Search Results - "MATHER, Stephen"

Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura by Murphy, Fiona A, Poland, Craig A, Duffin, Rodger, Al-Jamal, Khuloud T, Ali-Boucetta, Hanene, Nunes, Antonio, Byrne, Fiona, Prina-Mello, Adriele, Volkov, Yuri, Li, Shouping, Mather, Stephen J, Bianco, Alberto, Prato, Maurizio, MacNee, William, Wallace, William A, Kostarelos, Kostas, Donaldson, Ken

“…The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an asbestos-like inhalation hazard, leading to the development of diseases,…”
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Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging by Lozano-Perez, Sergio, Sim, Robert B, Ballesteros, Belén, Davis, Benjamin G, Hong, Sung You, Ali-Boucetta, Hanene, Tobias, Gerard, Al-Jamal, Khuloud T, Green, Malcolm L. H, Kostarelos, Kostas, Nellist, Peter D, Mather, Stephen J, Finucane, Ciara

“…Functionalization of nanomaterials for precise biomedical function is an emerging trend in nanotechnology. Carbon nanotubes are attractive as multifunctional…”
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Retargeting of Human T Cells to Tumor-Associated MUC1: The Evolution of a Chimeric Antigen Receptor by Wilkie, Scott, Picco, Gianfranco, Foster, Julie, Davies, David M, Julien, Sylvain, Cooper, Lucienne, Arif, Sefina, Mather, Stephen J, Taylor-Papadimitriou, Joyce, Burchell, Joy M, Maher, John

“…MUC1 is a highly attractive immunotherapeutic target owing to increased expression, altered glycosylation, and loss of polarity in >80% of human cancers. To…”
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Magnetically Decorated Multiwalled Carbon Nanotubes as Dual MRI and SPECT Contrast Agents by Wang, Julie Tzu-Wen, Cabana, Laura, Bourgognon, Maxime, Kafa, Houmam, Protti, Andrea, Venner, Kerrie, Shah, Ajay M., Sosabowski, Jane K., Mather, Stephen J., Roig, Anna, Ke, Xiaoxing, Van Tendeloo, Gustaaf, de Rosales, Rafael T. M., Tobias, Gerard, Al-Jamal, Khuloud T.

“…Carbon nanotubes (CNTs) are one of the most promising nanomaterials to be used in biomedicine for drug/gene delivery as well as biomedical imaging. This study…”
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The relationship between the diameter of chemically-functionalized multi-walled carbon nanotubes and their organ biodistribution profiles in vivo by Wang, Julie T-W, Fabbro, Chiara, Venturelli, Enrica, Ménard-Moyon, Cécilia, Chaloin, Olivier, Da Ros, Tatiana, Methven, Laura, Nunes, Antonio, Sosabowski, Jane K, Mather, Stephen J, Robinson, Martyn K, Amadou, Julien, Prato, Maurizio, Bianco, Alberto, Kostarelos, Kostas, Al-Jamal, Khuloud T

“…Abstract Carbon nanotubes (CNTs) exhibit unique properties which have led to their applications in the biomedical field as novel delivery systems for diagnosis…”
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Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging by ALLEN, Michael D, PHUONG LUONG, LATTANZIO, Laura, CHMIELEWSKA-KASSASSIR, Malgorzata, TOMLINSON, Ian, ROYLANCE, Rebecca, WHITAKER, Hayley C, WARREN, Anne Y, NEAL, David, FREZZA, Christian, BELTRAN, Luis, JONES, Louise J, HUDSON, Chantelle, CHELALA, Claude, WU, Bor-Wen, BOMALASKI, John S, JACKSON, Robert C, LU, Yong-Jie, CROOK, Tim, LEMOINE, Nicholas R, MATHER, Stephen, FOSTER, Julie, SOSABOWSKI, Jane, LEYTON, Julius, AVRIL, Norbert, LI, Chien-Feng, SZLOSAREK, Peter W, DELAGE, Barbara, GHAZALY, Essam, CUTTS, Rosalind, MING YUAN, SYED, Nelofer, LO NIGRO, Cristiana

“…Targeted therapies have yet to have significant impact on the survival of patients with bladder cancer. In this study, we focused on the urea cycle enzyme…”
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Degree of Chemical Functionalization of Carbon Nanotubes Determines Tissue Distribution and Excretion Profile by Al-Jamal, Khuloud T., Nunes, Antonio, Methven, Laura, Ali-Boucetta, Hanene, Li, Shouping, Toma, Francesca M., Herrero, M. Antonia, Al-Jamal, Wafa' T., ten Eikelder, Huub M. M., Foster, Julie, Mather, Stephen, Prato, Maurizio, Bianco, Alberto, Kostarelos, Kostas

“…Getting rid of the tubes: An assessment of the retention of functionalized multi‐walled carbon nanotubes (MWNTs) in the organs of mice was carried out using…”
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Cancer-specific transgene expression mediated by systemic injection of nanoparticles by Chisholm, Edward J, Vassaux, Georges, Martin-Duque, Pilar, Chevre, Raphael, Lambert, Olivier, Pitard, Bruno, Merron, Andrew, Weeks, Mark, Burnet, Jerome, Peerlinck, Inge, Dai, Ming-Shen, Alusi, Ghassan, Mather, Stephen J, Bolton, Katherine, Uchegbu, Ijeoma F, Schatzlein, Andreas G, Baril, Patrick

“…The lack of safe and efficient systemic gene delivery vectors has largely reduced the potential of gene therapy in the clinic. Previously, we have reported…”
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Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma by Laughery, Marian F., Brown, Alexander J., Bohm, Kaitlynne A., Sivapragasam, Smitha, Morris, Haley S., Tchmola, Mila, Washington, Angelica D., Mitchell, Debra, Mather, Stephen, Malc, Ewa P., Mieczkowski, Piotr A., Roberts, Steven A., Wyrick, John J.

“…Somatic mutations in skin cancers and other ultraviolet (UV)-exposed cells are typified by C>T and CC>TT substitutions at dipyrimidine sequences; however, many…”
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Generation and characterization of a diabody targeting the αvβ6 integrin by Kogelberg, Heide, Miranda, Enrique, Burnet, Jerome, Ellison, David, Tolner, Berend, Foster, Julie, Picón, Carmen, Thomas, Gareth J, Meyer, Tim, Marshall, John F, Mather, Stephen J, Chester, Kerry

“…The αvβ6 integrin is up-regulated in cancer and wound healing but it is not generally expressed in healthy adult tissue. There is increasing evidence that it…”
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GRP Receptor Imaging of Prostate Cancer Using [99mTc]Demobesin 4: a First-in-Man Study by Mather, Stephen J., Nock, Berthold A., Maina, Theodosia, Gibson, Vickie, Ellison, David, Murray, Iain, Sobnack, Ravin, Colebrook, Steve, Wan, Susan, Halberrt, Gavin, Szysko, Teresa, Powles, Thomas, Avril, Norbert

“…Purpose We explored the imaging of bombesin receptors and evaluated the clinical use of [ 99m Tc]Demobesin 4 ([ 99m Tc]DB4) in prostate cancer patients…”
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Flexible targeting of ErbB dimers that drive tumorigenesis by using genetically engineered T cells by Davies, David M, Foster, Julie, Van Der Stegen, Sjoukje J C, Parente-Pereira, Ana C, Chiapero-Stanke, Laura, Delinassios, George J, Burbridge, Sophie E, Kao, Vincent, Liu, Zhe, Bosshard-Carter, Leticia, Van Schalkwyk, May C I, Box, Carol, Eccles, Suzanne A, Mather, Stephen J, Wilkie, Scott, Maher, John

“…Pharmacological targeting of individual ErbB receptors elicits antitumor activity, but is frequently compromised by resistance leading to therapeutic failure…”
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Cyclic Minigastrin Analogues for Gastrin Receptor Scintigraphy with Technetium-99m: Preclinical Evaluation by von Guggenberg, Elisabeth, Sallegger, Werner, Helbok, Anna, Ocak, Meltem, King, Robert, Mather, Stephen J, Decristoforo, Clemens

“…Two cyclized minigastrin analogues for gastrin receptor scintigraphy were synthesized and derivatized with HYNIC at the N-terminus for labeling with 99mTc…”
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High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin αvβ6 by Saha, Antonio, Ellison, David, Thomas, Gareth J, Vallath, Sabarinath, Mather, Stephen J, Hart, Ian R, Marshall, John F

“…The integrin αvβ6 is expressed only on epithelia and then usually only during processes of tissue remodelling including cancer, where its high expression…”
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Identification of ZDHHC14 as a novel human tumour suppressor gene by Yeste-Velasco, Marc, Mao, Xueying, Grose, Richard, Kudahetti, Sakunthala C, Lin, Dongmei, Marzec, Jacek, Vasiljević, Natasa, Chaplin, Tracy, Xue, Liyan, Xu, Maojia, Foster, Julie M, Karnam, Santi S, James, Sharon Y, Chioni, Athina-Myrto, Gould, David, Lorincz, Attila T, Oliver, R Tim D, Chelala, Claude, Thomas, Gareth M, Shipley, Janet M, Mather, Stephen J, Berney, Daniel M, Young, Bryan D, Lu, Yong-Jie

“…Genomic changes affecting tumour suppressor genes are fundamental to cancer. We applied SNP array analysis to a panel of testicular germ cell tumours to search…”
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Structural guided scaffold phage display libraries as a source of bio-therapeutics by Man, Y K Stella, DiCara, Danielle, Chan, Nicole, Vessillier, Sandrine, Mather, Stephen J, Rowe, Michelle L, Howard, Mark J, Marshall, John F, Nissim, Ahuva

“…We have developed a structurally-guided scaffold phage display strategy for identification of ligand mimetic bio-therapeutics. As a proof of concept we used…”
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Contrasting effects of sunitinib within in vivo models of metastasis by Welti, Jonathan C., Powles, Thomas, Foo, Shane, Gourlaouen, Morgane, Preece, Natasha, Foster, Julie, Frentzas, Sophia, Bird, Demelza, Sharpe, Kevin, van Weverwijk, Antoinette, Robertson, David, Soffe, Julie, Erler, Janine T., Pili, Roberto, Springer, Caroline J., Mather, Stephen J., Reynolds, Andrew R.

“…Sunitinib is a potent and clinically approved tyrosine kinase inhibitor that can suppress tumour growth by inhibiting angiogenesis. However, conflicting data…”
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Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide by Wythe, Sarah E, DiCara, Danielle, Taher, Taher E I, Finucane, Ciara M, Jones, Rita, Bombardieri, Michele, Man, Y K Stella, Nissim, Ahuva, Mather, Stephen J, Chernajovsky, Yuti, Pitzalis, Costantino

“…The synovial endothelium targeting peptide (SyETP) CKSTHDRLC has been identified previously and was shown to preferentially localise to synovial xenografts in…”
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Conjugation of DOTA-like chelating agents to peptides and radiolabeling with trivalent metallic isotopes by Sosabowski, Jane K, Mather, Stephen J

“…Peptides can be labeled with various trivalent radiometals for imaging or targeted radionuclide-therapy applications. The peptide is first conjugated to a…”
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Pathogen identification by nuclear imaging – almost there? by Agrawal, Samir G., Mather, Stephen J.

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