Search Results - "MATSOUKAS, John"

A Global Review on Short Peptides: Frontiers and Perspectives by Apostolopoulos, Vasso, Bojarska, Joanna, Chai, Tsun-Thai, Elnagdy, Sherif, Kaczmarek, Krzysztof, Matsoukas, John, New, Roger, Parang, Keykavous, Lopez, Octavio Paredes, Parhiz, Hamideh, Perera, Conrad O, Pickholz, Monica, Remko, Milan, Saviano, Michele, Skwarczynski, Mariusz, Tang, Yefeng, Wolf, Wojciech M, Yoshiya, Taku, Zabrocki, Janusz, Zielenkiewicz, Piotr, AlKhazindar, Maha, Barriga, Vanessa, Kelaidonis, Konstantinos, Sarasia, Elham Mousavinezhad, Toth, Istvan

“…Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with…”
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A methamphetamine vaccine using short monoamine and diamine peptide linkers and poly-mannose by Hossain, Md Kamal, Davidson, Majid, Feehan, Jack, Matsoukas, John M, Nurgali, Kulmira, Apostolopoulos, Vasso

“…[Display omitted] •Methamphetamine (METH) substance use disorder growing public health concern, however current treatments are limited and ineffective.•There…”
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Molecular Epidemiology of SARS-CoV-2: The Dominant Role of Arginine in Mutations and Infectivity by Ridgway, Harry, Ntallis, Charalampos, Chasapis, Christos T, Kelaidonis, Konstantinos, Matsoukas, Minos-Timotheos, Plotas, Panagiotis, Apostolopoulos, Vasso, Moore, Graham, Tsiodras, Sotirios, Paraskevis, Dimitrios, Mavromoustakos, Thomas, Matsoukas, John M

“…, , , , Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global challenge due to its ability to mutate into variants that spread more rapidly…”
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Computational and Enzymatic Studies of Sartans in SARS-CoV-2 Spike RBD-ACE2 Binding: The Role of Tetrazole and Perspectives as Antihypertensive and COVID-19 Therapeutics by Kelaidonis, Konstantinos, Ligielli, Irene, Letsios, Spiros, Vidali, Veroniki P, Mavromoustakos, Thomas, Vassilaki, Niki, Moore, Graham J, Hoffmann, Weronika, Węgrzyn, Katarzyna, Ridgway, Harry, Chasapis, Christos T, Matsoukas, John M

“…This study is an extension of current research into a novel class of synthetic antihypertensive drugs referred to as "bisartans", which are bis-alkylated…”
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Multiple Sclerosis: Immunopathology and Treatment Update by Dargahi, Narges, Katsara, Maria, Tselios, Theodore, Androutsou, Maria-Eleni, de Courten, Maximilian, Matsoukas, John, Apostolopoulos, Vasso

“…The treatment of multiple sclerosis (MS) has changed over the last 20 years. All immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still…”
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Smart therapies against global pandemics: A potential of short peptides by Apostolopoulos, Vasso, Bojarska, Joanna, Feehan, Jack, Matsoukas, John, Wolf, Wojciech

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Role of Angiotensin II in Cardiovascular Diseases: Introducing Bisartans as a Novel Therapy for Coronavirus 2019 by Swiderski, Jordan, Gadanec, Laura Kate, Apostolopoulos, Vasso, Moore, Graham J, Kelaidonis, Konstantinos, Matsoukas, John M, Zulli, Anthony

“…Cardiovascular diseases (CVDs) are the main contributors to global morbidity and mortality. Major pathogenic phenotypes of CVDs include the development of…”
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Understanding the Driving Forces That Trigger Mutations in SARS-CoV-2: Mutational Energetics and the Role of Arginine Blockers in COVID-19 Therapy by Ridgway, Harry, Chasapis, Christos T, Kelaidonis, Konstantinos, Ligielli, Irene, Moore, Graham J, Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Mavromoustakos, Thomas, Matsoukas, John M

“…SARS-CoV-2 is a global challenge due to its ability to mutate into variants that spread more rapidly than the wild-type virus. Because the molecular biology of…”
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Diminazene aceturate uses different pathways to induce relaxation in healthy and atherogenic blood vessels by Kate Gadanec, Laura, Qaradakhi, Tawar, Renee McSweeney, Kristen, Matsoukas, John M., Apostolopoulos, Vasso, Burrell, Louise M, Zulli, Anthony

“…[Display omitted] Diminazene aceturate (DIZE), a putative angiotensin-converting enzyme 2 (ACE2) activator, elicits relaxation in various animal models. This…”
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Streptococcus thermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice by Dargahi, Narges, Matsoukas, John, Apostolopoulos, Vasso

“…Probiotic bacteria have beneficial effects to the development and maintenance of a healthy microflora that subsequently has health benefits to humans. Some of…”
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From Angiotensin II to Cyclic Peptides and Angiotensin Receptor Blockers (ARBs): Perspectives of ARBs in COVID-19 Therapy by Matsoukas, John, Apostolopoulos, Vasso, Zulli, Anthony, Moore, Graham, Kelaidonis, Konstantinos, Moschovou, Kalliopi, Mavromoustakos, Thomas

“…The octapeptide hormone angiotensin II is one of the most studied peptides with the aim of designing and synthesizing non-peptide mimetics for oral…”
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Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System by Moore, Graham J., Ridgway, Harry, Kelaidonis, Konstantinos, Chasapis, Christos T., Ligielli, Irene, Mavromoustakos, Thomas, Bojarska, Joanna, Matsoukas, John M.

“…Angiotensin receptor blockers (ARBs) used in the treatment of hypertension and potentially in SARS-CoV-2 infection exhibit inverse agonist effects at…”
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Existence of Quantum Pharmacology in Sartans: Evidence in Isolated Rabbit Iliac Arteries by Gadanec, Laura Kate, Swiderski, Jordan, Apostolopoulos, Vasso, Kelaidonis, Kostantinos, Vidali, Veroniki P, Canko, Aleksander, Moore, Graham J, Matsoukas, John M, Zulli, Anthony

“…Quantum pharmacology introduces theoretical models to describe the possibility of ultra-high dilutions to produce biological effects, which may help to explain…”
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Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease by Ioannou, Marianna, Alissafi, Themis, Lazaridis, Iakovos, Deraos, George, Matsoukas, John, Gravanis, Achille, Mastorodemos, Vasileios, Plaitakis, Andreas, Sharpe, Arlene, Boumpas, Dimitrios, Verginis, Panayotis

“…There is a need in autoimmune diseases to uncover the mechanisms involved in the natural resolution of inflammation. In this article, we demonstrate that…”
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Structural Features Influencing the Bioactive Conformation of Angiotensin II and Angiotensin A: Relationship between Receptor Desensitization, Addiction, and the Blood-Brain Barrier by Moore, Graham J, Ridway, Harry, Gadanec, Laura Kate, Apostolopoulos, Vasso, Zulli, Anthony, Swiderski, Jordan, Kelaidonis, Konstantinos, Vidali, Veroniki P, Matsoukas, Minos-Timotheos, Chasapis, Christos T, Matsoukas, John M

“…The N-terminal portion of the octapeptide angiotensin II (DRVYIHPF; AngII), a vasopressor peptide that favorably binds to, and activates, AngII type 1 receptor…”
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Myelin Oligodendrocyte Glycoprotein (MOG)35-55 Mannan Conjugate Induces Human T-Cell Tolerance and Can Be Used as a Personalized Therapy for Multiple Sclerosis by Rodi, Maria, de Lastic, Anne-Lise, Panagoulias, Ioannis, Aggeletopoulou, Ioanna, Kelaidonis, Kostas, Matsoukas, John, Apostolopoulos, Vasso, Mouzaki, Athanasia

“…We have previously performed preclinical studies with the oxidized mannan-conjugated peptide MOG35-55 (OM-MOG35-55) in vivo (EAE mouse model) and in vitro…”
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New Advances in Short Peptides: Looking Forward by Apostolopoulos, Vasso, Bojarska, Joanna, Chai, Tsun-Thai, Feehan, Jack, Kaczmarek, Krzysztof, Matsoukas, John M, Paredes Lopez, Octavio, Saviano, Michele, Skwarczynski, Mariusz, Smith-Carpenter, Jillian, Venanzi, Mariano, Wolf, Wojciech M, Zielenkiewicz, Piotr, Ziora, Zyta M

“…It is beyond doubt that short peptides hold significant promise in bio-medicine, as the most versatile molecules, both structurally and functionally [...]…”
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Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2 by Ridgway, Harry, Moore, Graham J., Mavromoustakos, Thomas, Tsiodras, Sotirios, Ligielli, Irene, Kelaidonis, Konstantinos, Chasapis, Christos T., Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Petty, Russell, Karakasiliotis, Ioannis, Gorgoulis, Vassilis G., Matsoukas, John M.

“…Binding energies and dissociation constants of sartans bound to RBD/ACE2 complex. [Display omitted] The discovery and facile synthesis of a new class of…”
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Novel benzimidazole angiotensin receptor blockers with anti-SARS-CoV-2 activity equipotent to that of nirmatrelvir: computational and enzymatic studies by Ridgway, Harry, Moore, Graham J, Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Hoffmann, Weronika, Węgrzyn, Katarzyna, Vassilaki, Niki, Mpekoulis, George, Zouridakis, Marios, Giastas, Petros, Vidali, Veroniki P, Kelaidonis, Konstantinos, Matsoukas, Minos-Timotheos, Dimitriou, Marios, Mavromoustakos, Thomas, Tsiodras, Sotirios, Gorgoulis, Vassilis G, Karakasiliotis, Ioannis, Chasapis, Christos T, Matsoukas, John M

“…Hypertension worsens outcomes in SARS-CoV-2 patients. Sartans, a type of antihypertensive angiotensin receptor blocker-(ARB), reduce COVID-19 morbidity and…”
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Receptor Interactions of Angiotensin II and Angiotensin Receptor Blockers—Relevance to COVID-19 by Moore, Graham J., Pires, Jose M., Kelaidonis, Konstantinos, Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Matsoukas, John M.

“…Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates a tyrosinate anion for receptor activation. Energy…”
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