Search Results - "MAUDSLEY, Stuart"

Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism by Luttrell, Louis M, Maudsley, Stuart, Bohn, Laura M

“…The fact that over 30% of current pharmaceuticals target heptahelical G protein-coupled receptors (GPCRs) attests to their tractability as drug targets…”
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"Control" laboratory rodents are metabolically morbid: Why it matters by Martin, Bronwen, Ji, Sunggoan, Maudsley, Stuart, Mattson, Mark P., Snyder, Solomon

“…Failure to recognize that many standard control rats and mice used in biomedical research are sedentary, obese, glucose intolerant, and on a trajectory to…”
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Editorial: Macromolecular interactions in signaling pathways: from classical approaches to virtual reality by Leopoldo, Marcello, Contino, Marialessandra, Maudsley, Stuart, Vrecl, Milka

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BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders by Mattson, Mark P., Maudsley, Stuart, Martin, Bronwen

“…Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal…”
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Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders by Cai, Huan, Cong, Wei-na, Ji, Sunggoan, Rothman, Sarah, Maudsley, Stuart, Martin, Bronwen

“…Alzheimer's disease and other related neurodegenerative diseases are highly debilitating disorders that affect millions of people worldwide. Efforts towards…”
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GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process by Maudsley, Stuart, Schrauwen, Claudia, Harputluoğlu, İrem, Walter, Deborah, Leysen, Hanne, McDonald, Patricia

“…G protein-coupled receptors (GPCRs) play a significant role in controlling biological paradigms such as aging and aging-related disease. We have previously…”
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Caloric restriction and intermittent fasting: two potential diets for successful brain aging by Martin, Bronwen, Mattson, Mark P, Maudsley, Stuart

“…The vulnerability of the nervous system to advancing age is all too often manifest in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases…”
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Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates by Mattison, Julie A., Wang, Mingyi, Bernier, Michel, Zhang, Jing, Park, Sung-Soo, Maudsley, Stuart, An, Steven S., Santhanam, Lakshmi, Martin, Bronwen, Faulkner, Shakeela, Morrell, Christopher, Baur, Joseph A., Peshkin, Leonid, Sosnowska, Danuta, Csiszar, Anna, Herbert, Richard L., Tilmont, Edward M., Ungvari, Zoltan, Pearson, Kevin J., Lakatta, Edward G., de Cabo, Rafael

“…Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial diseases, the leading cause of cardiovascular (CV) morbidity…”
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The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease by Leysen, Hanne, Walter, Deborah, Clauwaert, Lore, Hellemans, Lieselot, van Gastel, Jaana, Vasudevan, Lakshmi, Martin, Bronwen, Maudsley, Stuart

“…During the aging process our body becomes less well equipped to deal with cellular stress, resulting in an increase in unrepaired damage. This causes varying…”
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β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders by van Gastel, Jaana, Hendrickx, Jhana O, Leysen, Hanne, Santos-Otte, Paula, Luttrell, Louis M, Martin, Bronwen, Maudsley, Stuart

“…G protein coupled receptors (GPCRs) were first characterized as signal transducers that elicit downstream effects through modulation of guanine (G)…”
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Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice by Stranahan, Alexis M., Lee, Kim, Martin, Bronwen, Maudsley, Stuart, Golden, Erin, Cutler, Roy G., Mattson, Mark P.

“…Diabetes may adversely affect cognitive function, but the underlying mechanisms are unknown. To investigate whether manipulations that enhance neurotrophin…”
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Inhibitory actions of the NRG-1/ErbB4 pathway in macrophages during tissue fibrosis in the heart, skin, and lung by Vermeulen, Zarha, Hervent, Anne-Sophie, Dugaucquier, Lindsey, Vandekerckhove, Leni, Rombouts, Miche, Beyens, Matthias, Schrijvers, Dorien M, De Meyer, Guido R Y, Maudsley, Stuart, De Keulenaer, Gilles W, Segers, Vincent F M

“…The neuregulin-1 (NRG-1)/receptor tyrosine-protein kinase erbB (ErbB) system is an endothelium-controlled paracrine system modulating cardiac performance and…”
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Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process by Maudsley, Stuart, Walter, Deborah, Schrauwen, Claudia, Van Loon, Nore, Harputluoğlu, İrem, Lenaerts, Julia, McDonald, Patricia

“…G protein-coupled receptors (GPCRs) represent one of the most functionally diverse classes of transmembrane proteins. GPCRs and their associated signaling…”
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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets by Jiang, Mali, Wang, Jiawei, Fu, Jinrong, Du, Lin, Jeong, Hyunkyung, West, Tim, Xiang, Lan, Peng, Qi, Hou, Zhipeng, Cai, Huan, Seredenina, Tamara, Arbez, Nicolas, Zhu, Shanshan, Sommers, Katherine, Qian, Jennifer, Zhang, Jiangyang, Mori, Susumu, Yang, X William, Tamashiro, Kellie L K, Aja, Susan, Moran, Timothy H, Luthi-Carter, Ruth, Martin, Bronwen, Maudsley, Stuart, Mattson, Mark P, Cichewicz, Robert H, Ross, Christopher A, Holtzman, David M, Krainc, Dimitri, Duan, Wenzhen

“…Huntington's disease is a neurodegenerative disease caused by the accumulation of mutant htt protein. Now, two groups led by Dimitri Krainc and Wenzhen Duan…”
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Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone-Vascular Axis by De Maré, Annelies, Maudsley, Stuart, Azmi, Abdelkrim, Hendrickx, Jhana O, Opdebeeck, Britt, Neven, Ellen, D'Haese, Patrick C, Verhulst, Anja

“…Sclerostin is a well-known inhibitor of bone formation that acts on Wnt/β-catenin signaling. This manuscript considers the possible role of sclerostin in…”
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Chronic dehydration induces injury pathways in rats, but does not mimic histopathology of chronic interstitial nephritis in agricultural communities by Schreurs, Gerd, Maudsley, Stuart, Nast, Cynthia, Praet, Marleen, Da Silva Fernandes, Sylvina, Boor, Peter, D’Haese, Patrick, De Broe, Marc E., Vervaet, Benjamin A.

“…CINAC-patients present renal proximal tubular cell lysosomal lesions which are also observed in patients experiencing calcineurin inhibitor (CNI)…”
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The effects of the ketogenic diet on behavior and cognition by Hallböök, Tove, Ji, Sunggoan, Maudsley, Stuart, Martin, Bronwen

“…Summary Multiple forms of the ketogenic diet (KD) have been successfully used to treat drug-resistant epilepsy, however its mainstream use as a first-line…”
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GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease by Leysen, Hanne, Walter, Deborah, Christiaenssen, Bregje, Vandoren, Romi, Harputluoğlu, İrem, Van Loon, Nore, Maudsley, Stuart

“…GPCRs arguably represent the most effective current therapeutic targets for a plethora of diseases. GPCRs also possess a pivotal role in the regulation of the…”
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Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice by Mirsoian, Annie, Bouchlaka, Myriam N, Sckisel, Gail D, Chen, Mingyi, Pai, Chien-Chun Steven, Maverakis, Emanuel, Spencer, Richard G, Fishbein, Kenneth W, Siddiqui, Sana, Monjazeb, Arta M, Martin, Bronwen, Maudsley, Stuart, Hesdorffer, Charles, Ferrucci, Luigi, Longo, Dan L, Blazar, Bruce R, Wiltrout, Robert H, Taub, Dennis D, Murphy, William J

“…Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice…”
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G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes by Leysen, Hanne, van Gastel, Jaana, Hendrickx, Jhana O, Santos-Otte, Paula, Martin, Bronwen, Maudsley, Stuart

“…G protein-coupled receptors (GPCRs) and their associated proteins represent one of the most diverse cellular signaling systems involved in both physiological…”
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