Search Results - "MATHISEN, P. M"

In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis by RUDICK, R. A, RANSOHOFF, R. M, LEE, J.-C, PEPPLER, R, YU, M, MATHISEN, P. M, TUOHY, V. K

“…Recombinant interferon beta (IFNbeta) benefits patients with relapsing remitting multiple sclerosis (MS), but the mechanisms of action are unknown. We studied…”
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Identification of an Embryonic Isoform of Myelin Basic Protein That is Expressed Widely in the Mouse Embryo by Mathisen, Peter M., Pease, Stephanie, Garvey, Justine, Hood, Leroy, Readhead, Carol

“…We have identified a myelin basic protein (MBP) isoform in mouse embryos that includes an exon upstream of the usual transcription initiation site. This…”
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Thyroid hormone induces constitutive keratin gene expression during Xenopus laevis development by MATHISEN, P. M, MILLER, L

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pre-Emptive Targeting of the Epitope Spreading Cascade with Genetically Modified Regulatory T Cells During Autoimmune Demyelinating Disease by Yin, Ling, Yu, Min, Edling, Andrea E, Kawczak, Julie A, Mathisen, Peter M, Nanavati, Tania, Johnson, Justin M, Tuohy, Vincent K

“…Epitope spreading or endogenous self-priming has been implicated in mediating the progression of autoimmune disease. In the present study we created an…”
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Thyroid hormone induction of keratin genes: a two-step activation of gene expression during development by Mathisen, P M, Miller, L

“…To determine the mechanism of action of the thyroid hormone triiodothyronine (T3) during metamorphosis of the amphibian epidermis, we have investigated the…”
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Gene therapy in experimental autoimmune encephalomyelitis by MATHISEN, Peter M, TUOHY, Vincent K

“…Gene therapy traditionally has been associated with "gene replacement." where exogenous recombinant DNA is introduced ex vivo into somatic cells that are then…”
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Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells by Mathisen, P M, Yu, M, Johnson, J M, Drazba, J A, Tuohy, V K

“…The migratory properties of memory T cells provide a model vector system for site-specific delivery of therapeutic transgene factors to autoimmune inflammatory…”
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The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis by Tuohy, Vincent K., Yu, Min, Yin, Ling, Kawczak, Julie A., Johnson, Justin M., Mathisen, Peter M., Weinstock-Guttnnan, Bianca, Kinkel, R. Philip

“…We have made the following observations regarding self‐recognition during the development and progression of murine experimental autoimmune encephalomyelitis…”
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Gene discovery and validation for neurodegenerative diseases by Mathisen, Peter M

“…Treatment of neurodegenerative diseases, such as Alzheimer's disease, multiple sclerosis, Parkinson's disease and amyotrophic lateral sclerosis (ALS),…”
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Modulation of the IL-10/IL-12 cytokine circuit by interferon-β inhibits the development of epitope spreading and disease progression in murine autoimmune encephalomyelitis by Tuohy, Vincent K, Yu, Min, Yin, Ling, Mathisen, Peter M, Johnson, Justin M, Kawczak, Julie A

“…IFN-β has been shown to be effective in the treatment of multiple sclerosis (MS). However, the primary mechanism by which IFN-β mediates its therapeutic effect…”
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A comparison between haematological parameters in 'capillary' and venous blood from healthy adults by Daae, L N, Halvorsen, S, Mathisen, P M, Mironska, K

“…In 40 healthy adult volunteers of both sexes blood samples were taken simultaneously from an antecubital vein in EDTA-Vacutainers and from a fingertip in…”
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Visinin-like Protein (VILIP) Is a Neuron-specific Calcium-dependent Double-stranded RNA-binding Protein by Mathisen, Peter M., Johnson, Justin M., Kawczak, Julie A., Tuohy, Vincent K.

“…Double-stranded RNA-binding proteins function in regulating the stability, translation, and localization of specific mRNAs. In this study, we have demonstrated…”
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T cell design for therapy in autoimmune demyelinating disease by Tuohy, Vincent K, Mathisen, Peter M

“…It has become increasingly more evident that a considerable refinement of currently used reagents and conditions will be needed before an effective gene…”
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Developmental changes in keratin patterns during epidermal maturation by Ellison, Tami R., Mathisen, Peter M., Miller, Leo

“…The biochemical maturation of the epidermis of Xenopus laevis was examined through an identification of the keratins expressed at selected stages of…”
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Differential DM20 mRNA expression distinguishes two distinct patterns of spontaneous recovery from murine autoimmune encephalomyelitis by Mathisen, Peter M., Kawczak, Julie A., Yu, Min, Johnson, Justin M., Tuohy, Vincent K.

“…Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS) mediated by T cells responding to CNS myelin proteins…”
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T-cell design: optimizing the therapeutic potential of autoreactive T cells by genetic modification by Tuohy, V.K., Mathisen, P.M.

“…Autoreactive CD4+ Th2 cells have been shown to be therapeutic in the treatment of EAE. However, their full therapeutic potential has yet to be realized…”
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Th2 T cells Expressing Transgene PDGF-A Serve as Vectors for Gene Therapy in Autoimmune Demyelinating Disease by Mathisen, Peter M, Yu, Min, Yin, Ling, Johnson, Justin M, Kawczak, Julie A, Nishiyama, Akiko, Tuohy, Vincent K

“…We hypothesized that T cells can be genetically modified to express growth factor transgene products capable of inducing oligodendrocyte progenitor…”
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Digitized image analysis reveals diffuse abnormalities in normal-appearing white matter during acute experimental autoimmune encephalomyelitis by Kawczak, Julie A., Mathisen, Peter M., Drazba, Judith A., Fuss, Babette, Macklin, Wendy B., Tuohy, Vincent K.

“…Demyelination of the central nervous system is a hallmark of multiple sclerosis and its widely used animal model, experimental autoimmune encephalomyelitis…”
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Stabilization of myelin mRNAs as measured in a brain slice system by Mathisen, Peter M., Johnson, Justin M., Kawczak, Julie A.

“…The stabilization and destabilization of myelin mRNA is increasingly recognized as a major control point in regulating myelin gene expression. A brain slice…”
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Gene therapy in the treatment of autoimmune disease by Mathisen, P M, Tuohy, V K

“…The genetic modification of autoreactive memory T cells and autoimmune target cells to produce immunoregulatory cytokines and regenerative growth factors…”
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