Search Results - "MATHIS, CHESTER A"

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue by Marquié, Marta, Normandin, Marc D., Vanderburg, Charles R., Costantino, Isabel M., Bien, Elizabeth A., Rycyna, Lisa G., Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik L., Vasdev, Neil, Dickerson, Bradford C., Gomperts, Stephen N., Growdon, John H., Johnson, Keith A., Frosch, Matthew P., Hyman, Bradley T., Gómez-Isla, Teresa

“…Objective To examine region‐ and substrate‐specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F‐18]‐AV‐1451…”
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The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET by Klunk, William E, Koeppe, Robert A, Price, Julie C, Benzinger, Tammie L, Devous, Michael D, Jagust, William J, Johnson, Keith A, Mathis, Chester A, Minhas, Davneet, Pontecorvo, Michael J, Rowe, Christopher C, Skovronsky, Daniel M, Mintun, Mark A

“…Abstract Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced…”
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SNMMI Procedure Standard/EANM Practice Guideline for Amyloid PET Imaging of the Brain 1.0 by Minoshima, Satoshi, Drzezga, Alexander E, Barthel, Henryk, Bohnen, Nicolaas, Djekidel, Mehdi, Lewis, David H, Mathis, Chester A, McConathy, Jonathan, Nordberg, Agneta, Sabri, Osama, Seibyl, John P, Stokes, Margaret K, Van Laere, Koen

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The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015 by Jagust, William J, Landau, Susan M, Koeppe, Robert A, Reiman, Eric M, Chen, Kewei, Mathis, Chester A, Price, Julie C, Foster, Norman L, Wang, Angela Y

“…Abstract Introduction This article reviews the work done in the Alzheimer's Disease Neuroimaging Initiative positron emission tomography (ADNI PET) core over…”
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Pathological correlations of [F‐18]‐AV‐1451 imaging in non‐alzheimer tauopathies by Marquié, Marta, Normandin, Marc D., Meltzer, Avery C., Siao Tick Chong, Michael, Andrea, Nicolas V., Antón‐Fernández, Alejandro, Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik, Bien, Elizabeth A., Vanderburg, Charles R., Costantino, Isabel, Makaretz, Sara, DeVos, Sarah L., Oakley, Derek H., Gomperts, Stephen N., Growdon, John H., Domoto‐Reilly, Kimiko, Lucente, Diane, Dickerson, Bradford C., Frosch, Matthew P., Hyman, Bradley T., Johnson, Keith A., Gómez‐Isla, Teresa

“…Objective Recent studies have shown that positron emission tomography (PET) tracer AV‐1451 exhibits high binding affinity for paired helical filament (PHF)‐tau…”
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Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology by La Joie, Renaud, Ayakta, Nagehan, Seeley, William W., Borys, Ewa, Boxer, Adam L., DeCarli, Charles, Doré, Vincent, Grinberg, Lea T., Huang, Eric, Hwang, Ji-Hye, Ikonomovic, Milos D., Jack, Clifford, Jagust, William J., Jin, Lee-Way, Klunk, William E., Kofler, Julia, Lesman-Segev, Orit H., Lockhart, Samuel N., Lowe, Val J., Masters, Colin L., Mathis, Chester A., McLean, Catriona L., Miller, Bruce L., Mungas, Daniel, O'Neil, James P., Olichney, John M., Parisi, Joseph E., Petersen, Ronald C., Rosen, Howard J., Rowe, Christopher C., Spina, Salvatore, Vemuri, Prashanthi, Villemagne, Victor L., Murray, Melissa E., Rabinovici, Gil D.

“…We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [11C]PIB–positron emission tomography…”
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Subjective Cognitive Complaints, Personality and Brain Amyloid-beta in Cognitively Normal Older Adults by Snitz, Beth E., Ph.D, Weissfeld, Lisa A., Ph.D, Cohen, Ann D., Ph.D, Lopez, Oscar L., M.D, Nebes, Robert D., Ph.D, Aizenstein, Howard J., M.D., Ph.D, McDade, Eric, D.O, Price, Julie C., Ph.D, Mathis, Chester A., Ph.D, Klunk, William E., M.D., Ph.D

“…Objective Subjective cognitive complaints in otherwise normal aging are common but may be associated with preclinical Alzheimer disease in some individuals…”
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Effects of soy isoflavones on cognitive function: a systematic review and meta-analysis of randomized controlled trials by Cui, Chendi, Birru, Rahel L, Snitz, Beth E, Ihara, Masafumi, Kakuta, Chikage, Lopresti, Brian J, Aizenstein, Howard J, Lopez, Oscar L, Mathis, Chester A, Miyamoto, Yoshihiro, Kuller, Lewis H, Sekikawa, Akira

“…Abstract Context The results of preclinical and observational studies support the beneficial effect of soy isoflavones on cognition. Objective This review…”
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Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: a prospective cohort study by Yau, Wai-Ying Wendy, BS, Tudorascu, Dana L, PhD, McDade, Eric M, DO, Ikonomovic, Snezana, MD, James, Jeffrey A, BS, Minhas, Davneet, BS, Mowrey, Wenzhu, PhD, Sheu, Lei K, PhD, Snitz, Beth E, PhD, Weissfeld, Lisa, PhD, Gianaros, Peter J, PhD, Aizenstein, Howard J, MD, Price, Julie C, Prof, Mathis, Chester A, Prof, Lopez, Oscar L, Prof, Klunk, William E, Prof

“…Summary Background The biomarker model of Alzheimer's disease postulates a dynamic sequence of amyloidosis, neurodegeneration, and cognitive decline as an…”
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Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance by Bolmont, Tristan, Haiss, Florent, Eicke, Daniel, Radde, Rebecca, Mathis, Chester A, Klunk, William E, Kohsaka, Shinichi, Jucker, Mathias, Calhoun, Michael E

“…Microglial cells aggregate around amyloid plaques in Alzheimer's disease, but, despite their therapeutic potential, various aspects of their reactive kinetics…”
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Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease by Reiman, Eric M, Chen, Kewei, Liu, Xiaofen, Bandy, Daniel, Yu, Meixiang, Lee, Wendy, Ayutyanont, Napatkamon, Keppler, Jennifer, Reeder, Stephanie A, Langbaum, Jessica B.S, Alexander, Gene E, Klunk, William E, Mathis, Chester A, Price, Julie C, Aizenstein, Howard J, DeKosky, Steven T, Caselli, Richard J

“…Fibrillar amyloid-beta (Aβ) is found in the brains of many cognitively normal older people. Whether or not this reflects a predisposition to Alzheimer's…”
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[F-18]AV-1451 positron emission tomography retention in choroid plexus: More than "off-target" binding by Ikonomovic, Milos D., Abrahamson, Eric E., Price, Julie C., Mathis, Chester A., Klunk, William E.

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The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core by Jagust, William J, Bandy, Dan, Chen, Kewei, Foster, Norman L, Landau, Susan M, Mathis, Chester A, Price, Julie C, Reiman, Eric M, Skovronsky, Daniel, Koeppe, Robert A

“…Abstract Background This is a progress report of the Alzheimer's Disease Neuroimaging Initiative (ADNI) positron emission tomography (PET) Core. Methods The…”
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Beta Amyloid in Alzheimer's Disease: Increased Deposition in Brain Is Reflected in Reduced Concentration in Cerebrospinal Fluid by Grimmer, Timo, Riemenschneider, Matthias, Förstl, Hans, Henriksen, Gjermund, Klunk, William E, Mathis, Chester A, Shiga, Tohru, Wester, Hans-Jürgen, Kurz, Alexander, Drzezga, Alexander

“…Background A decreased concentration of beta amyloid (1-42) (Aβ42) has consistently been found in the cerebrospinal fluid (CSF) of patients with Alzheimer's…”
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Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease by Ikonomovic, Milos D., Klunk, William E., Abrahamson, Eric E., Mathis, Chester A., Price, Julie C., Tsopelas, Nicholas D., Lopresti, Brian J., Ziolko, Scott, Bi, Wenzhu, Paljug, William R., Debnath, Manik L., Hope, Caroline E., Isanski, Barbara A., Hamilton, Ronald L., DeKosky, Steven T.

“…The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds with high affinity to β-pleated sheet aggregates of the amyloid-β (Aβ)…”
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Development of Positron Emission Tomography β-Amyloid Plaque Imaging Agents by Mathis, Chester A., PhD, Mason, N. Scott, PhD, Lopresti, Brian J., BS, Klunk, William E., MD, PhD

“…For 100 years, β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) have been recognized as the neuropathological hallmarks of Alzheimer's disease (AD),…”
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Amyloid imaging in mild cognitive impairment subtypes by Wolk, David A., Price, Julie C., Saxton, Judy A., Snitz, Beth E., James, Jeffrey A., Lopez, Oscar L., Aizenstein, Howard J., Cohen, Ann D., Weissfeld, Lisa A., Mathis, Chester A., Klunk, William E., DeKosky, Steven T.

“…Objective We utilized the amyloid imaging ligand Pittsburgh Compound B (PiB) to determine the presence of Alzheimer's disease (AD) pathology in different mild…”
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PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer's disease progression in Down syndrome by Zammit, Matthew D., Tudorascu, Dana L., Laymon, Charles M., Hartley, Sigan L., Zaman, Shahid H., Ances, Beau M., Johnson, Sterling C., Stone, Charles K., Mathis, Chester A., Klunk, William E., Cohen, Ann D., Handen, Benjamin L., Christian, Bradley T.

“…Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and reveal early amyloid beta (Aβ) pathology in the brain. Positron emission…”
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Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET by Chen, Yin J, Rosario, Bedda L, Mowrey, Wenzhu, Laymon, Charles M, Lu, Xueling, Lopez, Oscar L, Klunk, William E, Lopresti, Brian J, Mathis, Chester A, Price, Julie C

“…The primary goal of this study was to assess the suitability of (11)C-Pittsburgh compound B ((11)C-PiB) blood-brain barrier delivery (K1) and relative delivery…”
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Imaging of amyloid burden and distribution in cerebral amyloid angiopathy by Johnson, Keith A., Gregas, Matt, Becker, John A., Kinnecom, Catherine, Salat, David H., Moran, Erin K., Smith, Erin E., Rosand, Jonathan, Rentz, Dorene M., Klunk, William E., Mathis, Chester A., Price, Julie C., DeKosky, Steven T., Fischman, Alan J., Greenberg, Steven M.

“…Objective Cerebrovascular deposition of β‐amyloid (cerebral amyloid angiopathy [CAA]) is a major cause of hemorrhagic stroke and a likely contributor to…”
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