Search Results - "MBALAVIELE, Gabriel"

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis by Arra, Manoj, Swarnkar, Gaurav, Ke, Ke, Otero, Jesse E., Ying, Jun, Duan, Xin, Maruyama, Takashi, Rai, Muhammad Farooq, O’Keefe, Regis J., Mbalaviele, Gabriel, Shen, Jie, Abu-Amer, Yousef

“…The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear, and this lack of clarity is detrimental to efforts to identify…”
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Inflammatory osteolysis: a conspiracy against bone by Mbalaviele, Gabriel, Novack, Deborah V, Schett, Georg, Teitelbaum, Steven L

“…There are many causes of inflammatory osteolysis, but regardless of etiology and cellular contexts, the osteoclast is the bone-degrading cell. Thus, the impact…”
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Editorial: Inflammasomes in human diseases and metabolism by Mbalaviele, Gabriel, Ryffel, Bernhard

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Chemotherapy activates inflammasomes to cause inflammation-associated bone loss by Wang, Chun, Kaur, Khushpreet, Xu, Canxin, Abu-Amer, Yousef, Mbalaviele, Gabriel

“…Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer…”
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Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice by Xiao, Jianqiu, Wang, Chun, Yao, Juo-Chin, Alippe, Yael, Xu, Canxin, Kress, Dustin, Civitelli, Roberto, Abu-Amer, Yousef, Kanneganti, Thirumala-Devi, Link, Daniel C, Mbalaviele, Gabriel

“…Mutated NLRP3 assembles a hyperactive inflammasome, which causes excessive secretion of interleukin (IL)-1β and IL-18 and, ultimately, a spectrum of…”
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IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology by Arra, Manoj, Swarnkar, Gaurav, Alippe, Yael, Mbalaviele, Gabriel, Abu-Amer, Yousef

“…Osteoarthritis is a joint disease characterized by a poorly-defined inflammatory response that does not encompass a massive immune cell infiltration yet…”
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Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO by Adapala, Naga Suresh, Swarnkar, Gaurav, Arra, Manoj, Shen, Jie, Mbalaviele, Gabriel, Ke, Ke, Abu-Amer, Yousef

“…Inflammatory osteolysis is governed by exacerbated osteoclastogenesis. Ample evidence points to central role of NF-κB in such pathologic responses, yet the…”
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Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals by Wang, Chun, Hockerman, Susan, Jacobsen, E Jon, Alippe, Yael, Selness, Shaun R, Hope, Heidi R, Hirsch, Jeffrey L, Mnich, Stephen J, Saabye, Matthew J, Hood, William F, Bonar, Sheri L, Abu-Amer, Yousef, Haimovich, Ariela, Hoffman, Hal M, Monahan, Joseph B, Mbalaviele, Gabriel

“…p38α activation of multiple effectors may underlie the failure of global p38α inhibitors in clinical trials. A unique inhibitor (CDD-450) was developed that…”
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Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation by Alippe, Yael, Wang, Chun, Ricci, Biancamaria, Xiao, Jianqiu, Qu, Chao, Zou, Wei, Novack, Deborah V., Abu-Amer, Yousef, Civitelli, Roberto, Mbalaviele, Gabriel

“…The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline…”
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Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells by Xiao, Jianqiu, Wang, Chun, Yao, Juo-Chin, Alippe, Yael, Yang, Tong, Kress, Dustin, Sun, Kai, Kostecki, Kourtney L, Monahan, Joseph B, Veis, Deborah J, Abu-Amer, Yousef, Link, Daniel C, Mbalaviele, Gabriel

“…Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation (BMT). Cytotoxicity limits the use of this life-saving therapy, but the…”
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Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling by Sun, Kai, Wang, Chun, Xiao, Jianqiu, Brodt, Michael D, Yuan, Luorongxin, Yang, Tong, Alippe, Yael, Hu, Huimin, Hao, Dingjun, Abu-Amer, Yousef, Silva, Matthew J, Shen, Jie, Mbalaviele, Gabriel

“…Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and…”
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Osteoclasts-Key Players in Skeletal Health and Disease by Novack, Deborah Veis, Mbalaviele, Gabriel

“…The differentiation of osteoclasts (OCs) from early myeloid progenitors is a tightly regulated process that is modulated by a variety of mediators present in…”
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Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes by Yang, Tong, Sun, Kai, Wang, Chun, Swarnkar, Gaurav, Quan, Songtao, Kress, Dustin, Xiao, Jianqiu, Alippe, Yael, Zheng, Hongjun, Brophy, Robert H, Hao, Dingjun, McAlinden, Audrey, Abu-Amer, Yousef, Shen, Jie, Mbalaviele, Gabriel

“…Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes. Caspase-1 also…”
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Glutamine metabolism modulates chondrocyte inflammatory response by Arra, Manoj, Swarnkar, Gaurav, Adapala, Naga Suresh, Naqvi, Syeda Kanwal, Cai, Lei, Rai, Muhammad Farooq, Singamaneni, Srikanth, Mbalaviele, Gabriel, Brophy, Robert, Abu-Amer, Yousef

“…Osteoarthritis is the most common joint disease in the world with significant societal consequences but lacks effective disease-modifying interventions. The…”
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Role of APD-Ribosylation in Bone Health and Disease by Wang, Chun, Mbalaviele, Gabriel

“…The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD ) to acceptor proteins is known as ADP-ribosylation…”
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N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms by Di Benedetto, Adriana, Watkins, Marcus, Grimston, Susan, Salazar, Valerie, Donsante, Christine, Mbalaviele, Gabriel, Radice, Glenn L, Civitelli, Roberto

“…We have previously shown that targeted expression of a dominant-negative truncated form of N-cadherin (Cdh2) delays acquisition of peak bone mass in mice and…”
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Inhibition of the NLRP3 inflammasome prevents ovarian aging by Navarro-Pando, José M, Alcocer-Gómez, Elísabet, Castejón-Vega, Beatriz, Navarro-Villarán, Elena, Condés-Hervás, Mónica, Mundi-Roldan, María, Muntané, Jordi, Pérez-Pulido, Antonio J, Bullon, Pedro, Wang, Chun, Hoffman, Hal M, Sanz, Alberto, Mbalaviele, Gabriel, Ryffel, Bernhard, Cordero, Mario D

“…Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian…”
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Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling by Swarnkar, Gaurav, Karuppaiah, Kannan, Mbalaviele, Gabriel, Chen, Tim (Hung-Po), Abu-Amer, Yousef

“…The MAP kinase TGFβ-activated kinase (TAK1) plays a crucial role in physiologic and pathologic cellular functions including cell survival, differentiation,…”
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Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria by González‐Dominguez, Alvaro, Montañez, Raúl, Castejón‐Vega, Beatriz, Nuñez‐Vasco, Jéssica, Lendines‐Cordero, Débora, Wang, Chun, Mbalaviele, Gabriel, Navarro‐Pando, José M, Alcocer‐Gómez, Elísabet, Cordero, Mario D

“…Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford progeria syndrome (HGPS). In this study, we present evidence of…”
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Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development by Swarnkar, Gaurav, Zhang, Kaihua, Mbalaviele, Gabriel, Long, Fanxin, Abu-Amer, Yousef

“…Pathologic conditions impair bone homeostasis. The transcription factor NF-κB regulates bone homeostasis and is central to bone pathologies. Whereas…”
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