Search Results - "MAXFIELD, Frederick R"

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing by Crespo, Miguel, Vilar, Eduardo, Tsai, Su-Yi, Chang, Kyle, Amin, Sadaf, Srinivasan, Tara, Zhang, Tuo, Pipalia, Nina H, Chen, Huanhuan Joyce, Witherspoon, Mavee, Gordillo, Miriam, Xiang, Jenny Zhaoying, Maxfield, Frederick R, Lipkin, Steven, Evans, Todd, Chen, Shuibing

“…A protocol based on chemical modulation of WNT activity is used to efficiently generate colonic organoids that recapitulate the molecular features of human…”
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Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages by Wang, Ying, Subramanian, Manikandan, Yurdagul, Arif, Barbosa-Lorenzi, Valéria C., Cai, Bishuang, de Juan-Sanz, Jaime, Ryan, Timothy A., Nomura, Masatoshi, Maxfield, Frederick R., Tabas, Ira

“…Clearance of apoptotic cells (ACs) by phagocytes (efferocytosis) prevents post-apoptotic necrosis and dampens inflammation. Defective efferocytosis drives…”
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Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches by Rosenbaum, Anton I, Maxfield, Frederick R

“…J. Neurochem. (2011) 116, 789-795. ABSTRACT: Cholesterol is an important lipid of mammalian cells. Its unique physicochemical properties modulate membrane…”
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Role of cholesterol and lipid organization in disease by Maxfield, Frederick R, Tabas, Ira

“…Membrane lipids are essential for biological functions ranging from membrane trafficking to signal transduction. The composition of lipid membranes influences…”
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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia by Tcw, Julia, Qian, Lu, Pipalia, Nina H, Chao, Michael J, Liang, Shuang A, Shi, Yang, Jain, Bharat R, Bertelsen, Sarah E, Kapoor, Manav, Marcora, Edoardo, Sikora, Elizabeth, Andrews, Elizabeth J, Martini, Alessandra C, Karch, Celeste M, Head, Elizabeth, Holtzman, David M, Zhang, Bin, Wang, Minghui, Maxfield, Frederick R, Poon, Wayne W, Goate, Alison M

“…The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's disease (AD), on human brain cellular function remains unclear…”
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The endocytic pathway in microglia during health, aging and Alzheimer’s disease by Solé-Domènech, Santiago, Cruz, Dana L, Capetillo-Zarate, Estibaliz, Maxfield, Frederick R

“…Abstract Microglia, the main phagocytes of the central nervous system (CNS), are involved in the surveillance and maintenance of nervous tissue. During normal…”
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Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity by Coats, Brittney R., Schoenfelt, Kelly Q., Barbosa-Lorenzi, Valéria C., Peris, Eduard, Cui, Chang, Hoffman, Alexandria, Zhou, Guolin, Fernandez, Sully, Zhai, Lijie, Hall, Ben A., Haka, Abigail S., Shah, Ajay M., Reardon, Catherine A., Brady, Matthew J., Rhodes, Christopher J., Maxfield, Frederick R., Becker, Lev

“…During obesity, adipose tissue macrophages (ATMs) adopt a metabolically activated (MMe) phenotype. However, the functions of MMe macrophages are poorly…”
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Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells by Rosenbaum, Anton I, Zhang, Guangtao, Warren, J. David, Maxfield, Frederick R

“…Niemann-Pick type C disease (NPC) is a lysosomal storage disorder causing accumulation of unesterified cholesterol in lysosomal storage organelles. Recent…”
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Sterols are mainly in the cytoplasmic leaflet of the plasma membrane and the endocytic recycling compartment in CHO cells by Mondal, Mousumi, Mesmin, Bruno, Mukherjee, Sushmita, Maxfield, Frederick R

“…The transbilayer distribution of many lipids in the plasma membrane and in endocytic compartments is asymmetric, and this has important consequences for…”
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Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation[S] by Haka, Abigail S., Barbosa-Lorenzi, Valéria C., Lee, Hyuek Jong, Falcone, Domenick J., Hudis, Clifford A., Dannenberg, Andrew J., Maxfield, Frederick R.

“…Many types of apoptotic cells are phagocytosed and digested by macrophages. Adipocytes can be hundreds of times larger than macrophages, so they are too large…”
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Membrane domains by Mukherjee, Sushmita, Maxfield, Frederick R

“…Considerable evidence shows that lateral inhomogeneities in lipid composition and physical properties exist in biological membranes. These membrane lipid…”
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Membrane order in the plasma membrane and endocytic recycling compartment by Iaea, David B, Maxfield, Frederick R

“…The cholesterol content of membranes plays an important role in organizing membranes for signal transduction and protein trafficking as well as in modulating…”
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Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane by Iaea, David B, Mao, Shu, Lund, Frederik W, Maxfield, Frederick R

“…Cholesterol is an essential constituent of membranes in mammalian cells. The plasma membrane and the endocytic recycling compartment (ERC) are both highly…”
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Cholesterol trafficking and distribution by Iaea, David B, Maxfield, Frederick R

“…Sterols are a critical component of cell membranes of eukaryotes. In mammalian cells there is approximately a six-fold range in the cholesterol content in…”
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Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts by Pipalia, Nina H, Cosner, Casey C, Huang, Amy, Chatterjee, Anamitra, Bourbon, Pauline, Farley, Nathan, Helquist, Paul, Wiest, Olaf, Maxfield, Frederick R

“…Niemann-Pick type C (NPC) disease is predominantly caused by mutations in the NPC1 protein that affect intracellular cholesterol trafficking and cause…”
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A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele by Praggastis, Maria, Tortelli, Brett, Zhang, Jessie, Fujiwara, Hideji, Sidhu, Rohini, Chacko, Anita, Chen, Zhouji, Chung, Chan, Lieberman, Andrew P, Sikora, Jakub, Davidson, Cristin, Walkley, Steven U, Pipalia, Nina H, Maxfield, Frederick R, Schaffer, Jean E, Ory, Daniel S

“…Niemann-Pick Type C1 (NPC1) disease is a rare neurovisceral, cholesterol-sphingolipid lysosomal storage disorder characterized by ataxia, motor impairment,…”
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Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells by Pipalia, Nina H., Subramanian, Kanagaraj, Mao, Shu, Ralph, Harold, Hutt, Darren M., Scott, Samantha M., Balch, William E., Maxfield, Frederick R.

“…Niemann-Pick C (NPC) disease is an autosomal recessive disorder that leads to excessive storage of cholesterol and other lipids in late endosomes and…”
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The formation and consequences of cholesterol-rich deposits in atherosclerotic lesions by Maxfield, Frederick R, Steinfeld, Noah, Ma, Cheng-I J

“…Cardiovascular diseases remain the leading cause of death throughout the world. Accumulation of lipoprotein-associated lipids and their interaction with…”
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Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils by Majumdar, Amitabha, Cruz, Dana, Asamoah, Nikiya, Buxbaum, Adina, Sohar, Istvan, Lobel, Peter, Maxfield, Frederick R

“…Microglia are the main immune cells of the brain, and under some circumstances they can play an important role in removal of fibrillar Alzheimer amyloid beta…”
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Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes by Majumdar, Amitabha, Capetillo-Zarate, Estibaliz, Cruz, Dana, Gouras, Gunnar K, Maxfield, Frederick R

“…Incomplete lysosomal acidification in microglia inhibits the degradation of fibrillar forms of Alzheimer's amyloid β peptide (fAβ). Here we show that in…”
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