Search Results - "MATTEUCCI, D"

Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer by SUN, Jessica D, QIAN LIU, HART, Charles P, JINGLI WANG, AHLUWALIA, Dharmendra, FERRARO, Damien, YAN WANG, DUAN, Jian-Xin, STEVE AMMONS, W, CURD, John G, MATTEUCCI, Mark D

“…Tumor hypoxia underlies treatment failure and yields a more aggressive, invasive, and metastatic cancer phenotype. TH-302 is a 2-nitroimidazole triggered…”
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Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302 by Meng, Fanying, Evans, James W, Bhupathi, Deepthi, Banica, Monica, Lan, Leslie, Lorente, Gustavo, Duan, Jian-Xin, Cai, Xiaohong, Mowday, Alexandra M, Guise, Christopher P, Maroz, Andrej, Anderson, Robert F, Patterson, Adam V, Stachelek, Gregory C, Glazer, Peter M, Matteucci, Mark D, Hart, Charles P

“…TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard currently undergoing clinical evaluation. Here, we…”
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Using local ecological knowledge to improve large terrestrial mammal surveys, build local capacity and increase conservation opportunities by Camino, Micaela, Thompson, Jeffrey, Andrade, Laura, Cortez, Sara, Matteucci, Silvia D., Altrichter, Mariana

“…Field information is essential for developing conservation actions, but standard methods for surveying wildlife are often inefficient in large, remote areas…”
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Spatial and seasonal dynamic of abundance and distribution of guanaco and livestock: insights from using density surface and null models by Schroeder, Natalia M, Matteucci, Silvia D, Moreno, Pablo G, Gregorio, Pablo, Ovejero, Ramiro, Taraborelli, Paula, Carmanchahi, Pablo D

“…Monitoring species abundance and distribution is a prerequisite when assessing species status and population viability, a difficult task to achieve for large…”
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Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models by Sun, Jessica D., Liu, Qian, Ahluwalia, Dharmendra, Ferraro, Damien J., Wang, Yan, Jung, Don, Matteucci, Mark D., Hart, Charles P.

“…Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide. In hypoxic conditions Br-IPM is released and alkylates DNA…”
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Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition by Meng, Fanying, Bhupathi, Deepthi, Sun, Jessica D, Liu, Qian, Ahluwalia, Dharmendra, Wang, Yan, Matteucci, Mark D, Hart, Charles P

“…The hypoxia-activated prodrug TH-302 is reduced at its nitroimidazole group and selectively under hypoxic conditions releases the DNA cross-linker…”
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Current concepts in antisense drug design by Milligan, John F, Matteucci, Mark D, Martin, John C

“…Antisense oligodeoxynucleotides (ODNs) have been proposed as a major class of new pharmaceuticals. In general, antisense refers to the use of small, synthetic…”
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Nucleosides with a Twist. Can Fixed Forms of Sugar Ring Pucker Influence Biological Activity in Nucleosides and Oligonucleotides? by Marquez, Victor E, Siddiqui, Maqbool A, Ezzitouni, Abdallah, Russ, Pamela, Wang, Jianying, Wagner, Richard W, Matteucci, Mark D

“…The sugar moiety of nucleosides in solution is known to exist in a rapid dynamic equilibrium between extreme Northern and Southern conformations as defined in…”
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Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines by Wagner, Richard W., Matteucci, Mark D., Lewis, Jason G., Gutierrez, Arnold J., Moulds, Courtney, Froehler, Brian C.

“…Phosphorothioate oligodeoxynucleotides containing the C-5 propyne analogs of uridine and cytidine bind RNA with high affinity and are potent antisense…”
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Abiotic factors related to the incidence of the Austrocedrus chilensis disease syndrome at a landscape scale by La Manna, L., Matteucci, S.D., Kitzberger, T.

“…In this paper, the incidence of the A. chilensis disease syndrome in the “16 de Octubre” Valley (Chubut, Argentinean Patagonia) was related to landscape…”
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A Cytosine Analogue Capable of Clamp-Like Binding to a Guanine in Helical Nucleic Acids by Lin, Kuei-Ying, Matteucci, Mark D

“…The Watson-Crick pairing of heterocycles within duplex DNA is the foundation of biomolecular recognition. The cytosine-guanine interaction is formed by three…”
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Methodological approaches to assess climate vulnerability and cumulative impacts on coastal landscapes by Olivares-Aguilar, Isabel C., Sánchez-Dávila, Gabriel, Wildermann, Natalie Elizabeth, Clark, Dana, Floerl, Lisa, Villamizar, Estrella, Matteucci, Silvia D., Muñoz Sevilla, Norma Patricia, Nagy, Gustavo J.

“…Natural and human-induced hazards and climatic risks threaten marine and coastal ecosystems worldwide, with severe consequences for these socio-ecological…”
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A Serum-Resistant Cytofectin for Cellular Delivery of Antisense Oligodeoxynucleotides and Plasmid DNA by Lewis, Jason G., Lin, Kuei-Ying, Kothavale, Avinash, Flanagan, W. Michael, Matteucci, Mark D., DePrince, Randolph B., Mook, Robert A., Hendren, R. Wayne, Wagner, Richard W.

“…Development of antisense technology has focused in part on creating improved methods for delivering oligodeoxynucleotides (ODNs) to cells. In this report, we…”
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Potent and selective inhibition of gene expression by an antisense heptanucleotide by Wagner, Richard W, Matteucci, Mark D, Grant, Deborah, Huang, Teresa, Froehler, Brian C

“…Factors that govern the specificity of an antisense oligonucleotide (ON) for its target RNA include accessibility of the targeted RNA to ON binding, stability…”
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Correction: Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer by Sun, Jessica D, Liu, Qian, Wang, Jingli, Ahluwalia, Dharmendra, Ferraro, Damien, Wang, Yan, Duan, Jian-Xin, Ammons, W Steve, Curd, John G, Matteucci, Mark D, Hart, Charles P

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Forest conservation: Remember Gran Chaco by Kuemmerle, Tobias, Altrichter, Mariana, Baldi, Germán, Cabido, Marcel, Camino, Micaela, Cuellar, Erika, Cuellar, Rosa Leny, Decarre, Julieta, Díaz, Sandra, Gasparri, Ignacio, Gavier-Pizarro, Gregorio, Ginzburg, Rubén, Giordano, Anthony J., Grau, H. Ricardo, Jobbágy, Esteban, Leynaud, Gerardo, Macchi, Leandro, Mastrangelo, Matias, Matteucci, Silvia D., Noss, Andrew, Paruelo, José, Piquer-Rodríguez, Maria, Romero-Muñoz, Alfredo, Semper-Pascual, Asunción, Thompson, Jeffrey, Torrella, Sebastián, Torres, Ricardo, Volante, José N., Yanosky, Alberto, Zak, Marcelo

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Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen by BENDINELLI, M, PISTELLO, M, LOMBARDI, S, POLI, A, GARZELLI, C, MATTEUCCI, D, CECCHERINI-NELLI, L, MALVALDI, G, TOZZINI, F

“…Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Less than six generations to save the chacoan peccary by Camino, Micaela, Thompson, Jeffrey, Arriaga Velasco-Aceves, Pablo, Cirignoli, Sebastián, Tiddi, Riccardo, Cortez, Sara, Matteucci, Silvia D., Altrichter, Mariana

“…The Dry Chaco has one of the highest deforestation rates of the world. The chacoan peccary ( Catagonus wagneri ; ChP) is endemic to the forests of this region…”
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A Cytosine Analog That Confers Enhanced Potency to Antisense Oligonucleotides by Flanagan, W. Michael, Wolf, John J., Olson, Peter, Grant, Debbie, Lin, Kuei-Ying, Wagner, Richard W., Matteucci, Mark D.

“…Antisense technology is based on the ability to design potent, sequence-specific inhibitors. The G-clamp heterocycle modification, a cytosine analog that…”
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Effects of feline immunodeficiency virus on feline monocyte-derived dendritic cells infected by spinoculation by Freer, G, Matteucci, D, Mazzetti, P, Tarabella, F, Catalucci, V, Bendinelli, M

“…During type 1 human immunodeficiency virus infection, not only can dendritic cells (DCs) prime T cells against the virus, but they can also infect them in…”
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