Search Results - "MATHIEU, Veronique"
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New Folate-Grafted Chitosan Derivative To Improve Delivery of Paclitaxel-Loaded Solid Lipid Nanoparticles for Lung Tumor Therapy by Inhalation
Published in Molecular pharmaceutics (05-03-2018)“…Inhaled chemotherapy for the treatment of lung tumors requires that drug delivery systems improve selectivity for cancer cells and tumor penetration and allow…”
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A review of the current status of siRNA nanomedicines in the treatment of cancer
Published in Biomaterials (01-09-2013)“…Abstract RNA interference currently offers new opportunities for gene therapy by the specific extinction of targeted gene(s) in cancer diseases. However, the…”
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3
Fungal metabolites with anticancer activity
Published in Natural product reports (01-01-2014)“…Covering: 1964 to 2013. Natural products from bacteria and plants have played a leading role in cancer drug discovery resulting in a large number of clinically…”
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4
Therapeutic Agents Triggering Nonapoptotic Cancer Cell Death
Published in Journal of medicinal chemistry (27-06-2013)“…It is widely recognized that the evasion of apoptotic cell death is one of the hallmarks of cancer. For many years cytotoxic agents have been developed to…”
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Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of glioblastoma multiforme via intranasal administration
Published in Journal of controlled release (10-04-2016)“…Galectin-1 (Gal-1) is a naturally occurring galactose-binding lectin, which is overexpressed in glioblastoma multiforme (GBM). Gal-1 is associated with tumor…”
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Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database
Published in Scientific reports (19-08-2022)“…Cancer patients could combine herbal treatments with their chemotherapy. We consulted VigiBase, a WHO database of individual case safety reports (ICSRs) which…”
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Chemistry and biology of ophiobolin A and its congeners
Published in Bioorganic & medicinal chemistry letters (01-04-2019)“…[Display omitted] Ophiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells…”
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Receptor‐binding Domain Severe Acute Respiratory Syndrome Coronavirus 2‐specific Antibodies in Human Milk From Mothers With Coronavirus Disease 2019 Polymerase Chain Reaction or With Symptoms Suggestive of Coronavirus Disease 2019
Published in Journal of pediatric gastroenterology and nutrition (01-07-2021)“…ABSTRACT This study aims to compare the receptor‐binding domain (RBD) severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐specific antibody titers in…”
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Narciclasine as well as other Amaryllidaceae Isocarbostyrils are Promising GTP-ase Targeting Agents against Brain Cancers
Published in Medicinal research reviews (01-03-2013)“…The anticancer activity of Amaryllidaceae isocarbostyrils is well documented. At pharmacological concentrations, that is, approximately 1 μM in vitro and…”
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Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight
Published in Journal of medicinal chemistry (22-10-2009)“…Twenty-two lycorine-related compounds were investigated for in vitro antitumor activity using four cancer cell lines displaying different levels of resistance…”
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Amaryllidaceae Alkaloids Belonging to Different Structural Subgroups Display Activity against Apoptosis-Resistant Cancer Cells
Published in Journal of natural products (Washington, D.C.) (23-07-2010)“…Fifteen Amaryllidaceae alkaloids (1−15) were evaluated for their antiproliferative activities against six distinct cancer cell lines. Several of these natural…”
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Tumor Targeting by Peptide-Decorated Gold Nanoparticles
Published in Molecular pharmaceutics (03-06-2019)“…Cancer remains one of the most important challenges in biomedical sciences. Chemotherapeutic agents are very potent molecules that exhibit a significant level…”
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13
Lapachol and its congeners as anticancer agents: a review
Published in Phytochemistry reviews (01-03-2014)“…Lapachol is a naturally occurring 1,4-naphthoquinone originally isolated by the Italian phytochemist E. Paterno from Tabebuia avellanedae (Bignoniaceae) in…”
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14
A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis
Published in European journal of pharmacology (15-06-2017)“…Growing evidence indicates that protein synthesis is deregulated in cancer onset and progression and targeting this process might be a selective way to combat…”
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Structure−Activity Relationship Analysis of Novel Derivatives of Narciclasine (an Amaryllidaceae Isocarbostyril Derivative) as Potential Anticancer Agents
Published in Journal of medicinal chemistry (26-02-2009)“…Narciclasine (1) is a plant growth regulator that has been previously demonstrated to be proapoptotic to cancer cells at high concentrations (≥1 μM). Data…”
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Tumor Cells Secrete Galectin-1 to Enhance Endothelial Cell Activity
Published in Cancer research (Chicago, Ill.) (01-08-2010)“…Tumor angiogenesis is a key event in cancer progression. Here, we report that tumors can stimulate tumor angiogenesis by secretion of galectin-1. Tumor growth…”
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In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts
Published in Molecules (Basel, Switzerland) (16-04-2022)“…Although is a plant widely used in traditional medicine in sub-Saharan Africa, its biological properties have been poorly investigated to date. We first…”
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Sesterterpenoids with Anticancer Activity
Published in Current medicinal chemistry (01-01-2015)“…Terpenes have received a great deal of attention in the scientific literature due to complex, synthetically challenging structures and diverse biological…”
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Synthesis and antiproliferative studies of 5-aryl-2-(3-thienylamino)-1,3,4-thiadiazoles
Published in Bioorganic & medicinal chemistry letters (15-06-2014)“…A series of 5-aryl-2-(3-thienylamino)-1,3,4-thiadiazoles 3a–m were synthesized in good yields in two steps starting from thiophen-3-isothiocyanates. Those…”
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Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure
Published in Journal of medicinal chemistry (10-08-2017)“…The heme enzyme myeloperoxidase (MPO) participates in innate immune defense mechanism through formation of microbicidal reactive oxidants. However, evidence…”
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