Search Results - "MAST, R. W"

Quantitative Exposure of Humans to an Octamethylcyclotetrasiloxane (D4) Vapor by Utell, M.J., Gelein, R., Yu, C.P., Kenaga, C., Geigel, E., Torres, A., Chalupa, D., Gibb, F.R., Speers, D.M., Mast, R.W., Morrow, P.E.

“…There is potential for human exposure to cyclic siloxanes by the respiratory route. To determine the pharmacokinetics of octamethylcyclotetrasiloxane (D4), a…”
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A RETROSPECTIVE REVIEW OF THE CARCINOGENICITY OF REFRACTORY CERAMIC FIBER IN TWO CHRONIC FISCHER 344 RAT INHALATION STUDIES: An Assessment of the MTD and Implications for Risk Assessment by Mast, R W, Yu, C P, Oberdörster, G, McConnell, E E, Utell, M J

“…The purpose of this article is to review previous chronic inhalation studies in rats with refractory ceramic fiber (RCF), the mathematical modeling efforts to…”
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Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5) by MCKIM, J. M, CHOUDHURI, S, WILGA, P. C, MADAN, A, BURNS-NAAS, L. A, GALLAVAN, R. H, MAST, R. W, NAAS, D. J, PARKINSON, A, MEEKS, R. G

“…Decamethylcyclopentasiloxane (D5) is a cyclic siloxane with a wide range of commercial applications. The present study was designed to investigate the effects…”
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Inhalation Toxicology of Decamethylcyclopentasiloxane (D5) Following a 3-Month Nose-Only Exposure in Fischer 344 Rats by Burns-Naas, Leigh Ann, Mast, Richard W., Meeks, Robert G., Mann, Peter C., Thevenaz, Philippe

“…D5 is a low-molecular-weight cyclic siloxane used for industrial and consumer product applications. The objective of the present study was to evaluate the…”
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REFRACTORY CERAMIC FIBER: Toxicology, Epidemiology, and Risk Analyses - A Review by Mast, R W, Maxim, L D, Utell, M J, Walker, A M

“…Refractory ceramic fiber (RCF) is an energy-efficient, high-temperature insulation, used principally in industrial furnaces, heaters, and reactors. Prior to…”
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Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats by Johnson, K A, Gorzinski, S J, Bodner, K M, Campbell, R A, Wolf, C H, Friedman, M A, Mast, R W

“…Male and female Fischer 344 rats were maintained on treated drinking water providing dosages of 0 (controls), 0.01, 0.1, 0.5, or 2.0 mg acrylamide/kg body…”
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Toxicology and Humoral Immunity Assessment of Decamethylcyclopentasiloxane (D5) Following a 1-Month Whole Body Inhalation Exposure in Fischer 344 Rats by Burns-Naas, Leigh Ann, Mast, Richard W., Klykken, Paal C., McCay, J.Ann, White, Kimber L., Mann, Peter C., Naas, Dennis J.

“…D5is a low-molecular-weight cyclic siloxane used for industrial and consumer product applications. The objective of the present study was to assess potential…”
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A clearance model of refractory ceramic fibers (RCF) in the rat lung including fiber dissolution and breakage by Yu, C.P., Ding, Y.J., Zhang, L., Oberdörster, G., Mast, R.W., Maxim, D., Utell, M.J.

“…A new model has been developed to describe the clearance and retention of kaolin refractory ceramic fibers (RCF) in the rat lung. Fiber dissolution, breakage…”
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Retention Modeling of Refractory Ceramic Fibers (RCF) in Humans by Yu, C.P., Ding, Y.J., Zhang, L., Oberdörster, G., Mast, R.W., Maxim, L.D., Utell, M.J.

“…A mathematical retention model has been developed to predict the lung burden and size distribution of kaolin refractory ceramic fibers (RCF) in the pulmonary…”
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Toxicology and Humoral Immunity Assessment of Octamethylcyclotetrasiloxane (D4) Following a 28-day whole body Vapor Inhalation Exposure in Fischer 344 Rats by Klykken, P. C., Galbraith, T. W., Kolesar, G. B., Jean, P. A., Woolhiser, M. R., Elwell, M. R., Burns-Naas, L. A., Mast, R. W., Mccay, J. A., White Jr, K. L., Munson, A. E.

“…ABSTRACT Octamethylcyclotetrasiloxane, D4, is a low viscosity, silicone fluid consisting of four dimethyl-siloxy units ((CH3)2SiO)4 in a cyclic structure. It…”
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Clearance of refractory ceramic fibers (RCF) from the rat lung: development of a model by Yu, C P, Zhang, L, Oberdörster, G, Mast, R W, Glass, L R, Utell, M J

“…Chronic exposure and postexposure experiments have been recently performed in rats to evaluate the biological responses of inhaled refractory ceramic fibers…”
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Hazard Assessment and Risk Analysis of Two New Synthetic Vitreous Fibers by Maxim, L.Daniel, Mast, Richard W., Utell, M.J., Yu, C.P., Boymel, Paul M., Zoitos, Bruce K., Cason, James E.

“…Isofrax and Insulfrax are two new synthetic vitreous fibers (SVFs) developed for high-temperature insulation (1800–2300°F) applications. In an attempt to…”
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Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part V: target animal safety/toxicity study in growing swine by Abril, Ruben, Garrett, Jack, Zeller, Samuel G, Sander, Wayne J, Mast, Richard W

“…The purpose of this study was to determine the potential toxicity of docosahexaenoic acid (DHA)-rich microalgae (DRM) from Schizochytrium sp., administered in…”
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The distribution of [14C]acrylamide in male and pregnant Swiss-Webster mice studied by whole-body autoradiography by Marlowe, C, Clark, M J, Mast, R W, Friedman, M A, Waddell, W J

“…Male and 13.5- and 17.5-day pregnant Swiss-Webster mice were administered 120 mg/kg [2,3-14C]acrylamide orally. The male mice were frozen 0.33, 1, 3, 9, 24,…”
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Acrylonitrile as a carcinogen. Research needs for better risk assessment by Strother, D E, Mast, R W, Kraska, R C, Frankos, V

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Nantradol hydrochloride: pharmacokinetics and behavioral effects after acute and chronic treatment by McIlhenny, H M, Mast, R W, Johnson, M R, Milne, G M

“…Studies with [3H]nantradol hydrochloride indicate that nantradol is extensively metabolized after oral administration. By using a liquid chromatography assay…”
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Chronic Inhalation and Biopersistence of Refractory Ceramic Fiber in Rats and Hamsters by Mast, R. W., Hesterberg, T. W., Glass, L. R., McConnell, E. E., Anderson, R., Bernstein, D. M.

“…Lifetime "nose-only" inhalation studies were conducted in rats using four types of refractory ceramic fibers (FCF), 1 μm in diameter × 22 to 26 μm length: High…”
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Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study by McKim, Jr, J M, Wilga, P C, Kolesar, G B, Choudhuri, S, Madan, A, Dochterman, L W, Breen, J G, Parkinson, A, Mast, R W, Meeks, R G

“…Repeated inhalation exposure to octamethylcyclotetrasiloxane (D4) produces a reversible and dose-related hepatomegaly and proliferation of hepatic endoplasmic…”
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Metabolism, disposition and excretion of [14C]melamine in male Fischer 344 rats by Mast, R W, Jeffcoat, A R, Sadler, B M, Kraska, R C, Friedman, M A

“…The metabolism, excretion and disposition of melamine were determined after administration of a single oral dose of 0.025 mCi (0.38 mg) [14C]melamine to adult…”
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Chronic Inhalation and Biopersistence of Refractory Ceramic Fiber in Rats and Hamsters by Mast, R. W., Hesterberg, T. W., Glass, L. R., McConnell, E. E., Anderson, R., Bernstein, D. M.

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