Search Results - "MATULIS, Daumantas"

Structural details of the enzymatic catalysis of carbonic anhydrase II via a mutation of valine to isoleucine by Matulis, Daumantas

“…Kim and co-workers [ (2020). , 985-994] advance our understanding of the catalytic mechanism of carbonic anhydrase II by studying a mutant V143I where the…”
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Inhibition of Carbonic Anhydrase IX Suppresses Breast Cancer Cell Motility at the Single-Cell Level by Janoniene, Agne, Mazutis, Linas, Matulis, Daumantas, Petrikaite, Vilma

“…Protein Carbonic Anhydrase IX (CA IX), which is expressed in various hypoxic solid tumors in order to maintain proper pH, is also related to cancer cell…”
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Isothermal titration calorimetry for characterization of recombinant proteins by Baranauskiene, Lina, Kuo, Tai-Chih, Chen, Wen-Yih, Matulis, Daumantas

“…[Display omitted] •ITC quantitatively determines the purity of recombinantly produced proteins.•Protein capability of binding a specific ligand is observed in…”
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Standard operating procedure for fluorescent thermal shift assay (FTSA) for determination of protein–ligand binding and protein stability by Kazlauskas, Egidijus, Petrauskas, Vytautas, Paketurytė, Vaida, Matulis, Daumantas

“…A standard operating procedure for a fluorescence-based thermal shift assay (FTSA) is provided describing its typical applications, advantages and limitations…”
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Thiazide and other Cl-benzenesulfonamide-bearing clinical drug affinities for human carbonic anhydrases by Baranauskiene, Lina, Škiudaitė, Lina, Michailovienė, Vilma, Petrauskas, Vytautas, Matulis, Daumantas

“…Twelve carbonic anhydrase (CA) isoforms catalyze carbon dioxide hydration to bicarbonate and acid protons and are responsible for many biological functions in…”
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Uncertainty in protein–ligand binding constants: asymmetric confidence intervals versus standard errors by Paketurytė, Vaida, Petrauskas, Vytautas, Zubrienė, Asta, Abian, Olga, Bastos, Margarida, Chen, Wen-Yih, Moreno, Maria João, Krainer, Georg, Linkuvienė, Vaida, Sedivy, Arthur, Velazquez-Campoy, Adrian, Williams, Mark A., Matulis, Daumantas

“…Equilibrium binding constants ( K b ) between chemical compounds and target proteins or between interacting proteins provide a quantitative understanding of…”
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A Quantitative Model of Thermal Stabilization and Destabilization of Proteins by Ligands by Cimmperman, Piotras, Baranauskienė, Lina, Jachimovičiūtė, Simona, Jachno, Jelena, Torresan, Jolanta, Michailovienė, Vilma, Matulienė, Jurgita, Sereikaitė, Jolanta, Bumelis, Vladas, Matulis, Daumantas

“…Equilibrium binding ligands usually increase protein thermal stability by an amount proportional to the concentration and affinity of the ligand…”
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A standard operating procedure for an enzymatic activity inhibition assay by Smirnovienė, Joana, Baranauskienė, Lina, Zubrienė, Asta, Matulis, Daumantas

“…This Standard Operating Protocol (SOP) describes the key steps of experimental setup for an inhibition assay of enzymatic activity. The protocol begins with…”
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POT1 stability and binding measured by fluorescence thermal shift assays by DeLeeuw, Lynn W, Monsen, Robert C, Petrauskas, Vytautas, Gray, Robert D, Baranauskiene, Lina, Matulis, Daumantas, Trent, John O, Chaires, Jonathan B

“…The protein POT1 (Protection of Telomeres 1) is an integral part of the shelterin complex that protects the ends of human chromosomes from degradation or end…”
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Special Issue "Advances in Monitoring Metabolic Activities of Microorganisms by Calorimetry" by Matulis, Daumantas, Wadsö, Lars, Fahmy, Karim

“…In recent decades, the calorimetric monitoring of microbial metabolism, i [...]…”
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Aerobic vaginitis is associated with carbonic anhydrase IX in cervical intraepithelial neoplasia by Grincevičienė, Švitrigailė, Vaitkienė, Daiva, Kanopienė, Daiva, Vansevičiūtė Petkevičienė, Rasa, Sukovas, Artūras, Celiešiūtė, Joana, Ivanauskaitė Didžiokienė, Ernesta, Čižauskas, Arvydas, Laurinavičienė, Aida, Stravinskienė, Dovilė, Grincevičius, Jonas, Matulis, Daumantas, Matulienė, Jurgita

“…The aim of this study was to analyze the association between vaginal microbiota, carbonic anhydrase IX (CAIX) and histological findings of cervical…”
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Intrinsic Solubility of Ionizable Compounds from pKa Shift by Preikša, Joku Bas, Petrikaitė, Vilma, Petrauskas, Vytautas, Matulis, Daumantas

“…Aqueous solubility of pharmaceutical substances plays an important role in small molecule drug discovery and development, with ionizable groups often employed…”
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Synthesis and structure–affinity relationship of chlorinated pyrrolidinone-bearing benzenesulfonamides as human carbonic anhydrase inhibitors by Balandis, Benas, Ivanauskaitė, Guostė, Smirnovienė, Joana, Kantminienė, Kristina, Matulis, Daumantas, Mickevičius, Vytautas, Zubrienė, Asta

“…[Display omitted] •Pyrrolidinone-bearing benzenesulfonamides with chlorine at position 3 were synthesized.•Compounds 12 and 15 exhibited low nanomolar…”
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Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes by Hilvo, Mika, Baranauskiene, Lina, Salzano, Anna Maria, Scaloni, Andrea, Matulis, Daumantas, Innocenti, Alessio, Scozzafava, Andrea, Monti, Simona Maria, Di Fiore, Anna, De Simone, Giuseppina, Lindfors, Mikaela, Jänis, Janne, Valjakka, Jarkko, Pastoreková, Silvia, Pastorek, Jaromir, Kulomaa, Markku S., Nordlund, Henri R., Supuran, Claudiu T., Parkkila, Seppo

“…Carbonic anhydrase IX (CA IX) is an exceptional member of the CA protein family; in addition to its classical role in pH regulation, it has also been proposed…”
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Screening, Synthesis and Biochemical Characterization of SARS-CoV-2 Protease Inhibitors by Bagdonas, Martynas, Čerepenkaitė, Kamilė, Mickevičiūtė, Aurelija, Kananavičiūtė, Rūta, Grybaitė, Birutė, Anusevičius, Kazimieras, Rukšėnaitė, Audronė, Kojis, Tautvydas, Gedgaudas, Marius, Mickevičius, Vytautas, Matulis, Daumantas, Zubrienė, Asta, Matulienė, Jurgita

“…The severe acute respiratory syndrome-causing coronavirus 2 (SARS-CoV-2) papain-like protease (PL ) and main protease (M ) play an important role in viral…”
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Thermodynamic Stability of Carbonic Anhydrase:  Measurements of Binding Affinity and Stoichiometry Using ThermoFluor by Matulis, Daumantas, Kranz, James K, Salemme, F. Raymond, Todd, Matthew J

“…ThermoFluor (a miniaturized high-throughput protein stability assay) was used to analyze the linkage between protein thermal stability and ligand binding…”
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Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX by Zakšauskas, Audrius, Čapkauskaitė, Edita, Paketurytė-Latvė, Vaida, Smirnov, Alexey, Leitans, Janis, Kazaks, Andris, Dvinskis, Elviss, Stančaitis, Laimonas, Mickevičiūtė, Aurelija, Jachno, Jelena, Jezepčikas, Linas, Linkuvienė, Vaida, Sakalauskas, Andrius, Manakova, Elena, Gražulis, Saulius, Matulienė, Jurgita, Tars, Kaspars, Matulis, Daumantas

“…Among the twelve catalytically active carbonic anhydrase isozymes present in the human body, the CAIX is highly overexpressed in various solid tumors. The…”
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Structure and mechanism of secondary sulfonamide binding to carbonic anhydrases by Baronas, Denis, Dudutienė, Virginija, Paketurytė, Vaida, Kairys, Visvaldas, Smirnov, Alexey, Juozapaitienė, Vaida, Vaškevičius, Aivaras, Manakova, Elena, Gražulis, Saulius, Zubrienė, Asta, Matulis, Daumantas

“…Zinc-containing metalloenzyme carbonic anhydrase (CA) binds primary sulfonamides with extremely high, up to picomolar, affinity by forming a coordination bond…”
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Thermodynamics of Interactions Between Charged Surfactants and Ionic Poly(amino acids) by Isothermal Titration Calorimetry by Skvarnavičius, Gediminas, Dvareckas, Danielius, Matulis, Daumantas, Petrauskas, Vytautas

“…Interactions between charges play a role in protein stability and contribute to the energetics of binding between various charged ligands. Ionic surfactants…”
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Improving the Hsp90 Inhibitors Containing 4-(2,4-Dihydroxyphenyl)-1,2,3-thiadiazole Scaffold: Synthesis, Affinity and Effect on Cancer Cells by Kazlauskas, Egidijus, Brukstus, Algirdas, Petrikas, Herkus, Petrikaite, Vilma, Cikotiene, Inga, Matulis, Daumantas

“…Human Hsp90 chaperone inhibitors are known to be potential anticancer drugs. Previously we have shown a couple of…”
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