Search Results - "MAY, Hui"

The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice by Segalin, Cristina, Williams, Jalani, Karigo, Tomomi, Hui, May, Zelikowsky, Moriel, Sun, Jennifer J, Perona, Pietro, Anderson, David J, Kennedy, Ann

“…The study of naturalistic social behavior requires quantification of animals' interactions. This is generally done through manual annotation-a highly…”
Get full text

Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers by Xu, Xiangmin, Holmes, Todd C., Luo, Min-Hua, Beier, Kevin T., Horwitz, Gregory D., Zhao, Fei, Zeng, Wenbo, Hui, May, Semler, Bert L., Sandri-Goldin, Rozanne M.

“…Viral tracers are important tools for neuroanatomical mapping and genetic payload delivery. Genetically modified viruses allow for cell-type-specific targeting…”
Get full text

The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress by Zelikowsky, Moriel, Hui, May, Karigo, Tomomi, Choe, Andrea, Yang, Bin, Blanco, Mario R., Beadle, Keith, Gradinaru, Viviana, Deverman, Benjamin E., Anderson, David J.

“…Chronic social isolation causes severe psychological effects in humans, but their neural bases remain poorly understood. 2 weeks (but not 24 hr) of social…”
Get full text

A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer’s disease by Prins, Niels D, Harrison, John E, Chu, Hui-May, Blackburn, Kelly, Alam, John J, Scheltens, Philip, Rowell, Zarate, Norden, Van

“…Abstract Background In preclinical studies, p38⍺ kinase is implicated in Alzheimer’s disease (AD) pathogenesis. In animal models, it mediates impaired synaptic…”
Get full text

The Application of microRNAs in Biomaterial Scaffold‐Based Therapies for Bone Tissue Engineering by Arriaga, Marco A., Ding, May‐Hui, Gutierrez, Astrid S., Chew, Sue Anne

“…In recent years, the application of microRNAs (miRNAs) or anti‐microRNAs (anti‐miRNAs) that can induce expression of the runt‐related transcription factor 2…”
Get full text

Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir by Sarrazin, Christoph, Kieffer, Tara L, Bartels, Doug, Hanzelka, Brian, Müh, Ute, Welker, Martin, Wincheringer, Dennis, Zhou, Yi, Chu, Hui–May, Lin, Chao, Weegink, Christine, Reesink, Henk, Zeuzem, Stefan, Kwong, Ann D

“…Background & Aims: Telaprevir (VX-950), a hepatitis C virus (HCV) NS3·4A protease inhibitor, has shown strong antiviral activity in phase 1 clinical studies…”
Get full text

Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration by Jiang, Ying, Alam, John J., Gomperts, Stephen N., Maruff, Paul, Lemstra, Afina W., Germann, Ursula A., Stavrides, Philip H., Darji, Sandipkumar, Malampati, Sandeep, Peddy, James, Bleiwas, Cynthia, Pawlik, Monika, Pensalfini, Anna, Yang, Dun-Sheng, Subbanna, Shivakumar, Basavarajappa, Balapal S., Smiley, John F., Gardner, Amanda, Blackburn, Kelly, Chu, Hui-May, Prins, Niels D., Teunissen, Charlotte E., Harrison, John E., Scheltens, Philip, Nixon, Ralph A.

“…The endosome-associated GTPase Rab5 is a central player in the molecular mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a…”
Get full text

Association of Plasma Phosphorylated Tau With the Response to Neflamapimod Treatment in Patients With Dementia With Lewy Bodies by Alam, John J., Maruff, Paul, Doctrow, Susan R., Chu, Hui-May, Conway, Jennifer, Gomperts, Stephen N., Teunissen, Charlotte

“…BACKGROUND AND OBJECTIVESIn a proportion of patients, dementia with Lewy bodies (DLB) is associated with Alzheimer disease (AD) copathology, which is linked to…”
Get full text

Defining the interconnectivity of the medial prefrontal cortex and ventral midbrain by Hui, May, Beier, Kevin T.

“…Dysfunction in dopamine (DA) signaling contributes to neurological disorders ranging from drug addiction and schizophrenia to depression and Parkinson’s…”
Get full text

Antiviral activity of telaprevir (VX‐950) and peginterferon alfa‐2a in patients with hepatitis C by Forestier, Nicole, Reesink, Hendrik W., Weegink, Christine J., McNair, Lindsay, Kieffer, Tara L., Chu, Hui‐May, Purdy, Susan, Jansen, Peter L.M., Zeuzem, Stefan

“…Telaprevir (VX‐950), an inhibitor of the hepatitis C virus (HCV) NS3/4A protease, substantially decreased plasma HCV RNA levels in a prior clinical study. The…”
Get full text

Pharmacometrics of clobazam in pediatrics: Prediction of effective clobazam doses for Dravet syndrome by Tolbert, Dwain, Chu, Hui-May, Ette, Ene I.

“…•An efficacious pediatric clobazam (CLB) dosing regimen identified by PopPK modeling.•Evaluation/validation showed the model adequately described CLB and N-CLB…”
Get full text

An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease by Scheltens, Philip, Prins, Niels, Lammertsma, Adriaan, Yaqub, Maqsood, Gouw, Alida, Wink, Alle Meije, Chu, Hui‐May, Berckel, Bart N. M., Alam, John

“…Objective The aim of this study was to preliminarily evaluate an oral small molecule p38α kinase inhibitor in patients with early Alzheimer's disease (AD) for…”
Get full text

An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement by Tian, Guilian, Hui, May, Macchia, Desiree, Derdeyn, Pieter, Rogers, Alexandra, Hubbard, Elizabeth, Liu, Chengfeng, Vasquez, Jose J., Taniguchi, Lara, Bartas, Katrina, Carroll, Sean, Beier, Kevin T.

“…Although midbrain dopamine (DA) circuits are central to motivated behaviors, our knowledge of how experience modifies these circuits to facilitate subsequent…”
Get full text

Drug-metabolism mechanism: Knowledge-based population pharmacokinetic approach for characterizing clobazam drug-drug interactions by Tolbert, Dwain, Bekersky, Ihor, Chu, Hui-May, Ette, Ene I.

“…A metabolic mechanism‐based characterization of antiepileptic drug‐drug interactions (DDIs) with clobazam in patients with Lennox‐Gastaut syndrome (LGS) was…”
Get full text

Uncovering the Connectivity Logic of the Ventral Tegmental Area by Derdeyn, Pieter, Hui, May, Macchia, Desiree, Beier, Kevin T

“…Decades of research have revealed the remarkable complexity of the midbrain dopamine (DA) system, which comprises cells principally located in the ventral…”
Get full text

Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen by Mosser, Eric A., Chiu, Cindy N., Tamai, T. Katherine, Hirota, Tsuyoshi, Li, Suna, Hui, May, Wang, Amy, Singh, Chanpreet, Giovanni, Andrew, Kay, Steve A., Prober, David A.

“…The circadian clock ensures that behavioral and physiological processes occur at appropriate times during the 24-hour day/night cycle, and is regulated at both…”
Get full text

An integrative population pharmacokinetics approach to the characterization of the effect of hepatic impairment on clobazam pharmacokinetics by Tolbert, Dwain, Bekersky, Ihor, Chu, Hui-May, Ette, Ene I.

“…An integrative population pharmacokinetics (PPK)–based approach was used to characterize the effect of hepatic impairment on clobazam PK and its major…”
Get full text

Live-cell phenotypic-biomarker microfluidic assay for the risk stratification of cancer patients via machine learning by Manak, Michael S., Varsanik, Jonathan S., Hogan, Brad J., Whitfield, Matt J., Su, Wendell R., Joshi, Nikhil, Steinke, Nicolai, Min, Andrew, Berger, Delaney, Saphirstein, Robert J., Dixit, Gauri, Meyyappan, Thiagarajan, Chu, Hui-May, Knopf, Kevin B., Albala, David M., Sant, Grannum R., Chander, Ashok C.

“…The risk stratification of prostate cancer and breast cancer tumours from patients relies on histopathology, selective genomic testing, or on other methods…”
Get full text

Strategies to better treat glioblastoma: antiangiogenic agents and endothelial cell targeting agents by Hasbum, Asbiel, Quintanilla, Jaqueline, Jr, Juan A Amieva, Ding, May-Hui, Levy, Arkene, Chew, Sue Anne

“…Glioblastoma multiforme (GBM) is the most prevalent and aggressive form of glioma, with poor prognosis and high mortality rates. As GBM is a highly…”
Get full text

EVIDENCE THAT ORAL P38 MAPK ALPHA ANTAGONISM IMPROVES EPISODIC MEMORY IN PATIENTS WITH EARLY ALZHEIMER’S DISEASE (AD) by Prins, Niels D., Alam, John, Chu, Hui-May, Scheltens, Philip

Get full text