The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

There is increasing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of common solid tumours. The aim of the present study was to examine the relationship between tumour T-lymphocyte subset infiltration, the systemic inflammatory res...

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Bibliographic Details
Published in:	British journal of cancer Vol. 92; no. 4; pp. 651 - 654
Main Authors:	CANNA, K, MCARDLE, P. A, MCATILLAN, D. C, MCNICOL, A.-M, SMITH, G. W, MCKEE, R. F, MCARDLE, C. S
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 28-02-2005
Subjects:	Aged Biological and medical sciences C-Reactive Protein - metabolism Cancer research CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Clinical Study Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - immunology Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Lymphatic Metastasis Lymphocytes Male Medical research Medical sciences Middle Aged Neoplasm Invasiveness Predictive Value of Tests Proteins Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Survival Analysis Systemic Inflammatory Response Syndrome - blood Systemic Inflammatory Response Syndrome - immunology Systemic Inflammatory Response Syndrome - mortality T-Lymphocytes Tumors United States > US Human Rectal disease Resection C-reactive protein Colorectal cancer colorectal cancer CD4+ and CD8+ T-lymphocytes Tumorous infiltration Inflammation Malignant tumor Survival Colonic disease Acute phase protein Cancerology T-Lymphocyte Digestive diseases Intestinal disease C reactive protein
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Summary:	There is increasing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of common solid tumours. The aim of the present study was to examine the relationship between tumour T-lymphocyte subset infiltration, the systemic inflammatory response and cancer-specific survival in patients with colorectal cancer. In all, 147 patients undergoing potentially curative resection for colorectal cancer were studied. Circulating concentrations of C-reactive protein were measured prior to surgery. CD4+ and CD8+ T-lymphocyte infiltration of the tumour was assessed using immunohistochemistry and a point counting technique. When patients were grouped according to the percentage tumour volume of CD4+ T-lymphocytes, there was no difference in terms of age, sex, tumour site, stage and tumour characteristics. However, there was an inverse relationship between percentage tumour CD4+ T-lymphocytes and C-reactive protein (P<0.01). On univariate analysis, both C-reactive protein concentrations (P<0.001) and percentage tumour volume of CD4+ (P<0.05) T-lymphocytes were associated with cancer-specific survival. The results of the present study show that low tumour CD4+ T-lymphocyte infiltration is associated with elevated C-reactive protein concentrations and both predict poor cancer-specific survival.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6602419