Search Results - "MATTIJSSEN, Frits"

Regulation of triglyceride metabolism by Angiopoietin-like proteins by Mattijssen, Frits, Kersten, Sander

“…Plasma triglyceride concentrations are determined by the balance between production of the triglyceride-rich lipoproteins VLDL and chylomicrons in liver and…”
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HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation by van Dierendonck, Xanthe A.M.H., de la Rosa Rodriguez, Montserrat A., Georgiadi, Anastasia, Mattijssen, Frits, Dijk, Wieneke, van Weeghel, Michel, Singh, Rajat, Borst, Jan Willem, Stienstra, Rinke, Kersten, Sander

“…Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined…”
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The glucocorticoid receptor in brown adipocytes is dispensable for control of energy homeostasis by Glantschnig, Christina, Mattijssen, Frits, Vogl, Elena Sophie, Ali Khan, Asrar, Rios Garcia, Marcos, Fischer, Katrin, Müller, Timo, Uhlenhaut, Henriette, Nawroth, Peter, Scheideler, Marcel, Rose, Adam J, Pellegata, Natalia, Herzig, Stephan

“…Aberrant activity of the glucocorticoid (GC)/glucocorticoid receptor (GR) endocrine system has been linked to obesity‐related metabolic dysfunction…”
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Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise by Catoire, Milène, Alex, Sheril, Paraskevopulos, Nicolas, Mattijssen, Frits, Gogh, Inkie Evers-van, Schaart, Gert, Jeppesen, Jacob, Kneppers, Anita, Mensink, Marco, Voshol, Peter J., Olivecrona, Gunilla, Tan, Nguan Soon, Hesselink, Matthijs K. C., Berbée, Jimmy F., Rensen, Patrick C. N., Kalkhoven, Eric, Schrauwen, Patrick, Kersten, Sander

“…Physical activity increases energy metabolism in exercising muscle. Whether acute exercise elicits metabolic changes in nonexercising muscles remains unclear…”
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Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels by BOSMA, Madeleen, HESSELINK, Matthijs K. C, KERSTEN, Sander, SCHRAUWEN, Patrick, SPARKS, Lauren M, TIMMERS, Silvie, FERRAZ, Maria Joao, MATTIJSSEN, Frits, BEURDEN, Denis Van, SCHAART, Gert, DE BAETS, Marc H, VERHEYEN, Fons K

“…Type 2 diabetes is characterized by excessive lipid storage in skeletal muscle. Excessive intramyocellular lipid (IMCL) storage exceeds intracellular needs and…”
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The ER-Associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism by Sha, Haibo, Sun, Shengyi, Francisco, Adam B., Ehrhardt, Nicole, Xue, Zhen, Liu, Lei, Lawrence, Peter, Mattijssen, Frits, Guber, Robert D., Panhwar, Muhammad S., Brenna, J. Thomas, Shi, Hang, Xue, Bingzhong, Kersten, Sander, Bensadoun, André, Péterfy, Miklós, Long, Qiaoming, Qi, Ling

“…Sel1L is an essential adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum (ER)-associated degradation (ERAD), a universal quality-control…”
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HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling by Giroud, Maude, Tsokanos, Foivos-Filippos, Caratti, Giorgio, Kotschi, Stefan, Khani, Sajjad, Jouffe, Céline, Vogl, Elena S., Irmler, Martin, Glantschnig, Christina, Gil-Lozano, Manuel, Hass, Daniela, Khan, Asrar Ali, Garcia, Marcos Rios, Mattijssen, Frits, Maida, Adriano, Tews, Daniel, Fischer-Posovszky, Pamela, Feuchtinger, Annette, Virtanen, Kirsi A., Beckers, Johannes, Wabitsch, Martin, Uhlenhaut, Henriette, Blüher, Matthias, Tuckermann, Jan, Scheideler, Marcel, Bartelt, Alexander, Herzig, Stephan

“…Aims/hypothesis Adipocytes are critical cornerstones of energy metabolism. While obesity-induced adipocyte dysfunction is associated with insulin resistance…”
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Hypoxia-inducible Lipid Droplet-associated (HILPDA) Is a Novel Peroxisome Proliferator-activated Receptor (PPAR) Target Involved in Hepatic Triglyceride Secretion by Mattijssen, Frits, Georgiadi, Anastasia, Andasarie, Tresty, Szalowska, Ewa, Zota, Annika, Krones-Herzig, Anja, Heier, Christoph, Ratman, Dariusz, De Bosscher, Karolien, Qi, Ling, Zechner, Rudolf, Herzig, Stephan, Kersten, Sander

“…Peroxisome proliferator-activated receptors (PPARs) play major roles in the regulation of hepatic lipid metabolism through the control of numerous genes…”
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Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2‐Dependent Mitotic Cell Death by Rios Garcia, Marcos, Meissburger, Bettina, Chan, Jessica, Guia, Roldan M., Mattijssen, Frits, Roessler, Stephanie, Birkenfeld, Andreas L., Raschzok, Nathanael, Riols, Fabien, Tokarz, Janina, Giroud, Maude, Gil Lozano, Manuel, Hartleben, Goetz, Nawroth, Peter, Haid, Mark, López, Miguel, Herzig, Stephan, Berriel Diaz, Mauricio

“…Aberrant energy metabolism and cell cycle regulation both critically contribute to malignant cell growth and both processes represent targets for anticancer…”
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Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue by Kroupa, Olessia, Vorrsjö, Evelina, Stienstra, Rinke, Mattijssen, Frits, Nilsson, Stefan K, Sukonina, Valentina, Kersten, Sander, Olivecrona, Gunilla, Olivecrona, Thomas

“…Lipoprotein lipase (LPL) hydrolyzes triglycerides in lipoproteins and makes fatty acids available for tissue metabolism. The activity of the enzyme is…”
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A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage by Niopek, Katharina, Üstünel, Bilgen Ekim, Seitz, Susanne, Sakurai, Minako, Zota, Annika, Mattijssen, Frits, Wang, Xiaoyue, Sijmonsma, Tjeerd, Feuchter, Yvonne, Gail, Anna M., Leuchs, Barbara, Niopek, Dominik, Staufer, Oskar, Brune, Maik, Sticht, Carsten, Gretz, Norbert, Müller-Decker, Karin, Hammes, Hans-Peter, Nawroth, Peter, Fleming, Thomas, Conkright, Michael D., Blüher, Matthias, Zeigerer, Anja, Herzig, Stephan, Berriel Diaz, Mauricio

“…Increased pro-inflammatory signaling is a hallmark of metabolic dysfunction in obesity and diabetes. Although both inflammatory and energy substrate handling…”
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Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages by Lichtenstein, Laeticia, Mattijssen, Frits, de Wit, Nicole J., Georgiadi, Anastasia, Hooiveld, Guido J., van der Meer, Roelof, He, Yin, Qi, Ling, Köster, Anja, Tamsma, Jouke T., Tan, Nguan Soon, Müller, Michael, Kersten, Sander

“…Dietary saturated fat is linked to numerous chronic diseases, including cardiovascular disease. Here we study the role of the lipoprotein lipase inhibitor…”
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Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence by Rios Garcia, Marcos, Steinbauer, Brigitte, Srivastava, Kshitij, Singhal, Mahak, Mattijssen, Frits, Maida, Adriano, Christian, Sven, Hess-Stumpp, Holger, Augustin, Hellmut G., Müller-Decker, Karin, Nawroth, Peter P., Herzig, Stephan, Berriel Diaz, Mauricio

“…Breast tumor recurrence and metastasis represent the main causes of cancer-related death in women, and treatments are still lacking. Here, we define…”
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Hypoxia-Inducible Lipid Droplet–Associated Is Not a Direct Physiological Regulator of Lipolysis in Adipose Tissue by Dijk, Wieneke, Mattijssen, Frits, de la Rosa Rodriguez, Montserrat, Loza Valdes, Angel, Loft, Anne, Mandrup, Susanne, Kalkhoven, Eric, Qi, Ling, Borst, Jan Willem, Kersten, Sander

“…Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins have been shown to be physically associated with lipid droplets and…”
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Angptl4 serves as an endogenous inhibitor of intestinal lipid digestion by Mattijssen, Frits, Alex, Sheril, Swarts, Hans J, Groen, Albert K, van Schothorst, Evert M, Kersten, Sander

“…Abstract Dietary triglycerides are hydrolyzed in the small intestine principally by pancreatic lipase. Following uptake by enterocytes and secretion as…”
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Saturated Fatty Acids and snoRNAs: Partners in Crime by Mattijssen, Frits, Kersten, Sander

“…Lipotoxicity describes the process of cellular dysfunction in response to lipid overload. In this issue of Cell Metabolism, Michel and colleagues (2011)…”
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Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes by Jonker, Jacqueline T, Smit, Johannes WA, Hammer, Sebastiaan, Snel, Marieke, van der Meer, Rutger W, Lamb, Hildo J, Mattijssen, Frits, Mudde, Karin, Jazet, Ingrid M, Dekkers, Olaf M, de Roos, Albert, Romijn, Johannes A, Kersten, Sander, Rensen, Patrick CN

“…Background: Angiopoietin-like protein 4 (ANGPTL4) has been identified as an inhibitor of lipoprotein lipase. Preliminary data suggest that plasma nonesterified…”
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Hepatic Deficiency in Transcriptional Cofactor TBL1 Promotes Liver Steatosis and Hypertriglyceridemia by Kulozik, Philipp, Jones, Allan, Mattijssen, Frits, Rose, Adam J., Reimann, Anja, Strzoda, Daniela, Kleinsorg, Stefan, Raupp, Christina, Kleinschmidt, Jürgen, Müller-Decker, Karin, Wahli, Walter, Sticht, Carsten, Gretz, Norbert, von Loeffelholz, Christian, Stockmann, Martin, Pfeiffer, Andreas, Stöhr, Sigrid, Dallinga-Thie, Geesje M., Nawroth, Peter P., Diaz, Mauricio Berriel, Herzig, Stephan

“…The aberrant accumulation of lipids in the liver (“fatty liver”) is tightly associated with several components of the metabolic syndrome, including type 2…”
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Functional Characterization of the PPAR Targets ANGPTL4 and HILPDA in Lipid Metabolism by Mattijssen, Frits

“…The peroxisomal proliferator activator receptors (PPARs) are ligand-activated transcription factors that play important roles in the regulation of lipid…”
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Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes123 by Jonker, Jacqueline T, Smit, Johannes WA, Hammer, Sebastiaan, Snel, Marieke, van der Meer, Rutger W, Lamb, Hildo J, Mattijssen, Frits, Mudde, Karin, Jazet, Ingrid M, Dekkers, Olaf M, de Roos, Albert, Romijn, Johannes A, Kersten, Sander, Rensen, Patrick CN

“…Angiopoietin-like protein 4 (ANGPTL4) has been identified as an inhibitor of lipoprotein lipase. Preliminary data suggest that plasma nonesterified fatty acids…”
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