Search Results - "MAYO, Lindsey D"

Alteration of tumor suppressors changes the endometrial tumor spectrum by Mayo, Lindsey D

“…The most common gynecological cancer in Europe and the United States is endometrial. Like most cancers, early‐stage endometrial cancer has a more favorable…”
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The effect of replication protein A inhibition and post-translational modification on ATR kinase signaling by Jordan, Matthew R., Oakley, Greg G., Mayo, Lindsey D., Balakrishnan, Lata, Turchi, John J.

“…The ATR kinase responds to elevated levels of single-stranded DNA (ssDNA) to activate the G2/M checkpoint, regulate origin utilization, preserve fork…”
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Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway by Chen, Sisi, Wang, Qiang, Yu, Hao, Capitano, Maegan L., Vemula, Sasidhar, Nabinger, Sarah C., Gao, Rui, Yao, Chonghua, Kobayashi, Michihiro, Geng, Zhuangzhuang, Fahey, Aidan, Henley, Danielle, Liu, Stephen Z., Barajas, Sergio, Cai, Wenjie, Wolf, Eric R., Ramdas, Baskar, Cai, Zhigang, Gao, Hongyu, Luo, Na, Sun, Yang, Wong, Terrence N., Link, Daniel C., Liu, Yunlong, Boswell, H. Scott, Mayo, Lindsey D., Huang, Gang, Kapur, Reuben, Yoder, Mervin C., Broxmeyer, Hal E., Gao, Zhonghua, Liu, Yan

“…Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and is associated with increased risks of hematological malignancies. While TP53…”
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Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness by Olivos, David J, Mayo, Lindsey D

“…Since its discovery nearly 40 years ago, p53 has ascended to the forefront of investigated genes and proteins across diverse research disciplines and is…”
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A Phosphatidylinositol 3-Kinase/Akt Pathway Promotes Translocation of Mdm2 from the Cytoplasm to the Nucleus by Mayo, Lindsey D., Donner, David B.

“…The Mdm2 oncoprotein promotes cell survival and cell cycle progression by inhibiting the p53 tumor suppressor protein. To regulate p53, Mdm2 must gain nuclear…”
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Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase by Batuello, Christopher N., Hauck, Paula M., Gendron, Jaimie M., Lehman, Jason A., Mayo, Lindsey D.

“…Murine double minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in regulating numerous proteins including the tumor suppressor…”
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Directing p53 to induce autophagy by Mayo, Lindsey D.

“…Comment on: Naidu SR, et al. Cell Cycle 2012; 11:2717-28…”
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The PTEN, Mdm2, p53 tumor suppressor–oncoprotein network by Mayo, Lindsey D, Donner, David B

“…Oncoproteins and tumor-suppressor proteins regulate cell growth and viability. Recent observations show that phosphoinositide 3-kinase (PtdIns 3-kinase)–Akt…”
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Levels of hdmx expression dictate the sensitivity of normal and transformed cells to nutlin-3 by PATTON, John T, MAYO, Lindsey D, SINGHI, Aatur D, GUDKOV, Andrei V, STARK, George R, JACKSON, Mark W

“…Hdm2 and HdmX coordinately regulate the stability and function of p53. Each is overexpressed in subsets of many different types of malignancy, and most of…”
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Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway by Chen, Sisi, Wang, Qiang, Yu, Hao, Capitano, Maegan L., Vemula, Sasidhar, Nabinger, Sarah C., Gao, Rui, Yao, Chonghua, Kobayashi, Michihiro, Geng, Zhuangzhuang, Fahey, Aidan, Henley, Danielle, Liu, Stephen Z., Barajas, Sergio, Cai, Wenjie, Wolf, Eric R., Ramdas, Baskar, Cai, Zhigang, Gao, Hongyu, Luo, Na, Sun, Yang, Wong, Terrence N., Link, Daniel C., Liu, Yunlong, Boswell, H. Scott, Mayo, Lindsey D., Huang, Gang, Kapur, Reuben, Yoder, Mervin C., Broxmeyer, Hal E., Gao, Zhonghua, Liu, Yan

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Delayed Activation of Insulin-like Growth Factor-1 Receptor/Src/MAPK/Egr-1 Signaling Regulates Clusterin Expression, a Pro-survival Factor by Criswell, Tracy, Beman, Meghan, Araki, Shinako, Leskov, Konstantin, Cataldo, Eva, Mayo, Lindsey D., Boothman, David A.

“…Secretory clusterin protein (sCLU) is a general genotoxic stress-induced, pro-survival gene product implicated in aging, obesity, heart disease, and cancer…”
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PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy by Mayo, Lindsey D, Dixon, Jack E, Durden, Donald L, Tonks, Nickolas K, Donner, David B

“…The PTEN tumor suppressor protein inhibits phosphatidylinositol 3-kinase (PI3K)/Akt signaling that promotes translocation of Mdm2 into the nucleus. When…”
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A Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway Mediates and PTEN Antagonizes Tumor Necrosis Factor Inhibition of Insulin Signaling through Insulin Receptor Substrate-1 by Ozes, Osman Nidai, Akca, Hakan, Mayo, Lindsey D., Gustin, Jason A., Maehama, Tomohiko, Dixon, Jack E., Donner, David B.

“…Tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) by the insulin receptor permits this docking protein to interact with signaling proteins that…”
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Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth by Zhang, YiWei, Zhang, Qi, Zeng, Shelya X., Zhang, Yu, Mayo, Lindsey D., Lu, Hua

“…Several proteins have been suggested in promoting tumor formation in numerous human tissues by inactivating the tumor suppressor p53. This has generated…”
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Phosphorylation of Human p53 at Serine 46 Determines Promoter Selection and whether Apoptosis Is Attenuated or Amplified by Mayo, Lindsey D., Seo, Young Rok, Jackson, Mark W., Smith, Martin L., Guzman, Javier Rivera, Korgaonkar, Chandrashekhar K., Donner, David B.

“…The capacity of DNA damaging agents to induce apoptosis is regulated by target gene induction by p53. We found that p53 targeted MDM2 in cells in which DNA…”
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Serdemetan antagonizes the Mdm2-HIF1α axis leading to decreased levels of glycolytic enzymes by Lehman, Jason A, Hauck, Paula M, Gendron, Jaimie M, Batuello, Christopher N, Eitel, Jacob A, Albig, Allan, Kadakia, Madhavi P, Mayo, Lindsey D

“…Serdemetan (JNJ-26854165), an antagonist to Mdm2, was anticipated to promote the activation of p53. While regulation of p53 by Mdm2 is important, Mdm2 also…”
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Humanized Bone Marrow Mouse Model as a Preclinical Tool to Assess Therapy-Mediated Hematotoxicity by SHANBAO CAI, HAIYAN WANG, SCOTT GOEBEL, W, POLLOK, Karen E, BAILEY, Barbara, ERNSTBERGER, Aaron, JULIAR, Beth E, SINN, Anthony L, CHAN, Rebecca J, JONES, David R, MAYO, Lindsey D, BALUYUT, Arthur R

“…Preclinical in vivo studies can help guide the selection of agents and regimens for clinical testing. However, one of the challenges in screening anticancer…”
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Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis by Lehman, Jason A, Mayo, Lindsey D

“…The alteration of tumorigenic pathways leading to cancer is a degenerative disease process typically involving inactivation of tumor suppressor proteins and…”
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Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis by Cipriano, Rocky, Patton, John T., Mayo, Lindsey D., Jackson, Mark W.

“…The p53 signaling pathway is frequently disrupted in carcinogenesis. However, roughly 50% of all cancers express wild-type p53 and have alterations in…”
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PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells by Eitel, Jacob A., Bijangi-Vishehsaraei, Khadijeh, Saadatzadeh, M. Reza, Murphy, Michael P., Pollok, Karen E., Mayo, Lindsey D.

“…In response to genotoxic stress, p53 induces the tumor suppressors maspin and PTEN.  Here we demonstrate that in response to limited oxygen conditions PTEN and…”
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