Search Results - "MATSUKUMA, Shoichi"

The associations between RAS mutations and clinical characteristics in follicular thyroid tumors: new insights from a single center and a large patient cohort by Fukahori, Michiko, Yoshida, Akira, Hayashi, Hiroyuki, Yoshihara, Mitsuyo, Matsukuma, Shoichi, Sakuma, Yuji, Koizume, Shiro, Okamoto, Naoyuki, Kondo, Tetsuo, Masuda, Munetake, Miyagi, Yohei

“…Many studies on thyroid follicular tumors have reported the presence of somatic mutations to three forms of RAS: HRAS, KRAS, and NRAS. However, the frequency…”
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Assessment of epidermal growth factor receptor mutation by endobronchial ultrasound-guided transbronchial needle aspiration by Nakajima, Takahiro, Yasufuku, Kazuhiro, Suzuki, Makoto, Hiroshima, Kenzo, Kubo, Rieko, Mohammed, Sherif, Miyagi, Yohei, Matsukuma, Shoichi, Sekine, Yasuo, Fujisawa, Takehiko

“…The presence of somatic mutations in epidermal growth factor receptor (EGFR) predicts the effectiveness of EGFR tyrosine kinase inhibitors (TKIs). It would be…”
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Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells by Sakuma, Yuji, Matsukuma, Shoichi, Nakamura, Yoshiyasu, Yoshihara, Mitsuyo, Koizume, Shiro, Sekiguchi, Hironobu, Saito, Haruhiro, Nakayama, Haruhiko, Kameda, Yoichi, Yokose, Tomoyuki, Oguni, Sachiko, Niki, Toshiro, Miyagi, Yohei

“…Lung cancers harboring epidermal growth factor receptor ( EGFR ) mutations depend on constitutive activation of the kinase for survival. Although most EGFR…”
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WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors by Sakuma, Yuji, Yamazaki, Yukiko, Nakamura, Yoshiyasu, Yoshihara, Mitsuyo, Matsukuma, Shoichi, Nakayama, Haruhiko, Yokose, Tomoyuki, Kameda, Yoichi, Koizume, Shiro, Miyagi, Yohei

“…Src has a role in the anoikis resistance in lung adenocarcinomas. We focused on two epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma cell…”
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Clonality analysis performed using human androgen receptor assay in a rare case of undifferentiated thymic carcinoma coexisting with type AB thymoma by Karino, Fumi, Yokose, Tomoyuki, Matsukuma, Shoichi, Miyagi, Yohei, Murakami, Shuji, Ito, Hiroyuki, Nakayama, Haruhiko, Yamada, Kouzo

“…We report a very rare case of combined thymic carcinomas: undifferentiated thymic carcinoma coexisting with type AB thymoma. The precise mechanism underlying…”
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Prognostic value of EGFR mutations in surgically resected pathological stage I lung adenocarcinoma by Nishii, Teppei, Yokose, Tomoyuki, Miyagi, Yohei, Daigo, Yataro, Isaka, Tetsuya, Furumoto, Hideyuki, Ito, Hiroyuki, Murakami, Shuji, Kondo, Tetsuro, Saito, Haruhiro, Oshita, Fumihiro, Yamada, Kouzo, Matsukuma, Shoichi, Nakayama, Haruhiko, Masuda, Munetaka

“…Aim With the advent of the molecular‐targeted therapy, rapid progress has been made in the treatment of advanced or recurrent non‐small‐cell lung cancer…”
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Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing phosphorylated Src by Sakuma, Yuji, Takeuchi, Tomoyo, Nakamura, Yoshiyasu, Yoshihara, Mitsuyo, Matsukuma, Shoichi, Nakayama, Haruhiko, Ohgane, Naoki, Yokose, Tomoyuki, Kameda, Yoichi, Tsuchiya, Eiju, Miyagi, Yohei

“…The ability to resist anoikis is critical for carcinoma cells to metastasize. Although several lung adenocarcinoma cell lines were shown to repress anoikis…”
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Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung by Sakuma, Yuji, Matsukuma, Shoichi, Yoshihara, Mitsuyo, Nakamura, Yoshiyasu, Nakayama, Haruhiko, Kameda, Yoichi, Tsuchiya, Eiju, Miyagi, Yohei

“…Activating epidermal growth factor receptor (EGFR) gene mutations are frequently detected in lung adenocarcinomas, especially adenocarcinomas with a…”
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Identification of colorectal cancer patients with tumors carrying the TP53 mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy by Godai, Ten-i, Suda, Tetsuji, Sugano, Nobuhiro, Tsuchida, Kazuhito, Shiozawa, Manabu, Sekiguchi, Hironobu, Sekiyama, Akiko, Yoshihara, Mitsuyo, Matsukuma, Shoichi, Sakuma, Yuji, Tsuchiya, Eiju, Kameda, Yoichi, Akaike, Makoto, Miyagi, Yohei

“…Although postoperative chemotherapy is widely accepted as the standard modality for Dukes' stage C or earlier stage colorectal cancer (CRC) patients,…”
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Rapid and Simple Detection of Hot Spot Point Mutations of Epidermal Growth Factor Receptor, BRAF, and NRAS in Cancers Using the Loop-Hybrid Mobility Shift Assay by Matsukuma, Shoichi, Yoshihara, Mitsuyo, Kasai, Fumio, Kato, Akinori, Yoshida, Akira, Akaike, Makoto, Kobayashi, Osamu, Nakayama, Haruhiko, Sakuma, Yuji, Yoshida, Tsutomu, Kameda, Yoichi, Tsuchiya, Eiju, Miyagi, Yohei

“…A simple and rapid method to detect the epidermal growth factor receptor hot spot mutation L858R in lung adenocarcinoma was developed based on principles…”
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Co-localization of Trax and Mea2 in Golgi Complex of Pachytene Spermatocytes in the Mouse by Matsuda, Miyuki, Kondo, Masaaki, Kashiwabara, Shin-ichi, Yoshihara, Mitsuyo, Sutou, Shizuyo, Matsukuma, Shoichi

“…A golgin family protein, Mea2, is expressed at enhanced level in pachytene spermatocytes and is indispensable for mouse spermatogenesis. Because Trax was shown…”
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Golgi matrix protein gene, Golga3/Mea2, rearranged and re-expressed in pachytene spermatocytes restores spermatogenesis in the mouse by Banu, Yasmin, Matsuda, Miyuki, Yoshihara, Mitsuyo, Kondo, Masaaki, Sutou, Sizuyo, Matsukuma, Shoichi

“…In a transgenic mouse, Golga3/Mea2 gene (human homolog: GOLGA3/golgin‐160) was disrupted by a translocation at the site of the transgene integration. Exons…”
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Expression of erythropoietin messenger ribonucleic acid in wild-type MED12 uterine leiomyomas under estrogenic influence: new insights into related growth disparities by Asano, Ryoko, Asai-Sato, Mikiko, Matsukuma, Shoichi, Mizushima, Taichi, Taguri, Masataka, Yoshihara, Mitsuyo, Inada, Mae, Fukui, Atsuko, Suzuki, Yukio, Miyagi, Yohei, Miyagi, Etsuko

“…To determine factors that impact erythropoietin (EPO) production in leiomyomas. We have previously implicated EPO production in promoting the growth of some…”
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Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas : Confirmation of the correlations with histologic subtypes and gene mutations by SAKUMA, Yuji, MATSUKUMA, Shoichi, YOSHIHARA, Mitsuyo, NAKAMURA, Yoshiyasu, NODA, Kazumasa, NAKAYAMA, Haruhiko, KAMEDA, Yoichi, TSUCHIYA, Eiju, MIYAGI, Yohei

“…Although adenocarcinomas of the lung are associated with epidermal growth factor receptor (EGFR) gene mutations and sensitivity to EGFR tyrosine kinase…”
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NF-κB signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells by Sakuma, Yuji, Yamazaki, Yukiko, Nakamura, Yoshiyasu, Yoshihara, Mitsuyo, Matsukuma, Shoichi, Koizume, Shiro, Miyagi, Yohei

“…► EGFR-mutant cells in 3D culture resist EGFR inhibition compared with suspended cells. ► Degradation of IκB and activation of NF-κB are observed in…”
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Clinicopathological features and EGFR gene mutation status in elderly patients with resected non-small-cell lung cancer by Nishii, Teppei, Yokose, Tomoyuki, Miyagi, Yohei, Daigo, Yataro, Ito, Hiroyuki, Isaka, Tetsuya, Imai, Kentaro, Murakami, Shuji, Kondo, Tetsuro, Saito, Haruhiro, Oshita, Fumihiro, Yamada, Kouzo, Matsukuma, Shoichi, Tsuboi, Masahiro, Nakayama, Haruhiko, Masuda, Munetaka

“…The rapid aging of the population in Japan has been accompanied by an increased rate of surgery for lung cancer among elderly patients. It is thus an urgent…”
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NF-{kappa}B signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells by Sakuma, Yuji, Yamazaki, Yukiko, Nakamura, Yoshiyasu, Yoshihara, Mitsuyo, Matsukuma, Shoichi, Koizume, Shiro, Miyagi, Yohei

“…Highlights: Black-Right-Pointing-Pointer EGFR-mutant cells in 3D culture resist EGFR inhibition compared with suspended cells. Black-Right-Pointing-Pointer…”
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ABT-263, a Bcl-2 inhibitor, enhances the susceptibility of lung adenocarcinoma cells treated with Src inhibitors to anoikis by SAKUMA, Yuji, TSUNEZUMI, Jun, NAKAMURA, Yoshiyasu, YOSHIHARA, Mitsuyo, MATSUKUMA, Shoichi, KOIZUME, Shiro, MIYAGI, Yohei

“…The tyrosine kinase Src plays an important role in the development of anoikis resistance in lung adenocarcinomas. Several suspension lung adenocarcinoma cell…”
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Differential detection of KRAS mutations in codons 12 and 13 with a modified loop-hybrid (LH) mobility shift assay using an insert-type LH-generator by Matsukuma, Shoichi, Yoshihara, Mitsuyo, Suda, Tetsuji, Shiozawa, Manabu, Akaike, Makoto, Ishikawa, Tomokazu, Koizume, Shiro, Sakuma, Yuji, Miyagi, Yohei

“…The loop-hybrid mobility shift assay (LH-MSA) was previously developed for the rapid detection of the EGFR mutation L858R for predicting clinical responses to…”
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Simple and precise detection of UGT1A1 polymorphisms with a modified loop-hybrid mobility shift assay using Cy5-labeled loop probes by Matsukuma, Shoichi, Saito, Haruhiro, Yamada, Kozo, Okamoto, Naoyuki, Ishikawa, Tomokazu, Yoshihara, Mitsuyo, Koizume, Shiro, Sakuma, Yuji, Miyagi, Yohei

“…Irinotecan, an inhibitor of topoisomerase I, has been widely used as an important anti-cancer therapeutic drug. Deleterious effects of the drug in…”
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