Search Results - "MASUDA, Tohru"

New metastatic model of human small‐cell lung cancer by orthotopic transplantation in mice by Sakamoto, Shuichi, Inoue, Hiroyuki, Ohba, Shunichi, Kohda, Yasuko, Usami, Ihomi, Masuda, Tohru, Kawada, Manabu, Nomoto, Akio

“…Small‐cell lung cancer (SCLC) is an aggressive cancer with high metastatic ability and novel strategies against the metastasis are urgently needed to improve…”
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Antitumor effects of tyropeptin‐boronic acid derivatives: New proteasome inhibitors by Momose, Isao, Abe, Hikaru, Watanabe, Takumi, Ohba, Shun‐ichi, Yamazaki, Kanami, Dan, Shingo, Yamori, Takao, Masuda, Tohru, Nomoto, Akio

“…The proteasome degrades numerous regulatory proteins that are critical for tumor growth. Thus, proteasome inhibitors are promising antitumor agents. New…”
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In vivo efficacy of β-lactam/tripropeptin C in a mouse septicemia model and the mechanism of reverse β-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin C by Hashizume, Hideki, Takahashi, Yoshiaki, Masuda, Tohru, Ohba, Shun-ichi, Ohishi, Tomokazu, Kawada, Manabu, Igarashi, Masayuki

“…Natural lipopeptide antibiotic tripropeptin C (TPPC) revitalizes and synergistically potentiates the activities of the class of β-lactam antibiotics against…”
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A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo by Kawada, Manabu, Inoue, Hiroyuki, Kajikawa, Masunori, Sugiura, Masahito, Sakamoto, Shuichi, Urano, Sakiko, Karasawa, Chigusa, Usami, Ihomi, Futakuchi, Mitsuru, Masuda, Tohru

“…To create a new anti-tumor antibody, we conducted signal sequence trap by retrovirus-meditated expression method and identified coxsackie virus and adenovirus…”
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Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction by Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun-ichi, Yoshida, Junjiro, Masuda, Tohru, Yamasaki, Manabu, Usami, Ihomi, Sakamoto, Shuichi, Abe, Hikaru, Watanabe, Takumi, Yamori, Takao, Shibasaki, Masakatsu, Nomoto, Akio

“…Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, but those factors are not fully understood. Here, we have identified…”
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Correction to: Metacytofilin, a novel immunomodulator produced by Metarhizium sp. TA2759 by Iijima, Masatomi, Masuda, Tohru, Nakamura, Hikaru, Naganawa, Hiroshi, Kurasawa, Shogo, Okami, Yoshiro, Ishizuka, Masaaki, Takeuchi, Tomio, Iitaka, Yoichi

“…The authors of the above article misjudged the structure determination of MCF (metacytofilin). Our recent analyses using X-ray crystallography and NMR…”
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Insulin-like growth factor I secreted from prostate stromal cells mediates tumor-stromal cell interactions of prostate cancer by KAWADA, Manabu, INOUE, Hiroyuki, MASUDA, Tohru, IKEDA, Daishiro

“…Prostate cancer shows high expression of type I insulin-like growth factor (IGF-I) receptor (IGF-IR) and prostate stromal cells (PrSC) produce IGF-I. Although…”
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Leucinostatin A inhibits prostate cancer growth through reduction of insulin‐like growth factor‐I expression in prostate stromal cells by Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun‐Ichi, Masuda, Tohru, Momose, Isao, Ikeda, Daishiro

“…Targeting stroma in tumor tissues is an attractive new strategy for cancer treatment. We developed in vitro coculture system, in which the growth of human…”
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Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2 by Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun-ichi, Hatano, Masaki, Amemiya, Masahide, Hayashi, Chigusa, Usami, Ihomi, Abe, Hikaru, Watanabe, Takumi, Kinoshita, Naoko, Igarashi, Masayuki, Masuda, Tohru, Ikeda, Daishiro, Nomoto, Akio

“…Because stromal cells can regulate the growth and metastasis of tumor cells, a compound that modulates the interaction between the stromal cells and the tumor…”
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In vivo imaging of proteasome inhibition using a proteasome‐sensitive fluorescent reporter by Momose, Isao, Tatsuda, Daisuke, Ohba, Shun‐ichi, Masuda, Tohru, Ikeda, Daishiro, Nomoto, Akio

“…A proteasome degrades numerous regulatory proteins that are critical for tumor growth and is therefore recognized as a promising anticancer target. Determining…”
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Mitochondrial inhibitors show preferential cytotoxicity to human pancreatic cancer PANC-1 cells under glucose-deprived conditions by Momose, Isao, Ohba, Shun-ichi, Tatsuda, Daisuke, Kawada, Manabu, Masuda, Tohru, Tsujiuchi, Go, Yamori, Takao, Esumi, Hiroyasu, Ikeda, Daishiro

“…Large areas of tumor are nutrient-starved and hypoxic due to a disorganized vascular system. Therefore, we screened small molecules to identify cytotoxic…”
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Structure–activity relationship study of intervenolin derivatives: synthesis, antitumor, and anti-Helicobacter pylori activities by Abe, Hikaru, Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun-ichi, Masuda, Tohru, Hayashi, Chigusa, Igarashi, Masayuki, Nomoto, Akio, Watanabe, Takumi, Shibasaki, Masakatsu

“…Intervenolin is a natural antitumor quinolone that inhibits the growth of MKN-74 gastric tumor cells cocultured with Hs738 gastric stromal cells, and exhibits…”
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NBRI16716A, a new antitumor compound against human prostate cancer cells, produced by Perisporiopsis melioloides Mer-f16716 by Kawada, Manabu, Someno, Tetsuya, Inoue, Hiroyuki, Ohba, Shun-ichi, Masuda, Tohru, Kato, Taira, Ikeda, Daishiro

“…Prostate stroma can regulate the growth and metastasis of prostate cancer through the tumor–stromal cell interactions. Thus, small molecules that modulate the…”
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Suppression of type II collagen-induced arthritis by ICM0301B, a new angiogenesis inhibitor by Kumagai, Hiroyuki, Masuda, Tohru, Ohba, Shun-ichi, Ikeda, Daishiro

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Highly tumorigenic human androgen receptor‐positive prostate cancer cells overexpress angiogenin by Kawada, Manabu, Inoue, Hiroyuki, Arakawa, Masayuki, Takamoto, Kozo, Masuda, Tohru, Ikeda, Daishiro

“…We have recently established a highly tumorigenic cell line, LNCaP‐CR, derived from human androgen‐dependent prostate cancer LNCaP cells. In the present study,…”
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Establishment of a highly tumorigenic LNCaP cell line having inflammatory cytokine resistance by Kawada, Manabu, Inoue, Hiroyuki, Usami, Ihomi, Takamoto, Kozo, Masuda, Tohru, Yamazaki, Yoko, Ikeda, Daishiro

“…Human androgen-dependent prostate cancer LNCaP cells are low tumorigenic even in immunodeficient mice and were killed by the synergistic effect of inflammatory…”
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NBRI17671, a new antitumor compound, produced by Acremonium sp. CR17671 by Kawada, Manabu, Usami, Ihomi, Someno, Tetsuya, Watanabe, Takumi, Abe, Hikaru, Inoue, Hiroyuki, Ohba, Shun-ichi, Masuda, Tohru, Tabata, Yuji, Yamaguchi, Sho-ichi, Ikeda, Daishiro

“…The interaction between the receptor for advanced glycation end-product (RAGE) and amphoterin has an important role in tumor growth and metastasis. Because the…”
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Spontaneous Large-Scale Lymphoid Neogenesis and Balanced Autoimmunity versus Tolerance in the Stomach of H+/K+-ATPase-Reactive TCR Transgenic Mouse by Katakai, Tomoya, Nomura, Takashi, Gonda, Hiroyuki, Sugai, Manabu, Agata, Yasutoshi, Nishio, Akiyoshi, Masuda, Tohru, Sakaguchi, Shimon, Shimizu, Akira

“…Autoimmunity is often accompanied by the development of ectopic lymphoid tissues in the target organ, and these tissues have been believed to have close…”
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Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell‐induced angiogenesis by Minamiguchi, Kazuhisa, Kumagai, Hiroyuki, Masuda, Tohru, Kawada, Manabu, Ishizuka, Masaaki, Takeuchi, Tomio

“…Recent studies have shown that integrin αvβ3, a receptor for vitronectin, plays an important role in tumor‐induced angiogenesis and tumor growth and that…”
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A Microplate Assay for Selective Measurement of Growth of Epithelial Tumor Cells in Direct Coculture with Stromal Cells by KAWADA, Manabu, YOSHIMOTO, Yuya, MINAMIGUCHI, Kazuhisa, KUMAGAI, Hiroyuki, SOMENO, Tetsuya, MASUDA, Tohru, ISHIZUKA, Masaaki, IKEDA, Daishiro

“…Stromal cells play an important role in regulating epithelial malignancies through diffusible factors and adhesion. Modulation of the tumor-stromal cell…”
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