Search Results - "MASEREEUW, R."

Bioengineered kidney tubules efficiently excrete uremic toxins by Jansen, J., Fedecostante, M., Wilmer, M. J., Peters, J. G., Kreuser, U. M., van den Broek, P. H., Mensink, R. A., Boltje, T. J., Stamatialis, D., Wetzels, J. F., van den Heuvel, L. P., Hoenderop, J. G., Masereeuw, R.

“…The development of a biotechnological platform for the removal of waste products (e.g. uremic toxins), often bound to proteins in plasma, is a prerequisite to…”
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Iron metabolism in the pathogenesis of iron-induced kidney injury by Martines, A. M. F., Masereeuw, R., Tjalsma, H., Hoenderop, J. G., Wetzels, J. F. M., Swinkels, D. W.

“…Patients with kidney disease are often exposed to high concentrations of iron as a result of the underlying pathological processes. Under these conditions,…”
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Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate by Peters, E, Geraci, S, Heemskerk, S, Wilmer, M J, Bilos, A, Kraenzlin, B, Gretz, N, Pickkers, P, Masereeuw, R

“…Background and Purpose Recently, two phase‐II trials demonstrated improved renal function in critically ill patients with sepsis‐associated acute kidney injury…”
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The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane by Huls, M., Brown, C.D.A., Windass, A.S., Sayer, R., van den Heuvel, J.J.M.W., Heemskerk, S., Russel, F.G.M., Masereeuw, R.

“…The Breast Cancer Resistance Protein (BCRP/ABCG2) is a transporter restricting absorption and enhancing excretion of many compounds including anticancer drugs…”
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KCNJ16-depleted kidney organoids recapitulate tubulopathy and lipid recovery upon statins treatment by Sendino Garví, E, van Slobbe, G J J, Zaal, E A, de Baaij, J H F, Hoenderop, J G, Masereeuw, R, Janssen, M J, van Genderen, A M

“…The KCNJ16 gene has been associated with a novel kidney tubulopathy phenotype, viz. disturbed acid-base homeostasis, hypokalemia and altered renal salt…”
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Development of an adverse outcome pathway network for nephrotoxicity by Barnes, D. A., Firman, J. W., Belfield, S. J., Cronin, M. T. D., Vinken, M., Janssen, M. J., Masereeuw, R.

“…Adverse outcome pathways (AOPs) were introduced in modern toxicology to provide evidence-based representations of the events and processes involved in the…”
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Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations by Jansen, J., De Napoli, I. E, Fedecostante, M., Schophuizen, C. M. S., Chevtchik, N. V., Wilmer, M. J., van Asbeck, A. H., Croes, H. J., Pertijs, J. C., Wetzels, J. F. M., Hilbrands, L. B., van den Heuvel, L. P., Hoenderop, J. G., Stamatialis, D., Masereeuw, R.

“…The bioartificial kidney (BAK) aims at improving dialysis by developing ‘living membranes’ for cells-aided removal of uremic metabolites. Here, unique human…”
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Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells by van Raaij, S.E.G., Masereeuw, R., Swinkels, D.W., van Swelm, R.P.L.

“…•Chronic renal iron exposure in systemic iron overload can induce injury.•Iron loading activates the antioxidative Nrf2 pathway and its target genes.•Chronic…”
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Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study by Suter-Dick, Laura, Mauch, L., Ramp, D., Caj, M., Vormann, M. K., Hutter, S., Lanz, H. L., Vriend, J., Masereeuw, R., Wilmer, M. J.

“…Drug-induced kidney injury is often observed in the clinics and can lead to long-term organ failure. In this work, we evaluated a novel in vitro system that…”
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Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration by Mutsaers, H A M, Wilmer, M J G, Reijnders, D, Jansen, J, van den Broek, P H H, Forkink, M, Schepers, E, Glorieux, G, Vanholder, R, van den Heuvel, L P, Hoenderop, J G, Masereeuw, R

“…During chronic kidney disease (CKD), drug metabolism is affected leading to changes in drug disposition. Furthermore, there is a progressive accumulation of…”
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Vascular units as advanced living materials for bottom-up engineering of perfusable 3D microvascular networks by Orge, I.D., Nogueira Pinto, H., Silva, M.A., Bidarra, S.J., Ferreira, S.A., Calejo, I., Masereeuw, R., Mihăilă, S.M., Barrias, C.C.

“…The timely establishment of functional neo-vasculature is pivotal for successful tissue development and regeneration, remaining a central challenge in tissue…”
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A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue by Jansen, J., Schophuizen, C.M.S., Wilmer, M.J., Lahham, S.H.M., Mutsaers, H.A.M., Wetzels, J.F.M., Bank, R.A., van den Heuvel, L.P., Hoenderop, J.G., Masereeuw, R.

“…Promising renal replacement therapies include the development of a bioartificial kidney using functional human kidney cell models. In this study, human…”
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Biotechnological challenges of bioartificial kidney engineering by Jansen, J., Fedecostante, M., Wilmer, M.J., van den Heuvel, L.P., Hoenderop, J.G., Masereeuw, R.

“…With the world-wide increase of patients with renal failure, the development of functional renal replacement therapies have gained significant interest and…”
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A bioartificial kidney device with polarized secretion of immune modulators by Chevtchik, N. V., Mihajlovic, M., Fedecostante, M., Bolhuis‐Versteeg, L., Sastre Toraño, J., Masereeuw, R., Stamatialis, D.

“…The accumulation of protein‐bound toxins in dialyzed patients is strongly associated with their high morbidity and mortality. The bioartificial kidney device…”
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Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model by Schirris, T. J. J., Jansen, J., Mihajlovic, M., van den Heuvel, L. P., Masereeuw, R., Russel, F. G. M.

“…Septic acute kidney injury (AKI) associates with poor survival rates and often requires renal replacement therapy. Glucocorticoids may pose renal protective…”
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Low‐titre inhibitors, undetectable by the Nijmegen assay, reduce factor VIII half‐life after immune tolerance induction by DARDIKH, M., ALBERT, T., MASEREEUW, R., OLDENBURG, J., NOVAKOVA, I., VAN HEERDE, W. L., VERBRUGGEN, B.

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Advanced in vitro models for nephrotoxicity testing: as complex as possible, but simple in use by Masereeuw, R.

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ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney by Huls, M., van den Heuvel, J.J.M.W., Dijkman, H.B.P.M., Russel, F.G.M., Masereeuw, R.

“…Renal ATP binding cassette (ABC) transporters have an important role in the elimination of metabolic waste products and compounds foreign to the body. The…”
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G.P.108 by den Besten, C, Jones, S, Wilmer, M, Masereeuw, R, Campion, G

“…Prosensa Therapeutics is developing 2′ O -modified phosphorothioate antisense oligonucleotides (AONs) to provide a mutation-specific therapy in the treatment…”
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Basolateral transport of the uraemic toxin p-cresyl sulfate: role for organic anion transporters? by Mutsaers, Henricus A. M., Wilmer, Martijn J. G., van den Heuvel, Lambertus P., Hoenderop, Joost G., Masereeuw, Rosalinde

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