Search Results - "MATSUKI, Yasushi"

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells by Kosaka, Nobuyoshi, Iguchi, Haruhisa, Yoshioka, Yusuke, Takeshita, Fumitaka, Matsuki, Yasushi, Ochiya, Takahiro

“…The existence of circulating microRNAs (miRNAs) in the blood of cancer patients has raised the possibility that miRNAs may serve as a novel diagnostic marker…”
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FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets by Nishino, Naonobu, Tamori, Yoshikazu, Tateya, Sanshiro, Kawaguchi, Takayuki, Shibakusa, Tetsuro, Mizunoya, Wataru, Inoue, Kazuo, Kitazawa, Riko, Kitazawa, Sohei, Matsuki, Yasushi, Hiramatsu, Ryuji, Masubuchi, Satoru, Omachi, Asako, Kimura, Kazuhiro, Saito, Masayuki, Amo, Taku, Ohta, Shigeo, Yamaguchi, Tomohiro, Osumi, Takashi, Cheng, Jinglei, Fujimoto, Toyoshi, Nakao, Harumi, Nakao, Kazuki, Aiba, Atsu, Okamura, Hitoshi, Fushiki, Tohru, Kasuga, Masato

“…White adipocytes are unique in that they contain large unilocular lipid droplets that occupy most of the cytoplasm. To identify genes involved in the…”
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Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex by NAKATSUKA, Atsuko, WADA, Jun, HIDA, Kazuyuki, EGUCHI, Jun, HORIGUCHI, Chikage Sato, OGAWA, Daisuke, MATSUKI, Yasushi, HIRAMATSU, Ryuji, YAGITA, Hideo, KAKUTA, Shigeru, IWAKURA, Yoichiro, MAKINO, Hirofumi, ISEDA, Izumi, TESHIGAWARA, Sanae, HIGASHIO, Kanji, MURAKAMI, Kazutoshi, KANZAKI, Motoko, INOUE, Kentaro, TERAMI, Takahiro, KATAYAMA, Akihiro

“…It is unknown whether adipokines derived from adipose tissues modulate endoplasmic reticulum (ER) stress induced in obesity. Here, we show that visceral…”
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Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity by Hida, K, Wada, J, Eguchi, J, Zhang, H, Baba, M, Seida, A, Hashimoto, I, Okada, T, Yasuhara, A, Nakatsuka, A

“…There is a rapid global rise in obesity, and the link between obesity and diabetes remains somewhat obscure. We identified an adipocytokine, designated as…”
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Identification of novel targets for antiangiogenic therapy by comparing the gene expressions of tumor and normal endothelial cells by Otsubo, Tsuguteru, Hida, Yasuhiro, Ohga, Noritaka, Sato, Hideshi, Kai, Toshihiro, Matsuki, Yasushi, Takasu, Hideo, Akiyama, Kosuke, Maishi, Nako, Kawamoto, Taisuke, Shinohara, Nobuo, Nonomura, Katsuya, Hida, Kyoko

“…Targeting tumor angiogenesis is an established strategy for cancer therapy. Because angiogenesis is not limited to pathological conditions such as cancer,…”
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Visceral Adipose Tissue-derived Serine Proteinase Inhibitor Inhibits Apoptosis of Endothelial Cells as a Ligand for the Cell-Surface GRP78/Voltage-dependent Anion Channel Complex by Nakatsuka, Atsuko, Wada, Jun, Iseda, Izumi, Teshigawara, Sanae, Higashio, Kanji, Murakami, Kazutoshi, Kanzaki, Motoko, Inoue, Kentaro, Terami, Takahiro, Katayama, Akihiro, Hida, Kazuyuki, Eguchi, Jun, Ogawa, Daisuke, Matsuki, Yasushi, Hiramatsu, Ryuji, Yagita, Hideo, Kakuta, Shigeru, Iwakura, Yoichiro, Makino, Hirofumi

“…RATIONALE:Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified from visceral adipose tissues of genetically obese…”
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Role of KLF15 in Regulation of Hepatic Gluconeogenesis and Metformin Action by TAKASHIMA, Mototsugu, OGAWA, Wataru, MATSUKI, Yasushi, WATANABE, Eijiro, HIRAMATSU, Ryuji, KASUGA, Masato, HAYASHI, Kumiko, INOUE, Hiroshi, KINOSHITA, Shinichi, OKAMOTO, Yasuo, SAKAUE, Hiroshi, WATAOKA, Yu, EMI, Aki, SENGA, Yoko

“…An increase in the rate of gluconeogenesis is largely responsible for the hyperglycemia in individuals with type 2 diabetes, with the antidiabetes action of…”
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In vitro human colon microbiota culture model for drug research by Shintani, Tomoya, Sasaki, Daisuke, Matsuki, Yasushi, Kondo, Akihiko

“…•Microbiota shapes human health, influenced by diet and habits.•Challenges in animal studies drive development of in vitro models.•Innovative KUHIMM reproduces…”
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Role of hepatic STAT3 in brain-insulin action on hepatic glucose production by Inoue, Hiroshi, Ogawa, Wataru, Asakawa, Akihiro, Okamoto, Yasuo, Nishizawa, Akihiko, Matsumoto, Michihiro, Teshigawara, Kiyoshi, Matsuki, Yasushi, Watanabe, Eijiro, Hiramatsu, Ryuji, Notohara, Kenji, Katayose, Koji, Okamura, Hitoshi, Kahn, C. Ronald, Noda, Tetsuo, Takeda, Kiyoshi, Akira, Shizuo, Inui, Akio, Kasuga, Masato

“…STAT3 regulates glucose homeostasis by suppressing the expression of gluconeogenic genes in the liver. The mechanism by which hepatic STAT3 is regulated by…”
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Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced Insulin Secretion by Nagare, Tomoki, Sakaue, Hiroshi, Matsumoto, Michihiro, Cao, Yongheng, Inagaki, Kenjiro, Sakai, Mashito, Takashima, Yasuhiro, Nakamura, Kyoko, Mori, Toshiyuki, Okada, Yuko, Matsuki, Yasushi, Watanabe, Eijiro, Ikeda, Kazutaka, Taguchi, Ryo, Kamimura, Naomi, Ohta, Shigeo, Hiramatsu, Ryuji, Kasuga, Masato

“…Krüppel-like factor 15 (KLF15), a member of the Krüppel-like factor family of transcription factors, has been found to play diverse roles in adipocytes in…”
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Skp2 Controls Adipocyte Proliferation during the Development of Obesity by Sakai, Tamon, Sakaue, Hiroshi, Nakamura, Takehiro, Okada, Mitsuru, Matsuki, Yasushi, Watanabe, Eijiro, Hiramatsu, Ryuji, Nakayama, Keiko, Nakayama, Keiichi I., Kasuga, Masato

“…The increase in the mass of adipose tissue during the development of obesity can arise through an increase in cell size, an increase in cell number, or both…”
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Role of Krüppel-like factor 15 in PEPCK gene expression in the liver by Teshigawara, Kiyoshi, Ogawa, Wataru, Mori, Toshiyuki, Matsuki, Yasushi, Watanabe, Eijiro, Hiramatsu, Ryuji, Inoue, Hiroshi, Miyake, Kazuaki, Sakaue, Hiroshi, Kasuga, Masato

“…Regulation of hepatic gene expression is important for energy homeostasis. We now show that hepatic expression of the gene for the transcription factor…”
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Muscle-Specific Overexpression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor Increases Peripheral Glucose Disposal and Insulin Sensitivity by Fukatsu, Yasuhide, Noguchi, Tetsuya, Hosooka, Tetsuya, Ogura, Takeshi, Kotani, Ko, Abe, Takaya, Shibakusa, Tetsuro, Inoue, Kazuo, Sakai, Mashito, Tobimatsu, Kazutoshi, Inagaki, Kenjiro, Yoshioka, Toyo, Matsuo, Masahiro, Nakae, Jun, Matsuki, Yasushi, Hiramatsu, Ryuji, Kaku, Kohei, Okamura, Hitoshi, Fushiki, Tohru, Kasuga, Masato

“…Physical exercise ameliorates metabolic disorders such as type 2 diabetes mellitus and obesity, but the molecular basis of these effects remains elusive. In…”
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Restoration of Glucokinase Expression in the Liver Normalizes Postprandial Glucose Disposal in Mice With Hepatic Deficiency of PDK1 by OKAMOTO, Yasuo, OGAWA, Wataru, NODA, Tetsuo, KASUGA, Masato, NISHIZAWA, Akihiko, INOUE, Hiroshi, TESHIGAWARA, Kiyoshi, KINOSHITA, Shinichi, MATSUKI, Yasushi, WATANABE, Eijiro, HIRAMATSU, Ryuji, SAKAUE, Hiroshi

“…Restoration of Glucokinase Expression in the Liver Normalizes Postprandial Glucose Disposal in Mice With Hepatic Deficiency of PDK1 Yasuo Okamoto 1 , Wataru…”
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The Krüppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes by Nagare, Tomoki, Sakaue, Hiroshi, Takashima, Mototsugu, Takahashi, Kazuhiro, Gomi, Hideyuki, Matsuki, Yasushi, Watanabe, Eijiro, Hiramatsu, Ryuji, Ogawa, Wataru, Kasuga, Masato

“…KLF15 (Krüppel-like factor 15) plays a key role in adipocyte differentiation and glucose transport in adipocytes through activation of its target genes. We…”
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Role of hepatic STAT3 in the regulation of lipid metabolism by Kinoshita, Shinichi, Ogawa, Wataru, Okamoto, Yasuo, Takashima, Mototsugu, Inoue, Hiroshi, Matsuki, Yasushi, Watanabe, Eijiro, Hiramatsu, Ryuji, Kasuga, Masato

“…Regulation of hepatic gene expression is largely responsible for the control of nutrient metabolism. We previously showed that the transcription factor STAT3…”
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Role of the E3 ubiquitin ligase gene related to anergy in lymphocytes in glucose and lipid metabolism in the liver by Nakamichi, Sachie, Senga, Yoko, Inoue, Hiroshi, Emi, Aki, Matsuki, Yasushi, Watanabe, Eijiro, Hiramatsu, Ryuji, Ogawa, Wataru, Kasuga, Masato

“…Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes. Whereas, the relevance of GRAIL to T lymphocyte…”
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PDK1 Regulates Cell Proliferation and Cell Cycle Progression through Control of Cyclin D1 and p27Kip1 Expression by Nakamura, Kyoko, Sakaue, Hiroshi, Nishizawa, Akihiko, Matsuki, Yasushi, Gomi, Hideyuki, Watanabe, Eijiro, Hiramatsua, Ryuji, Tamamori-Adachi, Mimi, Kitajima, Shigetaka, Noda, Tetsuo, Ogawa, Wataru, Kasuga, Masato

“…PDK1 (3-phosphoinositide-dependent protein kinase 1) is a key mediator of signaling by phosphoinositide 3-kinase. To gain insight into the physiological…”
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Abstract 4078: Enhanced anti-tumor activity through a combination of intravenous injectable TLR7 agonist, DSP-0509 and immune checkpoint inhibitors by Ota, Yosuke, Otsubo, Takeshi, Goto, Masashi, Matsuki, Yasushi

“…Abstract Toll-like receptors (TLRs) are a family of pattern-recognition receptors (PRR) that recognize pathogen-associated molecular patterns (PAMPs). TLR7 is…”
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Visfatin: A protein secreted by visceral fat that mimics the effects of insulin by Fukuhara, A, Matsuda, M, Nishizawa, M, Segawa, K, Tanaka, M, Kishimoto, K, Matsuki, Y, Murakami, M, Ichisaka, T, Murakami, H

“…Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin,…”
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