Search Results - "MAZZINGHI, Benedetta"

Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury by Lazzeri, Elena, Angelotti, Maria Lucia, Peired, Anna, Conte, Carolina, Marschner, Julian A., Maggi, Laura, Mazzinghi, Benedetta, Lombardi, Duccio, Melica, Maria Elena, Nardi, Sara, Ronconi, Elisa, Sisti, Alessandro, Antonelli, Giulia, Becherucci, Francesca, De Chiara, Letizia, Guevara, Ricardo Romero, Burger, Alexa, Schaefer, Beat, Annunziato, Francesco, Anders, Hans-Joachim, Lasagni, Laura, Romagnani, Paola

“…Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell…”
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Phenotypic and functional features of human Th17 cells by Annunziato, Francesco, Cosmi, Lorenzo, Santarlasci, Veronica, Maggi, Laura, Liotta, Francesco, Mazzinghi, Benedetta, Parente, Eliana, Filì, Lucia, Ferri, Simona, Frosali, Francesca, Giudici, Francesco, Romagnani, Paola, Parronchi, Paola, Tonelli, Francesco, Maggi, Enrico, Romagnani, Sergio

“…T helper (Th) 17 cells represent a novel subset of CD4+ T cells that are protective against extracellular microbes, but are responsible for autoimmune…”
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Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease by De Chiara, Letizia, Conte, Carolina, Semeraro, Roberto, Diaz-Bulnes, Paula, Angelotti, Maria Lucia, Mazzinghi, Benedetta, Molli, Alice, Antonelli, Giulia, Landini, Samuela, Melica, Maria Elena, Peired, Anna Julie, Maggi, Laura, Donati, Marta, La Regina, Gilda, Allinovi, Marco, Ravaglia, Fiammetta, Guasti, Daniele, Bani, Daniele, Cirillo, Luigi, Becherucci, Francesca, Guzzi, Francesco, Magi, Alberto, Annunziato, Francesco, Lasagni, Laura, Anders, Hans-Joachim, Lazzeri, Elena, Romagnani, Paola

“…Acute kidney injury (AKI) is frequent, often fatal and, for lack of specific therapies, can leave survivors with chronic kidney disease (CKD). We characterize…”
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Renal Progenitors Derived from Urine for Personalized Diagnosis of Kidney Diseases by Mazzinghi, Benedetta, Melica, Maria Elena, Lasagni, Laura, Romagnani, Paola, Lazzeri, Elena

“…Abstract Background: Chronic kidney disease affects 10% of the world population, and it is associated with progression to end-stage kidney disease and…”
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Isolation and characterization of multipotent progenitor cells from the bowman's capsule of adult human kidneys by SAGRINATI, Costanza, NETTI, Giuseppe Stefano, CARINI, Marco, GESUALDO, Loreto, FRANCINI, Fabio, MAGGI, Enrico, ANNUNZIATO, Francesco, LASAGNI, Laura, SERIO, Mario, ROMAGNANI, Sergio, ROMAGNANI, Paola, MAZZINGHI, Benedetta, LAZZERI, Elena, LIOTTA, Francesco, FROSALI, Francesca, RONCONI, Elisa, MEINI, Claudia, GACCI, Mauro, SQUECCO, Roberta

“…Regenerative medicine represents a critical clinical goal for patients with ESRD, but the identification of renal adult multipotent progenitor cells has…”
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Podocyte Regeneration Driven by Renal Progenitors Determines Glomerular Disease Remission and Can Be Pharmacologically Enhanced by Lasagni, Laura, Angelotti, Maria Lucia, Ronconi, Elisa, Lombardi, Duccio, Nardi, Sara, Peired, Anna, Becherucci, Francesca, Mazzinghi, Benedetta, Sisti, Alessandro, Romoli, Simone, Burger, Alexa, Schaefer, Beat, Buccoliero, Annamaria, Lazzeri, Elena, Romagnani, Paola

“…Podocyte loss is a general mechanism of glomerular dysfunction that initiates and drives the progression of chronic kidney disease, which affects 10% of the…”
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Notch Activation Differentially Regulates Renal Progenitors Proliferation and Differentiation Toward the Podocyte Lineage in Glomerular Disorders by Lasagni, Laura, Ballerini, Lara, Angelotti, Maria Lucia, Parente, Eliana, Sagrinati, Costanza, Mazzinghi, Benedetta, Peired, Anna, Ronconi, Elisa, Becherucci, Francesca, Bani, Daniele, Gacci, Mauro, Carini, Marco, Lazzeri, Elena, Romagnani, Paola

“…Glomerular diseases account for 90% of end‐stage kidney disease. Podocyte loss is a common determining factor for the progression toward glomerulosclerosis…”
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Human Urine-Derived Renal Progenitors for Personalized Modeling of Genetic Kidney Disorders by Lazzeri, Elena, Ronconi, Elisa, Angelotti, Maria Lucia, Peired, Anna, Mazzinghi, Benedetta, Becherucci, Francesca, Conti, Sara, Sansavini, Giulia, Sisti, Alessandro, Ravaglia, Fiammetta, Lombardi, Duccio, Provenzano, Aldesia, Manonelles, Anna, Cruzado, Josep M, Giglio, Sabrina, Roperto, Rosa Maria, Materassi, Marco, Lasagni, Laura, Romagnani, Paola

“…The critical role of genetic and epigenetic factors in the pathogenesis of kidney disorders is gradually becoming clear, and the need for disease models that…”
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Clinical and Genetic Characterization of Patients with Bartter and Gitelman Syndrome by Palazzo, Viviana, Raglianti, Valentina, Landini, Samuela, Cirillo, Luigi, Errichiello, Carmela, Buti, Elisa, Artuso, Rosangela, Tiberi, Lucia, Vergani, Debora, Dirupo, Elia, Romagnani, Paola, Mazzinghi, Benedetta, Becherucci, Francesca

“…Bartter (BS) and Gitelman (GS) syndrome are autosomal recessive inherited tubulopathies, whose clinical diagnosis can be challenging, due to rarity and…”
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Renal Progenitor Cells Contribute to Hyperplastic Lesions of Podocytopathies and Crescentic Glomerulonephritis by SMEETS, Bart, ANGELOTTI, Maria Lucia, RONCONI, Elisa, BECHERUCCI, Francesca, BENIGNI, Ariela, STEENBERGEN, Eric, LASAGNI, Laura, REMUZZI, Giuseppe, WETZELS, Jack, ROMAGNANI, Paola, RIZZO, Paola, DIJKMAN, Henry, LAZZERI, Elena, MOOREN, Fieke, BALLERINI, Lara, PARENTE, Eliana, SAGRINATI, Costanza, MAZZINGHI, Benedetta

“…Glomerular injury can involve excessive proliferation of glomerular epithelial cells, resulting in crescent formation and obliteration of Bowman's space. The…”
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An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4 by Lasagni, Laura, Francalanci, Michela, Annunziato, Francesco, Lazzeri, Elena, Giannini, Stefano, Cosmi, Lorenzo, Sagrinati, Costanza, Mazzinghi, Benedetta, Orlando, Claudio, Maggi, Enrico, Marra, Fabio, Romagnani, Sergio, Serio, Mario, Romagnani, Paola

“…The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation, and act as angiostatic…”
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Regenerative Potential of Embryonic Renal Multipotent Progenitors in Acute Renal Failure by LAZZERI, Elena, CRESCIOLI, Clara, MAGGI, Laura, GESUALDO, Loreto, ROTONDI, Mario, ANNUNZIATO, Francesco, MAGGI, Enrico, LASAGNI, Laura, SERIO, Mario, ROMAGNANI, Sergio, BARBARA VANNELLI, Gabriella, ROMAGNANI, Paola, RONCONI, Elisa, MAZZINGHI, Benedetta, SAGRINATI, Costanza, STEFANO NETTI, Giuseppe, ANGELOTTI, Maria Lucia, PARENTE, Eliana, BALLERINI, Lara, COSMI, Lorenzo

“…Bone marrow-and adult kidney-derived stem/progenitor cells hold promise in the development of therapies for renal failure. Here is reported the identification…”
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Preparation of Human Kidney Progenitor Cultures and Their Differentiation into Podocytes by Melica, Maria, Angelotti, Maria, Antonelli, Giulia, Peired, Anna, Conte, Carolina, Chiara, Letizia, Mazzinghi, Benedetta, Lazzeri, Elena, Lasagni, Laura, Romagnani, Paola

“…Kidney diseases are a global health concern. Modeling of kidney disease for translational research is often challenging because of species specificities or the…”
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Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction by LIOTTA, Francesco, FROSALI, Francesca, BIAGIOLI, Tiziana, LASAGNI, Laura, BALLERINI, Clara, PARRONCHI, Paola, SCHEFFOLD, Alexander, COSMI, Lorenzo, MAGGI, Enrico, ROMAGNANI, Sergio, ANNUNZIATO, Francesco, QUERCI, Valentina, MANTEI, Andrej, FILL, Lucia, MAGGI, Laura, MAZZINGHI, Benedetta, ANGELI, Roberta, RONCONI, Elisa, SANTARLASCI, Veronica

“…The mechanisms by which human dendritic cells (DCs) activate a TH1-polarizing or TH2-polarizing program are still partially unclear. Study of the mechanisms…”
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PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion by Lasagni, Laura, Grepin, Renaud, Mazzinghi, Benedetta, Lazzeri, Elena, Meini, Claudia, Sagrinati, Costanza, Liotta, Francesco, Frosali, Francesca, Ronconi, Elisa, Alain-Courtois, Nathalie, Ballerini, Lara, Netti, Giuseppe Stefano, Maggi, Enrico, Annunziato, Francesco, Serio, Mario, Romagnani, Sergio, Bikfalvi, Andreas, Romagnani, Paola

“…PF-4/CXCL4 is a member of the CXC chemokine family, which is mainly produced by platelets and known for its pleiotropic biological functions. Recently, the…”
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The role of endothelial progenitor cells in acute kidney injury by Becherucci, Francesca, Mazzinghi, Benedetta, Ronconi, Elisa, Peired, Anna, Lazzeri, Elena, Sagrinati, Costanza, Romagnani, Paola, Lasagni, Laura

“…Acute kidney injury (AKI) is characterized by a sudden impairment of kidney function, which results in the retention of urea and other nitrogenous waste…”
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Nephrotic Syndrome and Renal Failure After Allogeneic Stem Cell Transplantation: Novel Molecular Diagnostic Tools for a Challenging Differential Diagnosis by Romagnani, Paola, Lazzeri, Elena, Mazzinghi, Benedetta, Lasagni, Laura, Guidi, Stefano, Bosi, Alberto, Cirami, Calogero, Salvadori, Maurizio

“…Background: Sudden onset of nephrotic syndrome after allogeneic stem cell transplantation is rare and has been associated mostly with membranous…”
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Essential but differential role for CXCR4 and CXCR7 in the therapeutic homingof human renal progenitor cells by Mazzinghi, Benedetta, Ronconi, Elisa, Lazzeri, Elena, Sagrinati, Costanza, Ballerini, Lara, Angelotti, Maria Lucia, Parente, Eliana, Mancina, Rosa, Netti, Giuseppe Stefano, Becherucci, Francesca, Gacci, Mauro, Carini, Marco, Gesualdo, Loreto, Rotondi, Mario, Maggi, Enrico, Lasagni, Laura, Serio, Mario, Romagnani, Sergio, Romagnani, Paola

“…Recently, we have identified a population of renal progenitor cells in human kidneys showing regenerative potential for injured renal tissue of SCID mice. We…”
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2145 Sexual dimorphism in kidney regenerative capacity decline and in progressive tubular cell polyploidization during aging by Lazzeri, Elena, Antonelli, Giulia, Mazzinghi, Benedetta, Conte, Carolina, Carangiolo, Giulia, De Chiara, Letizia, Romagnani, Paola

“…Abstract Background and Aims Aging is characterized by a progressive kidney function decline, resulting in chronic kidney disease (CKD), which is steeper in…”
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Bioengineering strategies for nephrologists: kidney was not built in a day by Peired, Anna Julie, Mazzinghi, Benedetta, De Chiara, Letizia, Guzzi, Francesco, Lasagni, Laura, Romagnani, Paola, Lazzeri, Elena

“…: The number of patients with end-stage kidney disease is increasing worldwide, creating an unprecedented organ shortage. The kidney is a highly complex…”
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