”
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Abstract 152: A machine learning approach to detect FFPE artefacts leads to accurate estimation of tumor mutational burden from sequencing data without a matched normal by Leong, Hui Sun, O'Connor, Emma, McCabe, Nuala, Donegan, Sinead, Walker, Steven M., Mistry, Jayna, Keating, Karen, Harkin, Denis P., Kennedy, Richard D., Knight, Laura A., Bradford, James R.

“…Abstract Tumor mutational burden (TMB) is emerging as a promising predictive biomarker to select cancer patients who will benefit from immunotherapy. However,…”
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DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy by Parkes, Eileen E., Kennedy, Richard D., McCabe, Nuala, Gilmore, Elaine

“…Historically the development of anticancer treatments has been focused on their effect on tumor cells alone. However, newer treatments have shifted attention…”
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Abstract 3787: Exploring the effect of chemotherapies on STING-dependent cytokine release by Wilkinson, Richard D., Johnston, David I., Parkes, Eileen E., McCabe, Nuala, Kennedy, Richard D.

“…Abstract Introduction: Blockade of PD-1/PD-L1 has shown potent antitumor activity but these therapies are limited to certain diseases with higher intrinsic…”
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Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM by McCabe, Nuala, Hanna, Conor, Walker, Steven M, Gonda, David, Li, Jie, Wikstrom, Katarina, Savage, Kienan I, Butterworth, Karl T, Chen, Clark, Harkin, D Paul, Prise, Kevin M, Kennedy, Richard D

“…Ataxia telangiectasia mutated (ATM) is an important signaling molecule in the DNA damage response (DDR). ATM loss of function can produce a synthetic lethal…”
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Abstract 283: Identification of a high-risk subgroup in primary prostate cancers presenting with targetable immune biology by Reilly, Emma, McCavigan, Andrena, Walker, Steven M., McCabe, Nuala, Parkes, Eileen, Harkin, Denis P., Kennedy, Richard D., Knight, Laura A.

“…Abstract Background Recent studies have demonstrated limited success of immune checkpoint therapies in unselected prostate cancer. We therefore assessed an…”
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Exploration of the cGAS-STING pathway in prostate cancer by Reilly, Emma, McCavigan, Andrena, Walker, Steven M., McCabe, Nuala, Parkes, Eileen, Harkin, D. Paul, Kennedy, Richard D, Knight, Laura A

“…Abstract only…”
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