Search Results - "MASTERS, L. L"

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic by Hampel, Harald, O’Bryant, Sid E., Molinuevo, José L., Zetterberg, Henrik, Masters, Colin L., Lista, Simone, Kiddle, Steven J., Batrla, Richard, Blennow, Kaj

“…Biomarker discovery and development for clinical research, diagnostics and therapy monitoring in clinical trials have advanced rapidly in key areas of medicine…”
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Constitutive immune mechanisms: mediators of host defence and immune regulation by Paludan, Søren R., Pradeu, Thomas, Masters, Seth L., Mogensen, Trine H.

“…The immune system enables organisms to combat infections and to eliminate endogenous challenges. Immune responses can be evoked through diverse inducible…”
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The Amyloid-β Pathway in Alzheimer’s Disease by Hampel, Harald, Hardy, John, Blennow, Kaj, Chen, Christopher, Perry, George, Kim, Seung Hyun, Villemagne, Victor L., Aisen, Paul, Vendruscolo, Michele, Iwatsubo, Takeshi, Masters, Colin L., Cho, Min, Lannfelt, Lars, Cummings, Jeffrey L., Vergallo, Andrea

“…Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer’s disease (AD) pathophysiology. While the detailed…”
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Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease () by Masters, Seth L, Simon, Anna, Aksentijevich, Ivona, Kastner, Daniel L

“…The autoinflammatory diseases are characterized by seemingly unprovoked episodes of inflammation, without high-titer autoantibodies or antigen-specific T…”
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Galaxy Zoo DECaLS: Detailed visual morphology measurements from volunteers and deep learning for 314 000 galaxies by Walmsley, Mike, Lintott, Chris, Géron, Tobias, Kruk, Sandor, Krawczyk, Coleman, Willett, Kyle W, Bamford, Steven, Kelvin, Lee S, Fortson, Lucy, Gal, Yarin, Keel, William, Masters, Karen L, Mehta, Vihang, Simmons, Brooke D, Smethurst, Rebecca, Smith, Lewis, Baeten, Elisabeth M, Macmillan, Christine

“…ABSTRACT We present Galaxy Zoo DECaLS: detailed visual morphological classifications for Dark Energy Camera Legacy Survey images of galaxies within the SDSS…”
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miR‐223: infection, inflammation and cancer by Haneklaus, M., Gerlic, M., O'Neill, L. A. J., Masters, S. L.

“…Expression of the microRNA miR‐223 is deregulated during influenza or hepatitis B infection and in inflammatory bowel disease, type 2 diabetes, leukaemia and…”
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Trial of Solanezumab in Preclinical Alzheimer’s Disease by Sperling, Reisa A., Donohue, Michael C., Raman, Rema, Rafii, Michael S., Johnson, Keith, Masters, Colin L., van Dyck, Christopher H., Iwatsubo, Takeshi, Marshall, Gad A., Yaari, Roy, Mancini, Michele, Holdridge, Karen C., Case, Michael, Sims, John R., Aisen, Paul S.

“…In cognitively normal persons with brain amyloid deposition, solanezumab (an antibody targeting monomeric amyloid) did not slow cognitive decline as compared…”
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Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline by Ossenkoppele, Rik, Pichet Binette, Alexa, Groot, Colin, Smith, Ruben, Strandberg, Olof, Palmqvist, Sebastian, Stomrud, Erik, Tideman, Pontus, Ohlsson, Tomas, Jögi, Jonas, Johnson, Keith, Sperling, Reisa, Dore, Vincent, Masters, Colin L., Rowe, Christopher, Visser, Denise, van Berckel, Bart N. M., van der Flier, Wiesje M., Baker, Suzanne, Jagust, William J., Wiste, Heather J., Petersen, Ronald C., Jack, Clifford R., Hansson, Oskar

“…A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer’s disease neuropathological hallmarks…”
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Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice by Yu, Chien-Hsiung, Moecking, Jonas, Geyer, Matthias, Masters, Seth L.

“…NLRP1 was the first NOD-like receptor described to form an inflammasome, recruiting ASC to activate caspase-1, which processes interleukin-1β and…”
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Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner by Conos, Stephanie A., Chen, Kaiwen W., De Nardo, Dominic, Hara, Hideki, Whitehead, Lachlan, Núñez, Gabriel, Masters, Seth L., Murphy, James M., Schroder, Kate, Vaux, David L., Lawlor, Kate E., Lindqvist, Lisa M., Vince, James E.

“…Necroptosis is a physiological cell suicide mechanism initiated by receptor-interacting protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase…”
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The green valley is a red herring: Galaxy Zoo reveals two evolutionary pathways towards quenching of star formation in early- and late-type galaxies by Schawinski, Kevin, Urry, C. Megan, Simmons, Brooke D., Fortson, Lucy, Kaviraj, Sugata, Keel, William C., Lintott, Chris J., Masters, Karen L., Nichol, Robert C., Sarzi, Marc, Skibba, Ramin, Treister, Ezequiel, Willett, Kyle W., Wong, O. Ivy, Yi, Sukyoung K.

“…We use SDSS+GALEX+Galaxy Zoo data to study the quenching of star formation in low-redshift galaxies. We show that the green valley between the blue cloud of…”
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A precise extragalactic test of General Relativity by Collett, Thomas E, Oldham, Lindsay J, Smith, Russell J, Auger, Matthew W, Westfall, Kyle B, Bacon, David, Nichol, Robert C, Masters, Karen L, Koyama, Kazuya, van den Bosch, Remco

“…Einstein's theory of gravity, General Relativity, has been precisely tested on Solar System scales, but the long-range nature of gravity is still poorly…”
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Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease by Poulakis, Konstantinos, Pereira, Joana B., Muehlboeck, J.-Sebastian, Wahlund, Lars-Olof, Smedby, Örjan, Volpe, Giovanni, Masters, Colin L., Ames, David, Niimi, Yoshiki, Iwatsubo, Takeshi, Ferreira, Daniel, Westman, Eric

“…Understanding Alzheimer’s disease (AD) heterogeneity is important for understanding the underlying pathophysiological mechanisms of AD. However, AD atrophy…”
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Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding by Zhong, Franklin L., Robinson, Kim, Teo, Daniel Eng Thiam, Tan, Kiat-Yi, Lim, Chrissie, Harapas, Cassandra R., Yu, Chien-Hsiung, Xie, William H., Sobota, Radoslaw M., Au, Veonice Bijin, Hopkins, Richard, D'Osualdo, Andrea, Reed, John C., Connolly, John E., Masters, Seth L., Reversade, Bruno

“…The inflammasome is a critical molecular complex that activates interleukin-1 driven inflammation in response to pathogen- and danger-associated signals…”
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NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells by Masters, Seth L., Gerlic, Motti, Metcalf, Donald, Preston, Simon, Pellegrini, Marc, O’Donnell, Joanne A., McArthur, Kate, Baldwin, Tracey M., Chevrier, Stephane, Nowell, Cameron J., Cengia, Louise H., Henley, Katya J., Collinge, Janelle E., Kastner, Daniel L., Feigenbaum, Lionel, Hilton, Douglas J., Alexander, Warren S., Kile, Benjamin T., Croker, Ben A.

“…Cytopenias are key prognostic indicators of life-threatening infection, contributing to immunosuppression and mortality. Here we define a role for…”
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells by Balka, Katherine R., Louis, Cynthia, Saunders, Tahnee L., Smith, Amber M., Calleja, Dale J., D’Silva, Damian B., Moghaddas, Fiona, Tailler, Maximilien, Lawlor, Kate E., Zhan, Yifan, Burns, Christopher J., Wicks, Ian P., Miner, Jonathan J., Kile, Benjamin T., Masters, Seth L., De Nardo, Dominic

“…Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory…”
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases by Coll, Rebecca C, Robertson, Avril A B, Chae, Jae Jin, Higgins, Sarah C, Muñoz-Planillo, Raúl, Inserra, Marco C, Vetter, Irina, Dungan, Lara S, Monks, Brian G, Stutz, Andrea, Croker, Daniel E, Butler, Mark S, Haneklaus, Moritz, Sutton, Caroline E, Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L, Mills, Kingston H G, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, O'Neill, Luke A J

“…A selective, small-molecule inhibitor of NLRP3 suppresses activation of the inflammasome in vitro and in vivo and attenuates inflammatory disease. The NOD-like…”
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Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome by Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C, Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S, Gerich, Mark E, Mack, Matthias, Robertson, Avril A B, Cooper, Matthew A, Furuta, Glenn T, Dinarello, Charles A, O'Neill, Luke A, Eltzschig, Holger K, Masters, Seth L, McNamee, Eóin N

“…MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during…”
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SDSS-IV MaNGA: evidence of the importance of AGN feedback in low-mass galaxies by Penny, Samantha J, Masters, Karen L, Smethurst, Rebecca, Nichol, Robert C, Krawczyk, Coleman M, Bizyaev, Dmitry, Greene, Olivia, Liu, Charles, Marinelli, Mariarosa, Rembold, Sandro B, Riffel, Rogemar A, Ilha, Gabriele da Silva, Wylezalek, Dominika, Andrews, Brett H, Bundy, Kevin, Drory, Niv, Oravetz, Daniel, Pan, Kaike

“…Abstract We present new evidence for AGN feedback in a subset of 69 quenched low-mass galaxies (M⋆ ≲ 5 × 109 M⊙, Mr > −19) selected from the first 2 yr of the…”
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Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation by Zhong, Franklin L., Mamaï, Ons, Sborgi, Lorenzo, Boussofara, Lobna, Hopkins, Richard, Robinson, Kim, Szeverényi, Ildikó, Takeichi, Takuya, Balaji, Reshmaa, Lau, Aristotle, Tye, Hazel, Roy, Keya, Bonnard, Carine, Ahl, Patricia J., Jones, Leigh Ann, Baker, Paul J., Lacina, Lukas, Otsuka, Atsushi, Fournie, Pierre R., Malecaze, François, Lane, E. Birgitte, Akiyama, Masashi, Kabashima, Kenji, Connolly, John E., Masters, Seth L., Soler, Vincent J., Omar, Salma Samir, McGrath, John A., Nedelcu, Roxana, Gribaa, Moez, Denguezli, Mohamed, Saad, Ali, Hiller, Sebastian, Reversade, Bruno

“…Inflammasome complexes function as key innate immune effectors that trigger inflammation in response to pathogen- and danger-associated signals. Here, we…”
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