Search Results - "MC, Southey"

Design considerations for massively parallel sequencing studies of common familial cancers by Feng, BJ, Tavtigian, SV, Southey, MC, Goldgar, DE

“…Doc number: A38…”
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Early exploration of two candidate breast cancer susceptibility genes identified by whole-exome sequencing by Blanc, R, Jammot, A, Nguyen-Dumont, T, Teo, ZL, Odefrey, FA, Hammet, F, Goldgar, DE, Park, DJ, Southey, MC

“…Doc number: A91…”
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Identification of a novel disease-associated variant in the BRCA1 3’UTR that introduces a functional miR-103 target site by Brewster, BL, Rossiello, F, French, JD, Edwards, SL, Wong, EM, Whiley, P, Waddell, N, Chen, X, Bove, B, Spurdle, AB, Radice, P, Godwin, AK, Southey, MC, Brown, MA, Peterlongo, P

“…Doc number: A88…”
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Expanded genetic analysis of a PALB2 c.3113G>A mutation carrying multiple-case breast cancer family via exome sequencing by Teo, ZL, Park, DJ, Odefrey, F, Hammet, F, Nguyen-Dumont, T, Tsimiklis, H, Pope, BJ, Lonie, A, Winship, I, Giles, GG, Hopper, JL, Southey, MC

“…Doc number: A92…”
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Identification of new breast cancer predisposition genes via whole exome sequencing by Southey, MC, Park, DJ, Lesueur, F, Odefrey, F, Nguyen-Dumont, T, Hammet, F, Neuhausen, SL, John, EM, Andrulis, IL, Chenevix-Trench, G, Baglietto, L, Le Calvez-Kelm, F, Pertesi, M, Lonie, A, Pope, B, Sinilnikova, O, Tsimiklis, H, Giles, GG, Hopper, JL, Tavtigian, SV, Goldgar, DE

“…Doc number: A40…”
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Estrogen receptor polymorphism at codon 325 and risk of breast cancer in women before age forty by SOUTHEY, M. C, BATTEN, L. E, MCCREDIE, M. R. E, GILES, G. G, DITE, G, HOPPER, J. L, VENTER, D. J

“…The estrogen receptor (ER) protein is believed to play a role in the development and progression of breast cancer. In a previously published U.S. clinic-based…”
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Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer by Darst, Burcu F, Dadaev, Tokhir, Saunders, Ed, Sheng, Xin, Wan, Peggy, Pooler, Loreall, Xia, Lucy Y, Chanock, Stephen, Berndt, Sonja I, Gapstur, Susan M, Stevens, Victoria, Albanes, Demetrius, Weinstein, Stephanie J, Gnanapragasam, Vincent, Giles, Graham G, Nguyen-Dumont, Tu, Milne, Roger L, Pomerantz, Mark, Schmidt, Julie A, Mucci, Lorelei, Catalona, William J, Hetrick, Kurt N, Doheny, Kimberly F, MacInnis, Robert J, Southey, Melissa C, Eeles, Rosalind A, Wiklund, Fredrik, Kote-Jarai, Zsofia, Conti, David V, Haiman, Christopher A

“…Abstract Background There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We investigated whether…”
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Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium by Rudolph, Anja, Song, Minsun, Brook, Mark N, Milne, Roger L, Mavaddat, Nasim, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Wilcox, Amber N, Hopper, John L, Southey, Melissa C, Keeman, Renske, Fasching, Peter A, Beckmann, Matthias W, Gago-Dominguez, Manuela, Castelao, Jose E, Guénel, Pascal, Truong, Thérèse, Bojesen, Stig E, Flyger, Henrik, Brenner, Hermann, Arndt, Volker, Brauch, Hiltrud, Brüning, Thomas, Mannermaa, Arto, Kosma, Veli-Matti, Lambrechts, Diether, Keupers, Machteld, Couch, Fergus J, Vachon, Celine, Giles, Graham G, MacInnis, Robert J, Figueroa, Jonine, Brinton, Louise, Czene, Kamila, Brand, Judith S, Gabrielson, Marike, Humphreys, Keith, Cox, Angela, Cross, Simon S, Dunning, Alison M, Orr, Nick, Swerdlow, Anthony, Hall, Per, Pharoah, Paul D P, Schmidt, Marjanka K, Easton, Douglas F, Chatterjee, Nilanjan, Chang-Claude, Jenny, García-Closas, Montserrat

“…Polygenic risk scores (PRS) for breast cancer can be used to stratify the population into groups at substantially different levels of risk. Combining PRS and…”
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Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer by Schaid, Daniel J., McDonnell, Shannon K., FitzGerald, Liesel M., DeRycke, Lissa, Fogarty, Zachary, Giles, Graham G., MacInnis, Robert J., Southey, Melissa C., Nguyen-Dumont, Tu, Cancel-Tassin, Geraldine, Cussenot, Oliver, Whittemore, Alice S., Sieh, Weiva, Ioannidis, Nilah Monnier, Hsieh, Chih-Lin, Stanford, Janet L., Schleutker, Johanna, Cropp, Cheryl D., Carpten, John, Hoegel, Josef, Eeles, Rosalind, Kote-Jarai, Zsofia, Ackerman, Michael J., Klein, Christopher J., Mandal, Diptasri, Cooney, Kathleen A., Bailey-Wilson, Joan E., Helfand, Brian, Catalona, William J., Wiklund, Fredrick, Riska, Shaun, Bahetti, Saurabh, Larson, Melissa C., Cannon Albright, Lisa, Teerlink, Craig, Xu, Jianfeng, Isaacs, William, Ostrander, Elaine A., Thibodeau, Stephen N.

“…Family history of prostate cancer (PCa) is a well-known risk factor, and both common and rare genetic variants are associated with the disease. To detect new…”
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Distinct Reproductive Risk Profiles for Intrinsic-Like Breast Cancer Subtypes: Pooled Analysis of Population-Based Studies by Jung, Audrey Y, Ahearn, Thomas U, Behrens, Sabine, Middha, Pooja, Bolla, Manjeet K, Wang, Qin, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Beane Freeman, Laura E, Becher, Heiko, Brenner, Hermann, Canzian, Federico, Carey, Lisa A, Czene, Kamila, Eliassen, A Heather, Eriksson, Mikael, Evans, D Gareth, Figueroa, Jonine D, Fritschi, Lin, Gabrielson, Marike, Giles, Graham G, Guénel, Pascal, Hadjisavvas, Andreas, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hoppe, Reiner, Hopper, John L, Howell, Anthony, Hunter, David J, Hüsing, Anika, Kaaks, Rudolf, Kosma, Veli-Matti, Koutros, Stella, Kraft, Peter, Lacey, James V, Le Marchand, Loic, Lissowska, Jolanta, Loizidou, Maria A, Mannermaa, Arto, Maurer, Tabea, Murphy, Rachel A, Olshan, Andrew F, Olsson, Håkan, Patel, Alpa V, Perou, Charles M, Rennert, Gad, Shibli, Rana, Shu, Xiao-Ou, Southey, Melissa C, Stone, Jennifer, Tamimi, Rulla M, Teras, Lauren R, Troester, Melissa A, Truong, Thérèse, Vachon, Celine M, Wang, Sophia S, Wolk, Alicja, Wu, Anna H, Yang, Xiaohong R, Zheng, Wei, Dunning, Alison M, Pharoah, Paul D P, Easton, Douglas F, Milne, Roger L, Chatterjee, Nilanjan, Schmidt, Marjanka K, García-Closas, Montserrat, Chang-Claude, Jenny

“…Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER)-positive and ER-negative breast cancer. However, their…”
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Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk by Lindström, Sara, Thompson, Deborah J., Paterson, Andrew D., Li, Jingmei, Gierach, Gretchen L., Scott, Christopher, Stone, Jennifer, Douglas, Julie A., dos-Santos-Silva, Isabel, Fernandez-Navarro, Pablo, Verghase, Jajini, Smith, Paula, Brown, Judith, Luben, Robert, Wareham, Nicholas J., Loos, Ruth J. F., Heit, John A., Shane Pankratz, V., Norman, Aaron, Goode, Ellen L., Cunningham, Julie M., deAndrade, Mariza, Vierkant, Robert A., Czene, Kamila, Fasching, Peter A., Baglietto, Laura, Southey, Melissa C., Giles, Graham G., Shah, Kaanan P., Chan, Heang-Ping, Helvie, Mark A., Beck, Andrew H., Knoblauch, Nicholas W., Hazra, Aditi, Hunter, David J., Kraft, Peter, Pollan, Marina, Figueroa, Jonine D., Couch, Fergus J., Hopper, John L., Hall, Per, Easton, Douglas F., Boyd, Norman F., Vachon, Celine M., Tamimi, Rulla M.

“…Mammographic density reflects the amount of stromal and epithelial tissues in relation to adipose tissue in the breast and is a strong risk factor for breast…”
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Genetic modifiers of CHEK21100delC-associated breast cancer risk by Muranen, Taru A., Greco, Dario, Blomqvist, Carl, Aittomäki, Kristiina, Khan, Sofia, Hogervorst, Frans, Verhoef, Senno, Pharoah, Paul D.P., Dunning, Alison M., Shah, Mitul, Luben, Robert, Bojesen, Stig E., Nordestgaard, Børge G., Schoemaker, Minouk, Swerdlow, Anthony, García-Closas, Montserrat, Figueroa, Jonine, Dörk, Thilo, Bogdanova, Natalia V., Hall, Per, Li, Jingmei, Khusnutdinova, Elza, Bermisheva, Marina, Kristensen, Vessela, Borresen-Dale, Anne-Lise, Investigators, NBCS, Peto, Julian, dos Santos Silva, Isabel, Couch, Fergus J., Olson, Janet E., Hillemans, Peter, Park-Simon, Tjoung-Won, Brauch, Hiltrud, Hamann, Ute, Burwinkel, Barbara, Marme, Frederik, Meindl, Alfons, Schmutzler, Rita K., Cox, Angela, Cross, Simon S., Sawyer, Elinor J., Tomlinson, Ian, Lambrechts, Diether, Moisse, Matthieu, Lindblom, Annika, Margolin, Sara, Hollestelle, Antoinette, Martens, John W.M., Fasching, Peter A., Beckmann, Matthias W., Andrulis, Irene L., Knight, Julia A., Investigators, kConFab/AOCS, Anton-Culver, Hoda, Ziogas, Argyrios, Giles, Graham G., Milne, Roger L., Brenner, Hermann, Arndt, Volker, Mannermaa, Arto, Kosma, Veli-Matti, Chang-Claude, Jenny, Rudolph, Anja, Devilee, Peter, Seynaeve, Caroline, Hopper, John L., Southey, Melissa C., John, Esther M., Whittemore, Alice S., Bolla, Manjeet K., Wang, Qin, Michailidou, Kyriaki, Dennis, Joe, Easton, Douglas F., Schmidt, Marjanka K., Nevanlinna, Heli

“…Purpose: CHEK2 *1100delC is a founder variant in European populations that confers a two- to threefold increased risk of breast cancer (BC). Epidemiologic and…”
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Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men by Wang, Anqi, Xu, Yili, Yu, Yao, Nead, Kevin T, Kim, TaeBeom, Xu, Keren, Dadaev, Tokhir, Saunders, Ed, Sheng, Xin, Wan, Peggy, Pooler, Loreall, Xia, Lucy Y, Chanock, Stephen, Berndt, Sonja I, Gapstur, Susan M, Stevens, Victoria, Albanes, Demetrius, Weinstein, Stephanie J, Gnanapragasam, Vincent, Giles, Graham G, Nguyen-Dumont, Tu, Milne, Roger L, Pomerantz, Mark M, Schmidt, Julie A, Stopsack, Konrad H, Mucci, Lorelei A, Catalona, William J, Hetrick, Kurt N, Doheny, Kimberly F, MacInnis, Robert J, Southey, Melissa C, Eeles, Rosalind A, Wiklund, Fredrik, Kote-Jarai, Zsofia, de Smith, Adam J, Conti, David V, Huff, Chad, Haiman, Christopher A, Darst, Burcu F

“…Little is known regarding the potential relationship between clonal hematopoiesis (CH) of indeterminate potential (CHIP), which is the expansion of…”
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PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients by Giardiello, Daniele, Hooning, Maartje J, Hauptmann, Michael, Keeman, Renske, Heemskerk-Gerritsen, B A M, Becher, Heiko, Blomqvist, Carl, Bojesen, Stig E, Bolla, Manjeet K, Camp, Nicola J, Czene, Kamila, Devilee, Peter, Eccles, Diana M, Fasching, Peter A, Figueroa, Jonine D, Flyger, Henrik, García-Closas, Montserrat, Haiman, Christopher A, Hamann, Ute, Hopper, John L, Jakubowska, Anna, Leeuwen, Floor E, Lindblom, Annika, Lubiński, Jan, Margolin, Sara, Martinez, Maria Elena, Nevanlinna, Heli, Nevelsteen, Ines, Pelders, Saskia, Pharoah, Paul D P, Siesling, Sabine, Southey, Melissa C, van der Hout, Annemieke H, van Hest, Liselotte P, Chang-Claude, Jenny, Hall, Per, Easton, Douglas F, Steyerberg, Ewout W, Schmidt, Marjanka K

“…Prediction of contralateral breast cancer (CBC) risk is challenging due to moderate performances of the known risk factors. We aimed to improve our previous…”
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A Genome-wide Association Study of Early-Onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age by AHSAN, Habibul, HALPERN, Jerry, ROY, Shantanu, BRUTUS, Rachelle, ARGOS, Maria, MELKONIAN, Stephanie, CHANG-CLAUDE, Jenny, ANDRULIS, Irene, HOPPER, John L, JOHN, Esther M, MALONE, Kathi, URSIN, Giske, KIBRIYA, Muhammad G, GAMMON, Marilie D, THOMAS, Duncan C, SEMINARA, Daniela, CASEY, Graham, KNIGHT, Julia A, SOUTHEY, Melissa C, GILES, Graham G, SANTELLA, Regina M, EUNJUNG LEE, CONTI, David, PIERCE, Brandon L, DUGGAN, David, GALLINGER, Steve, HAILE, Robert, JENKINS, Mark, LINDOR, Noralane M, NEWCOMB, Polly, MICHAILIDOU, Kyriaki, APICELLA, Carmel, PARK, Daniel J, PETO, Julian, LIN TONG, FLETCHER, Olivia, DOS SANTOS SILVA, Isabel, LATHROP, Mark, HUNTER, David J, CHANOCK, Stephen J, MEINDL, Alfons, SCHMUTZLER, Rita K, MÜLLER-MYHSOK, Bertram, LOCHMANN, Magdalena, BECKMANN, Lars, GAMAZON, Eric, HEIN, Rebecca, MAKALIC, Enes, SCHMIDT, Daniel F, QUANG MINH BUI, STONE, Jennifer, FLESCH-JANYS, Dieter, DAHMEN, Norbert, NEVANLINNA, Heli, AITTOMÄKI, Kristiina, BLOMQVIST, Carl, MCGUIRE, Valerie, FELBERG, Anna, JIANXIN SHI, JASMINE, Farzana

“…Early-onset breast cancer (EOBC) causes substantial loss of life and productivity, creating a major burden among women worldwide. We analyzed 1,265,548 Hapmap3…”
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Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk by Vachon, Celine M, Scott, Christopher G, Tamimi, Rulla M, Thompson, Deborah J, Fasching, Peter A, Stone, Jennifer, Southey, Melissa C, Winham, Stacey, Lindström, Sara, Lilyquist, Jenna, Giles, Graham G, Milne, Roger L, MacInnis, Robert J, Baglietto, Laura, Li, Jingmei, Czene, Kamila, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Haeberle, Lothar, Eriksson, Mikael, Kraft, Peter, Luben, Robert, Wareham, Nick, Olson, Janet E, Norman, Aaron, Polley, Eric C, Maskarinec, Gertraud, Le Marchand, Loic, Haiman, Christopher A, Hopper, John L, Couch, Fergus J, Easton, Douglas F, Hall, Per, Chatterjee, Nilanjan, Garcia-Closas, Montse

“…Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of common genetic variation, are both strong…”
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Prediction of contralateral breast cancer: external validation of risk calculators in 20 international cohorts by Giardiello, Daniele, Hauptmann, Michael, Steyerberg, Ewout W., Adank, Muriel A., Akdeniz, Delal, Blom, Jannet C., Blomqvist, Carl, Bojesen, Stig E., Bolla, Manjeet K., Brinkhuis, Mariël, Chang-Claude, Jenny, Czene, Kamila, Devilee, Peter, Dunning, Alison M., Easton, Douglas F., Eccles, Diana M., Fasching, Peter A., Figueroa, Jonine, Flyger, Henrik, García-Closas, Montserrat, Haeberle, Lothar, Haiman, Christopher A., Hall, Per, Hamann, Ute, Hopper, John L., Jager, Agnes, Jakubowska, Anna, Jung, Audrey, Keeman, Renske, Koppert, Linetta B., Kramer, Iris, Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Lubiński, Jan, Manoochehri, Mehdi, Mariani, Luigi, Nevanlinna, Heli, Oldenburg, Hester S. A., Pelders, Saskia, Pharoah, Paul D. P., Shah, Mitul, Siesling, Sabine, Smit, Vincent T. H. B. M., Southey, Melissa C., Tapper, William J., Tollenaar, Rob A. E. M., van den Broek, Alexandra J., van Deurzen, Carolien H. M., van Leeuwen, Flora E., van Ongeval, Chantal, Van’t Veer, Laura J., Wang, Qin, Wendt, Camilla, Westenend, Pieter J., Hooning, Maartje J., Schmidt, Marjanka K.

“…Background Three tools are currently available to predict the risk of contralateral breast cancer (CBC). We aimed to compare the performance of the Manchester…”
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Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer by Wichert, Katharina, Hoppe, Reiner, Ickstadt, Katja, Behrens, Thomas, Winter, Stefan, Herold, Robert, Terschüren, Claudia, Lo, Wing-Yee, Guénel, Pascal, Truong, Thérèse, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Lush, Michael, Andrulis, Irene L., Brenner, Hermann, Chang-Claude, Jenny, Cox, Angela, Cross, Simon S., Czene, Kamila, Eriksson, Mikael, Figueroa, Jonine D., García-Closas, Montserrat, Goldberg, Mark S., Hamann, Ute, He, Wei, Holleczek, Bernd, Hopper, John L., Jakubowska, Anna, Ko, Yon-Dschun, Lubiński, Jan, Mulligan, Anna Marie, Obi, Nadia, Rhenius, Valerie, Shah, Mitul, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C., Zheng, Wei, Dunning, Alison M., Pharoah, Paul D. P., Hall, Per, Easton, Douglas F., Brüning, Thomas, Brauch, Hiltrud, Harth, Volker, Rabstein, Sylvia

“…Light-at-night triggers the decline of pineal gland melatonin biosynthesis and secretion and is an IARC-classified probable breast-cancer risk factor. We…”
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Correction: PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients by Giardiello, Daniele, Hooning, Maartje J, Hauptmann, Michael, Keeman, Renske, Heemskerk-Gerritsen, B A M, Becher, Heiko, Blomqvist, Carl, Bojesen, Stig E, Bolla, Manjeet K, Camp, Nicola J, Czene, Kamila, Devilee, Peter, Eccles, Diana M, Fasching, Peter A, Figueroa, Jonine D, Flyger, Henrik, García-Closas, Montserrat, Haiman, Christopher A, Hamann, Ute, Hopper, John L, Jakubowska, Anna, Leeuwen, Floor E, Lindblom, Annika, Lubiński, Jan, Margolin, Sara, Martinez, Maria Elena, Nevanlinna, Heli, Nevelsteen, Ines, Pelders, Saskia, Pharoah, Paul D P, Siesling, Sabine, Southey, Melissa C, van der Hout, Annemieke H, van Hest, Liselotte P, Chang-Claude, Jenny, Hall, Per, Easton, Douglas F, Steyerberg, Ewout W, Schmidt, Marjanka K

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Common variants in ZNF365 are associated with both mammographic density and breast cancer risk by Tamimi, Rulla M, Lindström, Sara, Vachon, Celine M, Li, Jingmei, Varghese, Jajini, Thompson, Deborah, Warren, Ruth, Brown, Judith, Leyland, Jean, Audley, Tina, Wareham, Nicholas J, Loos, Ruth J F, Paterson, Andrew D, Rommens, Johanna, Waggott, Darryl, Martin, Lisa J, Scott, Christopher G, Pankratz, V Shane, Hankinson, Susan E, Hazra, Aditi, Hunter, David J, Hopper, John L, Southey, Melissa C, Chanock, Stephen J, Silva, Isabel dos Santos, Liu, JianJun, Eriksson, Louise, Couch, Fergus J, Stone, Jennifer, Apicella, Carmel, Czene, Kamila, Kraft, Peter, Hall, Per, Easton, Douglas F, Boyd, Norman F

“…High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of…”
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