Search Results - "MAYERSOHN, M"

A NOVEL MODEL FOR PREDICTION OF HUMAN DRUG CLEARANCE BY ALLOMETRIC SCALING by Tang, Huadong, Mayersohn, Michael

“…Sixty-one sets of clearance (CL) values in animal species were allometrically scaled for predicting human clearance. Unbound fractions ( f u ) of drug in…”
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ACCURACY OF ALLOMETRICALLY PREDICTED PHARMACOKINETIC PARAMETERS IN HUMANS: ROLE OF SPECIES SELECTION by Tang, Huadong, Mayersohn, Michael

“…A general equation was derived, which directly describes the mathematical relationship between the allometrically predicted pharmacokinetic (PK) parameters in…”
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Dermal Absorption of Camphor, Menthol, and Methyl Salicylate in Humans by Martin, Debra, Valdez, Jennifer, Boren, James, Mayersohn, Michael

“…Camphor, menthol, and methyl salicylate occur in numerous over‐the‐counter products. Although extensively used, there have been no estimates of human exposure…”
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On the Observed Large Interspecies Overprediction of Human Clearance ("Vertical Allometry") of UCN-01: Further Support for a Proposed Model Based on Plasma Protein Binding by Tang, Huadong, Mayersohn, Michael

“…The prediction of a human clearance (CL) value for UCN‐01, an extreme example of vertical allometry (a large overprediction by allometric scaling), was…”
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Pharmacokinetics in the Elderly by Mayersohn, M

“…Animals undergo substantial changes in many physiologic and biochemical functions as a natural consequence of aging. In the absence of disease or other…”
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Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [2H6]ethanol: preliminary in vitro findings using a rat liver preparation by Bourland, J A, Martin, D K, Mayersohn, M

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Antiphencyclidine monoclonal Fab fragments reverse phencyclidine-induced behavioral effects and ataxia in rats by Valentine, J L, Mayersohn, M, Wessinger, W D, Arnold, L W, Owens, S M

“…Antiphencyclidine monoclonal antibody binding fragments (anti-PCP Fab) were studied in rats as a possible treatment for phencyclidine (PCP) overdose. Each male…”
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Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. I. Theoretical considerations by Khor, S P, Mayersohn, M

“…Physiological pharmacokinetic models require the determination of tissue to blood distribution coefficients. A theoretical model has been developed and the…”
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Vitamin C Bioavailability by MAYERSOHN, M.

“…The above brief review indicates that the bioavailability of vitamin C in humans is complex and that our current understanding of that process and factors that…”
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Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat by Khor, S P, Bozigian, H, Mayersohn, M

“…A model for predicting the magnitude of error (% Err) in measuring tissue concentrations of a compound that have not been corrected for residual blood in the…”
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p -HYDROXYMETHAMPHETAMINE ENANTIOMER PHARMACOKINETICS AND METABOLISM IN RATS: ABSENCE OF N-DEMETHYLATION by HUTCHALEELAHA, A., MAYERSOHN, M.

“…p ‐hydroxymethamphetamine (OHMAP) is one of the major metabolites of the widely abused drug methamphetamine (MAP). The demethylation of OHMAP to p…”
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Allometric analysis of organ extraction ratios by Tannenbaum, S, Boxenbaum, H, Mayersohn, M

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Pharmacokinetics tricks and traps: drug dosage adjustment in renal failure by Boxenbaum, H, Tannenbaum, S, Mayersohn, M, Oleson, F

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Determination and metabolism of dithiol chelating agents. XVI: Pharmacokinetics of 2,3-dimercapto-1-propanesulfonate after intravenous administration to human volunteers by Hurlbut, K M, Maiorino, R M, Mayersohn, M, Dart, R C, Bruce, D C, Aposhian, H V

“…The pharmacokinetics of 2,3-dimercaptopropane-1-sulfonate (DMPS), an effective chelating agent for mercury, were determined in five healthy adults after i.v…”
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Ascorbic and dehydroascorbic acids simultaneously quantified in biological fluids by liquid chromatography with fluorescence detection, and comparison with a colorimetric assay by Lopez-Anaya, A, Mayersohn, M

“…We describe a "high-performance" liquid-chromatographic method for separating and quantifying ascorbic acid (AA) and dehydroascorbic acid (DHA) in plasma and…”
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Relationship between the terminal disposition half-life and mean residence time in multicompartment models by Mayersohn, M, Hamilton, R

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Enantiomeric Determination of Amphetamine and Methamphetamine in Urine by Precolumn Derivatization with Marfey's Reagent and HPLC by Foster, Bryan S., Gilbert, Don D., Hutchaleelaha, Athiwat, Mayersohn, Michael

“…An analytical method was developed for enantiomeric determination of amphetamine and methamphetamine in human urine. The enantiomers were isolated from urine…”
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Moricizine Bioavailability via Simultaneous, Dual, Stable Isotope Administration: Bioequivalence Implications by Pieniaszek Jr, Henry J., Mayersohn, Michael, Adams, Michael P., Reinhart, Rosann J., Barrett, Jeffrey S.

“…The relative bioavailability of a 200 mg film‐coated tablet of [12C]moricizine•HCl in comparison toa200 mg [13C6]moricizine•HCl oral solution was determined…”
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3,3',4,4'-tetrachloroazobenzene absorption, disposition, and metabolism in male Fischer 344 rats by Pillai, U A, Ziegler, T L, Wang, D X, Kattnig, M J, McClure, T, Liebler, D C, Mayersohn, M, Sipes, I G

“…3,3',4,4'-Tetrachloroazobenzene (TCAB) is a contaminant generated during the synthesis of 3,4-dichloroaniline and 3,4-dichloroaniline-derived pesticides. TCAB…”
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Isolation of monoclonal antibodies to phencyclidine from ascites fluid by preparative isoelectric focusing in the Rotofor by Egen, N B, Bliss, M, Mayersohn, M, Owens, S M, Arnold, L, Bier, M

“…A monoclonal antibody to phencyclidine was developed, produced in mouse ascites fluid, and purified. The purification used only preparative-scale isoelectric…”
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