Search Results - "MATERAZZI, Serena"

TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress by Trevisan, Gabriela, Benemei, Silvia, Materazzi, Serena, De Logu, Francesco, De Siena, Gaetano, Fusi, Camilla, Fortes Rossato, Mateus, Coppi, Elisabetta, Marone, Ilaria Maddalena, Ferreira, Juliano, Geppetti, Pierangelo, Nassini, Romina

“…Despite intense investigation, the mechanisms of the different forms of trigeminal neuropathic pain remain substantially unidentified. The transient receptor…”
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TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice by Marone, Ilaria Maddalena, De Logu, Francesco, Nassini, Romina, De Carvalho Goncalves, Muryel, Benemei, Silvia, Ferreira, Juliano, Jain, Piyush, Li Puma, Simone, Bunnett, Nigel W, Geppetti, Pierangelo, Materazzi, Serena

“…Glyceryl trinitrate administration causes prolonged mechanical allodynia in rodents, which correlates temporally with delayed migraine attacks in patients…”
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Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice by De Logu, Francesco, Nassini, Romina, Materazzi, Serena, Carvalho Gonçalves, Muryel, Nosi, Daniele, Rossi Degl’Innocenti, Duccio, Marone, Ilaria M., Ferreira, Juliano, Li Puma, Simone, Benemei, Silvia, Trevisan, Gabriela, Souza Monteiro de Araújo, Daniel, Patacchini, Riccardo, Bunnett, Nigel W., Geppetti, Pierangelo

“…It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is…”
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The TRPA1 channel in inflammatory and neuropathic pain and migraine by Nassini, Romina, Materazzi, Serena, Benemei, Silvia, Geppetti, Pierangelo

“…The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of channels, is primarily localized to a subpopulation of primary sensory…”
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Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents by Baraldi, Pier Giovanni, Preti, Delia, Materazzi, Serena, Geppetti, Pierangelo

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Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade by TREVISAN, Gabriela, MATERAZZI, Serena, FUSI, Camilla, ALTOMARE, Alessandra, ALDINI, Giancarlo, LODOVICI, Maura, PATACCHINI, Riccardo, GEPPETTI, Pierangelo, NASSINI, Romina

“…Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and painful adverse reaction of cancer treatment in patients that is little understood or…”
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The TGR5 receptor mediates bile acid-induced itch and analgesia by Alemi, Farzad, Kwon, Edwin, Poole, Daniel P, Lieu, TinaMarie, Lyo, Victoria, Cattaruzza, Fiore, Cevikbas, Ferda, Steinhoff, Martin, Nassini, Romina, Materazzi, Serena, Guerrero-Alba, Raquel, Valdez-Morales, Eduardo, Cottrell, Graeme S, Schoonjans, Kristina, Geppetti, Pierangelo, Vanner, Stephen J, Bunnett, Nigel W, Corvera, Carlos U

“…Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms underlying these symptoms are unknown. We report that bile acids, which…”
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TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism by Materazzi, Serena, Fusi, Camilla, Benemei, Silvia, Pedretti, Pamela, Patacchini, Riccardo, Nilius, Bernd, Prenen, Jean, Creminon, Christophe, Geppetti, Pierangelo, Nassini, Romina

“…Paclitaxel produces a sensory neuropathy, characterized by mechanical and cold hypersensitivity, which are abated by antioxidants. The transient receptor…”
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The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice by Lieu, TinaMarie, Jayaweera, Gihan, Zhao, Peishen, Poole, Daniel P, Jensen, Dane, Grace, Megan, McIntyre, Peter, Bron, Romke, Wilson, Yvette M, Krappitz, Matteus, Haerteis, Silke, Korbmacher, Christoph, Steinhoff, Martin S, Nassini, Romina, Materazzi, Serena, Geppetti, Pierangelo, Corvera, Carlos U, Bunnett, Nigel W

“…Background & Aims Patients with cholestatic disease have increased systemic concentrations of bile acids (BAs) and profound pruritus. The G-protein–coupled BA…”
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Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation by Nassini, Romina, Gees, Maarten, Harrison, Selena, De Siena, Gaetano, Materazzi, Serena, Moretto, Nadia, Failli, Paola, Preti, Delia, Marchetti, Nicola, Cavazzini, Alberto, Mancini, Francesca, Pedretti, Pamela, Nilius, Bernd, Patacchini, Riccardo, Geppetti, Pierangelo

“…Platinum-based anticancer drugs cause neurotoxicity. In particular, oxaliplatin produces early-developing, painful, and cold-exacerbated paresthesias. However,…”
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Transient receptor potential ankyrin 1 contributes to somatic pain hypersensitivity in experimental colitis by Jain, Piyush, Materazzi, Serena, De Logu, Francesco, Rossi Degl’Innocenti, Duccio, Fusi, Camilla, Li Puma, Simone, Marone, Ilaria M., Coppi, Elisabetta, Holzer, Peter, Geppetti, Pierangelo, Nassini, Romina

“…Pain evoked by visceral inflammation is often ‘referred’ to the somatic level. Transient receptor potential ankyrin 1 (TRPA1) has been reported to contribute…”
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Transient Receptor Potential Vanilloid 4 (TRPV4) Is Downregulated in Keratinocytes in Human Non-Melanoma Skin Cancer by Fusi, Camilla, Materazzi, Serena, Minocci, Daiana, Maio, Vincenza, Oranges, Teresa, Massi, Daniela, Nassini, Romina

“…A subgroup of the transient receptor potential (TRP) channels, including vanilloid 1 (TRPV1), TRPV2, TRPV3, TRPV4, and TRP ankyrin 1 (TRPA1), is expressed in…”
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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 by Trevisani, Marcello, Siemens, Jan, Materazzi, Serena, Bautista, Diana M, Nassini, Romina, Campi, Barbara, Imamachi, Noritaka, Andrè, Eunice, Patacchini, Riccardo, Cottrell, Graeme S, Gatti, Raffaele, Basbaum, Allan I, Bunnett, Nigel W, Julius, David, Geppetti, Pierangelo

“…TRPA1 is an excitatory ion channel expressed by a subpopulation of primary afferent somatosensory neurons that contain substance P and calcitonin gene-related…”
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The anti‐migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel by Benemei, Silvia, De Logu, Francesco, Li Puma, Simone, Marone, Ilaria Maddalena, Coppi, Elisabetta, Ugolini, Filippo, Liedtke, Wolfgang, Pollastro, Federica, Appendino, Giovanni, Geppetti, Pierangelo, Materazzi, Serena, Nassini, Romina

“…Background and Purpose The mechanism of the anti‐migraine action of extracts of butterbur [Petasites hybridus (L.) Gaertn.] is unknown. Here, we investigated…”
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The concept of neurogenic inflammation by Geppetti, Pierangelo, Nassini, Romina, Materazzi, Serena, Benemei, Silvia

“…Neurogenic inflammatory responses have recently been linked to both acute and chronic pathological conditions in the urinary tract. Neurogenic inflammation…”
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TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout by Trevisan, Gabriela, Hoffmeister, Carin, Rossato, Mateus Fortes, Oliveira, Sara Marchesan, Silva, Mariane Arnoldi, Silva, Cássia Regina, Fusi, Camilla, Tonello, Raquel, Minocci, Daiana, Guerra, Gustavo Petri, Materazzi, Serena, Nassini, Romina, Geppetti, Pierangelo, Ferreira, Juliano

“…Acute gout attacks produce severe joint pain and inflammation associated with monosodium urate (MSU) crystals leading to oxidative stress production. The…”
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The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives by Nassini, Romina, Fusi, Camilla, Materazzi, Serena, Coppi, Elisabetta, Tuccinardi, Tiziano, Marone, Ilaria M, De Logu, Francesco, Preti, Delia, Tonello, Raquel, Chiarugi, Alberto, Patacchini, Riccardo, Geppetti, Pierangelo, Benemei, Silvia

“…Background and Purpose Although still used by hundreds of millions of people worldwide, the mechanism of the analgesic action of the pyrazolone derivatives…”
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Critical role of calcitonin gene-related peptide receptors in cortical spreading depression by Tozzi, Alessandro, de Iure, Antonio, Di Filippo, Massimiliano, Costa, Cinzia, Caproni, Stefano, Pisani, Antonio, Bonsi, Paola, Picconi, Barbara, Cupini, Letizia M., Materazzi, Serena, Geppetti, Pierangelo, Sarchielli, Paola, Calabresi, Paolo

“…Cortical spreading depression (CSD) is a key pathogenetic step in migraine with aura. Dysfunctions of voltage-dependent and receptor-operated channels have…”
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Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation by Nassini, Romina, Pedretti, Pamela, Moretto, Nadia, Fusi, Camilla, Carnini, Chiara, Facchinetti, Fabrizio, Viscomi, Arturo Roberto, Pisano, Anna Rita, Stokesberry, Susan, Brunmark, Charlott, Svitacheva, Naila, McGarvey, Lorcan, Patacchini, Riccardo, Damholt, Anders B, Geppetti, Pierangelo, Materazzi, Serena

“…The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by…”
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Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4 by De Logu, Francesco, Trevisan, Gabriela, Marone, Ilaria Maddalena, Coppi, Elisabetta, Padilha Dalenogare, Diéssica, Titiz, Mustafa, Marini, Matilde, Landini, Lorenzo, Souza Monteiro de Araujo, Daniel, Li Puma, Simone, Materazzi, Serena, De Siena, Gaetano, Geppetti, Pierangelo, Nassini, Romina

“…The mechanism underlying the pain symptoms associated with chemotherapeutic-induced peripheral neuropathy (CIPN) is poorly understood. Transient receptor…”
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