Search Results - "MATTHEWS, Ian T. W"

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1 by Menear, Keith A, Adcock, Claire, Boulter, Robert, Cockcroft, Xiao-ling, Copsey, Louise, Cranston, Aaron, Dillon, Krystyna J, Drzewiecki, Jan, Garman, Sheila, Gomez, Sylvie, Javaid, Hashim, Kerrigan, Frank, Knights, Charlotte, Lau, Alan, Loh, Vincent M, Matthews, Ian T. W, Moore, Stephen, O’Connor, Mark J, Smith, Graeme C. M, Martin, Niall M. B

“…Poly(ADP-ribose) polymerase activation is an immediate cellular response to metabolic-, chemical-, or ionizing radiation-induced DNA damage and represents a…”
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Antibodies for neoplastic disease: Solid tumors by MATTHEWS, Ian T. W

“…The ease with which polyclonal, monoclonal, and engineered antibody fragments can be prepared allows access to a series of reagents with high selectivity and…”
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Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase by Loh, Vincent M., Cockcroft, Xiao-ling, Dillon, Krystyna J., Dixon, Lesley, Drzewiecki, Jan, Eversley, Penny J., Gomez, Sylvie, Hoare, Janet, Kerrigan, Frank, Matthews, Ian T.W., Menear, Keith A., Martin, Niall M.B., Newton, Roger F., Paul, Jane, Smith, Graeme C.M., Vile, Julia, Whittle, Alan J.

“…Screening of the Maybridge compound collection identified 4-arylphthalazinones as micromolar inhibitors of PARP-1 catalytic activity. Subsequent optimisation…”
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4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2 H -phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1 by Menear, Keith A., Adcock, Claire, Boulter, Robert, Cockcroft, Xiao-ling, Copsey, Louise, Cranston, Aaron, Dillon, Krystyna J., Drzewiecki, Jan, Garman, Sheila, Gomez, Sylvie, Javaid, Hashim, Kerrigan, Frank, Knights, Charlotte, Lau, Alan, Loh, Vincent M., Matthews, Ian T. W., Moore, Stephen, O’Connor, Mark J., Smith, Graeme C. M., Martin, Niall M. B.

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