Search Results - "MAYO, J. G"

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay by ALLEY, M. C, SCUDIERO, D. A, MONKS, A, HURSEY, M. L, CZERWINSKI, M. J, FINE, D. L, ABBOTT, B. J, MAYO, J. G, SHOEMAKER, R. H, BOYD, M. R

“…For the past 30 years strategies for the preclinical discovery and development of potential anticancer agents have been based largely upon the testing of…”
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Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model by Casciari, J J, Hollingshead, M G, Alley, M C, Mayo, J G, Malspeis, L, Miyauchi, S, Grever, M R, Weinstein, J N

“…Cancer treatments that appear promising in tissue culture are often less effective in solid tumors, in part because of the proliferative and microenvironmental…”
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Expression of β-tubulin isotypes in human ovarian carcinoma xenografts and in a sub-panel of human cancer cell lines from the NCI-anticancer drug screen: Correlation with sensitivity to microtubule active agents by NICOLETTI, Maria Ines, VALOTI, Giorgio, GIANNAKAKOU, Paraskevi, ZHIRONG ZHAN, KIM, Jon-Hyeok, LUCCHINI, Valeria, LANDONI, Fabio, MAYO, Joseph G, GIAVAZZI, Raffaella, FOJO, Tito

“…Paclitaxel resistance has been associated with overexpression of P-glycoprotein and alterations involving tubulin. To investigate the clinical relevance of…”
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Establishment of human acute myelogenous leukemia lines secreting interleukin-1 beta in SCID mice by Giavazzi, R, Di Berardino, C, Garofalo, A, Motta, T, Gobbi, A, Scanziani, E, Giudici, G, Galli, M, Mayo, J G, Barbui, T

“…A reproducible in vivo model of human acute myelogenous leukemia (AML) was established in severe combined immunodeficient (SCID) mice. The AML-CL and AML-PS…”
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Comparison of intrapulmonary, percutaneous intrathoracic, and subcutaneous models for the propagation of human pulmonary and nonpulmonary cancer cell lines in athymic nude mice by MCLEMORE, T. L, EGGLESTON, J. C, SHOEMAKER, R. H, ABBOTT, B. J, BOHLMAN, M. E, LIU, M. C, FINE, D. L, MAYO, J. G, BOYD, M. R

“…The propagation efficiencies, growth patterns, histological appearances, and roentgenographic demonstration of tumors derived from six continuous human…”
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In vivo cultivation of tumor cells in hollow fibers by Hollingshead, M G, Alley, M C, Camalier, R F, Abbott, B J, Mayo, J G, Malspeis, L, Grever, M R

“…Advancement of potential anti-cancer agents from "discovery" in an in vitro screen to pre-clinical development requires a demonstration of in vivo efficacy in…”
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Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype by QIUWEN MI, BAOLIANG CUI, PEZZUTO, John M, SILVA, Gloria L, LANTVIT, Daniel, LIM, Eula, HEEBYUNG CHAI, MIN YOU, HOLLINGSHEAD, Melinda G, MAYO, Joseph G, KINGHORN, A. Douglas

“…P-Glycoprotein-mediated drug efflux can yield a multidrug-resistance (MDR) phenotype that is associated with a poor response to cancer chemotherapy…”
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Comparative study on the metastatic behavior of human tumors in nude, beige/nude/xid and severe combined immunodeficient mice by Garofalo, A, Chirivi, R G, Scanziani, E, Mayo, J G, Vecchi, A, Giavazzi, R

“…The growth and metastatic behavior of human tumor cell lines were studied in nude, beige/nude/xid (bg/nu/xid) and severe combined immunodeficient (SCID) mice…”
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Excision assay for initial evaluation of antitumor drug activity in mice bearing human tumor xenografts by Dykes, D J, Harrison, Jr, S D, Mayo, J G, Griswold, Jr, D P

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Cyclophosphamide-adriamycin combination chemotherapy of transplantable murine tumors by Corbett, T H, Griswold, D P, Mayo, J G, Laster, W R, Schabel, Jr, F M

“…The two-drug combination of cyclophosphamide plus adriamycin was found to be therapeutically potentiating against four different C3H mammary tumor lines, the…”
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Biologic characterization of the subcutaneously implanted Lewis lung tumor by Mayo, J G

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Novel intrapulmonary model orthotopic propagation of human lung cancers in athymic nude mice by MCLEMORE, T. L, LIU, M. C, BRENNAN, R. H, MCMAHON, J. B, FINE, D. L, EGGLESTON, J. C, MAYO, J. G, BOYD, M. R, BLACKER, P. C, GREGG, M, ALLEY, M. C, ABBOTT, B. J, SHOEMAKER, R. H, BOHLMAN, M. E, LITTERST, C. C, HUBBARD, W. C

“…A major impediment to the study of human lung cancer pathophysiology, as well as to the discovery and development of new specific antitumor agents for the…”
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Helicobacter-associated hepatitis of mice by Donovan, J C, Mayo, J G, Rice, J M, Ward, J M, Fox, J G

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Development of human tumor cell line panels for use in disease-oriented drug screening by Shoemaker, R H, Monks, A, Alley, M C, Scudiero, D A, Fine, D L, McLemore, T L, Abbott, B J, Paull, K D, Mayo, J G, Boyd, M R

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Practical spontaneous metastasis model for in vivo therapeutic studies using a human melanoma by SHOEMAKER, R. H, DYKES, D, PLOWMAN, J, HARRISON, S. D, GRISWOLD, D. P, ABBOTT, B. J, MAYO, J. G, FODSTAD, O, BOYD, M. R

“…In vivo studies aimed at therapy of spontaneous human tumor metastases have been hampered by the lack of practical experimental models. The LOX amelanotic…”
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Success and failure in the treatment of solid tumors. 3. "Cure" of metastatic Lewis lung carcinoma with methyl-CCNU (NSC-95442) and surgery-chemotherapy by Mayo, J G, Laster, Jr, W R, Andrews, C M, Schabel, Jr, F M

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Quantitative structure-activity relationships in anticancer agents. Activity of selected nitrosoureas against a solid tumor, the Lewis lung carcinoma by Montgomery, J A, Mayo, J G

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Use of the KB cell line for in vitro cytotoxicity assays by Shoemaker, R H, Abbott, B J, Macdonald, M M, Mayo, J G, Venditti, J M, Wolpert-DeFilippes, M K

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Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma by Montgomery, John A, McCaleb, George S, Johnston, Thomas P, Mayo, Joseph G, Laster, W. Russell

“…The utility of the Lewis lung carcinoma as a secondary screen for the evaluation of nitrosoureas as anticancer agents has been assessed. The activity of this…”
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Metastasis models for human tumors in athymic mice: useful models for drug development by Fine, D L, Shoemaker, R, Gazdar, A, Mayo, J G, Fodstad, O, Boyd, M R, Abbott, B J, Donovan, P A

“…Although human tumor xenografts have been extensively used for preclinical evaluation of antitumor agents, most of this work has utilized subcutaneous or…”
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