Search Results - "MATTHEW WHITBY, C"

The FANCM family of DNA helicases/translocases by Whitby, Matthew C.

“…FANCM and its relatives, Hef, Mph1 and Fml1, are DNA junction-specific helicases/translocases that target and process perturbed replication forks and…”
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Gene duplication and deletion caused by over-replication at a fork barrier by Oehler, Judith, Morrow, Carl A., Whitby, Matthew C.

“…Replication fork stalling can provoke fork reversal to form a four-way DNA junction. This remodelling of the replication fork can facilitate repair, aid bypass…”
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Rad52’s DNA annealing activity drives template switching associated with restarted DNA replication by Kishkevich, Anastasiya, Tamang, Sanjeeta, Nguyen, Michael O., Oehler, Judith, Bulmaga, Elena, Andreadis, Christos, Morrow, Carl A., Jalan, Manisha, Osman, Fekret, Whitby, Matthew C.

“…It is thought that many of the simple and complex genomic rearrangements associated with congenital diseases and cancers stem from mistakes made during the…”
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The Fission Yeast FANCM Ortholog Directs Non-Crossover Recombination During Meiosis by Lorenz, Alexander, Osman, Fekret, Sun, Weili, Nandi, Saikat, Steinacher, Roland, Whitby, Matthew C.

“…The formation of healthy gametes depends on programmed DNA double-strand breaks (DSBs), which are each repaired as a crossover (CO) or non-crossover (NCO) from…”
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Factors affecting template switch recombination associated with restarted DNA replication by Jalan, Manisha, Oehler, Judith, Morrow, Carl A, Osman, Fekret, Whitby, Matthew C

“…Homologous recombination helps ensure the timely completion of genome duplication by restarting collapsed replication forks. However, this beneficial function…”
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Author Correction: Rad52’s DNA annealing activity drives template switching associated with restarted DNA replication by Kishkevich, Anastasiya, Tamang, Sanjeeta, Nguyen, Michael O., Oehler, Judith, Bulmaga, Elena, Andreadis, Christos, Morrow, Carl A., Jalan, Manisha, Osman, Fekret, Whitby, Matthew C.

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The FANCM Ortholog Fml1 Promotes Recombination at Stalled Replication Forks and Limits Crossing Over during DNA Double-Strand Break Repair by Sun, Weili, Nandi, Saikat, Osman, Fekret, Ahn, Jong Sook, Jakovleska, Jovana, Lorenz, Alexander, Whitby, Matthew C.

“…The Fanconi anemia (FA) core complex promotes the tolerance/repair of DNA damage at stalled replication forks by catalyzing the monoubiquitination of FANCD2…”
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The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair by Nandi, Saikat, Whitby, Matthew C

“…In fission yeast, the DNA helicase Fml1, which is an orthologue of human FANCM, is a key component of the machinery that drives and governs homologous…”
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A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability by Yan, Zhijiang, Delannoy, Mathieu, Ling, Chen, Daee, Danielle, Osman, Fekret, Muniandy, Parameswary A., Shen, Xi, Oostra, Anneke B., Du, Hansen, Steltenpool, Jurgen, Lin, Ti, Schuster, Beatrice, Décaillet, Chantal, Stasiak, Andrzej, Stasiak, Alicja Z., Stone, Stacie, Hoatlin, Maureen E., Schindler, Detlev, Woodcock, Christopher L., Joenje, Hans, Sen, Ranjan, de Winter, Johan P., Li, Lei, Seidman, Michael M., Whitby, Matthew C., Myung, Kyungjae, Constantinou, Angelos, Wang, Weidong

“…FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved…”
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The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability by Steinacher, Roland, Osman, Fekret, Dalgaard, Jacob Z, Lorenz, Alexander, Whitby, Matthew C

“…Bidirectionally moving DNA replication forks merge at termination sites composed of accidental or programmed DNA-protein barriers. If merging fails, then…”
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Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse by Nguyen, Michael O, Jalan, Manisha, Morrow, Carl A, Osman, Fekret, Whitby, Matthew C

“…The completion of genome duplication during the cell cycle is threatened by the presence of replication fork barriers (RFBs). Following collision with a RFB,…”
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Fbh1 Limits Rad51-Dependent Recombination at Blocked Replication Forks by Lorenz, Alexander, Osman, Fekret, Folkyte, Victoria, Sofueva, Sevil, Whitby, Matthew C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Emerging roles for centromere-associated proteins in DNA repair and genetic recombination by Osman, Fekret, Whitby, Matthew C

“…Centromere proteins CENP-S and CENP-X are members of the constitutive centromere-associated network, which is a conserved group of proteins that are needed for…”
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Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein by Sarangi, Prabha, Steinacher, Roland, Altmannova, Veronika, Fu, Qiong, Paull, Tanya T, Krejci, Lumir, Whitby, Matthew C, Zhao, Xiaolan

“…Protein modifications regulate both DNA repair levels and pathway choice. How each modification achieves regulatory effects and how different modifications…”
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human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant by Lorenz, Alexander, West, Stephen C, Whitby, Matthew C

“…A key step in meiotic recombination involves the nucleolytic resolution of Holliday junctions to generate crossovers. Although the enzyme that performs this…”
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Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability by Steinacher, Roland, Osman, Fekret, Lorenz, Alexander, Bryer, Claire, Whitby, Matthew C

“…The SUMO-dependent ubiquitin ligase Slx8 plays key roles in promoting genome stability, including the processing of trapped Topoisomerase I (Top1) cleavage…”
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The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast by Wong, Io Nam, Neo, Jacqueline Ps, Oehler, Judith, Schafhauser, Sophie, Osman, Fekret, Carr, Stephen B, Whitby, Matthew C

“…Previously we reported that a process called inter-fork strand annealing (IFSA) causes genomic deletions during the termination of DNA replication when an…”
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The PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast by Tamang, Sanjeeta, Kishkevich, Anastasiya, Morrow, Carl A, Osman, Fekret, Jalan, Manisha, Whitby, Matthew C

“…Protein-DNA complexes can impede DNA replication and cause replication fork collapse. Whilst it is known that homologous recombination is deployed in such…”
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Structure-Specific Endonucleases Xpf and Mus81 Play Overlapping but Essential Roles in DNA Repair by Homologous Recombination by KIKUCHI, Koji, NARITA, Takeo, ESSERS, Jeroen, KANAAR, Roland, MATTHEW WHITBY, C, SUGASAWA, Kaoru, TANIGUCHI, Yoshihito, KITAGAWA, Katsumi, TAKEDA, Shunichi, VAN PHAM, T, IIJIMA, Junko, HIROTA, Kouji, KEKA, Islam Shamima, MOHIUDDIN, OKAWA, Katsuya, HORI, Tetsuya, FUKAGAWA, Tatsuo

“…DNA double-strand breaks (DSB) occur frequently during replication in sister chromatids and are dramatically increased when cells are exposed to…”
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The F-Box DNA Helicase Fbh1 Prevents Rhp51-Dependent Recombination without Mediator Proteins by Osman, Fekret, Dixon, Julie, Barr, Alexis R., Whitby, Matthew C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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