Search Results - "MARTORANA, Alessandra M"

The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria by Sperandeo, Paola, Martorana, Alessandra M., Polissi, Alessandra

“…The outer membrane (OM) of Gram-negative is a unique lipid bilayer containing LPS in its outer leaflet. Because of the presence of amphipathic LPS molecules,…”
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Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect by Morè, Niccolò, Martorana, Alessandra M, Biboy, Jacob, Otten, Christian, Winkle, Matthias, Serrano, Carlos K Gurnani, Montón Silva, Alejandro, Atkinson, Lisa, Yau, Hamish, Breukink, Eefjan, den Blaauwen, Tanneke, Vollmer, Waldemar, Polissi, Alessandra

“…Gram-negative bacteria have a tripartite cell envelope with the cytoplasmic membrane (CM), a stress-bearing peptidoglycan (PG) layer, and the asymmetric outer…”
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Thanatin Impairs Lipopolysaccharide Transport Complex Assembly by Targeting LptC–LptA Interaction and Decreasing LptA Stability by Moura, Elisabete C. C. M., Baeta, Tiago, Romanelli, Alessandra, Laguri, Cedric, Martorana, Alessandra M., Erba, Emanuela, Simorre, Jean-Pierre, Sperandeo, Paola, Polissi, Alessandra

“…The outer membrane (OM) of Gram-negative bacteria is a highly selective permeability barrier due to its asymmetric structure with lipopolysaccharide (LPS) in…”
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Escherichia coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export Is Assembled via Conserved Structurally Homologous Domains by Villa, Riccardo, Martorana, Alessandra M, Okuda, Suguru, Gourlay, Louise J, Nardini, Marco, Sperandeo, Paola, Dehò, Gianni, Bolognesi, Martino, Kahne, Daniel, Polissi, Alessandra

“…Lipopolysaccharide is a major glycolipid component in the outer leaflet of the outer membrane (OM), a peculiar permeability barrier of Gram-negative bacteria…”
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DpaA Detaches Braun's Lipoprotein from Peptidoglycan by Winkle, Matthias, Hernández-Rocamora, Víctor M, Pullela, Karthik, Goodall, Emily C A, Martorana, Alessandra M, Gray, Joe, Henderson, Ian R, Polissi, Alessandra, Vollmer, Waldemar

“…Gram-negative bacteria have a unique cell envelope with a lipopolysaccharide-containing outer membrane that is tightly connected to a thin layer of…”
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Dissecting Escherichia coli outer membrane biogenesis using differential proteomics by Martorana, Alessandra M, Motta, Sara, Di Silvestre, Dario, Falchi, Federica, Dehò, Gianni, Mauri, Pierluigi, Sperandeo, Paola, Polissi, Alessandra

“…The cell envelope of Gram-negative bacteria is a complex multi-layered structure comprising an inner cytoplasmic membrane and an additional asymmetric lipid…”
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New Insights into the Lpt Machinery for Lipopolysaccharide Transport to the Cell Surface: LptA-LptC Interaction and LptA Stability as Sensors of a Properly Assembled Transenvelope Complex by SPERANDEO, Paola, VILLA, Riccardo, MARTORANA, Alessandra M, SAMALIKOVA, Maria, GRANDORI, Rita, DEHO, Gianni, POLISSI, Alessandra

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pseudomonas aeruginosa LptE is crucial for LptD assembly, cell envelope integrity, antibiotic resistance and virulence by Lo Sciuto, Alessandra, Martorana, Alessandra M., Fernández-Piñar, Regina, Mancone, Carmine, Polissi, Alessandra, Imperi, Francesco

“…Lipopolysaccharide (LPS) is an essential structural component of the outer membrane (OM) of most Gram-negative bacteria. In the model organism Escherichia…”
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The Landscape of Pseudomonas aeruginosa Membrane-Associated Proteins by Motta, Sara, Vecchietti, Davide, Martorana, Alessandra M, Brunetti, Pietro, Bertoni, Giovanni, Polissi, Alessandra, Mauri, Pierluigi, Di Silvestre, Dario

“…cell envelope-associated proteins play a relevant role in infection mechanisms. They can contribute to the antibiotic resistance of the bacterial cells and be…”
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Lipopolysaccharide biogenesis and transport at the outer membrane of Gram-negative bacteria by Sperandeo, Paola, Martorana, Alessandra M., Polissi, Alessandra

“…The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer containing a unique glycolipid, lipopolysaccharide (LPS) in its outer leaflet…”
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Degradation of Components of the Lpt Transenvelope Machinery Reveals LPS-Dependent Lpt Complex Stability in Escherichia coli by Martorana, Alessandra M, Moura, Elisabete C C M, Sperandeo, Paola, Di Vincenzo, Flavia, Liang, Xiaofei, Toone, Eric, Zhou, Pei, Polissi, Alessandra

“…Lipopolysaccharide (LPS) is a peculiar component of the outer membrane (OM) of many Gram-negative bacteria that renders these bacteria highly impermeable to…”
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Targeting the LPS export pathway for the development of novel therapeutics by Sperandeo, Paola, Martorana, Alessandra M, Zaccaria, Marta, Polissi, Alessandra

“…The rapid rise of multi-resistant bacteria is a global health threat. This is especially serious for Gram-negative bacteria in which the impermeable outer…”
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The Lpt ABC transporter for lipopolysaccharide export to the cell surface by Sperandeo, Paola, Martorana, Alessandra M., Polissi, Alessandra

“…The surface of the outer membrane of Gram-negative bacteria is covered by a tightly packed layer of lipopolysaccharide molecules which provide a barrier…”
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Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins by Peters, Katharina, Pazos, Manuel, Edoo, Zainab, Hugonnet, Jean-Emmanuel, Martorana, Alessandra M., Polissi, Alessandra, VanNieuwenhze, Michael S., Arthur, Michel, Vollmer, Waldemar

“…The peptidoglycan (PG) layer stabilizes the bacterial cell envelope to maintain the integrity and shape of the cell. Penicillin-binding proteins (PBPs)…”
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ActS activates peptidoglycan amidases during outer membrane stress in Escherichia coli by Gurnani Serrano, Carlos K., Winkle, Matthias, Martorana, Alessandra M., Biboy, Jacob, Morè, Niccolo, Moynihan, Patrick, Banzhaf, Manuel, Vollmer, Waldemar, Polissi, Alessandra

“…The integrity of the cell envelope of E. coli relies on the concerted activity of multi‐protein machineries that synthesize the peptidoglycan (PG) and the…”
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Lipopolysaccharide Biosynthesis and Transport to the Outer Membrane of Gram-Negative Bacteria by Sperandeo, Paola, Martorana, Alessandra M, Polissi, Alessandra

“…Gram-negative bacteria have an outer membrane that is positioned at the frontline of the cell's interaction with the environment and that serves as a barrier…”
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Mutation and Suppressor Analysis of the Essential Lipopolysaccharide Transport Protein LptA Reveals Strategies To Overcome Severe Outer Membrane Permeability Defects in Escherichia coli by Falchi, Federica A, Maccagni, Elisa A, Puccio, Simone, Peano, Clelia, De Castro, Cristina, Palmigiano, Angelo, Garozzo, Domenico, Martorana, Alessandra M, Polissi, Alessandra, Dehò, Gianni, Sperandeo, Paola

“…In Gram-negative bacteria, lipopolysaccharide (LPS) contributes to the robust permeability barrier of the outer membrane (OM), preventing the entry of toxic…”
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Solid State NMR Studies of Intact Lipopolysaccharide Endotoxin by Laguri, Cedric, Silipo, Alba, Martorana, Alessandra M, Schanda, Paul, Marchetti, Roberta, Polissi, Alessandra, Molinaro, Antonio, Simorre, Jean-Pierre

“…Lipopolysaccharides (LPS) are complex glycolipids forming the outside layer of Gram-negative bacteria. Their hydrophobic and heterogeneous nature greatly…”
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Functional Interaction between the Cytoplasmic ABC Protein LptB and the Inner Membrane LptC Protein, Components of the Lipopolysaccharide Transport Machinery in Escherichia coli by Martorana, Alessandra M, Benedet, Mattia, Maccagni, Elisa A, Sperandeo, Paola, Villa, Riccardo, Dehò, Gianni, Polissi, Alessandra

“…The assembly of lipopolysaccharide (LPS) in the outer leaflet of the outer membrane (OM) requires the transenvelope Lpt (lipopolysaccharide transport) complex,…”
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Crystal structure of LptH, the periplasmic component of the lipopolysaccharide transport machinery from Pseudomonas aeruginosa by Bollati, Michela, Villa, Riccardo, Gourlay, Louise J, Benedet, Mattia, Dehò, Gianni, Polissi, Alessandra, Barbiroli, Alberto, Martorana, Alessandra M, Sperandeo, Paola, Bolognesi, Martino, Nardini, Marco

“…Lipopolysaccharide (LPS) is the main glycolipid present in the outer leaflet of the outer membrane (OM) of Gram‐negative bacteria, where it modulates OM…”
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