Search Results - "MAXWELL, R. J"
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Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study
Published in Journal of neurology, neurosurgery and psychiatry (01-04-2017)“…ObjectiveTo assess reductions of cerebral glucose metabolism in Parkinson's disease (PD) with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET),…”
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The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition
Published in British journal of cancer (10-04-2012)“…Background: Combined targeting of MAPK and PI3K signalling pathways may be necessary for optimal therapeutic activity in cancer. This study evaluated the MEK…”
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3
Medical graduate views on statistical learning needs for clinical practice: a comprehensive survey
Published in BMC medical education (31-12-2019)“…This paper seeks to contribute to a reputable evidence base for required competencies across different topics in statistics and probability (statistical…”
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4
Pulse transit time measured from the ECG: an unreliable marker of beat-to-beat blood pressure
Published in Journal of applied physiology (1985) (01-01-2006)“…Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom Submitted 3 June 2005 ; accepted in final form 30…”
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The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations
Published in British journal of cancer (09-05-2005)“…Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used…”
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Uric acid reduces exercise-induced oxidative stress in healthy adults
Published in Clinical science (1979) (01-10-2003)“…Uric acid (UA) possesses free-radical-scavenging properties, and systemic administration is known to increase serum antioxidant capacity. However, it is not…”
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Effects of short-term isocapnic hyperoxia and hypoxia on cardiovascular function
Published in Journal of applied physiology (1985) (01-09-2006)“…1 Department of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary, and 2 Clinical Pharmacology Unit, Centre for Cardiovascular Science, Queens…”
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8
Genetic influences modulating the radiological severity of rheumatoid arthritis
Published in Annals of the rheumatic diseases (01-03-2010)“…This review focuses on the contribution of genetic markers to the severity of radiological damage in rheumatoid arthritis (RA). Currently available biomarkers…”
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9
Carbogen breathing increases prostate cancer oxygenation: a translational MRI study in murine xenografts and humans
Published in British journal of cancer (24-02-2009)“…Hypoxia has been associated with poor local tumour control and relapse in many cancer sites, including carcinoma of the prostate. This translational study…”
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The availability of prescription‐only analgesics purchased from the internet in the UK
Published in British journal of clinical pharmacology (01-02-2009)“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Increasing numbers of people are accessing medicines from the internet. • This online market is poorly regulated and…”
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11
Lowering serum urate does not improve endothelial function in patients with type 2 diabetes
Published in Diabetologia (01-12-2007)“…Endothelial dysfunction contributes to excess cardiovascular risk in patients with type 2 diabetes. There is strong evidence of an association between high…”
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Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude
Published in Chest (01-05-2007)“…Both tissue hypoxia in vitro, and whole-body hypoxia in vivo, have been found to promote the release of reactive oxygen species (ROS) that are potentially…”
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Undergraduate preparation for prescribing: the views of 2413 UK medical students and recent graduates
Published in British journal of clinical pharmacology (01-07-2008)“…WHAT IS ALREADY KNOWN ON THIS SUBJECT • Adverse drug events are common in National Health Service (NHS) hospitals where junior doctors take responsibility for…”
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14
Rational prescribing: the principles of drug selection
Published in Clinical medicine (London, England) (01-10-2016)“…Prescribing is the most important tool used by physicians to cure illness, relieve symptoms and prevent future disease. It is also a complex intellectual task…”
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Morphine is an arteriolar vasodilator in man
Published in British journal of clinical pharmacology (01-04-2009)“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • It has been recognized for about 10 years that morphine is a veno‐dilator in man and that this effect may be related…”
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Systemic Uric Acid Administration Increases Serum Antioxidant Capacity in Healthy Volunteers
Published in Journal of cardiovascular pharmacology (01-09-2001)“…Oxidative stress plays an important role in the development of atherosclerosis and contributes to tissue damage that occurs as a consequence, particularly in…”
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Educating European (Junior) Doctors for Safe Prescribing
Published in Basic & clinical pharmacology & toxicology (01-12-2007)“…: Evidence of poor prescribing is widespread including overuse of medicines, underuse of effective medicines, avoidable adverse drug reactions and medication…”
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Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers
Published in Diabetes (New York, N.Y.) (01-11-2006)“…Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers W. Stephen Waring 1 , John A. McKnight 2 , David J. Webb 1 and…”
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A generalized arterial transfer function derived at rest underestimates augmentation of central pressure after exercise
Published in Journal of hypertension (01-11-2007)“…OBJECTIVESPeripheral exercise blood pressure and resting central blood pressure are considered more relevant to cardiovascular health than resting peripheral…”
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Significance of systemic endotoxaemia in inflammatory bowel disease
Published in Gut (01-06-1995)“…Quantitative and qualitative disturbances in faecal flora suggest a role for enteric bacteria and their products in the pathogenesis of inflammatory bowel…”
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