Search Results - "MAURER, H. Rainer"
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Prothymosin .alpha.: A Biologically Active Protein with Random Coil Conformation
Published in Biochemistry (Easton) (10-10-1995)“…Prothymosin is an acidic protein with an unusual amino acid composition. Though its exact function is not yet known, its high evolutionary conservation and…”
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Bromelain Reversibly Inhibits Invasive Properties of Glioma Cells
Published in Neoplasia (New York, N.Y.) (01-11-2001)“…Bromelain is an aqueous extract from pineapple stem that contains proteinases and exhibits pleiotropic therapeutic effects, i.e., antiedematous,…”
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Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro
Published in International journal of oncology (01-01-2002)“…Tributyrin (glyceryl tributyrate, TB) is known to induce malignant cells to differentiate followed by arrest of cell growth and death via apoptosis. We…”
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Development and application of a simple assay to quantify cellular adducts of platinum complexes with DNA
Published in Pharmaceutical research (01-03-1999)Get full text
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Effects of differentiation inducers on cell phenotypes of cultured nontransformed and immortalized mammary epithelial cells: a comparative immunocytochemical analysis
Published in Tumor biology (01-07-2000)“…We examined the effects of the differentiation-inducing agents 1, 25-dihydroxyvitamin D(3) (calcitriol), phorbol myristate acetate (PMA), the cytokine…”
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Antineoplastic activity and tolerability of a novel heterocyclic alkylphospholipid, D-20133
Published in Cancer chemotherapy and pharmacology (1993)“…Octadecyl-[2-(N-methylpiperidinio)ethyl]-phosphate (OMPEP, D-20133), a heterocyclic analogue of hexadecylphosphocholine (MIL), has been synthesized in an…”
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Tributyrin induces growth inhibitory and differentiating effects on HT-29 colon cancer cells in vitro
Published in International journal of oncology (01-12-1998)“…Tributyrin (TB) is a prodrug of butyrate known to induce tumor cells to differentiate. We examined its effects on cell growth, viability, cellular morphology…”
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Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo
Published in In vivo (Athens) (01-01-1999)“…The thiol protease, bromelain, an extract from pineapple stem, was suggested to have antithrombotic and anticoagulant activities in vivo. We studied the…”
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Isolation and characterization of two forms of an acidic bromelain stem proteinase
Published in Journal of Protein Chemistry (01-05-1998)“…Two forms of an acidic bromelain proteinase isolated from crude bromelain, an extract from pineapple stem, were found by a two-step FPLC purification…”
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Tributyrin enhances the cytotoxic activity of interleukin-2 interleukin-12 stimulated human natural killer cells against LS 174T colon cancer cells in vitro
Published in Cancer Immunology, Immunotherapy (01-04-2001)“…Tributyrin has been shown to be cytostatic to tumor cells by inducing differentiation and apoptosis. On the other hand, immunological NK cells can kill tumor…”
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Docetaxel treatment of HT-29 colon carcinoma cells reinforces the adhesion and immunocytotoxicity of peripheral blood lymphocytes in vitro
Published in International journal of oncology (01-04-1998)“…In vitro effects of docetaxel on the human colon carcinoma cell line HT-29 were studied with respect to the expression of different adhesion and surface marker…”
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Expression and modulation of the Lewis x antigen (CD15) on the T cell line Molt-4
Published in FEBS letters (22-09-1997)“…The T cell lines Molt-4 and H9 exhibited a characteristic distribution of the cell adhesion molecule Lewis x (CD15, lacto- N-fucopentanose III) showing an…”
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A rapid and sensitive fluorometric screening assay using YO-PRO-1 to quantify tumour cell invasion through Matrigel
Published in Clinical & experimental metastasis (01-10-1996)“…A new quantitative assay for the study of tumour cell invasion in vitro is described. Employing the novel fluorescent dye YO-PRO-1, cells that penetrate…”
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Induction of the c- myc but not the cH- ras promoter by platinum compounds
Published in Biochemical pharmacology (29-06-1995)“…The recombinant plasmids p324, p330 and p323 carrying the aminoglycoside phosphotransferase ( aph) gene and 5′ flanking c- myc sequences linked to the reporter…”
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The thymus extract Thymex-L potentiates the retinoic acid-induced differentiation of the human myeloid leukemia cell line HL-60
Published in Biochimica et biophysica acta (16-03-1995)“…The human promyelocytic cell line HL-60 can be differentiated with retinoic acid (RA) along the granulocytic pathway. Numerous studies have identified many…”
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Growth kinetics of L1210 leukemic cells exposed to different concentration courses of methotrexate in vitro
Published in Cancer chemotherapy and pharmacology (1994)“…At present, pharmacokinetic aspects in existing in vitro assays for cytotoxic drug screening are considered only insufficiently. Using a new microperfusion…”
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Prothymosin α1 effects, in vitro, on the antitumor activity and cytokine production of blood monocytes from colorectal tumor patients
Published in International journal of immunopharmacology (01-06-1997)“…Recent animal studies demonstrate that prothymosin α1 (ProTα) enhances the antitumor response by stimulation of mononuclear phagocyte functions. The present…”
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Lymphokine-activated killer cells: determination of their tumor cytolytic capacity by a clonogenic microassay using agar capillaries
Published in Journal of immunological methods (20-09-1991)“…A lymphokine activated killer (LAK) cell assay has been developed using a clonogenic microassay in agar-containing capillaries with KB tumor target cells. The…”
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Agar capillary clonogenic microassays for cellular immunocytotoxic activities in human leukaemia and lymphoma
Published in Leukemia & lymphoma (1993)“…Current concepts of immunotherapeutic approaches in leukemias and lymphomas using activated cytotoxic lymphocytes and macrophages are briefly reviewed…”
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