Search Results - "MATTERA, Rafael"

Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon by Guo, Xiaoli, Farías, Ginny G., Mattera, Rafael, Bonifacino, Juan S.

“…An open question in cell biology is how the general intracellular transport machinery is adapted to perform specialized functions in polarized cells such as…”
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Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome by De Pace, Raffaella, Skirzewski, Miguel, Damme, Markus, Mattera, Rafael, Mercurio, Jeffrey, Foster, Arianne M, Cuitino, Loreto, Jarnik, Michal, Hoffmann, Victoria, Morris, H Douglas, Han, Tae-Un, Mancini, Grazia M S, Buonanno, Andrés, Bonifacino, Juan S

“…The hereditary spastic paraplegias (HSP) are a clinically and genetically heterogeneous group of disorders characterized by progressive lower limb spasticity…”
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Intrathecal AAV9/AP4M1 gene therapy for hereditary spastic paraplegia 50 shows safety and efficacy in preclinical studies by Chen, Xin, Dong, Thomas, Hu, Yuhui, De Pace, Raffaella, Mattera, Rafael, Eberhardt, Kathrin, Ziegler, Marvin, Pirovolakis, Terry, Sahin, Mustafa, Bonifacino, Juan S, Ebrahimi-Fakhari, Darius, Gray, Steven J

“…Spastic paraplegia 50 (SPG50) is an ultrarare childhood-onset neurological disorder caused by biallelic loss-of-function variants in the AP4M1 gene. SPG50 is…”
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The Clathrin Adaptor AP-1A Mediates Basolateral Polarity by Gravotta, Diego, Carvajal-Gonzalez, Jose Maria, Mattera, Rafael, Deborde, Sylvie, Banfelder, Jason R., Bonifacino, Juan S., Rodriguez-Boulan, Enrique

“…Clathrin and the epithelial-specific clathrin adaptor AP-1B mediate basolateral trafficking in epithelia. However, several epithelia lack AP-1B, and mice…”
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Conservation and Diversification of Dileucine Signal Recognition by Adaptor Protein (AP) Complex Variants by Mattera, Rafael, Boehm, Markus, Chaudhuri, Rittik, Prabhu, Yogikala, Bonifacino, Juan S.

“…The clathrin-associated, heterotetrameric adaptor protein (AP) complexes, AP-1, AP-2, and AP-3, recognize signals in the cytosolic domains of transmembrane…”
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The Adaptor Protein-1 μ1B Subunit Expands the Repertoire of Basolateral Sorting Signal Recognition in Epithelial Cells by Guo, Xiaoli, Mattera, Rafael, Ren, Xuefeng, Chen, Yu, Retamal, Claudio, González, Alfonso, Bonifacino, Juan S.

“…An outstanding question in protein sorting is why polarized epithelial cells express two isoforms of the μ1 subunit of the AP-1 clathrin adaptor complex: the…”
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Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes by Mattera, Rafael, Bonifacino, Juan S

“…Rab GTPases and ubiquitination are critical regulators of transmembrane cargo sorting in endocytic and lysosomal targeting pathways. The endosomal protein…”
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Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXΦ motif with the clathrin adaptors AP-1A and AP-1B by Carvajal-Gonzalez, Jose Maria, Gravotta, Diego, Mattera, Rafael, Diaz, Fernando, Perez Bay, Andres, Roman, Angel C, Schreiner, Ryan P, Thuenauer, Roland, Bonifacino, Juan S, Rodriguez-Boulan, Enrique

“…The coxsackie and adenovirus receptor (CAR) plays key roles in epithelial barrier function at the tight junction, a localization guided in part by a…”
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Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5 by Hurley, James H, Lee, Sangho, Tsai, Yien Che, Mattera, Rafael, Smith, William J, Kostelansky, Michael S, Weissman, Allan M, Bonifacino, Juan S

“…Rabex-5 is an exchange factor for Rab5, a master regulator of endosomal trafficking. Rabex-5 binds monoubiquitin, undergoes covalent ubiquitination and…”
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Co-assembly of viral envelope glycoproteins regulates their polarized sorting in neurons by Mattera, Rafael, Farías, Ginny G, Mardones, Gonzalo A, Bonifacino, Juan S

“…Newly synthesized envelope glycoproteins of neuroinvasive viruses can be sorted in a polarized manner to the somatodendritic and/or axonal domains of neurons…”
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Human Immunodeficiency Virus Type 1 Nef Protein Targets CD4 to the Multivesicular Body Pathway by DASILVA, Luis L. P, SOUGRAT, Rachid, BURGOS, Patricia V, JANVIER, Katy, MATTERA, Rafael, BONIFACINO, Juan S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Basic Patch on α-Adaptin Is Required for Binding of Human Immunodeficiency Virus Type 1 Nef and Cooperative Assembly of a CD4-Nef-AP-2 Complex by CHAUDHURI, Rittik, MATTERA, Rafael, WOLF LINDWASSER, O, ROBINSON, Margaret S, BONIFACINO, Juan S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Rab5 Guanine Nucleotide Exchange Factor Rabex-5 Binds Ubiquitin (Ub) and Functions as a Ub Ligase through an Atypical Ub-interacting Motif and a Zinc Finger Domain by Mattera, Rafael, Tsai, Yien Che, Weissman, Allan M., Bonifacino, Juan S.

“…Rabex-5, the mammalian orthologue of yeast Vps9p, is a guanine nucleotide exchange factor for Rab5. Rabex-5 forms a tight complex with Rabaptin-5, a…”
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Structural Mechanism for Ubiquitinated-Cargo Recognition by the Golgi-Localized, γ-Ear-Containing, ADP-Ribosylation-Factor-Binding Proteins by Prag, Gali, Lee, Sangho, Mattera, Rafael, Arighi, Cecilia N., Beach, Bridgette M., Bonifacino, Juan S., Hurley, James H., Davies, David R.

“…The Golgi-localized, γ-ear-containing, Arf (ADP-ribosylation factor)-binding (GGA) proteins are clathrin adaptors that mediate the sorting of…”
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Epidermal Growth Factor-Dependent Phosphorylation of the GGA3 Adaptor Protein Regulates Its Recruitment to Membranes by Kametaka, Satoshi, Mattera, Rafael, Bonifacino, Juan S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Trihelical Bundle Subdomain of the GGA Proteins Interacts with Multiple Partners through Overlapping but Distinct Sites by Mattera, Rafael, Puertollano, Rosa, Smith, William J, Bonifacino, Juan S

“…The Golgi-localized, γ-adaptin ear-containing, ARF-binding (GGA) proteins are monomeric clathrin adaptors that mediate the sorting of cargo at the trans…”
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AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation by Mattera, Rafael, Park, Sang Yoon, De Pace, Raffaella, Guardia, Carlos M., Bonifacino, Juan S.

“…AP-4 is a member of the heterotetrameric adaptor protein (AP) complex family involved in protein sorting in the endomembrane system of eukaryotic cells…”
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Neuronal functions of adaptor complexes involved in protein sorting by Guardia, Carlos M, De Pace, Raffaella, Mattera, Rafael, Bonifacino, Juan S

“…•AP complexes mediate intracellular sorting of transmembrane proteins.•Although present in all cells, AP complexes have specialized functions in…”
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The adaptor protein chaperone AAGAB stabilizes AP-4 complex subunits by Mattera, Rafael, De Pace, Raffaella, Bonifacino, Juan S

“…Adaptor protein 4 (AP-4) is a heterotetrameric complex composed of ε, β4, μ4, and σ4 subunits that mediates export of a subset of transmembrane cargos,…”
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RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery by Guardia, Carlos M, Jain, Akansha, Mattera, Rafael, Friefeld, Alex, Li, Yan, Bonifacino, Juan S

“…Autophagy-related protein 9 (ATG9) is a transmembrane protein component of the autophagy machinery that cycles between the -Golgi network (TGN) in the…”
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