Search Results - "MASSE, Stéphane"

Engineered heart tissue enables study of residual undifferentiated embryonic stem cell activity in a cardiac environment by Dengler, Jana, Song, Hannah, Thavandiran, Nimalan, Massé, Stéphane, Wood, Geoffrey A, Nanthakumar, Kumaraswamy, Zandstra, Peter W, Radisic, Milica

“…Embryonic stem cell (ESC) derivatives are a promising cell source for cardiac cell therapy. Mechanistic studies upon cell injection in conventional animal…”
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Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy by MUELLER, Erin E, MOMEN, Abdul, MASSE, Stéphane, ZHOU, Yu-Qing, JIE LIU, BACKX, Peter H, HENKELMAN, R. Mark, NANTHAKUMAR, Kumaraswamy, STEWART, Duncan J, HUSAIN, Mansoor

“…Binary transgenic (BT) mice with doxycycline (DOX)-suppressible cardiac-specific overexpression of endothelin-1 (ET-1) exhibit progressive heart failure (HF),…”
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Intraoperative High-Density Global Mapping in Adult-Repaired Tetralogy of Fallot: Altered Left Ventricular and Right Ventricular Activation and Implications for Resynchronization Strategies by Nanthakumar, Kumaraswamy, Massé, Stéphane, Poku, Kwaku, Silversides, Candice K., Chauhan, Vijay S., Mariani, Justin A., Sivagangabalan, Gopal, Oechslin, Erwin N., Downar, Eugene, Harris, Louise

“…[...]it has been proposed that RV apical pacing may improve RV function on the basis of resynchronizing late activated segments (2). A comparison group of 4…”
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Pro-arrhythmic role of adrenergic spatial densities in the human atria: An in-silico study by Magtibay, Karl, Massé, Stéphane, Nanthakumar, Kumaraswamy, Umapathy, Karthikeyan

“…Chronic stress among young patients (≤ 45 years old) could result in autonomic dysfunction. Autonomic dysfunction could be exhibited via sympathetic…”
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Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes by Nunes, Sara S, Miklas, Jason W, Liu, Jie, Aschar-Sobbi, Roozbeh, Xiao, Yun, Zhang, Boyang, Jiang, Jiahua, Massé, Stéphane, Gagliardi, Mark, Hsieh, Anne, Thavandiran, Nimalan, Laflamme, Michael A, Nanthakumar, Kumaraswamy, Gross, Gil J, Backx, Peter H, Keller, Gordon, Radisic, Milica

“…The combination of controlled three-dimensional assembly and electrical stimulation allows the maturation of stem cell–derived cardiomyocytes. Directed…”
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Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias by Romagnuolo, Rocco, Masoudpour, Hassan, Porta-Sánchez, Andreu, Qiang, Beiping, Barry, Jennifer, Laskary, Andrew, Qi, Xiuling, Massé, Stéphane, Magtibay, Karl, Kawajiri, Hiroyuki, Wu, Jun, Valdman Sadikov, Tamilla, Rothberg, Janet, Panchalingam, Krishna M., Titus, Emily, Li, Ren-Ke, Zandstra, Peter W., Wright, Graham A., Nanthakumar, Kumaraswamy, Ghugre, Nilesh R., Keller, Gordon, Laflamme, Michael A.

“…Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show considerable promise for regenerating injured hearts, and we therefore tested their capacity…”
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Design and formulation of functional pluripotent stem cell-derived cardiac microtissues by Thavandiran, Nimalan, Dubois, Nicole, Mikryukov, Alexander, Massé, Stéphane, Beca, Bogdan, Simmons, Craig A, Deshpande, Vikram S, McGarry, J Patrick, Chen, Christopher S, Nanthakumar, Kumaraswamy, Keller, Gordon M, Radisic, Milica, Zandstra, Peter W

“…Access to robust and information-rich human cardiac tissue models would accelerate drug-based strategies for treating heart disease. Despite significant…”
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Death, discharge and arrhythmias among patients with COVID-19 and cardiac injury by Si, Daoyuan, Du, Beibei, Ni, Lujia, Yang, Bo, Sun, Huan, Jiang, Nan, Liu, Guohui, Massé, Stéphane, Jin, Lina, Nanthakumar, Jared, Bhaskaran, Abhishek, Yang, Ping, Nanthakumar, Kumaraswamy

“…Cardiac injury is common in severe coronavirus disease 2019 (COVID-19) and is associated with poor outcomes. We aimed to study predictors of in-hospital death,…”
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Spontaneous termination of ventricular tachycardia in the human heart by Hayashi, Takahiro, Denham, Nathan, Nettlefold, Chloe, Kakarla, Jayant, Anderson, Robert, Bhaskaran, Abhishek, Massé, Stéphane, Downar, Eugene, Nanthakumar, Kumaraswamy

“…Introduction Understanding the spatiotemporal location of the spontaneous termination of ventricular tachycardia (VT) may provide new insights for ablation. To…”
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Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis by Zhang, Boyang, Montgomery, Miles, Chamberlain, M. Dean, Ogawa, Shinichiro, Korolj, Anastasia, Pahnke, Aric, Wells, Laura A., Massé, Stéphane, Kim, Jihye, Reis, Lewis, Momen, Abdul, Nunes, Sara S., Wheeler, Aaron R., Nanthakumar, Kumaraswamy, Keller, Gordon, Sefton, Michael V., Radisic, Milica

“…We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the assembly of parenchymal cells on a mechanically tunable matrix…”
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To the Editor— Determinants of bipolar amplitude by Nayyar, Sachin, Massé, Stéphane, Nanthakumar, Kumaraswamy

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Restoration of calcium release synchrony: A novel target for heart failure and ventricular arrhythmia by Chakraborty, Praloy, Aggarwal, Arjun K, Nair, Madhav Krishna Kumar, Massé, Stéphane, Riazi, Sheila, Nanthakumar, Kumaraswamy

“…Myocardial calcium (Ca ) signaling plays a crucial role in contractile function and membrane electrophysiology. An abnormal myocardial Ca transient is linked…”
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Decrement Evoked Potential (DEEP) Mapping: The Basis of a Mechanistic Strategy for Ventricular Tachycardia Ablation by Jackson, Nicholas, Gizurarson, Sigfus, Viswanathan, Karthik, King, Benjamin, Massé, Stéphane, Kusha, Marjan, Porta-Sanchez, Andreu, Roshan Jacob, John, Khan, Fakhar, Das, Moloy, Ha, Andrew C.T, Pashaei, Ali, Vigmond, Edward, Downar, Eugene, Nanthakumar, Kumaraswamy

“…BACKGROUND—Substrate based mapping for ventricular tachycardia (VT) ablation is hampered by its inability to determine critical sites of the VT circuit. We…”
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A 3-D human model of complex cardiac arrhythmias by Williams, Kenneth, Liang, Timothy, Massé, Stéphane, Khan, Safwat, Hatkar, Rupal, Keller, Gordon, Nanthakumar, Kumaraswamy, Nunes, Sara S.

“…Cardiac arrhythmias impact over 12 million people globally, with an increasing incidence of acquired arrhythmias. Although animal models have shed light onto…”
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Cardiac mapping with irreverence to time: Replacing isochrones with omnipolar vectors by Burg, Melanie R., Anderson, Robert D., Massé, Stéphane, Nanthakumar, Kumaraswamy

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Arrhythmogenic Ventricular Remodeling by Next-Generation Bruton's Tyrosine Kinase Inhibitor Acalabrutinib by Zhao, Yanan, Chakraborty, Praloy, Tomassetti, Julianna, Subha, Tasnia, Massé, Stéphane, Thavendiranathan, Paaladinesh, Billia, Filio, Lai, Patrick F H, Abdel-Qadir, Husam, Nanthakumar, Kumaraswamy

“…Cardiac arrhythmias remain a significant concern with Ibrutinib (IBR), a first-generation Bruton's tyrosine kinase inhibitor (BTKi). Acalabrutinib (ABR), a…”
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Signature signal strategy: Electrogram-based ventricular tachycardia mapping by Nayyar, Sachin, Downar, Eugene, Bhaskaran, Abhishek P., Massé, Stéphane, Nanthakumar, Kumaraswamy

“…Multiple decades of work have recognized complexities of substrates responsible for ventricular tachycardia (VT). There is sufficient evidence that 3 critical…”
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Anti-arrhythmic and inotropic effects of empagliflozin following myocardial ischemia by Azam, Mohammed Ali, Chakraborty, Praloy, Si, Daoyuan, Du, BeiBei, Massé, Stéphane, Lai, Patrick F.H., Ha, Andrew C.T., Nanthakumar, Kumaraswamy

“…Empagliflozin (EMPA) reduces heart failure hospitalization and mortality. The benefit in terms of ventricular arrhythmia and contractility has not been…”
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Safety, efficacy, and monitoring of bipolar radiofrequency ablation in beating myopathic human and healthy swine hearts by Bhaskaran, Abhishek, Niri, Ahmed, Azam, Mohammed Ali, Nayyar, Sachin, Porta-Sánchez, Andreu, Massé, Stéphane, Liang, Timothy, Veluppillai, Arulalan, Du, Beibei, Lai, Patrick F.H., Ha, Andrew, Nanthakumar, Kumaraswamy

“…The safety and efficacy parameters for bipolar radiofrequency (RF) ablation are not well defined. The purpose of this study was to investigate the safe range…”
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Dantrolene Improves Survival After Ventricular Fibrillation by Mitigating Impaired Calcium Handling in Animal Models by Zamiri, Nima, Massé, Stéphane, Ramadeen, Andrew, Kusha, Marjan, Hu, Xudong, Azam, Mohammed Ali, Liu, Jie, Lai, Patrick F H, Vigmond, Edward J, Boyle, Patrick M, Behradfar, Elham, Al-Hesayen, Abdul, Waxman, Menashe B, Backx, Peter, Dorian, Paul, Nanthakumar, Kumaraswamy

“…BACKGROUND—Resistant ventricular fibrillation, refibrillation. and diminished myocardial contractility are important factors leading to poor survival after…”
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