Search Results - "MATSUKAWA, AKIHIRO"

Role of Macrophages in Liver Fibrosis by Sun, Cuiming, Matsukawa, Akihiro

“…Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis…”
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In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1 by Shams, Raef, Matsukawa, Akihiro, Ochi, Yukari, Ito, Yoshihiro, Miyatake, Hideyuki

“…Cancer-specific metabolic alterations hyperactivate the kinase activity of the mammalian/mechanistic target of rapamycin (mTOR) for overcoming stressful…”
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Decreased miR-200b-3p in cancer cells leads to angiogenesis in HCC by enhancing endothelial ERG expression by Moh-Moh-Aung, Aye, Fujisawa, Masayoshi, Ito, Sachio, Katayama, Hiroshi, Ohara, Toshiaki, Ota, Yoko, Yoshimura, Teizo, Matsukawa, Akihiro

“…Transcription factor ERG (erythroblast transformation-specific (ETS)-related gene) is essential in endothelial differentiation and angiogenesis, in which…”
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Influence of the coronavirus disease 2019 pandemic on the post-graduate career paths of medical students: a cross-sectional study by Nishimura, Ayumu, Miyoshi, Tomoko, Otsuka, Fumio, Matsukawa, Akihiro

“…The World Health Organization first declared the coronavirus disease 2019 (COVID-19) pandemic in March 2020 and announced the end of the emergency in May 2023…”
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Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite by Matsuo, Kenya, Yoshihara, Kumiko, Nagaoka, Noriyuki, Makita, Yoji, Obika, Hideki, Okihara, Takumi, Matsukawa, Akihiro, Yoshida, Yasuhiro, Van Meerbeek, Bart

“…Long-term anti-bacterial effect is a desired ability of any dental material in combating tooth caries as one of the most common and widespread persistent…”
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SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes by Wang, Tianyi, Gao, Tong, Fujisawa, Masayoshi, Ohara, Toshiaki, Sakaguchi, Masakiyo, Yoshimura, Teizo, Matsukawa, Akihiro

“…Sprouty-related enabled/vasodilator-stimulated phosphoprotein homology 1 domain containing 2 (SPRED2) is an inhibitor of the mitogen-activated protein kinase…”
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Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin by Kawara, Akina, Mizuta, Ryo, Fujisawa, Masayoshi, Ito, Toshihiro, Li, Chunning, Nakamura, Kaoru, Sun, Cuiming, Kuwabara, Masaki, Kitabatake, Masahiro, Yoshimura, Teizo, Matsukawa, Akihiro

“…The mitogen-activated protein kinase (MAPK) pathways are involved in many cellular processes, including the development of fibrosis. Here, we examined the role…”
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Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways by Miyahara, Hiroyuki, Hasegawa, Kosei, Yashiro, Masato, Ohara, Toshiaki, Fujisawa, Masayoshi, Yoshimura, Teizo, Matsukawa, Akihiro, Tsukahara, Hirokazu

“…Under normal conditions, fasting results in decreased protein disulfide isomerase (PDI) activity and accumulation of unfolded proteins, leading to the…”
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Ovarian stromal cells as a source of cancer-associated fibroblasts in human epithelial ovarian cancer: A histopathological study by Fujisawa, Masayoshi, Moh-Moh-Aung, Aye, Zeng, Zheng, Yoshimura, Teizo, Wani, Yoji, Matsukawa, Akihiro

“…Fibroblasts are a major component of cancer tissue and known to contribute to cancer progression. However, it remains unknown whether they are derived from…”
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Author Correction: Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways by Miyahara, Hiroyuki, Hasegawa, Kosei, Yashiro, Masato, Ohara, Toshiaki, Fujisawa, Masayoshi, Yoshimura, Teizo, Matsukawa, Akihiro, Tsukahara, Hirokazu

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The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages by Carson, 4th, William F, Cavassani, Karen A, Soares, Elyara M, Hirai, Soichiro, Kittan, Nicolai A, Schaller, Matthew A, Scola, Melissa M, Joshi, Amrita, Matsukawa, Akihiro, Aronoff, David M, Johnson, Craig N, Dou, Yali, Gallagher, Katherine A, Kunkel, Steven L

“…Macrophages are critical immune cells for the clearance of microbial pathogens and cellular debris from peripheral tissues. Macrophage inflammatory responses…”
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SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells by Gao, Tong, Yang, Xu, Fujisawa, Masayoshi, Ohara, Toshiaki, Wang, Tianyi, Tomonobu, Nahoko, Sakaguchi, Masakiyo, Yoshimura, Teizo, Matsukawa, Akihiro

“…The downregulation of SPRED2, a negative regulator of the ERK1/2 pathway, was previously detected in human cancers; however, the biological consequence remains…”
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Utility of gastric biopsy in diagnosing IgG4‐related gastrointestinal disease by Uchino, Kaori, Notohara, Kenji, Uehara, Takeshi, Kuraishi, Yasuhiro, Itakura, Junya, Matsukawa, Akihiro

“…The utility of gastric biopsy for diagnosing immunoglobulin (Ig)G4‐related gastrointestinal disease (IgG4‐GID) remains unclear. Bottom‐heavy plasmacytosis…”
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Nanog is a promising chemoresistant stemness marker and therapeutic target by iron chelators for esophageal cancer by Narusaka, Toru, Ohara, Toshiaki, Noma, Kazuhiro, Nishiwaki, Noriyuki, Katsura, Yuki, Kato, Takuya, Sato, Hiroaki, Tomono, Yasuko, Kikuchi, Satoru, Tazawa, Hiroshi, Shirakawa, Yasuhiro, Matsukawa, Akihiro, Fujiwara, Toshiyoshi

“…Esophageal cancer is a disease showing poor prognosis. Although combination chemotherapy using cisplatin (CDDP) and 5‐fluorouracil is standard for unresectable…”
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Protective effects of anti-HMGB1 monoclonal antibody on lung ischemia reperfusion injury in mice by Nakata, Kentaro, Okazaki, Mikio, Shimizu, Dai, Suzawa, Ken, Shien, Kazuhiko, Miyoshi, Kentaroh, Otani, Shinji, Yamamoto, Hiromasa, Sugimoto, Seiichiro, Yamane, Masaomi, Ousaka, Daiki, Ohara, Toshiaki, Matsukawa, Akihiro, Nishibori, Masahiro, Toyooka, Shinichi

“…During ischemia reperfusion (IR) injury, high mobility group box 1 (HMGB1), a chromatin binding protein, is released from necrotic cells and triggers…”
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Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder by Oda, Shinsuke, Fujisawa, Masayoshi, Chunning, Li, Ito, Toshihiro, Yamaguchi, Takahiro, Yoshimura, Teizo, Matsukawa, Akihiro

“…Aberrant activation of the Ras/Raf/ERK (extracellular-signal-regulated kinase)-MAPK (mitogen-activated protein kinase) pathway is involved in the progression…”
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Abrogated Caveolin-1 expression via histone modification enzyme Setdb2 regulates brain edema in a mouse model of influenza-associated encephalopathy by Imakita, Natsuko, Kitabatake, Masahiro, Ouji-Sageshima, Noriko, Hara, Atsushi, Morita-Takemura, Shoko, Kasahara, Kei, Matsukawa, Akihiro, Wanaka, Akio, Mikasa, Keiichi, Ito, Toshihiro

“…Influenza-associated encephalopathy (IAE) is a serious complication that can follow influenza virus infection. Once a cytokine storm is induced during…”
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Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer by Li, Chunning, Yoshimura, Teizo, Tian, Miao, Wang, Yuze, Kondo, Takamasa, Yamamoto, Ken-Ichi, Fujisawa, Masayoshi, Ohara, Toshiaki, Sakaguchi, Masakiyo, Matsukawa, Akihiro

“…Background Patients with triple-negative breast cancer (TNBC) often have poorer prognosis than those with other subtypes because of its aggressive behaviors…”
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Spred2 Regulates High Fat Diet-Induced Adipose Tissue Inflammation, and Metabolic Abnormalities in Mice by Ohkura, Takahiro, Yoshimura, Teizo, Fujisawa, Masayoshi, Ohara, Toshiaki, Marutani, Rie, Usami, Kaya, Matsukawa, Akihiro

“…Chronic low-grade inflammation in visceral adipose tissues triggers the development of obesity-related insulin resistance, leading to the metabolic syndrome, a…”
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Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice by Nosaka, Nobuyuki, Yashiro, Masato, Yamada, Mutsuko, Fujii, Yosuke, Tsukahara, Hirokazu, Liu, Keyue, Nishibori, Masahiro, Matsukawa, Akihiro, Morishima, Tsuneo

“…Provision for the emergence of an influenza pandemic is an urgent issue. The discovery of a novel anti-influenza therapeutic approach would increase the…”
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