Search Results - "MARTINI, V."

Messenger RNA therapy for rare genetic metabolic diseases by Berraondo, Pedro, Martini, Paolo G V, Avila, Matias A, Fontanellas, Antonio

“…Decades of intense research in molecular biology and biochemistry are fructifying in the emergence of therapeutic messenger RNAs (mRNA) as a new class of…”
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Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency by Truong, Brian, Allegri, Gabriella, Liu, Xiao-Bo, Burke, Kristine E., Zhu, Xuling, Cederbaum, Stephen D., Häberle, Johannes, Martini, Paolo G. V., Lipshutz, Gerald S.

“…Arginase deficiency is caused by biallelic mutations in arginase 1 (ARG1), the final step of the urea cycle, and results biochemically in hyperargininemia and…”
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Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia by Jiang, Lei, Park, Ji-Sun, Yin, Ling, Laureano, Rodrigo, Jacquinet, Eric, Yang, Jinsong, Liang, Shi, Frassetto, Andrea, Zhuo, Jenny, Yan, Xinhua, Zhu, Xuling, Fortucci, Steven, Hoar, Kara, Mihai, Cosmin, Tunkey, Christopher, Presnyak, Vlad, Benenato, Kerry E., Lukacs, Christine M., Martini, Paolo G. V., Guey, Lin T.

“…Propionic acidemia/aciduria (PA) is an ultra-rare, life-threatening, inherited metabolic disorder caused by deficiency of the mitochondrial enzyme,…”
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Vr exposure in cbt is effective and efficacious treatment for simple phobia (flight phobia) by D’Ambrosio, A., Tonelli, C., Martini, V., Ambrosio, C.

“…Introduction The virtual environment with realistically rendered fear-inducing stimuli is enough to conduct VR exposure therapy (VRE), although the total…”
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Factors correlating with circulating T-zone-like cells of undetermined significance (TZUS) in dogs resident in Italy by Martini, V., Moretti, P., Sini, F., Ubiali, A., Poggi, A., Riondato, F.

“…T-zone-like cells of undetermined significance (TZUS) share the same phenotypic pattern (CD45-CD5+) with T-zone lymphoma cells and were first described a few…”
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Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria by Baek, Rena, Coughlan, Kimberly, Jiang, Lei, Liang, Min, Ci, Lei, Singh, Harkewal, Zhang, Hannah, Kaushal, Neeraj, Rajlic, Ivana Liric, Van, Linh, Dimen, Rain, Cavedon, Alexander, Yin, Ling, Rice, Lisa, Frassetto, Andrea, Guey, Lin, Finn, Patrick, Martini, Paolo G. V.

“…Messenger RNA (mRNA) therapeutics delivered via lipid nanoparticles hold the potential to treat metabolic diseases caused by protein deficiency, including…”
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Can peri-surgical electroacupuncture relieve immunity suppression? A pilot study in dogs by Rabbogliatti, V., Brioschi, F.A., Pecile, A., Bronzo, V., Martini, V., Dall’Ara, P., Ravasio, G., Groppetti, D.

“…General anesthesia and surgical stress can suppress the immunological response by acting both directly on the immune system and indirectly on the…”
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mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease by Cao, Jingsong, Choi, Minjung, Guadagnin, Eleonora, Soty, Maud, Silva, Marine, Verzieux, Vincent, Weisser, Edward, Markel, Arianna, Zhuo, Jenny, Liang, Shi, Yin, Ling, Frassetto, Andrea, Graham, Anne-Renee, Burke, Kristine, Ketova, Tatiana, Mihai, Cosmin, Zalinger, Zach, Levy, Becca, Besin, Gilles, Wolfrom, Meredith, Tran, Barbara, Tunkey, Christopher, Owen, Erik, Sarkis, Joe, Dousis, Athanasios, Presnyak, Vladimir, Pepin, Christopher, Zheng, Wei, Ci, Lei, Hard, Marjie, Miracco, Edward, Rice, Lisa, Nguyen, Vi, Zimmer, Mike, Rajarajacholan, Uma, Finn, Patrick F., Mithieux, Gilles, Rajas, Fabienne, Martini, Paolo G. V., Giangrande, Paloma H.

“…Glycogen Storage Disease 1a (GSD1a) is a rare, inherited metabolic disorder caused by deficiency of glucose 6-phosphatase (G6Pase-α). G6Pase-α is critical for…”
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Storage method, drying processes and extraction procedures strongly affect the phenolic fraction of rosemary leaves: An HPLC/DAD/MS study by Mulinacci, N., Innocenti, M., Bellumori, M., Giaccherini, C., Martini, V., Michelozzi, M.

“…The Rosmarinus officinalis L. is widely known for its numerous applications in the food field but also for the increasing interest in its pharmaceutical…”
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mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria by Gurung, Sonam, Timmermand, Oskar Vilhelmsson, Perocheau, Dany, Gil-Martinez, Ana Luisa, Minnion, Magdalena, Touramanidou, Loukia, Fang, Sherry, Messina, Martina, Khalil, Youssef, Spiewak, Justyna, Barber, Abigail R, Edwards, Richard S, Pinto, Patricia Lipari, Finn, Patrick F, Cavedon, Alex, Siddiqui, Summar, Rice, Lisa, Martini, Paolo G V, Ridout, Deborah, Heywood, Wendy, Hargreaves, Ian, Heales, Simon, Mills, Philippa B, Waddington, Simon N, Gissen, Paul, Eaton, Simon, Ryten, Mina, Feelisch, Martin, Frassetto, Andrea, Witney, Timothy H, Baruteau, Julien

“…The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic ammonia and the biosynthesis of arginine. Patients with ASL deficiency…”
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Early effects of bone marrow-derived mononuclear cells on lung and kidney in experimental sepsis by Silva, Carla M., Ornellas, Debora S., Ornellas, Felipe M., Santos, Raquel S., Martini, Sabrina V., Ferreira, Debora, Muiler, Caroline, Cruz, Fernanda F., Takiya, Christina M., Rocco, Patricia R.M., Morales, Marcelo M., Silva, Pedro L.

“…In experimental sepsis, functional and morphological effects of bone marrow-derived mononuclear cell (BMDMC) administration in lung tissue have been evaluated…”
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Outcomes of Fat Grafting in the Active Versus Quiescent Phase of Localized Scleroderma by Wang, Anna, Grünherz, Lisanne, De Martini, Ilaria V., Vasella, Mauro, Giovanoli, Pietro, Lindenblatt, Nicole

“…Introduction: Progressive hemifacial atrophy (PHA) and linear scleroderma (LS) are both rare conditions and defined by atrophy and/or sclerosis of the skin and…”
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Canine small clear cell/T-zone lymphoma: clinical presentation and outcome in a retrospective case series by Martini, V., Marconato, L., Poggi, A., Riondato, F., Aresu, L., Cozzi, M., Comazzi, S.

“…Published studies, taken together, suggest the existence of a single canine lymphoma entity, with a small clear cell appearance by cytological evaluation, a…”
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Cytomorphological description and intra-observer agreement in whole slide imaging for canine lymphoma by Bonsembiante, F., Martini, V., Bonfanti, U., Casarin, G., Trez, D., Gelain, M.E.

“…•A whole slide imaging scanner is a robotic microscope able to digitise a glass slide to a composite digital image.•The cytomorphological capability of a whole…”
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Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism by Cambien, B, Karimdjee, B F, Richard-Fiardo, P, Bziouech, H, Barthel, R, Millet, M A, Martini, V, Birnbaum, D, Scoazec, J Y, Abello, J, Saati, T Al, Johnson, M G, Sullivan, T J, Medina, J C, Collins, T L, Schmid-Alliana, A, Schmid-Antomarchi, H

“…Liver and lung metastases are the predominant cause of colorectal cancer (CRC)-related mortality. Recent research has indicated that CXCR3/chemokines…”
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Prognostic factors in canine acute leukaemias: a retrospective study by Novacco, M., Comazzi, S., Marconato, L., Cozzi, M., Stefanello, D., Aresu, L., Martini, V.

“…Canine acute leukaemias (ALs) have a poor prognosis, with reported survival times (ST) of only a few weeks or months. Also, clinical studies assessing…”
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Canine nodal marginal zone lymphoma: Descriptive insight into the biological behaviour by Cozzi, M., Marconato, L., Martini, V., Aresu, L., Riondato, F., Rossi, F., Stefanello, D., Comazzi, S.

“…Canine nodal marginal zone lymphoma (nMZL) is classified as an indolent lymphoma. Such lymphomas are typified by low mitotic rate and slow clinical…”
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Recent Insights into the Pathogenesis of Acute Porphyria Attacks and Increasing Hepatic PBGD as an Etiological Treatment by Jericó, Daniel, Córdoba, Karol M, Sampedro, Ana, Jiang, Lei, Joucla, Gilles, Cabanne, Charlotte, Lanciego, José Luis, Martini, Paolo G V, Berraondo, Pedro, Ávila, Matías A, Fontanellas, Antonio

“…Rare diseases, especially monogenic diseases, which usually affect a single target protein, have attracted growing interest in drug research by encouraging…”
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European Veterinary Renal Pathology Service: A Survey Over a 7‐Year Period (2008–2015) by Aresu, L., Martini, V., Benali, S.L., Brovida, C., Cianciolo, R.E., Dalla Riva, R., Trez, D., Van Der Lugt, J.J., Van Dongen, A., Zini, E.

“…Background The European Veterinary Renal Pathology Service (EVRPS) is the first Web‐based registry for canine renal biopsy specimens in Europe…”
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Photochemical performance and source-sink relationships in galls induced by Pseudophacopteron longicaudatum (Hemiptera) on leaves of Aspidosperma tomentosum (Apocynaceae) by MARTINI, V., MOREIRA, A.S.F.P., KUSTER, V.C., OLIVEIRA, D.C.

“…The establishment of the galling insect generates a biotic stress that leads to tissue transformation. However, galls can maintain chlorophyll (Chl) and…”
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