Search Results - "MASSFELDER, Thierry"

Editorial: in vitro and in vivo non-clinical models of kidney cancers by Dormoy, Valérian, Filhol, Odile, Sourbier, Carole, Massfelder, Thierry

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Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes by Harmouch, Ezeddine, Seitlinger, Joseph, Chaddad, Hassan, Ubeaud-Sequier, Geneviève, Barths, Jochen, Saidu, Sani, Désaubry, Laurent, Grandemange, Stéphanie, Massfelder, Thierry, Fuhrmann, Guy, Fioretti, Florence, Dontenwill, Monique, Benkirane-Jessel, Nadia, Idoux-Gillet, Ysia

“…Glioblastoma (GBM) is one of the most aggressive types of cancer, which begins within the brain. It is the most invasive type of glioma developed from…”
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Editorial: Identifying novel biomarkers in bladder cancer by Ecke, Thorsten H, Lotan, Yair, Massfelder, Thierry

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Recurrent activating mutations of PPARγ associated with luminal bladder tumors by Rochel, Natacha, Krucker, Clémentine, Coutos-Thévenot, Laure, Osz, Judit, Zhang, Ruiyun, Guyon, Elodie, Zita, Wayne, Vanthong, Séverin, Hernandez, Oscar Alba, Bourguet, Maxime, Badawy, Kays Al, Dufour, Florent, Peluso-Iltis, Carole, Heckler-Beji, Syrine, Dejaegere, Annick, Kamoun, Aurélie, de Reyniès, Aurélien, Neuzillet, Yann, Rebouissou, Sandra, Béraud, Claire, Lang, Hervé, Massfelder, Thierry, Allory, Yves, Cianférani, Sarah, Stote, Roland H., Radvanyi, François, Bernard-Pierrot, Isabelle

“…The upregulation of PPARγ/RXRα transcriptional activity has emerged as a key event in luminal bladder tumors. It renders tumor cell growth PPARγ-dependent and…”
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The Lim1 oncogene as a new therapeutic target for metastatic human renal cell carcinoma by Hamaidi, Imène, Coquard, Catherine, Danilin, Sabrina, Dormoy, Valérian, Béraud, Claire, Rothhut, Sylvie, Barthelmebs, Mariette, Benkirane-Jessel, Nadia, Lindner, Véronique, Lang, Hervé, Massfelder, Thierry

“…Metastatic clear cell renal cell carcinoma (CCC) remains incurable despite advances in the development of anti-angiogenic targeted therapies and the emergence…”
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An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers by Mahe, Mélanie, Dufour, Florent, Neyret‐Kahn, Hélène, Moreno‐Vega, Aura, Beraud, Claire, Shi, Mingjun, Hamaidi, Imene, Sanchez‐Quiles, Virginia, Krucker, Clementine, Dorland‐Galliot, Marion, Chapeaublanc, Elodie, Nicolle, Remy, Lang, Hervé, Pouponnot, Celio, Massfelder, Thierry, Radvanyi, François, Bernard‐Pierrot, Isabelle

“…FGFR3 alterations (mutations or translocation) are among the most frequent genetic events in bladder carcinoma. They lead to an aberrant activation of FGFR3…”
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A new tumorgraft panel to accelerate precision medicine in prostate cancer by Béraud, Claire, Bidan, Nadege, Lassalle, Myriam, Lang, Hervé, Lindner, Véronique, Krucker, Clémentine, Masliah-Planchon, Julien, Potiron, Eric, Lluel, Philippe, Massfelder, Thierry, Allory, Yves, Misseri, Yolande

“…Despite the significant advances in the management of advanced prostate cancer (PCa), metastatic PCa is currently considered incurable. For further…”
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Establishment of a large panel of patient-derived preclinical models of human renal cell carcinoma by Lang, Hervé, Béraud, Claire, Bethry, Audrey, Danilin, Sabrina, Lindner, Véronique, Coquard, Catherine, Rothhut, Sylvie, Massfelder, Thierry

“…The objective of the present work was to establish a large panel of preclinical models of human renal cell carcinoma (RCC) directly from patients, faithfully…”
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Vitamin D3 triggers antitumor activity through targeting hedgehog signaling in human renal cell carcinoma by DORMOY, Valerian, BERAUD, Claire, LINDNER, Véronique, COQUARD, Catherine, BARTHELMEBS, Mariette, BRASSE, David, JACQMIN, Didier, LANG, Hervé, MASSFELDER, Thierry

“…Human clear cell renal cell carcinoma (CCC) remains resistant to treatments despite the progress in targeted therapies. Several signaling pathways acting…”
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The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth by Dormoy, Valérian, Danilin, Sabrina, Lindner, Véronique, Thomas, Lionel, Rothhut, Sylvie, Coquard, Catherine, Helwig, Jean-Jacques, Jacqmin, Didier, Lang, Hervé, Massfelder, Thierry

“…Human clear cell renal cell carcinoma (CRCC) remains resistant to therapies. Recent advances in Hypoxia Inducible Factors (HIF) molecular network led to…”
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The phosphoinositide 3-Kinase/Akt pathway : A new target in human renal cell carcinoma therapy by SOURBIER, Carole, LINDNER, Véronique, LANG, Hervé, AGOUNI, Abdelali, SCHORDAN, Eric, DANILIN, Sabrina, ROTHHUT, Sylvie, JACQMIN, Didier, HELWIG, Jean-Jacques, MASSFELDER, Thierry

“…Metastatic renal cell carcinoma is resistant to current therapies. The phosphoinositide 3-kinase (PI3K)/Akt signaling cascade induces cell growth, cell…”
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Parathyroid Hormone-Related Protein Is a Mitogenic and a Survival Factor of Mesangial Cells from Male Mice: Role of Intracrine and Paracrine Pathways by Hochane, Mazène, Raison, Denis, Coquard, Catherine, Imhoff, Olivier, Massfelder, Thierry, Moulin, Bruno, Helwig, Jean-Jacques, Barthelmebs, Mariette

“…Glomerulonephritis is characterized by the proliferation and apoptosis of mesangial cells (MC). The parathyroid-hormone related protein (PTHrP) is a locally…”
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Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapies by Lang, Hervé, Béraud, Claire, Cabel, Luc, Fontugne, Jacqueline, Lassalle, Myriam, Krucker, Clémentine, Dufour, Florent, Groeneveld, Clarice S., Dixon, Victoria, Meng, Xiangyu, Kamoun, Aurélie, Chapeaublanc, Elodie, De Reynies, Aurélien, Gamé, Xavier, Rischmann, Pascal, Bieche, Ivan, Masliah-Planchon, Julien, Beaurepere, Romane, Allory, Yves, Lindner, Véronique, Misseri, Yolande, Radvanyi, François, Lluel, Philippe, Bernard-Pierrot, Isabelle, Massfelder, Thierry

“…Background Muscle-invasive bladder cancer (MIBC) and upper urinary tract urothelial carcinoma (UTUC) are molecularly heterogeneous. Despite chemotherapies,…”
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Parathyroid hormone-related protein in human renal cell carcinoma by Sourbier, Carole, Massfelder, Thierry

“…Parathyroid hormone-related protein (PTHrP), a polyprotein discovered in 1987, plays crucial roles not only in development and in various physiological events…”
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Opposing Mitogenic and Anti-Mitogenic Actions of Parathyroid Hormone-Related Protein in Vascular Smooth Muscle Cells: A Critical Role for Nuclear Targeting by Massfelder, Thierry, Dann, Pamela, Wu, Terence L., Vasavada, Rupangi, Helwig, Jean-Jacques, Stewart, Andrew F.

“…Parathyroid hormone-related protein (PTHrP) is a prohormone that is posttranslationally processed to a family of mature secretory forms, each of which has its…”
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Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene by MASSFELDER, Thierry, LANG, Herve, SCHORDAN, Eric, LINDNER, Veronique, ROTHHUT, Sylvie, WELSCH, Sandra, SIMON-ASSMANN, Patricia, BARTHELMEBS, Mariette, JACQMIN, Didier, HELWIG, Jean-Jacques

“…Clear cell renal carcinoma (CCRC) is responsible for 2% of cancer-related deaths worldwide and is resistant to virtually all therapies, indicating the…”
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Structural and Physiologic Characterization of the Mid-region Secretory Species of Parathyroid Hormone-related Protein by Wu, T L, Vasavada, R C, Yang, K, Massfelder, T, Ganz, M, Abbas, S K, Care, A D, Stewart, A F

“…Parathyroid hormone-related protein (PTHrP) is initially translated as a preprohormone which is posttranslationally processed to yield a family of mature…”
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Editorial: in vitro and in vivo non-clinical models of kidney cancers by Dormoy, Valérian, Filhol, Odile, Sourbier, Carole, Massfelder, Thierry

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Type 1 parathyroid hormone receptor expression level modulates renal tone and plasma renin activity in spontaneously hypertensive rat by MASSFELDER, Thierry, TAESCH, Nathalie, FRITSCH, Samuel, EICHINGER, Anne, BARTHELMEBS, Mariette, STEWART, Andrew F, HELWIG, Jean-Jacques

“…These studies examine whether PTHrP(1-36), a vasodilator, modulates BP and renal vascular resistance (RVR) in spontaneously hypertensive rat (SHR). Within the…”
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A vitamin D‐based strategy overcomes chemoresistance in prostate cancer by Len‐Tayon, Kateryna, Beraud, Claire, Fauveau, Clara, Belorusova, Anna Y., Chebaro, Yassmine, Mouriño, Antonio, Massfelder, Thierry, Chauchereau, Anne, Metzger, Daniel, Rochel, Natacha, Laverny, Gilles

“…Background and purpose Castration‐resistant prostate cancer (CRPC) is a common male malignancy that requires new therapeutic strategies due to acquired…”
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