Search Results - "MATSUNO, Kenji"

Cell chirality: its origin and roles in left–right asymmetric development by Inaki, Mikiko, Liu, Jingyang, Matsuno, Kenji

“…An item is chiral if it cannot be superimposed on its mirror image. Most biological molecules are chiral. The homochirality of amino acids ensures that…”
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Live imaging of delamination in Drosophila shows epithelial cell motility and invasiveness are independently regulated by Inaki, Mikiko, Vishnu, Smitha, Matsuno, Kenji

“…Delaminating cells undergo complex, precisely regulated changes in cell–cell adhesion, motility, polarity, invasiveness, and other cellular properties…”
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High-Precision Calorimetry-Based Analysis of Pupal-Pharate Adult Development in Drosophila melanogaster by Nagano, Yatsuhisa, Inaki, Mikiko, Matsuno, Kenji

“…In holometabolous insects, the larval body is almost completely decomposed and reconstructed into the adult body during the pupal-pharate adult stages…”
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Chirality in Planar Cell Shape Contributes to Left-Right Asymmetric Epithelial Morphogenesis by Taniguchi, Kiichiro, Maeda, Reo, Ando, Tadashi, Okumura, Takashi, Nakazawa, Naotaka, Hatori, Ryo, Nakamura, Mitsutoshi, Hozumi, Shunya, Fujiwara, Hiroo, Matsuno, Kenji

“…Some organs in animals display left-right (LR) asymmetry. To better understand LR asymmetric morphogenesis in Drosophila, we studied LR directional rotation of…”
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Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-( p -tolyl)pyridin-3-yl]benzonitrile by Niwa, Hideaki, Sato, Shin, Hashimoto, Tomoko, Matsuno, Kenji, Umehara, Takashi

“…Because lysine-specific demethylase 1 (LSD1) regulates the maintenance of cancer stem cell properties, small-molecule inhibitors of LSD1 are expected to be…”
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Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation by Sawada, Jun-ichi, Matsuno, Kenji, Ogo, Naohisa, Asai, Akira

“…[Display omitted] Kinesin-5 has received considerable attention as a new target for mitosis. Various small-molecule compounds targeting kinesin-5 have been…”
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Antiapoptotic activity of methyl (3R,4E,6Z,15E)-3-hydroxyoctadecatrienoate in human cervical carcinoma HeLa cells by Ohno, Osamu, Sato, Keigo, Honma, Ryo, Chiba, Ruri, Matsuno, Kenji

“…Inhibitors of thapsigargin-induced cell death in human cervical carcinoma HeLa cells were screened among the metabolites of marine organisms. The MeOH extract…”
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Inhibitory effects of biseokeaniamide A against lipopolysaccharide-induced signal transduction by Ohno, Osamu, Terasaki, Takuro, Sano, Takuya, Hitomi, Yuki, Miyamoto, Junichiro, Matsuno, Kenji

“…[Display omitted] Lipopolysaccharides (LPS) are associated with various inflammatory diseases; therefore, the inhibition of LPS-induced nitric oxide (NO)…”
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Chiral cell sliding drives left-right asymmetric organ twisting by Inaki, Mikiko, Hatori, Ryo, Nakazawa, Naotaka, Okumura, Takashi, Ishibashi, Tomoki, Kikuta, Junichi, Ishii, Masaru, Matsuno, Kenji, Honda, Hisao

“…Polarized epithelial morphogenesis is an essential process in animal development. While this process is mostly attributed to directional cell intercalation, it…”
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Proper direction of male genitalia is prerequisite for copulation in Drosophila, implying cooperative evolution between genitalia rotation and mating behavior by Inatomi, Momoko, Shin, Dongsun, Lai, Yi-Ting, Matsuno, Kenji

“…Animal morphology and behavior often appear to evolve cooperatively. However, it is difficult to assess how strictly these two traits depend on each other. The…”
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Collective nuclear behavior shapes bilateral nuclear symmetry for subsequent left-right asymmetric morphogenesis in Drosophila by Shin, Dongsun, Nakamura, Mitsutoshi, Morishita, Yoshitaka, Eiraku, Mototsugu, Yamakawa, Tomoko, Sasamura, Takeshi, Akiyama, Masakazu, Inaki, Mikiko, Matsuno, Kenji

“…ABSTRACT Proper organ development often requires nuclei to move to a specific position within the cell. To determine how nuclear positioning affects left-right…”
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Acylative Coupling of Amine and Indole Using Chloroform as a Carbonyl Group by Nishida, Yuika, Takeda, Norihiko, Matsuno, Kenji, Miyata, Okiko, Ueda, Masafumi

“…Chloroform‐mediated acylative coupling of amines with indoles has been developed. When indoles and amines in chloroform were treated with dimethylzinc in the…”
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Cell Chirality Drives Left-Right Asymmetric Morphogenesis by Inaki, Mikiko, Sasamura, Takeshi, Matsuno, Kenji

“…Most macromolecules found in cells are chiral, meaning that they cannot be superimposed onto their mirror image. However, cells themselves can also be chiral,…”
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Notch Signalling Under Maternal-to-Zygotic Transition by Yamakawa, Tomoko, Yuslimatin Mujizah, Elzava, Matsuno, Kenji

“…The development of all animal embryos is initially directed by the gene products supplied by their mothers. With the progression of embryogenesis, the embryo's…”
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Inhibition of Lipopolysaccharide-Induced Inflammatory Signaling by Soft Coral-Derived Prostaglandin A2 in RAW264.7 Cells by Ohno, Osamu, Mizuno, Eika, Miyamoto, Junichiro, Hoshina, Tomoyuki, Sano, Takuya, Matsuno, Kenji

“…Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria and causes inflammatory diseases. We searched MeOH extracts of…”
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TM2D3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors by Masuda, Wataru, Yamakawa, Tomoko, Ajima, Rieko, Miyake, Katsuya, Umemiya, Toshifumi, Azuma, Kazuhiko, Tamaru, Jun-ichi, Kiso, Makoto, Das, Puspa, Saga, Yumiko, Matsuno, Kenji, Kitagawa, Motoo

“…Notch signaling is an evolutionarily conserved mechanism required for numerous types of cell fate decisions in metazoans. It mediates short-range communication…”
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E and ID proteins regulate cell chirality and left–right asymmetric development in Drosophila by Ishibashi, Tomoki, Hatori, Ryo, Maeda, Reo, Nakamura, Mitsutoshi, Taguchi, Tomohiro, Matsuyama, Yoko, Matsuno, Kenji

“…How left–right (LR) asymmetric forms in the animal body is a fundamental problem in Developmental Biology. Although the mechanisms for LR asymmetry are well…”
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Statistical Validation Verifies That Enantiomorphic States of Chiral Cells Are Determinant Dictating the Left- or Right-Handed Direction of the Hindgut Rotation in Drosophila by Ishibashi, Tomoki, Inaki, Mikiko, Matsuno, Kenji

“…In the left–right (LR) asymmetric development of invertebrates, cell chirality is crucial. A left- or right-handed cell structure directs morphogenesis with…”
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Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands by Beniyama, Yoko, Matsuno, Kenji, Miyachi, Hiroyuki

“…In order to create FABP3 ligands, a new series of pyrazole-based carboxylic acids were designed and synthesized based on the X-ray crystallographic result of…”
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Selective Inhibition of Spindle Microtubules by a Tubulin-Binding Quinazoline Derivative by Sawada, Jun-Ichi, Ishii, Hirosuke, Matsuno, Kenji, Sato, Masayuki, Suzuki, Yumiko, Asai, Akira

“…In the research field of tubulin-binding agents for the development of anticancer agents, hidden targets are emerging as a problem in understanding the exact…”
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