Search Results - "MATTHYS, Patrick"

Hemophagocytic lymphohistiocytosis (HLH): A heterogeneous spectrum of cytokine-driven immune disorders by Brisse, Ellen, Wouters, Carine H, Matthys, Patrick

“…Highlights • HLH comprises a broad spectrum of disorders that all present with a cytokine storm. • Diverse animal models of HLH have enhanced our understanding…”
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Advances in the pathogenesis of primary and secondary haemophagocytic lymphohistiocytosis: differences and similarities by Brisse, Ellen, Wouters, Carine H., Matthys, Patrick

“…Summary Haemophagocytic lymphohistiocytosis (HLH) comprises a heterogeneous spectrum of hyperinflammatory conditions that are inherited (primary HLH) or…”
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Natural Killer Cells in Systemic Autoinflammatory Diseases: A Focus on Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome by Vandenhaute, Jessica, Wouters, Carine H, Matthys, Patrick

“…Natural killer (NK) cells are innate immune lymphocytes with potent cytolytic and immune-regulatory activities. NK cells are well-known for their ability to…”
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Natural Killer Cells in Multiple Sclerosis: Entering the Stage by Beliën, Jarne, Goris, An, Matthys, Patrick

“…Studies investigating the immunopathology of multiple sclerosis (MS) have largely focused on adaptive T and B lymphocytes. However, in recent years there has…”
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Neutrophil Homeostasis and Emergency Granulopoiesis: The Example of Systemic Juvenile Idiopathic Arthritis by Malengier-Devlies, Bert, Metzemaekers, Mieke, Wouters, Carine, Proost, Paul, Matthys, Patrick

“…Neutrophils are key pathogen exterminators of the innate immune system endowed with oxidative and non-oxidative defense mechanisms. More recently, a more…”
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How Viruses Contribute to the Pathogenesis of Hemophagocytic Lymphohistiocytosis by Brisse, Ellen, Wouters, Carine H, Andrei, Graciela, Matthys, Patrick

“…Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, hyperinflammatory syndrome, characterized by the uncontrolled activation of macrophages and T…”
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Multinucleated Giant Cells: Current Insights in Phenotype, Biological Activities, and Mechanism of Formation by Ahmadzadeh, Kourosh, Vanoppen, Margot, Rose, Carlos D, Matthys, Patrick, Wouters, Carine Helena

“…Monocytes and macrophages are innate immune cells with diverse functions ranging from phagocytosis of microorganisms to forming a bridge with the adaptive…”
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CHIT1 at diagnosis predicts faster disability progression and reflects early microglial activation in multiple sclerosis by Beliën, Jarne, Swinnen, Stijn, D’hondt, Robbe, Verdú de Juan, Laia, Dedoncker, Nina, Matthys, Patrick, Bauer, Jan, Vens, Celine, Moylett, Sinéad, Dubois, Bénédicte

“…Multiple sclerosis (MS) is characterized by heterogeneity in disease course and prediction of long-term outcome remains a major challenge. Here, we investigate…”
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A novel kindred with inherited STAT2 deficiency and severe viral illness by Moens, Leen, PhD, Van Eyck, Lien, MSc, MD, Jochmans, Dirk, PhD, Mitera, Tania, BSc, Frans, Glynis, MPharm, Bossuyt, Xavier, MD, PhD, Matthys, Patrick, PhD, Neyts, Johan, PhD, Ciancanelli, Michael, PhD, Zhang, Shen-Ying, MD, PhD, Gijsbers, Rik, PhD, Casanova, Jean-Laurent, MD, PhD, Boisson-Dupuis, Stephanie, PhD, Meyts, Isabelle, MD, PhD, Liston, Adrian, PhD

“…IFN-α-induced IFN-stimulated gene factor 3 complex-mediated binding to IFN-α sequence response element was specifically abolished in P2, whereas IFN-γ and…”
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Modes of action of Freund’s adjuvants in experimental models of autoimmune diseases by Billiau, Alfons, Matthys, Patrick

“…Freund’s adjuvants are irreplaceable components of induction protocols of many experimental animal models of autoimmune disease. Apart from the early studies…”
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Molecular imaging of rheumatoid arthritis: emerging markers, tools, and techniques by Put, Stéphanie, Westhovens, René, Lahoutte, Tony, Matthys, Patrick

“…Early diagnosis and effective monitoring of rheumatoid arthritis (RA) are important for a positive outcome. Instant treatment often results in faster reduction…”
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Regulatory Role for NK Cells in a Mouse Model of Systemic Juvenile Idiopathic Arthritis by Vandenhaute, Jessica, Avau, Anneleen, Filtjens, Jessica, Malengier-Devlies, Bert, Imbrechts, Maya, Van den Berghe, Nathalie, Ahmadzadeh, Kourosh, Mitera, Tania, Boon, Louis, Leclercq, Georges, Wouters, Carine, Matthys, Patrick

“…Mice deficient in IFN-γ (IFN-γ knockout [KO] mice) develop a systemic inflammatory syndrome in response to CFA, in contrast to CFA-challenged wild-type (WT)…”
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Aspecific binding of anti-NK1.1 antibodies on myeloid cells in an experimental model for malaria-associated acute respiratory distress syndrome by Pollenus, Emilie, Prenen, Fran, Possemiers, Hendrik, Knoops, Sofie, Mitera, Tania, Lamote, Jochen, De Visscher, Amber, Vandermosten, Leen, Pham, Thao-Thy, Matthys, Patrick, Van den Steen, Philippe E

“…Conventional natural killer (cNK) cells play an important role in the innate immune response by directly killing infected and malignant cells and by producing…”
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Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis by Imbrechts, Maya, Avau, Anneleen, Vandenhaute, Jessica, Malengier-Devlies, Bert, Put, Karen, Mitera, Tania, Berghmans, Nele, Burton, Oliver, Junius, Steffie, Liston, Adrian, de Somer, Lien, Wouters, Carine, Matthys, Patrick

“…Systemic juvenile idiopathic arthritis (sJIA) is a childhood-onset immune disorder of unknown cause. One of the concepts is that the disease results from an…”
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Cytokine balance and cytokine-driven natural killer cell dysfunction in systemic juvenile idiopathic arthritis by Avau, Anneleen, Put, Karen, Wouters, Carine H, Matthys, Patrick

“…Abstract Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory childhood disorder, characterized by a specific pattern of systemic features…”
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IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis by Humblet-Baron, Stéphanie, MD, PhD, Franckaert, Dean, MSc, Dooley, James, MSc, Bornschein, Simon, MSc, Cauwe, Bénédicte, PhD, Schönefeldt, Susann, MSc, Bossuyt, Xavier, MD, PhD, Matthys, Patrick, PhD, Baron, Frédéric, MD, PhD, Wouters, Carine, MD, PhD, Liston, Adrian, PhD

“…Background Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8+ T-cell activation. HLH occurs as both acquired…”
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NK cells contribute to the resolution of experimental malaria-associated acute respiratory distress syndrome after antimalarial treatment by Pollenus, Emilie, Possemiers, Hendrik, Knoops, Sofie, Prenen, Fran, Vandermosten, Leen, Pham, Thao-Thy, Buysrogge, Laura, Matthys, Patrick, Van den Steen, Philippe E

“…In both humans and mice, natural killer (NK) cells are important lymphocytes of the innate immune system. They are often considered pro-inflammatory effector…”
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T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells by Kiekens, Laura, Van Loocke, Wouter, Taveirne, Sylvie, Wahlen, Sigrid, Persyn, Eva, Van Ammel, Els, De Vos, Zenzi, Matthys, Patrick, Van Nieuwerburgh, Filip, Taghon, Tom, Van Vlierberghe, Pieter, Vandekerckhove, Bart, Leclercq, Georges

“…T-bet and Eomes are transcription factors that are known to be important in maturation and function of murine natural killer (NK) cells. Reduced T-BET and…”
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Therapeutic Potential of Interferon-γ and Its Antagonists in Autoinflammation: Lessons from Murine Models of Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome by Avau, Anneleen, Matthys, Patrick

“…Interferon-γ (IFN-γ) affects immune responses in a complex fashion. Its immunostimulatory actions, such as macrophage activation and induction of T helper…”
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Protection of stromal cell-derived factor-1 SDF-1/CXCL12 against proteases yields improved skin wound healing by Pereira, Rafaela Vaz Sousa, EzEldeen, Mostafa, Ugarte-Berzal, Estefania, Vandooren, Jennifer, Martens, Erik, Gouwy, Mieke, Ganseman, Eva, Van Damme, Jo, Matthys, Patrick, Vranckx, Jan Jeroen, Proost, Paul, Opdenakker, Ghislain

“…SDF-1/CXCL12 is a unique chemotactic factor with multiple functions on various types of precursor cells, all carrying the cognate receptor CXCR4. Whereas…”
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