Search Results - "MAYUMI, Tadanori"

Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application by Nabeshi, Hiromi, Yoshikawa, Tomoaki, Matsuyama, Keigo, Nakazato, Yasutaro, Matsuo, Kazuhiko, Arimori, Akihiro, Isobe, Masaaki, Tochigi, Saeko, Kondoh, Sayuri, Hirai, Toshiro, Akase, Takanori, Yamashita, Takuya, Yamashita, Kohei, Yoshida, Tokuyuki, Nagano, Kazuya, Abe, Yasuhiro, Yoshioka, Yasuo, Kamada, Haruhiko, Imazawa, Takayoshi, Itoh, Norio, Nakagawa, Shinsaku, Mayumi, Tadanori, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

“…Abstract Currently, nanomaterials (NMs) with particle sizes below 100 nm have been successfully employed in various industrial applications in medicine,…”
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Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure by Nabeshi, Hiromi, Yoshikawa, Tomoaki, Matsuyama, Keigo, Nakazato, Yasutaro, Arimori, Akihiro, Isobe, Masaaki, Tochigi, Saeko, Kondoh, Sayuri, Hirai, Toshiro, Akase, Takanori, Yamashita, Takuya, Yamashita, Kohei, Yoshida, Tokuyuki, Nagano, Kazuya, Abe, Yasuhiro, Yoshioka, Yasuo, Kamada, Haruhiko, Imazawa, Takayoshi, Itoh, Norio, Kondoh, Masuo, Yagi, Kiyohito, Mayumi, Tadanori, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

“…We previously reported that well-dispersed amorphous nanosilicas with particle size 70 nm (nSP70) penetrate skin and produce systemic exposure after topical…”
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The use of PVP as a polymeric carrier to improve the plasma half-life of drugs by Kaneda, Yoshihisa, Tsutsumi, Yasuo, Yoshioka, Yasuo, Kamada, Haruhiko, Yamamoto, Yoko, Kodaira, Hiroshi, Tsunoda, Shin-ichi, Okamoto, Takayuki, Mukai, Yohei, Shibata, Hiroko, Nakagawa, Shinsaku, Mayumi, Tadanori

“…To achieve an optimum drug delivery such as targeting or controlled release utilizing bioconjugation with polymeric modifier, the conjugate between drugs and…”
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Synthesis of a poly(vinylpyrrolidone-co -dimethyl maleic anhydride) co-polymer and its application for renal drug targeting by Tsutsumi, Yasuo, Kamada, Haruhiko, Sato-Kamada, Keiko, Yamamoto, Yoko, Yoshioka, Yasuo, Okamoto, Takayuki, Nakagawa, Shinsaku, Nagata, Satoshi, Mayumi, Tadanori

“…We have synthesized a polymeric drug carrier, polyvinylpyrrolidone-co-dimethyl maleic anhydride [poly(VP-co-DMMAn)], for use in renal drug delivery. About 80%…”
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Tryprostatin A, a specific and novel inhibitor of microtubule assembly by Usui, T, Kondoh, M, Cui, C B, Mayumi, T, Osada, H

“…We have investigated the cell cycle inhibition mechanism and primary target of tryprostatin A (TPS-A) purified from Aspergillus fumigatus. TPS-A inhibited cell…”
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Optimization of transcriptional regulatory elements for constructing plasmid vectors by Xu, Z L, Mizuguchi, H, Ishii-Watabe, A, Uchida, E, Mayumi, T, Hayakawa, T

“…In studies regarding both gene therapy and gene function, transgene expression by plasmid vectors benefits from the use of transcriptional regulatory elements…”
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PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability by Eto, Yusuke, Gao, Jian-Qing, Sekiguchi, Fumiko, Kurachi, Shinnosuke, Katayama, Kazufumi, Maeda, Mitsuko, Kawasaki, Koichi, Mizuguchi, Hiroyuki, Hayakawa, Takao, Tsutsumi, Yasuo, Mayumi, Tadanori, Nakagawa, Shinsaku

“…Background PEGylation of adenovirus vectors (Ads) is an attractive strategy in gene therapy. Although many types of PEGylated Ad (PEG‐Ads), which exhibit…”
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Pharmacotherapy by intracellular delivery of drugs using fusogenic liposomes: application to vaccine development by Kunisawa, Jun, Nakagawa, Shinsaku, Mayumi, Tadanori

“…We prepared fusogenic liposomes by fusing conventional liposomes with an ultra-violet inactivated Sendai virus. Fusogenic liposomes can deliver encapsulated…”
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Functionalization of Tumor Necrosis Factor-α Using Phage Display Technique and PEGylation Improves Its Antitumor Therapeutic Window by SHIBATA, Hiroko, YOSHIOKA, Yasuo, NAKAGAWA, Shinsaku, HAYAKAWA, Takao, NAGATA, Satoshi, YAMAGATA, Yuriko, MAYUMI, Tadanori, KAMADA, Haruhiko, TSUTSUMI, Yasuo, IKEMIZU, Shinji, KOBAYASHI, Kyoko, YAMAMOTO, Yoko, MUKAI, Yohei, OKAMOTO, Takayuki, TANIAI, Madoka, KAWAMURA, Maki, ABE, Yasuhiro

“…Purpose: In this study, the optimization of antitumor therapy with tumor necrosis factor-α (TNF-α) was attempted. Experimental Design: Using the phage display…”
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Neutralizing Antibody Evasion Ability of Adenovirus Vector Induced by the Bioconjugation of Methoxypolyethylene Glycol Succinimidyl Propionate (MPEG-SPA) by Eto, Yusuke, Gao, Jian-Qing, Sekiguchi, Fumiko, Kurachi, Shinnosuke, Katayama, Kazufumi, Mizuguchi, Hiroyuki, Hayakawa, Takao, Tsutsumi, Yasuo, Mayumi, Tadanori, Nakagawa, Shinsaku

“…Although adenovirus vectors (Ad) which possesses high transduction efficiency are widely used for gene therapy in animal models, clinical use is very limited…”
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Creation of Novel Cell-Penetrating Peptides for Intracellular Drug Delivery Using Systematic Phage Display Technology Originated from Tat Transduction Domain by Kamada, Haruhiko, Okamoto, Takayuki, Kawamura, Maki, Shibata, Hiroko, Abe, Yasuhiro, Ohkawa, Akiko, Nomura, Tetsuya, Sato, Masaki, Mukai, Yohei, Sugita, Toshiki, Imai, Sunao, Nagano, Kazuya, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Mayumi, Tadanori, Tsunoda, Shin-ichi

“…Many biologically active proteins need to be delivered intracellularly to exert their therapeutic action inside the cytoplasm. Cell penetrating peptides (CPPs)…”
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Urban Aerosols Induce Pro-inflammatory Cytokine Production in Macrophages and Cause Airway Inflammation in Vivo by Yoshida, Tokuyuki, Yoshioka, Yasuo, Fujimura, Maho, Kayamuro, Hiroyuki, Yamashita, Kohei, Higashisaka, Kazuma, Nakanishi, Ryosuke, Morishita, Yuki, Nabeshi, Hiromi, Yamashita, Takuya, Muroi, Masashi, Tanamoto, Kenichi, Nagano, Kazuya, Abe, Yasuhiro, Kamada, Haruhiko, Kawai, Yuichi, Mayumi, Tadanori, Itoh, Norio, Yoshikawa, Tomoaki, Tsunoda, Shinichi, Tsutsumi, Yasuo

“…Urban air pollution, especially in developing countries, is a crucial environmental problem. Urban aerosols may contain various kinds of substances and induce…”
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The targeting of anionized polyvinylpyrrolidone to the renal system by Kodaira, Hiroshi, Tsutsumi, Yasuo, Yoshioka, Yasuo, Kamada, Haruhiko, Kaneda, Yoshihisa, Yamamoto, Yoko, Tsunoda, Shin-ichi, Okamoto, Takayuki, Mukai, Yohei, Shibata, Hiroko, Nakagawa, Shinsaku, Mayumi, Tadanori

“…We reported that the co-polymer composed of vinylpyrrolidone and maleic acid selectively distributed into the kidneys after i.v. injection. To further optimize…”
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A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity by Hayashi, Akira, Wakita, Hisashi, Yoshikawa, Tomoaki, Nakanishi, Tsuyoshi, Tsutsumi, Yasuo, Mayumi, Tadanori, Mukai, Yohei, Yoshioka, Yasuo, Okada, Naoki, Nakagawa, Shinsaku

“…The activation of antitumor cytotoxic T-lymphocytes (CTLs) depends on how efficiently the relevant tumor antigen peptides are delivered into the major…”
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Positively charged liposome functions as an efficient immunoadjuvant in inducing cell-mediated immune response to soluble proteins by NAKANISHI, T, KUNISAWA, J, HAYASHI, A, TSUTSUMI, Y, KUBO, K, NAKAGAWA, S, NAKANISHI, M, TANAKA, K, MAYUMI, T

“…In order to design an optimized liposome immunoadjuvant for inducing cell-mediated immune response against soluble proteinaceous antigens, we investigated the…”
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Design of a pH-Sensitive Polymeric Carrier for Drug Release and Its Application in Cancer Therapy by KAMADA, Haruhiko, TSUTSUMI, Yasuo, MAYUMI, Tadanori, YOSHIOKA, Yasuo, YAMAMOTO, Yoko, KODAIRA, Hiroshi, TSUNODA, Shin-Ichi, OKAMOTO, Takayuki, MUKAI, Yohei, SHIBATA, Hiroko, NAKAGAWA, Shinsaku

“…Purpose: In this study, to optimize the polymeric drug delivery system for cancer chemotherapy, we developed a new pH-sensitive polymeric carrier,…”
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Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions by Mizuguchi, Hiroyuki, Xu, Zhi-Li, Sakurai, Fuminori, Mayumi, Tadanori, Hayakawa, Takao

“…We previously developed single adenovirus (Ad) vectors that contained the components for a tetracycline-regulatable gene-expression system in the E1 and E3…”
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Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma-associated antigen and interleukin-12 by Okada, Naoki, Iiyama, Sayaka, Okada, Yuka, Mizuguchi, Hiroyuki, Hayakawa, Takao, Nakagawa, Shinsaku, Mayumi, Tadanori, Fujita, Takuya, Yamamoto, Akira

“…Interleukin (IL)-12 is a key factor for inducing cellular immune responses, which play a central role in the eradication of cancer. In the present study, in…”
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Vaccine Efficacy of Fusogenic Liposomes Containing Tumor Cell-Lysate against Murine B16BL6 Melanoma by Yoshikawa, Tomoaki, Okada, Naoki, Tsujino, Masaki, Gao, Jian-Qing, Hayashi, Akira, Tsutsumi, Yasuo, Mayumi, Tadanori, Yamamoto, Akira, Nakagawa, Shinsaku

“…Recent advances in tumor immunology have facilitated the development of cancer immunotherapy targeting tumor-associated antigens (TAAs). However, because TAAs…”
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Optimal construction of non-immune scFv phage display libraries from mouse bone marrow and spleen established to select specific scFvs efficiently binding to antigen by Okamoto, Takayuki, Mukai, Yohei, Yoshioka, Yasuo, Shibata, Hiroko, Kawamura, Maki, Yamamoto, Yoko, Nakagawa, Shinsaku, Kamada, Haruhiko, Hayakawa, Takao, Mayumi, Tadanori, Tsutsumi, Yasuo

“…Monoclonal antibodies (MAbs) are widely applied in basic research, medicine, and the pharmaceutical industry. Recently, applications and generations of MAbs…”
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