Search Results - "MAXWELL, Anthony"

The Microbial Toxin Microcin B17: Prospects for the Development of New Antibacterial Agents by Collin, Frederic, Maxwell, Anthony

“…Microcin B17 (MccB17) is an antibacterial peptide produced by strains of Escherichia coli harboring the plasmid-borne mccB17 operon. MccB17 possesses many…”
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Galleria mellonella (greater wax moth) larvae as a model for antibiotic susceptibility testing and acute toxicity trials by Ignasiak, Katarzyna, Maxwell, Anthony

“…Infectivity trials and toxicity testing in rodents are important prerequisites to the use of compounds in man. However, trials in rats and mice are expensive…”
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Exploiting bacterial DNA gyrase as a drug target: current state and perspectives by Collin, Frédéric, Karkare, Shantanu, Maxwell, Anthony

“…DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at the expense of ATP hydrolysis. It is essential in all bacteria but…”
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Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance by Bush, Natassja G, Diez-Santos, Isabel, Abbott, Lauren R, Maxwell, Anthony

“…Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times. They have enjoyed over 30 years of clinical usage and become…”
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Risk factors for the development of invasive cancer in unresected ductal carcinoma in situ by Maxwell, Anthony J., Clements, Karen, Hilton, Bridget, Dodwell, David J., Evans, Andrew, Kearins, Olive, Pinder, Sarah E., Thomas, Jeremy, Wallis, Matthew G., Thompson, Alastair M., Thompson, Alastair, Clements, Karen, Dobson, Hilary, Dodwell, David, Evans, Andrew, Hanby, Andrew, Hilton, Bridget, Kearins, Olive, Lawrence, Gill, Maxwell, Anthony, Pinder, Sarah, Sawyer, Elinor, Sibbering, Mark, Speirs, Valerie, Thomas, Jeremy, Tomlinson, Ian, Ball, Graham, Wallis, Matthew, Wilcox, Maggie

“…The natural history of ductal carcinoma in situ (DCIS) remains uncertain. The risk factors for the development of invasive cancer in unresected DCIS are…”
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Safety and feasibility of breast lesion localization using magnetic seeds (Magseed): a multi-centre, open-label cohort study by Harvey, James R., Lim, Yit, Murphy, John, Howe, Miles, Morris, Julie, Goyal, Amit, Maxwell, Anthony J.

“…Purpose Wire localization has several disadvantages, notably wire migration and difficulty scheduling the procedure close to surgery. Radioactive seed…”
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DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion by Bax, Benjamin D., Murshudov, Garib, Maxwell, Anthony, Germe, Thomas

“…Type II topoisomerases regulate DNA topology by making a double-stranded break in one DNA duplex, transporting another DNA segment through this break and then…”
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Is the future magnetic? Magseed localisation for non palpable breast cancer. A multi-centre non randomised control study by Zacharioudakis, Konstantinos, Down, Sue, Bholah, Zaheerah, Lee, Sum, Khan, Taherah, Maxwell, Anthony J., Howe, Miles, Harvey, James

“…Magseed is an alternative method of localising non-palpable breast lesions that has addressed many of the limitations of wire guided localisation (WGL). It…”
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Oxytetracycline reduces the diversity of tetracycline-resistance genes in the Galleria mellonella gut microbiome by Ignasiak, Katarzyna, Maxwell, Anthony

“…Clinically-relevant multidrug resistance is sometimes present in bacteria not exposed to human-made antibiotics, in environments without extreme selective…”
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Identification of key signaling pathways induced by SARS‐CoV2 that underlie thrombosis and vascular injury in COVID‐19 patients by Maxwell, Anthony J., Ding, Jiahui, You, Yuan, Dong, Zhong, Chehade, Hussein, Alvero, Ayesha, Mor, Yechiel, Draghici, Sorin, Mor, Gil

“…The SARS‐CoV‐2 pandemic has led to hundreds of thousands of deaths and billions of dollars in economic damage. The immune response elicited from this virus is…”
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Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy by Ding, Jiahui, Maxwell, Anthony, Adzibolosu, Nicholas, Hu, Anna, You, Yuan, Liao, Aihua, Mor, Gil

“…Pregnancy is a unique condition where the maternal immune system is continuously adapting in response to the stages of fetal development and signals from the…”
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Antibiotic-resistant bacteria in the guts of insects feeding on plants: prospects for discovering plant-derived antibiotics by Ignasiak, Katarzyna, Maxwell, Anthony

“…Although plants produce many secondary metabolites, currently none of these are commercial antibiotics. Insects feeding on specific plants can harbour…”
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DNA topoisomerase I and DNA gyrase as targets for TB therapy by Nagaraja, Valakunja, Godbole, Adwait A., Henderson, Sara R., Maxwell, Anthony

“…•DNA topoisomerases are key targets for antibacterial and anticancer chemotherapy.•TB topo I is validated as an antibacterial target.•Inhibitors that target TB…”
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Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project by Thompson, Alastair M., Clements, Karen, Cheung, Shan, Pinder, Sarah E., Lawrence, Gill, Sawyer, Elinor, Kearins, Olive, Ball, Graham R., Tomlinson, Ian, Hanby, Andrew, Thomas, Jeremy St J., Maxwell, Anthony J., Wallis, Matthew G., Dodwell, David J., Thompson, Alastair, Francis, Adele, Sibbering, Mark, Bishop, Hugh, Carpenter, Robert, George, W.D., Lee, Martin, Nicholson, Stewart, Dobson, Hilary, Evans, Andy, Maxwell, Anthony, Wallis, Matthew, Dodwell, David, Sawyer, Elinor, Adlard, Julian, Dewar, John, Ross, Gillian, Wilcox, Maggie, Hanby, Andrew, Pinder, Sarah, Speirs, Valerie, Thomas, Jeremy, Ellis, Ian, Lakhani, Sunil, Macartney, James, Tomlinson, Ian, Cheung, Shan, Lawrence, Gill, Ball, Graham, Clements, Karen, Hilton, Bridget, Kearins, Olive, Wheaton, Margot

“…Management of screen-detected ductal carcinoma in situ (DCIS) remains controversial. A prospective cohort of patients with DCIS diagnosed through the UK…”
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Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides by Pyne, Alice L. B., Noy, Agnes, Main, Kavit H. S., Velasco-Berrelleza, Victor, Piperakis, Michael M., Mitchenall, Lesley A., Cugliandolo, Fiorella M., Beton, Joseph G., Stevenson, Clare E. M., Hoogenboom, Bart W., Bates, Andrew D., Maxwell, Anthony, Harris, Sarah A.

“…In the cell, DNA is arranged into highly-organised and topologically-constrained (supercoiled) structures. It remains unclear how this supercoiling affects the…”
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MRI breast screening in high-risk women: cancer detection and survival analysis by Gareth, Evans D., Nisha, Kesavan, Yit, Lim, Soujanye, Gadde, Emma, Hurley, Massat, Nathalie J., Maxwell, Anthony J., Sarah, Ingham, Rosalind, Eeles, Leach, Martin O., Anthony, Howell, Stephen, Duffy

“…Women with a genetic predisposition to breast cancer tend to develop the disease at a younger age with denser breasts making mammography screening less…”
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Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses by Iyer, Shankar S., Gensollen, Thomas, Gandhi, Amit, Oh, Sungwhan F., Neves, Joana F., Collin, Frederic, Lavin, Richard, Serra, Carme, Glickman, Jonathan, de Silva, Punyanganie S.A., Sartor, R. Balfour, Besra, Gurdyal, Hauser, Russell, Maxwell, Anthony, Llebaria, Amadeu, Blumberg, Richard S.

“…Genome-wide association studies have identified risk loci associated with the development of inflammatory bowel disease, while epidemiological studies have…”
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What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420) by French, David P, Astley, Susan, Brentnall, Adam R, Cuzick, Jack, Dobrashian, Richard, Duffy, Stephen W, Gorman, Louise S, Harkness, Elaine F, Harrison, Fiona, Harvie, Michelle, Howell, Anthony, Jerrison, Andrew, Machin, Matthew, Maxwell, Anthony J, McWilliams, Lorna, Payne, Katherine, Qureshi, Nadeem, Ruane, Helen, Sampson, Sarah, Stavrinos, Paula, Thorpe, Emma, Ulph, Fiona, van Staa, Tjeerd, Woof, Victoria, Evans, D Gareth

“…In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce a better balance of benefits and harms. The…”
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TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion by You, Yuan, Stelzl, Patrick, Joseph, Dana N, Aldo, Paulomi B, Maxwell, Anthony J, Dekel, Nava, Liao, Aihua, Whirledge, Shannon, Mor, Gil

“…Successful implantation requires the coordinated migration and invasion of trophoblast cells from out of the blastocyst and into the endometrium. This process…”
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Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds by Kolarič, Anja, Germe, Thomas, Hrast, Martina, Stevenson, Clare E. M., Lawson, David M., Burton, Nicolas P., Vörös, Judit, Maxwell, Anthony, Minovski, Nikola, Anderluh, Marko

“…Novel bacterial type II topoisomerase inhibitors (NBTIs) stabilize single-strand DNA cleavage breaks by DNA gyrase but their exact mechanism of action has…”
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