Effects of 2,3-Butanedione Monoxime on Atrial-Atrioventricular Nodal Conduction in Isolated Rabbit Heart

BDM Effects on AVN Conduction. Introduction: 2,3‐Butanedione monoxime (BDM) has been found to reversibly block cardiac contraction, without blocking electrical conduction. This study characterizes the dose‐dependent effects of BDM on the conduction through the atrioventricular node (AVN) of rabbit h...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of cardiovascular electrophysiology Vol. 8; no. 7; pp. 790 - 802
Main Authors:	CHENG, YUANNA, MOWREY, KENT, EFIMOV, IGOR R., Van WAGONER, DAVID R., TCHOU, PATRICK J., MAZGALBV, TODOR N.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-07-1997
Subjects:	2,3‐butanedione monoxime 3-butanedione monoxime Action Potentials - drug effects Action Potentials - physiology Animals Atrial Function atrioventricular node Atrioventricular Node - drug effects Atrioventricular Node - innervation Atrioventricular Node - physiology Bundle of His - drug effects Bundle of His - physiology Cardiac Pacing, Artificial - methods Cholinesterase Reactivators - administration & dosage Cholinesterase Reactivators - pharmacology conduction of cardiac impulse Diacetyl - administration & dosage Diacetyl - analogs & derivatives Diacetyl - pharmacology diacetyl monoxime Electric Countershock Electric Stimulation - methods Evoked Potentials - drug effects Evoked Potentials - physiology Female Heart - drug effects Heart - physiology Heart Atria - drug effects Heart Conduction System - physiology In Vitro Techniques Male Rabbits Refractory Period, Electrophysiological - drug effects Refractory Period, Electrophysiological - physiology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	BDM Effects on AVN Conduction. Introduction: 2,3‐Butanedione monoxime (BDM) has been found to reversibly block cardiac contraction, without blocking electrical conduction. This study characterizes the dose‐dependent effects of BDM on the conduction through the atrioventricular node (AVN) of rabbit heart. Methods and Results: Thirteen isolated atrial‐AVN preparations were used in control, during and after exposure to 5, 10, and 20 mM BDM. Anterograde and retrograde pacing protocols were used to obtain the Wenckebach cycle length, effective and functional refractory periods of the AVN, index of AVN conduction delay (the area under the AVN conduction curve), as well as index of intra‐atrial conduction delay between the AVN inputs. Compared to control, 5 and 10 mM BDM produced either shortening or no effect on all of the above parameters except a slight (6% and 14%, respectively) increase in the intra‐atrial delay. At 20 mM, BDM produced a further increase in the intra‐atrial delay (up to 50%) as well as in the retrograde AVN conduction delay (up to 16%), while the characteristics of the anterograde conduction were still improved. The effects of perfusion with BDM on these parameters were reversible after washout. Conclusions: Aside from its known effect as an electromechanical uncoupler, BDM reversibly altered some of the electrical responses of the AVN. Most of these alterations, however, did not impede but rather improved AVN conduction. Since a dose of 10 mM is sufficient to fully eliminate undesirable motion, BDM should be considered a safe and valuable tool in AVN studies in vitro requiring a mechanically quiescent preparation.
Bibliography:	istex:447F87D2B981673611AAB2FFB763F6AF8BA5AB07 ArticleID:JCE790 ark:/67375/WNG-3FRFXB5T-1 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1045-3873 1540-8167
DOI:	10.1111/j.1540-8167.1997.tb00837.x