Search Results - "MAYEUX, P"

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells by Poulain, L, Sujobert, P, Zylbersztejn, F, Barreau, S, Stuani, L, Lambert, M, Palama, T L, Chesnais, V, Birsen, R, Vergez, F, Farge, T, Chenevier-Gobeaux, C, Fraisse, M, Bouillaud, F, Debeissat, C, Herault, O, Récher, C, Lacombe, C, Fontenay, M, Mayeux, P, Maciel, T T, Portais, J-C, Sarry, J-E, Tamburini, J, Bouscary, D, Chapuis, N

“…Alterations in metabolic activities are cancer hallmarks that offer a wide range of new therapeutic opportunities. Here we decipher the interplay between…”
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Distinct cytokine profiles in human brains resilient to Alzheimer's pathology by Barroeta-Espar, Isabel, Weinstock, Laura D., Perez-Nievas, Beatriz G., Meltzer, Avery C., Siao Tick Chong, Michael, Amaral, Ana C., Murray, Melissa E., Moulder, Krista L., Morris, John C., Cairns, Nigel J., Parisi, Joseph E., Lowe, Val J., Petersen, Ronald C., Kofler, Julia, Ikonomovic, Milos D., López, Oscar, Klunk, William E., Mayeux, Richard P., Frosch, Matthew P., Wood, Levi B., Gomez-Isla, Teresa

“…Our group has previously studied the brains of some unique individuals who are able to tolerate robust amounts of Alzheimer's pathological lesions (amyloid…”
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An Inflammation-related Nutrient Pattern is Associated with Both Brain and Cognitive Measures in a Multiethnic Elderly Population by Gu, Yian, Manly, Jennifer J, Mayeux, Richard P, Brickman, Adam M

“…Accumulating evidence suggests that dietary factors are associated with Alzheimer's disease, cognition, and brain health in older adults. It is however unclear…”
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The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia by Willems, L, Chapuis, N, Puissant, A, Maciel, T T, Green, A S, Jacque, N, Vignon, C, Park, S, Guichard, S, Herault, O, Fricot, A, Hermine, O, Moura, I C, Auberger, P, Ifrah, N, Dreyfus, F, Bonnet, D, Lacombe, C, Mayeux, P, Bouscary, D, Tamburini, J

“…The serine/threonine kinase mammalian target of rapamycin (mTOR) is crucial for cell growth and proliferation, and is constitutively activated in primary acute…”
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Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies by Chapuis, N, Tamburini, J, Green, A S, Willems, L, Bardet, V, Park, S, Lacombe, C, Mayeux, P, Bouscary, D

“…Mammalian target of rapamycin (mTOR) is a protein kinase implicated in the regulation of various cellular processes, including those required for tumor…”
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Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease by Yang, Hyun-Sik, Teng, Ling, Kang, Daniel, Menon, Vilas, Ge, Tian, Finucane, Hilary K., Schultz, Aaron P., Properzi, Michael, Klein, Hans-Ulrich, Chibnik, Lori B., Schneider, Julie A., Bennett, David A., Hohman, Timothy J., Mayeux, Richard P., Johnson, Keith A., De Jager, Philip L., Sperling, Reisa A.

“…Many of the Alzheimer’s disease (AD) risk genes are specifically expressed in microglia and astrocytes, but how and when the genetic risk localizing to these…”
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PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML by Park, S, Chapuis, N, Bardet, V, Tamburini, J, Gallay, N, Willems, L, Knight, Z A, Shokat, K M, Azar, N, Viguié, F, Ifrah, N, Dreyfus, F, Mayeux, P, Lacombe, C, Bouscary, D

“…The phosphatidylinositol 3-kinase (PI3K)/Akt and mammalian target of rapamycin complex 1 (mTORC1) signaling pathways are frequently activated in acute…”
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Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) by Tang, Mengxuan, AB, Ryman, Davis C, MD, McDade, Eric, DO, Jasielec, Mateusz S, MS, Buckles, Virginia D, Prof, Cairns, Nigel J, Prof, Fagan, Anne M, Prof, Goate, Alison, Prof, Marcus, Daniel S, PhD, Xiong, Chengjie, PhD, Allegri, Ricardo F, MD, Chhatwal, Jasmeer P, MD, Danek, Adrian, Prof, Farlow, Martin R, Prof, Fox, Nick C, Prof, Ghetti, Bernardino, Prof, Graff-Radford, Neill R, MD, Laske, Christopher, Prof, Martins, Ralph N, Prof, Masters, Colin L, Prof, Mayeux, Richard P, Prof, Ringman, John M, Prof, Rossor, Martin N, Prof, Salloway, Stephen P, Prof, Schofield, Peter R, Prof, Morris, John C, Prof, Bateman, Randall J, Prof

“…Summary Background Autosomal dominant familial Alzheimer's disease (ADAD) is a rare disorder with non-amnestic neurological symptoms in some clinical…”
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Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia by PARK, Sophie, CHAPUIS, Nicolas, TAMBURINI, Jérôme, BARDET, Valérie, CORNILLET-LEFEBVRE, Pascale, WILLEMS, Lise, GREEN, Alexa, MAYEUX, Patrick, LACOMBE, Catherine, BOUSCARY, Didier

“…The PI3K/AKT and mTOR signaling pathways are activated in acute myeloid leukemia, including in the more immature leukemic populations. Constitutive PI3K…”
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Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis by MASTROGIANNAKI, Maria, MATAK, Pavle, MATHIEU, Jacques R. R, DELGA, Stephanie, MAYEUX, Patrick, VAULONT, Sophie, PEYSSONNAUX, Carole

“…Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected. We…”
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Targeting mitochondrial oxidants may facilitate recovery of renal function during infant sepsis by Sims, C R, MacMillan-Crow, L A, Mayeux, P R

“…Sepsis‐induced acute kidney injury (SAKI) is a frequent complication of infant sepsis that approximately doubles the mortality rate. The poor prognosis of…”
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A nonhuman primate model of lung regeneration: detergent-mediated decellularization and initial in vitro recellularization with mesenchymal stem cells by Bonvillain, Ryan W, Danchuk, Svitlana, Sullivan, Deborah E, Betancourt, Aline M, Semon, Julie A, Eagle, Michelle E, Mayeux, Jacques P, Gregory, Ashley N, Wang, Guangdi, Townley, Ian K, Borg, Zachary D, Weiss, Daniel J, Bunnell, Bruce A

“…Currently, patients with end-stage lung disease are limited to lung transplantation as their only treatment option. Unfortunately, the lungs available for…”
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Reproducibility of serum cytokines in an elderly population by Guo, Jing, Schupf, Nicole, Mayeux, Richard P, Gu, Yian

“…It is important to assess the temporal reproducibility of circulating cytokines for their utility in epidemiological studies. However, existing evidence is…”
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Assessment of Leisure Time Physical Activity and Brain Health in a Multiethnic Cohort of Older Adults by Gu, Yian, Beato, Juliet M, Amarante, Erica, Chesebro, Anthony G, Manly, Jennifer J, Schupf, Nicole, Mayeux, Richard P, Brickman, Adam M

“…Results from longitudinal studies suggest that regular leisure time physical activity (LTPA) is associated with reduced risk of dementia or Alzheimer disease…”
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RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia by Hospital, M-A, Jacquel, A, Mazed, F, Saland, E, Larrue, C, Mondesir, J, Birsen, R, Green, A S, Lambert, M, Sujobert, P, Gautier, E-F, Salnot, V, Le Gall, M, Decroocq, J, Poulain, L, Jacque, N, Fontenay, M, Kosmider, O, Récher, C, Auberger, P, Mayeux, P, Bouscary, D, Sarry, J-E, Tamburini, J

“…Acute myeloid leukemia (AML) with the FLT3 internal tandem duplication (FLT3-ITD AML) accounts for 20–30% of AML cases. This subtype usually responds poorly to…”
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Altered DNA methylation in leukocytes with trisomy 21 by Kerkel, Kristi, Schupf, Nicole, Hatta, Kota, Pang, Deborah, Salas, Martha, Kratz, Alexander, Minden, Mark, Murty, Vundavalli, Zigman, Warren B, Mayeux, Richard P, Jenkins, Edmund C, Torkamani, Ali, Schork, Nicholas J, Silverman, Wayne, Croy, B Anne, Tycko, Benjamin

“…The primary abnormality in Down syndrome (DS), trisomy 21, is well known; but how this chromosomal gain produces the complex DS phenotype, including immune…”
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A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores by Kang, Moonil, Ang, Ting Fang Alvin, Devine, Sherral A, Sherva, Richard, Mukherjee, Shubhabrata, Trittschuh, Emily H, Gibbons, Laura E, Scollard, Phoebe, Lee, Michael, Choi, Seo-Eun, Klinedinst, Brandon, Nakano, Connie, Dumitrescu, Logan C, Durant, Alaina, Hohman, Timothy J, Cuccaro, Michael L, Saykin, Andrew J, Kukull, Walter A, Bennett, David A, Wang, Li-San, Mayeux, Richard P, Haines, Jonathan L, Pericak-Vance, Margaret A, Schellenberg, Gerard D, Crane, Paul K, Au, Rhoda, Lunetta, Kathryn L, Mez, Jesse B, Farrer, Lindsay A

“…More than 75 common variant loci account for only a portion of the heritability for Alzheimer's disease (AD). A more complete understanding of the genetic…”
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Fas expression at diagnosis as a biomarker of azacitidine activity in high-risk MDS and secondary AML by Ettou, S, Audureau, E, Humbrecht, C, Benet, B, Jammes, H, Clozel, T, Bardet, V, Lacombe, C, Dreyfus, F, Mayeux, P, Solary, E, Fontenay, M

“…absent…”
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Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody by CHAPUIS, Nicolas, TAMBURINI, Jérôme, MAYEUX, Patrick, LACOMBE, Catherine, BOUSCARY, Didier, CORNILLET-LEFEBVRE, Pascale, GILLOT, Lucile, BARDET, Valérie, WILLEMS, Lise, PARK, Sophie, GREEN, Alexa S, IFRAH, Norbert, DREYFUS, François

“…Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer…”
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A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse by Park, S, Chapuis, N, Saint Marcoux, F, Recher, C, Prebet, T, Chevallier, P, Cahn, J-Y, Leguay, T, Bories, P, Witz, F, Lamy, T, Mayeux, P, Lacombe, C, Demur, C, Tamburini, J, Merlat, A, Delepine, R, Vey, N, Dreyfus, F, Béné, M C, Ifrah, N, Bouscary, D

“…The mTORC1 signaling pathway is constitutively activated in almost all acute myelogenous leukemia (AML) patients. We conducted a phase Ib trial combining…”
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